Common use of Position; Duties Clause in Contracts

Position; Duties. The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice President, Chief Medical Officer. In this position, the Executive shall report to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control of the CEO and the Board of Directors of the Company (the “Board”)), support and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee of the Company, the Executive will devote his full business time and efforts to the Company, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoing, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment with the Company and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needs.

Position; Duties. The Executive’s Executive shall continue employment with the Company shall commence on September under the terms of this Agreement effective as of March 1, 2014 2008 (the “Commencement Effective Date”). . (a) While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice President, Chief Medical Officer. In this position, the Executive shall report to the Company’s President and Chief Executive Officer (“CEO”) and of the Company. The Executive shall have such duties, authorities and responsibilities as are customary with his positionposition in a Delaware corporation, including general supervision supervision, direction and direction of all clinical drug development activities (subject to the control of the CEO business and officers of the Company, subject to control of the Board of Directors of the Company (the “Board”))) and its committees, support and management of day-to-day clinical operations, strategic planning activities as well as shall perform such other duties as reasonably requested by the CEO Board (the “Primary Responsibilities”). The Executive shall report directly to the Board. The Executive shall also serve as a member of the Board to the extent nominated pursuant to the Third Amended and Restated Stockholders Agreement dated as of December 22, 2006, as amended to date and as it may be amended hereafter from time to time, or if otherwise nominated by the stockholders of the Company. (b) As an employee of the Company, the Executive will devote his full primary business time and efforts to the Company, and will not engage in any other gainful employment during the term hereof without the prior written consent of the CEOBoard; provided, however that nothing in this Agreement shall prevent the Executive from serving as a director of Tokai Pharmaceuticals, Inc. or continuing as a venture partner of Apple Tree Partners, provided that such activities do not interfere with the Executive’s obligations to the Company. In addition, nothing in this Agreement shall prevent the Executive from engaging in any of the following activities outside of normal working hours: (i) managing personal investments and affairs and the personal investments and affairs of any of the Executive’s family members (provided that no such investment may exceed five percent (5%) of the equity securities of any entity without prior notice to the Board and further provided that nothing herein shall limit any investment in an entity whose primary purpose is not the day-to-day operation of a particular business); (ii) acquiring any interest in any entity, whether or not part of a control group, that is directly or indirectly owned or controlled, in whole or in part, by the Executive and/or one or more members of his family, or a partnership, trust or other entity held by or for the benefit of the Executive and/or one or more members of his family, and/or (iii) performing services for any entity, whether or not part of a control group, that is directly or indirectly owned or controlled, in whole or in part, by the Executive and/or one or more members of his family, or a partnership, trust or other entity held by or for the benefit of the Executive and/or one or more members of his family; provided, however, that any such services shall be insubstantial and shall not include any active involvement in the management of such entity. The Executive shall report his activities on behalf of Apple Tree Partners to the Board with such frequency and detail as any Board member may reasonably request from time to time, provided, however, that the Executive shall not be required to disclose any confidential information. The Executive shall also be required to comply with all published Company policies and procedures as in effect from time to timelime. Without limiting the foregoing, in particular, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment with the Company and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needs.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1Employment Term, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice Presidentthe Company’s Chairman, President and Chief Medical Executive Officer. In this such position, the Executive shall report to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control of the CEO and the Board of Directors of the Company (the “Board”))) and the Board of Directors of American Media, support Inc. (the “Parent”) (the “Parent Board”) and management shall have duties, responsibilities and authority commensurate with his position as Chairman, President and Chief Executive Officer of the Company, subject to reasonable and customary oversight and review by the Board; provided that it is understood that the day-to-day clinical operations, strategic planning activities ordinary course operations of the Company will be managed by Executive without requirement for approval of the Board. (b) Executive also shall be a member of the Board and the Parent Board at all times during which the Executive is serving as well as such other duties as reasonably requested by the CEO (the “Responsibilities”)Company’s President and Chief Executive Officer. As While Executive remains an employee of the Company, Executive agrees to serve as a member of the Board and the Parent Board at no additional compensation. (c) During the Employment Term, Executive will devote his full business time and best efforts to the Company, performance of his duties hereunder and will not engage in any other gainful employment business, profession or occupation for compensation or otherwise which would materially conflict with the rendition of such services either directly or indirectly, without the prior written consent of the CEO. The Board; provided that nothing herein shall preclude Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoing, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted continuing to serve on the scientific advisory board and/or of directors or trustees of any business corporation or any charitable organization on which he currently serves and which is identified on Exhibit A hereto or, subject to the prior approval of the Board (which approval shall not be unreasonably withheld), from accepting appointment to any additional directorships or trusteeships (other than additional charitable or civic directorships which shall not require Board approval), provided in each case, and in the aggregate, that such activities do not materially interfere with the performance of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment duties hereunder or conflict with the Company and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the CompanySection 8. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needs.

