Modeling exposure assessment Clause Samples

Modeling exposure assessment. Deterministic exposure assessments are straightforward spreadsheet calculations that do not take into account the demographic diversity, variability or uncertainty of an exposure assessment. These calculations are typically performed using simple tools such as Microsoft Excel. The result is intended to be a conservative point value estimate which is thought to be well above any realistic range of exposure, but does not provide any estimate of how likely the exposure would be to occur. Simplistic probabilistic exposure assessments can be performed by products like @Risk or Crystal Ball where probability distributions are used to quantify uncertainty and variability in the inputs and outputs of exposure assessment. Specific food safety exposure assessment models have been developed which allow more detailed probabilistic models to be used, these models include the CREMe 2.0 model (▇▇▇.▇▇▇▇▇▇▇▇▇▇▇▇▇.▇▇▇), the MCRA model (RIKILT) and the CSL model. These tools have allowed uncertainty and variability to be quantified in more detailed exposure assessments. Issues with the current state of the art include the following. Although current deterministic methods are thought to be conservative – or perhaps over-conservative – their true relation to actual intakes has not been established. Therefore it is not known whether they provide an appropriate level of protection for consumers. The existing probabilistic models require data from detailed food consumption surveys. They are thus restricted to the minority of EU member states where which such data exist, and their benefits cannot be realised for EU-level assessments. The existing probabilistic models quantify only a few of the uncertainties affecting dietary intakes, typically only sampling uncertainty for consumption and concentrations. Consequently, confidence intervals produced by these models represent only part of the overall uncertainty. In practice, many current exposure assessments follow standard screening procedures that are intended to produce conservative estimates of exposure. These screening assessments do not involve an analysis of uncertainty, provided that they include conservative assumptions. The requirement for increased transparency in risk assessment in food has been articulated in recent publications by the European Commission. Furthermore, it is necessary to characterise scientific uncertainty so that risk managers can determine when to take appropriate measures and where best to target the...

Related to Modeling exposure assessment

  • Environmental Site Assessment Perform in accordance with the City Design Manual and other City requirements as designated in writing by the Director.

  • Environmental Assessment Buyer shall have the right for a period commencing upon execution of this Agreement by both parties and ending on November 28, 2012, to conduct an environmental assessment of the Assets, at Buyer’s sole risk, liability and expense. Seller shall make available to Buyer, during the environmental assessment period described above, Seller’s historical files regarding prior operations on the Assets, and provide Buyer and its representatives with reasonable access to the Assets to conduct the environmental assessment. Buyer shall provide Seller three (3) days prior written notice of a desired date(s) for such assessment and Seller shall have the right to be present during any assessment and, if any testing is conducted pursuant to Seller’s express prior written consent, Seller may require splitting of all samples. Notwithstanding any other provision of this Agreement to the contrary, Buyer shall not have the right to drill any test, monitor or other ▇▇▇▇▇ or to extract samples of any air, soil, water or other substance from the Assets without Seller’s express prior written consent. If Buyer proposes a reasonable request to drill a test well or extract a sample pursuant to a systematic and customary procedure for the assessment of the environmental condition of the Assets and Seller refuses to grant its consent to such a well or sampling, then Buyer shall have the right, for a period of seventy-two (72) hours following notification of Seller’s refusal to consent, to deliver written notice to Seller of Buyer’s election to exclude from this transaction the portion of the Assets affected by such proposed test well or sample, and the Purchase Price shall be adjusted accordingly by the Allocated Value of such portion of the Assets so excluded. Under no circumstances whatsoever shall Seller ever be obligated to grant its consent to any such test ▇▇▇▇▇ or sampling proposed by Buyer, and Buyer’s sole and exclusive remedy for any refusal by Seller to grant its consent shall be the limited right contained in the preceding sentence to exclude the affected Assets from the transactions contemplated by this Agreement. If Buyer fails to exercise the right to exclude such Assets by written notice to Seller delivered prior to the expiration of the seventy-two hour period described above, then Buyer shall be conclusively deemed to have waived such right and shall be obligated to purchase the affected Assets without conducting such testing or sampling or any adjustment of the Purchase Price unless otherwise provided in this Agreement.

  • Environmental Assessment and Mitigation Development of a transportation project must comply with applicable environmental laws. The party named in article 1, Responsible Parties, under AGREEMENT is responsible for the following: A. The identification and assessment of any environmental problems associated with the development of a local project governed by this Agreement. B. The cost of any environmental problem’s mitigation and remediation. C. Providing any public meetings or public hearings required for the environmental assessment process. Public hearings will not be held prior to the approval of Project schematic. D. The preparation of the NEPA documents required for the environmental clearance of this Project. If the Local Government is responsible for the environmental assessment and mitigation, before the advertisement for bids, the Local Government shall provide to the State written documentation from the appropriate regulatory agency or agencies that all environmental clearances have been obtained.

  • No Material Deterioration in Financial Condition; Financial Statements All consolidated financial statements for Borrower and its Subsidiaries, delivered to Collateral Agent fairly present, in conformity with GAAP, in all material respects the consolidated financial condition of Borrower and its Subsidiaries, and the consolidated results of operations of Borrower and its Subsidiaries. There has not been any material deterioration in the consolidated financial condition of Borrower and its Subsidiaries since the date of the most recent financial statements submitted to any Lender.

  • SITE EXAMINATION Contractor has examined the Site and certifies that it accepts all measurements, specifications and conditions affecting the Work to be performed at the Site. By submitting its quote, Contractor warrants that it has made all Site examination(s) that it deems necessary as to the condition of the Site, its accessibility for materials, workers and utilities, and Contractor’s ability to protect existing surface and subsurface improvements. No claim for allowance of time or money will be allowed as to any other undiscovered condition on the Site.