Macrocyclisation by metathesis reaction Clause Samples

Macrocyclisation by metathesis reaction. Biology evaluation In Selvita. Biological evaluation in Selvita will be based on determination of kinase inhibitory activity of synthesized compounds using the commercially available ADP-Glo system already installed and qualified by Selvita. The compounds also will be tested for their effect on cell viability assay against selected cell line (or cell lines). Exhibit A Computational chemistry evaluation. Initial period of the project requires computational analysis of various DYRK1 inhibitors. This includes Selvita initial compounds, Felicitex identified hits as well as chosen literature compounds. Conclusions from docking studies will be the basis for designing of initial proposal for the macro cyclic inhibitors (Figure 17).
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