Position; Duties. (a) The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice President, the Chief Medical OfficerCompliance Officer (the “Position”) of the Company and of additional companies within the Group. In this position, the The Company and INX Services should be jointly known as “INX US”. The Executive shall report directly to the Company’s Chief Executive Officer Mr. Shy Datika (“CEOSupervising Officer”) and or to any other person designated for such purpose by him. (b) The Executive shall have such duties, authorities and responsibilities as are customary commensurate with his position, including general supervision such position and direction of all clinical drug development activities (subject to such other duties and responsibilities as the control of the CEO and the Company’s Board of Directors of the Company (the “Board”) and INX Limited’s Board of Directors (the “INX Ltd Board”) shall designate that are consistent with the Executive’s position (the “Services”)). The Executive’s Services shall include but not be limited to: (i) Coordinate the preparation and filing of applications to money transmitter authorities, support the Financial Industry Regulatory Authority, and management the Commodity Futures Trading Commission for money transmitter, Broker-Dealer, ATS, SEF, DCM and other similar licenses and approvals, as shall be instructed by the Supervising Officer or other officers of daythe Group; (ii) Establish effective supervision and control of the Company and INX US’s activities to ensure it complies with applicable laws and regulations; (iii) Establish anti-tomoney laundering and know-day clinical operationsyour-client policies and procedures for INX US for the onboarding and continuous monitoring of customers; (iv) Daily review for errors, strategic planning unusual activities, and compliance with all applicable laws and regulations according to INX US policies; (v) Coordinate staff training programs to keep INX US employees and officers aware of changes and updates in applicable legislation; (vi) Monitor INX US’s marketing activities as well as such the sales practices of INX US representatives in order to adhere to compliance policies of INX US; (vii) Participate in various meetings of the management of the Group (in person or via remote communication, as shall be desirable for effective participation); and (viii) Perform all other duties tasks customarily related to the Position. (c) During the Employment Term, the Executive agrees to devote his full business time, attention and energies to the performance of all of the lawful duties, responsibilities and authority that may be assigned to him hereunder. Nothing contained in this Agreement will preclude the Executive from (i) devoting time to personal and family investments, (ii) serving as reasonably requested a director of any not-for-profit company, (iii) serving as a director for-profit company that is pre-approved by the CEO Board, or (iv) from participating in charitable or industry associations, in each case, provided that such activities or services do not (x) materially interfere with the “Responsibilities”Executive’s performance of duties hereunder or (y) violate the terms of the Confidentiality Agreement (as defined below). As an employee of . (d) Upon the Executive’s termination from the Company for any reason, unless otherwise specified in a written agreement between the Executive and the Company, the Executive will devote his full business time and efforts be deemed to the Companyhave resigned from all offices, directorships, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoingpositions if any, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment then held with the Company or any of its affiliates, and it does not violate agrees to take all actions reasonably requested by the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and Company to effectuate the Companyforegoing. (ae) Location: The Company and During the Executive agree that Executive will work a minimum term of three business days per week this Agreement, the Executive’s principal place of engagement shall be in the Company’s headquarters (currently CambridgeNew York City Metropolitan Area, MA). subject to customary business travel consistent with the Executive’s schedule will be agreed upon between Executive duties and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsresponsibilities.

Position; Duties. The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreementa) Except as provided in Section 2(b) below, the Executive shall serve as Senior Vice Presidentthe Chairman and Chief Executive Officer of the Company and its US subsidiary, Eloxx Pharmaceuticals U.S. Sub, Inc. during the Employment Term. As Chairman and Chief Medical Executive Officer. In this position, the Executive shall report to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary commensurate with his position, including general supervision the position of Chairman and direction of all clinical drug development activities (subject to Chief Executive Officer and such other duties and responsibilities as the control of the CEO and the Company’s Board of Directors of the Company (the “Board”))) shall designate that are consistent with the Executive’s position as Chairman and Chief Executive Officer. (b) During the Employment Term, support the Executive agrees to devote his full business time, attention and management energies to the performance of dayall of the lawful duties, responsibilities and authority that may be assigned to him hereunder. Nothing contained in this Agreement will preclude the Executive from (i) devoting time to personal and family investments, (ii) serving as a director of any not-tofor-day clinical operationsprofit company, strategic planning activities (iii) serving as well as such a director for Akari Therapeutics and any other duties as reasonably requested for-profit company that is approved by the CEO Board (such approval not to be unreasonably withheld) or (iv) from participating in charitable or industry associations, in each case, provided that such activities or services do not (x) materially interfere with the “Responsibilities”Executive’s performance of duties hereunder or (y) violate the terms of the Confidentiality Agreement (as defined below). (c) During the Employment Term, the Executive shall serve as a member of the Board, and the Executive agrees to serve as a member of the Board without additional compensation. As an employee Upon the Executive’s termination of employment from the Company for any reason, unless otherwise specified in a written agreement between the Executive and the Company, the Executive will devote his full business time and efforts be deemed to the Companyhave resigned from all offices, directorships, and will not engage in other employment positions if any, then held with the Company or any other gainful employment without of its affiliates, and agrees to take all actions reasonably requested by the prior written consent of the CEO. The Executive shall also be required Company to comply with all Company policies and procedures as in effect from time to time. Without limiting effectuate the foregoing. (d) During the Employment Term, the Executive will in particular Executive’s principal place of employment shall be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted offices in Waltham, Massachusetts, subject to serve on customary business travel consistent with the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment with the Company duties and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Companyresponsibilities. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needs.

