Development Work (all quotations are in Euros Clause Samples

Development Work (all quotations are in Euros. €; (pro memoriam, as of Oct.14, ’11, the US $ / € exchange rate was 1.38) · Objective: Define the best conditions for the preparation of BA-058 peptide. First of all, Lonza will have to define clearly which parameters have influenced the unexpected high yield in the C2 campaign. Moreover, Lonza needs to investigate the chemistry to ensure repeatability / reproducibility of such results for future campaigns. Various criteria will have to be evaluated. 1. Concerning raw materials: · In order to achieve the same quality for future campaigns, Lonza will have to test different resin suppliers and qualify at least two of them. · Specifications of the starting resin should then be modified in order to fit the defined parameters. 2. Concerning process, Lonza will have to challenge the different steps. · Loading: a) use of preloaded resin or in-house loading? b) working range of loading. It has to be defined in terms of productivity and quality of the resulting crude material. · Assembly: a) Identification of critical impurities in the crude coming from mono deletion or double addition. This analysis will be performed based on impurities present in C1 and C2 materials. · Cleavage: a) Define the best conditions of cleavage in order to minimize impurities linked to this step (almost 15% HPLC area for two impurities formed during this cleavage step). · Purification: a) Assessment of the potential impact of upstream development work on the purification process. b) Development of UPLC method for in process control corresponding to FG1 method (analysis time reduction). · Deliverables: Upstream (7 to 8 weeks) · Development work - experimental part € [*] · Process development report — Compilation of the process knowledge (C1, C2, and development work) € [*] Downstream (2 to 3 weeks) · Development work - experimental part € [*] · Process development report — Compilation of the process knowledge (C1, C2, and development work) € [*] In order to reach Radius target in terms of price and timing, it has been decided to reduce tests performed during this development work. Quotation for development activities (in Euros €): € 50,000 (Breakdown: see quotation for each activity; duration: almost 2.5 months with activities performed in parallel).
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Development Work (all quotations are in Euros. €; (pro memoriam, as of Oct.14, ’11, the US $ / € exchange rate was 1.38) · Objective: Define the best conditions for the preparation of BA-058 peptide. First of all, Lonza will have to define clearly which parameters have influenced the unexpected high yield in the C2 campaign. Moreover, Lonza needs to investigate the chemistry to ensure repeatability / reproducibility of such results for future campaigns. Various criteria will have to be evaluated. 1. Concerning raw materials: · In order to achieve the same quality for future campaigns, Lonza will have to test different resin suppliers and qualify at least two of them. · Specifications of the starting resin should then be modified in order to fit the defined parameters. 2. Concerning process, Lonza will have to challenge the different steps. · Loading: a) use of preloaded resin or in-house loading? b) working range of loading. It has to be defined in terms of productivity and quality of the resulting crude material. · Assembly: a) Identification of critical impurities in the crude coming from mono deletion or double addition. This analysis will be performed based on impurities present in C1 and C2 materials. · Cleavage: a) Define the best conditions of cleavage in order to minimize impurities linked to this step (almost 15% HPLC area for two impurities formed during this cleavage step). · Purification:
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Related to Development Work (all quotations are in Euros

  • DEVELOPMENT OR ASSISTANCE IN DEVELOPMENT OF SPECIFICATIONS REQUIREMENTS/ STATEMENTS OF WORK

  • Development Work The Support Standards do not include development work either (i) on software not licensed from CentralSquare or (ii) development work for enhancements or features that are outside the documented functionality of the Solutions, except such work as may be specifically purchased and outlined in Exhibit 1. CentralSquare retains all Intellectual Property Rights in development work performed and Customer may request consulting and development work from CentralSquare as a separate billable service.

  • SPECIFIC TERMS FOR THIRD PARTY COMPONENTS The specific terms relating to the use of certain third party components or products not developed by or for a DS Group Company and granted to Customer to be used in connection with or within a DS Offering are defined hereafter:

  • Sector Sub-Sector Industry Classification Level of Government Type of Obligation Description of Measure Source of Measure All sectors : : - : Central : National Treatment Senior Management and Board of Directors : National Treatment and the Senior Management and Board of Directors obligations shall not apply to any measure relating to small and medium sized domestic market enterprise2. Foreign equity is restricted to a maximum of 40% for domestic market enterprises with paid-in equity capital of less than the equivalent of USD 200,000 Note: Members of the Board of Directors or governing body of corporation or associations shall be allowed in proportion to their allowable participation or share in the capital of such enterprises. : -1987 Constitution of the Republic of the Philippines. - Foreign Investments Act of 1991 (R.A. No. 7042, as amended by R.A. No. 8179). -Presidential and Administrative Issuances. ∞ 2 The concept of a small and medium sized domestic market enterprise is an enterprise with paid in equity capital of less than the equivalent of USD 200,000.00.

  • Supplier Development lf the Buyer identifies problems in supplier performance based on supplier monitoring, he shall initiate improvement measures at the Supplier. The Buyer shall pursue the possibilities of continuous improvement of the Supplier. The supplier audit is a form of supplier development; the exchange of information and experience between the Buyer and the Supplier also serves this purpose.