Position; Duties. The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreementa) Except as provided in Section 2(b) below, the Executive shall serve as Senior Vice President, the Company’s President and Chief Medical Executive Officer during the Employment Term. As President and Chief Executive Officer. In this position, the Executive shall report to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary commensurate with his position, including general supervision the position of President and direction of all clinical drug development activities (subject to Chief Executive Officer and such other duties and responsibilities as the control of the CEO and the Company’s Board of Directors of the Company (the “Board”) shall designate that are consistent with the Executive’s position as President and Chief Executive Officer. (b) During the Employment Term, the Executive agrees to devote his full business time, attention and energies to the performance of all of the lawful duties, responsibilities and authority that may be assigned to him hereunder. Nothing contained in this Agreement will preclude the Executive from (i) devoting time to personal and family investments, (ii) serving as a director of any not-for-profit company or (iii) from participating in charitable or industry associations, in each case, provided that such activities or services do not (x) materially interfere with the Executive’s performance of duties hereunder or (y) violate the terms of the Confidentiality Agreement (as defined below)). (c) During the Employment Term, support the Executive shall serve as a member of the Board, and management the Executive agrees to serve as a member of day-to-day clinical operationsthe Board without additional compensation. Upon the Executive’s termination of employment from the Company for any reason, strategic planning activities as well as such other duties as reasonably requested by unless otherwise specified in a written agreement between the CEO (the “Responsibilities”). As an employee of Executive and the Company, the Executive will devote his full business time and efforts be deemed to the Companyhave resigned from all offices, directorships, and will not engage in other employment positions if any, then held with the Company or any other gainful employment without of its affiliates, and agrees to take all actions reasonably requested by the prior written consent of the CEO. The Executive shall also be required Company to comply with all Company policies and procedures as in effect from time to time. Without limiting effectuate the foregoing. (d) During the Employment Term, the Executive will in particular Executive’s principal place of employment shall be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted offices in Cambridge, Massachusetts, subject to serve on customary business travel consistent with the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment with the Company duties and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Companyresponsibilities. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needs.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this AgreementEmployment Term, the Executive shall serve as Senior Vice President, the Chief Medical OfficerFinancial Officer of the Company. In this positioncapacity the Executive shall be responsible to lead and manage the operations of the Company that are related to finance and capital market, including, but is not limited to, providing expertise in making financial plan and strategy, accompanying the Company’s investment bankers and investor relations professionals to meeting with investors, analysts and other market professionals, and working with the Company’s U.S. legal counsel and auditors to implement, monitor and oversee the Company’s compliance with the requirements of the ▇▇▇▇▇▇▇▇-▇▇▇▇▇ Act, the Securities Act of 1933, the Exchange Act of 1934, and the listing rules as a public company and to advise the Board of Directors (the “Board”) with respect to the Company’s internal controls and procedures, including disclosure controls and procedures. (b) During the Employment Term, the Executive shall report directly to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control of the CEO and the Board of Directors of the Company (the “Board”)), support and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee of the Company, the Executive will devote his full business time and efforts to the Company, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required obey the lawful directions of the Chief Executive Officer and the Board to comply with all whom the Executive reports and shall use his diligent efforts to promote the interests of the Company policies and procedures as to maintain and promote the reputation thereof. (c) Unless the Parties agree otherwise in effect writing, during the Employment Term, the Executive shall perform the services contemplated by this Agreement at the Executive’s office located in River Vale, New Jersey in the United States; provided, however, that the Company may, from time to time, require the Executive to travel for up to an aggregate of five (5) months per annum to other locations on the Company's business. Without limiting Notwithstanding the foregoing, nothing in this Agreement is to be construed as prohibiting the Executive will in particular be required from serving as a director of other entities whether or not for profit, so long as his service as such does not substantially prevent or prohibit the Executive from effectively discharging his duties hereunder and such positions are disclosed to familiarize himself with the Board. (d) During the Employment Term, the Executive shall lead and to comply with coordinate the Company’s published policy prohibiting unlawful harassment investor relations activities which shall include, but is not limited to, communications with investors, analysts and discrimination media, and its published policy concerning drugs the Company’s public disclosure, and alcohol. Executive shall be permitted to serve on implement and monitor the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors corporate governance of the Company and such service does not create a conflict of interest with Executive’s employment in complianpartce with the Company applicable laws and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between regulations. The Executive and the Company. (a) Location: The Company and the Executive agree that Executive will shall work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting conjunction with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs other members of the Company may from time-to-time require Executive executive management team to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by support the Company’s business needsgrowth. (e) During the Employment Term, in the event that the Company engages in any capital markets activities, the Executive shall take a leading role in such transactions by overseeing underwriters, counsels and auditors, and preparing and/or reviewing requisite documentations in connection with such transactions.

Position; Duties. The Executive’s employment (a) During the Term, you will hold the title and office, and serve in the position of, Chairman of the Board of Directors, with such duties and authority as provided in the Amended and Restated By-laws of the Company shall commence on September 1, 2014 (the “Commencement Date”as amended from time to time). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice President, Chief Medical Officer. In this position, the Executive You shall report directly to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control of the CEO and the Board of Directors and, in addition to the foregoing, shall assist and advise the Company with respect to strategic and transactional matters and shall perform such other specific duties and services (including service as a director or equivalent position of any subsidiary or affiliate of the Company (Company, without additional compensation) as the “Board”)), support and management Board of day-to-day clinical operations, strategic planning activities as well as such other duties as Directors shall reasonably requested by the CEO (the “Responsibilities”)request consistent with your position. As You shall not be an employee of the CompanyCompany or any of its subsidiaries, the Executive will devote his full business time and efforts any services you provide to the Company, and will not engage Company shall be provided solely in any other gainful employment without the prior written consent your capacity as Chairman of the CEO. The Executive Board of Directors. (b) During the Term, you shall also be required not take personal advantage of any business opportunity relating to comply the operation of tankers transporting crude oil or other petroleum products anywhere in the world if such opportunity is or reasonably could become competitive with all the business of the Company policies and procedures as in effect from or any natural expansion of the business of the Company within the tanker industry at the time to of such opportunity, or a business that the Company is actively contemplating entering at such time. Without limiting You further agree to disclose in writing all such opportunities and the foregoingmaterial facts attendant thereto, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment with the Company and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required consideration by the Company’s . If within ten (10) business needsdays of your disclosing such business opportunities to the Board of Directors, the Board of Directors fails to adopt a resolution (and to provide a ▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇ October 24, 2008 Page 3 copy of same to you) that it may pursue such business opportunity, the Company will be deemed to have declined to pursue such opportunity, in which event you shall be free to pursue it. You shall be at liberty to take personal advantage of any other business opportunities, whether or not such opportunities arise during the performance of your services hereunder and whether or not such opportunities could reasonably be expected to be business opportunities that the Company might pursue.

Position; Duties. (a) The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice President, Chief Medical Officerthe General Counsel (the “Position”) of the Company and of additional companies within the Group. In this position, the The Executive shall report directly to ▇▇. ▇▇▇▇ ▇▇▇▇▇▇▇ (“Supervising Officer”) or to any other person designated for such purpose by him or, if ▇▇. ▇▇▇▇ ▇▇▇▇▇▇▇ is no longer at the Company, to the CEO or President (or equivalent role) of the Company’s Chief . (b) The Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary commensurate with his position, including general supervision such position and direction of all clinical drug development activities (subject to such other duties and responsibilities as the control of the CEO and the Company’s Board of Directors of the Company (the “Board”)), support ) and management INX Limited's Board of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by Directors (the CEO "INX Ltd Board") shall designate that are consistent with the Executive’s position (the “ResponsibilitiesServices”). As If there is a conflict between the instructions or delegation of duties, the Board will control. The Executive’s Services shall include but not be limited to: (i) Develop and lead corporate legal strategy to promote and protect the company’s matters; (ii) Oversee delivery of legal services and resources to accomplish corporate goals, strategies, and priorities; (iii) Maintain proper corporate interactions with the relevant local, state and federal government bodies, legislatures and the community at large; (iv) Advising the Supervising Officer and other senior corporate officers on a variety of issues; (v) Developing and leading internal audit and corporate compliance programs; (vi) Participate in the formulation of general management policy as a member of the executive management team; and (vii) Manage a team of corporate counsel and other members of the legal department. (c) During the Employment Term, the Executive agrees to devote her full business time, attention and energies to the performance of all of the lawful duties, responsibilities and authority that may be assigned to heri hereunder. Nothing contained in this Agreement will preclude the Executive from (i) devoting time to personal and family investments, (ii) serving as a director of any not-for-profit company, (iii) serving as a director for-profit company that is pre-approved by the Board, (iv) from participating in charitable or industry associations, or (v) acting as an employee unpaid advisor to other companies pre-approved by the Board, in each case, provided that such activities or services do not (x) materially interfere with the Executive’s performance of duties hereunder or (y) violate the terms of the Confidentiality Agreement (as defined below). (d) Upon the Executive’s termination from the Company for any reason, unless otherwise specified in a written agreement between the Executive and the Company, the Executive will devote his full business time and efforts be deemed to the Companyhave resigned from all offices, directorships, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoingpositions if any, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment then held with the Company or any of its affiliates, and it does not violate agrees to take all actions reasonably requested by the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and Company to effectuate the Companyforegoing. (ae) Location: The Company and During the Executive agree that Executive will work a minimum term of three business days per week this Agreement, the Executive’s principal place of engagement shall be in the Company’s headquarters (currently CambridgeNew York City Metropolitan Area, MA). subject to customary business travel consistent with the Executive’s schedule will be agreed upon between Executive duties and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsresponsibilities.

Position; Duties. The Executive’s employment with Employee shall be employed in the position of Chairman of the Board ("Chairman") and, commencing upon the date of the proposed reorganization pursuant to which Company shall commence on September 1, 2014 will become a public holding company (the “Commencement "Reorganization Date”"). While employed by the Company under the terms of this Agreement, the Executive Employee shall serve as Senior Vice President, Chief Medical Officer. In this position, the Executive shall report to the Company’s also become Chief Executive Officer (“CEO”) of Company. Between the Effective Date and shall have such dutiesthe Reorganization Date, authorities and responsibilities Employee will serve as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control Acting Chief Executive Officer of the CEO and Company. Notwithstanding the Board of Directors of the Company (the “Board”))foregoing, support and management of at no time shall Employee assume day-to-day clinical operationsoperational and/or direct managerial control over the Company's existing electronics components business, strategic planning activities as well as such other which duties as reasonably requested shall at all times remain with and be performed by ▇▇▇ ▇▇▇▇ in accordance with the CEO (the “Responsibilities”). As an employee terms of the employment agreement, as amended, between ▇▇. ▇▇▇▇ and the Company. During the Term, the Executive Employee will devote his full business time and best efforts to the Company, Company and will not engage in any other gainful outside employment or business (whether for compensation or otherwise) without the prior written consent of Company's Board of Directors. Employee shall at all times faithfully, industriously and to the CEObest of Employee's ability, experience and talent perform all of the duties that may be assigned to Employee hereunder. The Executive services to be rendered by Employee shall also include, without limitation, all services customarily rendered by persons engaged in the same capacity or in a similar capacity in the Internet industry, and such other services as may be required to comply with all reasonably requested by Company policies and procedures as in effect from time to time. Without limiting the foregoing, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive Employee shall be permitted to serve on responsible for the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors day-to-day operation of the Company and its businesses. Employee's responsibilities shall specifically include, but not be limited to, directing the operations of the Company's in-house public relations, investor relations, investment banking and Internet functions, with responsibility for originating, negotiating and closing all contracts and other agreements related thereto; provided, however, that Employee may hire and/or designate all such service does persons reasonably necessary to carry out these functions under Employee's general supervision. Notwithstanding the foregoing, however, this Agreement shall not create a conflict be interpreted to prohibit Employee from making personal investments, serving on other boards of interest with Executive’s employment directors and advisory boards, attending educational classes, or conducting private business affairs if those activities do not materially interfere with the Company and it does services required under this Agreement, provided that Employee shall not violate the Confidentialitydirectly or indirectly acquire, Inventionshold or retain any material interest in any business competing, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridgedirectly or indirectly, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the business of Company’s business needs, except for investments in mutual and other similar funds.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1, 2014 Employment Term (the “Commencement Date”as defined in Section 2 below). While employed by the Company under the terms of this Agreement, the Executive shall serve the Company in the following positions: (i) from the Effective Date (as Senior defined below) through July 31, 2015, as an Executive Vice President, reporting to Paul Mar▇▇▇▇▇, ▇▇▇ ▇▇mpany’s Chief Medical Executive Officer. In this position; and (ii) commencing August 1, 2015 for the Executive shall report to duration of the Employment Term, as the Company’s Chief Executive Officer Officer, reporting to the Company’s Board of Directors (the “CEOBoard”) and ). The Executive shall have such duties, authorities and responsibilities as are customary responsibilities, commensurate with his such position, including general supervision as the Board shall determine from time to time. (b) During the Employment Term (as defined below), the Executive agrees that the Executive will devote all of his business time and direction of all clinical drug development activities (subject attention to the control of the CEO and the Board of Directors of the Company (the “Board”)), support and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee business of the Company, that the Executive will devote use his full business time and best efforts to perform his duties and responsibilities for the CompanyCompany in a faithful and efficient manner, and that the Executive will not engage in any other gainful employment without employment, consulting, business or charitable activity that would create a conflict of interest with the prior written consent Company or any of its affiliates or otherwise impair the CEOExecutive’s ability to effectively perform his duties with the Company. The Executive shall also be required agrees that he has no contractual commitments or other legal obligations that would prohibit him from commencing employment with the Company, or that would in any way limit his ability to comply with all Company policies and procedures as in effect from time perform his duties for the Company. Subject to time. Without limiting the foregoingBoard approval, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to may serve on the scientific board of directors or advisory board and/or the Board boards of Directors of private or public other for profit companies so long as the companies are not competitors of the Company and provided that such service does not create a potential business conflict or the appearance thereof. Nothing in this Agreement shall prevent the Executive from managing his family’s personal investments so long as such activities do not materially interfere with the performance of interest with the Executive’s employment with duties hereunder or create a potential business conflict or the appearance thereof. In addition, the Company acknowledges that for a limited period of time the Executive may provide transition support to his former employer. The Executive agrees that such transition support will be provided other than as an officer, director or employee, will not continue for more than 30 days following the Effective Date, and it does will not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and materially interfere with his obligations to the Company. (ac) Location: The Upon or promptly following August 1, 2015 and subject to the Executive’s employment by the Company on that date, the Board shall appoint the Executive as a member of the Board. During the Employment Term, the Board shall nominate the Executive for re-election as a member of the Board at the expiration of the Executive’s then-current term. (d) While the Executive’s relocation contemplated by Section 7(c) is pending, the Company and the Executive will mutually agree that Executive will work on the Executive’s place of employment, and the Executive’s employment may be by a minimum subsidiary of three business days per week in the Company. After such relocation, the Executive’s principal place of employment shall be at the Company’s headquarters (currently Cambridge, MA). in the Los Angeles metropolitan area and Executive’s schedule will employment during the Employment Term (as such term is defined below) shall be agreed upon between by the Company. (e) During the Employment Term, the Executive shall be provided with appropriate office and the CEO. It is understood that, in addition to managing secretarial support at the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsprincipal executive offices.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1, 2014 Transition Employment Term (the “Commencement Date”as defined in Section 2). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice Presidentthe Chief Operating Officer and President of the Company, Chief Medical Officeras set forth in Section 2. In this positionsuch capacities, the Executive shall report to the Company’s Chief Executive Officer. Immediately subsequent to the Transition Employment Term, the Executive shall serve as the Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control President of the CEO Company, as set forth in Section 2. Upon appointment as Chief Executive Officer, the Executive shall no longer serve as Chief Operating Officer but shall continue in his position as President. In his positions as Chief Executive Officer and President, the Executive shall report exclusively to the Board of Directors of the Company (the “Board”)), support and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by . At the CEO (the “Responsibilities”). As an employee first regularly scheduled meeting of the Board following the end of the Transition Employment Term, the Board (and its Governance and Nominating Committee) will consider a proposal to increase the size of the Board from nine (9) members to ten (10) members and to appoint the Executive to serve as a member of the Board. (b) In each of his respective capacities the Executive shall have the duties, authorities and responsibilities for such positions set forth in the Company’s Code of Regulations. In addition, the Executive will devote his full business time shall have the duties, authorities and efforts responsibilities (to the Company, and will extent not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoing, the Executive will in particular be required to familiarize himself with and to comply inconsistent with the Company’s published policy prohibiting unlawful harassment Code of Regulations) commensurate with the duties, authorities and discrimination responsibilities of persons in similar capacities in similarly sized companies and its published policy concerning drugs such other duties and alcohol. responsibilities as the Chief Executive Officer or the Board, as applicable pursuant to Section 1(a), shall designate that are consistent with the Executive’s positions under this Agreement. (c) During the Employment Term (as defined in Section 2), the Executive shall be permitted devote substantially all of his business time (excluding periods of vacation and other approved leaves of absence) to serve the performance of his duties with the Company, provided the foregoing shall not prevent the Executive from (i) participating in charitable, civic, educational, professional, community or industry affairs or, with prior written approval of the Board, serving on the scientific boards of directors or advisory board and/or the Board boards of Directors of private or public companies other companies, and (ii) managing his and his family’s personal investments, so long as such activities do not materially interfere with the companies are not competitors performance of his duties hereunder or create a potential business conflict or the appearance thereof. If at any time service on any board of directors or advisory board would, in the good faith judgment of the Company and such service does not create a Board, conflict of interest with the Executive’s employment with fiduciary duty to the Company and it does not violate the Confidentialityor create any appearance thereof, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that shall, as soon as reasonably practicable considering any fiduciary duty to the other entity, resign from such other board of directors or advisory board after written notice of the conflict is received from the Board. Service on the boards of directors or advisory boards disclosed by the Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when on which he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and serving as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days Effective Date (as defined in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsSection 2) is hereby approved.

Position; Duties. The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreement, the a) Executive shall serve as Senior Vice President, the President and Chief Medical OfficerExecutive Officer of the Company. In this positioncapacity, the Executive shall report to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities commensurate with the duties, authorities and responsibilities of persons in similar capacities in similar size companies and such other duties and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control of the CEO and the Board of Directors of the Company (the “Board”)), support ) shall from time to time assign to him consistent with the Executive’s position as President and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee Chief Executive Officer of the Company. (b) During the Employment Term (as defined in Section 2), the Executive will shall devote substantially all his full business time and efforts to the Companybusiness and affairs of the Company and the performance of his duties hereunder. The Executive, who currently serves as a member of the Board of Directors of Titanium Metals Corporation and will Kronos Worldwide Inc., shall not engage in accept any other gainful employment outside directorships of business enterprises during the Employment Term without the prior written consent of the CEOBoard. The In addition, Executive shall also not render services of a business, professional or commercial nature to any other person, firm or corporation, whether for compensation or otherwise, during the Employment Term. (c) Executive’s primary workplace shall be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoing, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment offices in Hebron, Kentucky, except for usual and discrimination and its published policy concerning drugs and alcoholcustomary travel on the Company’s business. Pursuant to the provisions of Section 7(d), Executive will lease temporary housing in the Greater Cincinnati/Northern Kentucky area during the Employment Term. Company acknowledges that Executive will be commuting to Company’s headquarters from Plano, Texas during the term of this Agreement. Executive shall be permitted to serve on work in Plano, Texas, for such periods of time as may be agreed upon by Executive and the scientific advisory board and/or Board, but in no event less than one day each week. (d) Upon the Effective Date, Executive shall be appointed a member of the Company’s Board of Directors of private or public companies so long as to serve without compensation until the companies are not competitors next Annual Shareholders Meeting of the Company and such service does not create Company. Thereafter, during the remaining Employment Term, the Board or, if applicable, a conflict committee thereof, shall nominate the Executive for re-election as a member of interest with Executive’s employment with the Company and it does not violate Board at the Confidentiality, Inventions, Nonexpiration of each then-Solicitation and Non-Competition Agreement between Executive and the Companycurrent term. (ae) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel serve without additional compensation as required by an Officer and Director of any direct or indirect subsidiaries and affiliates of the Company as the Company’s business needs, acting through the Board, may request from time to time. In addition, it is agreed that the Company may deem the Executive to be an employee of one of its subsidiaries for payroll purposes but said arrangement shall not relieve the Company of its obligations hereunder.

Position; Duties. The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreementa) Except as provided in Section 2(b) below, the Executive shall serve as Senior Vice President, the Company’s Chairman and Chief Medical Executive Officer during the Employment Term. As Chairman and Chief Executive Officer. In this position, the Executive shall report to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary commensurate with his position, including general supervision the position of Chairman and direction of all clinical drug development activities (subject to Chief Executive Officer and such other duties and responsibilities as the control of the CEO and the Company’s Board of Directors of the Company (the “Board”) shall designate that are consistent with the Executive’s position as Chairman and Chief Executive Officer. (b) During the Employment Term, the Executive agrees to devote his full business time, attention and energies to the performance of all of the lawful duties, responsibilities and authority that may be assigned to him hereunder. Nothing contained in this Agreement will preclude the Executive from (i) devoting time to personal and family investments, (ii) serving as a director of any company or (iii) from participating in charitable or industry associations, in each case, provided that such activities or services do not (x) materially interfere with the Executive’s performance of duties hereunder or (y) violate the terms of the Confidentiality Agreement (as defined below)). (c) During the Employment Term, support the Executive shall serve as a member of the Board, and management the Executive agrees to serve as a member of day-to-day clinical operationsthe Board without additional compensation. Upon the Executive’s termination of employment from the Company for any reason, strategic planning activities as well as such other duties as reasonably requested by unless otherwise specified in a written agreement between the CEO (the “Responsibilities”). As an employee of Executive and the Company, the Executive will devote his full business time and efforts be deemed to the Companyhave resigned from all offices, directorships, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoingpositions if any, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment then held with the Company or any of its affiliates, and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition agrees to managing the Company’s clinical activities, Executive is expected to play a leadership role in take all actions reasonably requested by the Company and that, as such, his working in to effectuate the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needs.foregoin

Position; Duties. The Executive’s employment with the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this Agreementa) Except as provided in Section 2(b) below, the Executive shall serve as Senior the Company’s Executive Vice President, Chief Medical Officer. In this position, the Executive Business Officer and shall report to the Company’s President and Chief Executive Officer (the “CEO”) and during the Employment Term. As Executive Vice President, Chief Business Officer, the Executive shall have such duties, authorities and responsibilities as are customary commensurate with the position of Executive Vice President, Chief Business Officer and such other duties and responsibilities as the CEO or the Company’s Board of Directors (the “Board”) shall designate that are consistent with the Executive’s position as Executive Vice President, Chief Business Officer. (b) During the Employment Term, the Executive agrees to devote his positionfull business time, including general supervision attention and direction energies to the performance of all clinical drug development activities of the lawful duties, responsibilities and authority that may be assigned to him hereunder. Nothing contained in this Agreement will preclude the Executive from (i) serving as a director of, or member of a committee of the directors of one (1) corporation or organization during the first year of the Employment Term, provided that after the first anniversary of the Employment Term the Executive may serve as a director of, or member of a committee of the directors of, up to two (2) corporations or organizations and any such service shall be subject to the control prior written approval of the CEO and the Board Board, (ii) devoting time to personal and family investments, (iii) serving as a director of Directors any not-for-profit company, or (iv) from participating in charitable or industry associations, in each case, provided that such activities or services do not (x) materially interfere with the Executive’s performance of duties hereunder or (y) violate the terms of the Company Confidentiality Agreement (as defined below). (c) During the “Board”))Employment Term, support the Executive’s principal place of employment shall be the Company’s offices in Cambridge, Massachusetts, provided that the Executive shall divide his time among the Company’s office in Cambridge, Massachusetts and management of day-to-day clinical operations, strategic planning activities as well as such other duties location(s) as reasonably requested may be agreed upon by the CEO (Executive and the “Responsibilities”). As an employee of CEO, subject to customary business travel consistent with the Company, Executive’s duties and responsibilities and provided further that the Executive will devote not be required to relocate from his full business time and efforts current residence to the Company, and will not engage in any other gainful employment without the prior written consent of the CEOMassachusetts or elsewhere. The Executive shall also will be required permitted to comply with all Company policies and procedures as work a reasonable amount of time from the Company’s office to be established in effect from time to time. Without limiting the foregoingnorthern New Jersey area, provided that the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create maintain a conflict of interest with Executive’s employment with the Company and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week consistent presence in the Company’s headquarters (currently office in Cambridge, MA). Massachusetts and provided further that the Executive’s schedule principal place of employment will be agreed upon between Executive and the CEO. It is understood that, in addition to managing remain the Company’s clinical activitiesoffice in Cambridge, Massachusetts unless otherwise agreed between the CEO and the Executive is expected to play a leadership role in and approved by the Company and thatBoard. For purposes of this Agreement, as such, his working in “Initial Public Offering” means the consummation of the Company’s headquarters first underwritten initial public offering of common equity securities under the Securities Act of 1933, as amended, after the Effective Date, that results in such common equity securities being listed for trading on a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsnational securities exchange.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1, 2014 Employment Term (the “Commencement Date”as defined in Section 2 below). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice President, a Chief Medical OfficerFinancial Officer of the Company. In this positioncapacity the Executive shall be responsible to lead and manage all of the operations of the Company that are related to finances, including, but is not limited to, providing expertise in making financial plan and strategy, and working with the Company’s U.S. legal counsel and auditors to implement, monitor and oversee the Company’s compliance with the requirements of the ▇▇▇▇▇▇▇▇-▇▇▇▇▇ Act, Securities Act of the 1933, Exchange Act of the 1934, and the listing rules of the OTC Bulletin Board and to advise the Board of the Directors with respect to the Company’s internal controls and procedures, including disclosure controls and procedures. (b) During the Employment Term, the Executive shall report directly to the Company’s Chief Executive Officer (“CEO”) and shall have such duties, authorities and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control of the CEO and the Board of Directors of the Company (the “Board”)), support and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee of the Company, the Executive will devote his full business time and efforts to the Company, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting obey the foregoing, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or lawful directions of the Board of Directors of private or public companies so long as to whom the companies are not competitors Executive reports and shall use his diligent efforts to promote the interests of the Company and such service does to maintain and promote the reputation thereof. (c) During the Employment Term, the Executive shall assist the CEO in coordinating the Company’s investor relations activities which shall include, but is not create a conflict of interest limited to, communications with Executive’s employment with the Company investors, analysts and it does not violate the Confidentialitymedia, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company ’s public disclosure, and shall implement and monitor the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs corporate governance of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation compliance with the CEOapplicable laws and regulations. The Executive further agrees shall work in conjunction with other members of the executive management team to travel as required by support the Company’s business needsgrowth. (d) During the Employment Term, in the event that the Company engages in any capital markets activities, the Executive shall participate in such transactions by assisting the CEO, underwriters, counsels and auditors, and preparing and/or reviewing requisite documentations in connection with such transactions. (e) During the Employment Term, the Executive shall use his best efforts to perform his duties under this Agreement and shall devote all of his business time, energy and skill in the performance of his duties with the Company. The Executive shall not during the Employment Term (except as a representative of the Company or with consent in writing of the Board) be directly or indirectly engaged or concerned in any other business activity. (f) During the Employment Term, the Company shall maintain appropriate office space in Pinellas County, Florida which shall be the principal place of employment of the Executive. The Company shall provide appropriate furnishing and equipment at the principal place of employment to allow the Executive to perform the duties under this Agreement.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1Term, 2014 (you will hold the “Commencement Date”). While employed by titles and offices, and serve in the Company under the terms positions of this Agreement, the Executive shall serve as Senior Vice President, Chief Medical Officer. In this position, the Executive shall report to the Company’s Co-Chief Executive Officer (“CEO”) and CFO of the Nautilus Group. You shall have such duties, authorities and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject report directly to the control board of the CEO and the Board of Directors directors of the Company (the “BoardBoard of Directors”))) and shall perform such specific duties and services of a senior executive nature (including service as an officer, support and management director or equivalent position of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee any subsidiary or affiliate of the Company, without additional compensation) as the Executive Board of Directors shall reasonably request consistent with your positions. All senior officers and senior executives of the Nautilus Group will report to you directly or to your designee. (b) During the Term, you shall devote his full business the necessary time and attention to the business and affairs of the Company and use your reasonable best efforts to the Company, faithfully perform your duties and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting responsibilities but notwithstanding the foregoing, the Executive will nothing in particular be required to familiarize himself this Agreement shall preclude you (i) from engaging, consistent with your duties and to comply with the Company’s published policy prohibiting unlawful harassment responsibilities hereunder, in charitable, educational and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve community affairs, including serving on the scientific advisory board and/or the Board of Directors of private any charitable, educational or public companies so long community organization, (iii) from managing your personal investments, (iv) upon written approval of the Board of Directors, which approval shall not be unreasonably withheld, from serving as a director of another company and (v) from engaging in other business activities. However, you agree to disclose any Offshore Supply Vessel opportunities and the companies are not competitors material facts attendant thereto, that you wish to pursue privately, to the Board of Directors for consideration by the Company. If within 10 business days of your disclosing such business opportunities to the Board of Directors, the Board of Directors fails to adopt a resolution (and to provide a copy of same to you) that it will pursue such business opportunity, the Company will be deemed to have declined to pursue such opportunity, in which event you shall be free to pursue it. (c) Without limiting any obligation of the Company to you, your services hereunder shall be for the benefit of the members of the Nautilus Group and such service does not create a conflict of interest with Executive’s employment with the Company and it does not violate shall allocate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum cost of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs these arrangements among such members of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so Nautilus Group as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsit determines appropriate.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1, 2014 (the “Commencement Date”). While employed by the Company under the terms of this AgreementEmployment Term, the Executive shall serve as Senior Vice President, Chief Medical Officer. In this position, the Executive shall report to the Company’s Chief Executive Officer (“CEO”) and Chairman of the Board of the Parent and the Company with the responsibility and authority to manage and supervise the operations of the Parent, the Company, any subsidiary thereof or a successor to the Employer in the ordinary course of its business and shall have such dutiesresponsibilities, authorities duties and authority as are generally associated with each such position. The Executive's services shall be performed primarily at the Parent's headquarters office in the New York City metropolitan area or, if so agreed, as otherwise mutually agreed in writing between the Executive and the Parent. (b) During the Employment Term, and excluding any periods of vacation and sick leave to which the Executive is entitled, the Executive agrees to devote reasonable attention and time during normal business hours to the business and affairs of the Employer and, to the extent necessary to discharge the responsibilities assigned to the Executive hereunder, to use the Executive's reasonable best efforts to perform faithfully and efficiently such responsibilities. During the Employment Term, it shall not be a violation of this Agreement for the Executive to (A) serve on corporate, civic or charitable boards or committees, (B) deliver lectures, fulfill speaking engagements or teach at educational institutions and (C) manage personal investments, so long as such activities do not significantly interfere with the performance of the Executive's responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to the control an employee of the CEO Employer in accordance with this Agreement and are not directly competitive with the operating businesses of the Employer. The parties hereto acknowledge and agree that the Executive also serves, and shall be entitled to continue to serve, as the Chief Executive Officer and Chairman of the Board of Directors of the Company (the “Board”)), support Alpine and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee of the Company, the Executive will devote his full business time and efforts to the Company, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoing, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive that he shall be permitted to serve on allocate his time and efforts between the scientific advisory board and/or Employer and Alpine as he sees fit in his good faith business judgment. In addition, the Board of Directors of private or public companies so long Employer hereby acknowledges that the Executive shall be entitled to continue serving as the companies are not competitors a member of the Company board of directors of Spherion Corporation and such service does not create as a conflict member of interest with Executive’s employment the board of directors of, and/or consultant to, PolyVision Corporation. The Parent shall continue to nominate the Executive as a director of the Parent during the term hereof consistent with the Company and it does not violate the Confidentiality, Inventions, NonParent's By-Solicitation and Non-Competition Agreement between Executive and the CompanyLaws. (ac) Location: The Company and Notwithstanding anything to the contrary in this Section 1, the Executive agree agrees to serve without additional compensation, if elected or appointed thereto, as a director of the Parent and any of its subsidiaries, provided that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role indemnified for serving in the Company any and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsall such capacities.

Position; Duties. The Executive’s employment with (a) During the Company shall commence on September 1, 2014 Employment Term (the “Commencement Date”as defined in Section 2 below). While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice Presidenta Chief Executive Officer and President of the Company, Chief Medical Officerand shall exercise such authority and perform such executive duties as are commensurate with the authority being exercised and duties being performed by the Executive for the Company immediately prior to the date hereof, provided, however, that the Executive shall not serve as Chairman of the Board. In this positionconnection therewith, the Executive shall have general management responsibility and authority for the day-to-day operations of the Company in all areas of its business, shall provide direction and oversight with respect thereto, and shall be its senior executive officer. (b) During the Employment Term, the Executive shall report directly to the Board of Directors of the Company. The Executive shall obey the lawful directions of the Board of Directors to whom the Executive reports and shall use his diligent efforts to promote the interests of the Company and to maintain and promote the reputation thereof. Notwithstanding the foregoing, any new duties and responsibilities assigned by the Board which are not duties being performed by the Executive for the Company immediately prior to the date hereof must be acceptable to the Executive in his reasonable discretion. (c) During the Employment Term, the Executive shall lead and coordinate the Company’s Chief Executive Officer (“CEO”) investor relations activities which shall include, but is not limited to, communications with investors, analysts and media, and the Company’s public disclosure, and shall have such duties, authorities implement and responsibilities as are customary with his position, including general supervision and direction of all clinical drug development activities (subject to monitor the control corporate governance of the CEO Company in compliance with the applicable laws and regulations. The Executive shall work in conjunction with other members of the executive management team to support the Company’s business growth. (d) During the Employment Term, in the event that the Company engages in any capital markets activities, the Executive shall take a leading role in such transactions by overseeing underwriters, counsels and auditors, and preparing and/or reviewing requisite documentations in connection with such transactions. (e) During the Employment Term, the Executive shall use his best efforts to perform his duties under this Agreement and shall devote all of his business time, energy and skill in the performance of his duties with the Company, provided that nothing shall prohibit the Executive from participating on the board of directors of companies unaffiliated and not in competition with the Company or from participating in charitable, civic or educational activities or managing his personal investments without the consent of the Board of Directors of the Company (provided that such activities do not interfere with the “Board”)), support Employee’s performance of his duties and management responsibilities hereunder and involve no conflict of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by interest with the CEO (the “Responsibilities”). As an employee interests of the Company. (f) During the Employment Term, the Executive will devote Executive’s principal place of business in the performance of his full business time duties and efforts to the Company, and will not engage in any other gainful employment without the prior written consent of the CEO. The Executive obligations under this Agreement shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoing, the Executive will in particular be required to familiarize himself with and to comply with at the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. executive offices currently located in Westbury, New York, provided, however, that the Executive shall be permitted to serve on perform his duties and obligations from his home office up to two (2) days per week. Notwithstanding the scientific advisory board and/or foregoing, and subject to the Board of Directors of private or public companies so long as the companies are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment with the Company and it does not violate the Confidentialityavailability, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week engage in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will such travel as may be agreed upon between Executive and the CEO. It is understood that, necessary or appropriate in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component furtherance of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needsduties hereunder.

Position; Duties. 2.1 The Executive’s employment with Employee shall serve the Company shall commence on September 1, 2014 (as the “Commencement Date”)President of the A M Medica Communications Group of the Company. While employed by the Company under the terms of this Agreement, the Executive shall serve as Senior Vice President, Chief Medical Officer. In this position, the Executive The Employee shall report to the Company’s Chief Executive Officer (“CEO”) to, and shall have such duties, authorities duties and responsibilities as are customary consistent with his such position, including general supervision the hiring and direction firing of all clinical drug development activities (subject Employees and the authority to increase the control compensation of the CEO employees of the A M Medica Communications Group consistent with the historical salary practices of the Group, and as are reasonably requested of her by the Board of Directors President of the Company (the “Board”)), support which such duties and management of day-to-day clinical operations, strategic planning activities as well as such other duties as reasonably requested by the CEO (the “Responsibilities”). As an employee of responsibilities shall be consistent with the Company, 's "client-business first" corporate culture. The parties recognize that the Executive Employee's primary focus will be on the A M Medica Communications Group. The Employee's office shall be located in the Borough of Manhattan in New York City. 2.2 The Employee shall perform her duties and responsibilities hereunder faithfully and diligently. The Employee shall devote his her full business time and efforts attention to the Companyperformance of her duties and responsibilities hereunder; provided, however, that it is understood that the Employee may devote no more than five percent (5%) of her time to her activities as an investor and director in AMM-Adelphi (it being understood that the Employee may devote up to ten percent (10%) of her time to various activities for AMM-Adelphi, until April 1, 1999), provided, that, at all times AMM-Adelphi continues to engage in activities which are substantially similar to, and consistent with, its activities on the date hereof. The parties agree that with respect to the four quarterly corporate meetings that the Company holds each year, the Employee may send a designated representative from the A M Medica Communications Group to such meetings. The Employee hereby represents that she is not bound by any confidentiality agreements or restrictive covenants which restrict or may restrict her ability to perform her duties hereunder, and agrees that she will not engage in enter into any other gainful such agreements or covenants during the term of her employment without the prior written consent of the CEO. The Executive shall also be required to comply with all Company policies and procedures as in effect from time to time. Without limiting the foregoinghereunder, the Executive will in particular be required to familiarize himself with and to comply with the Company’s published policy prohibiting unlawful harassment and discrimination and its published policy concerning drugs and alcohol. Executive shall be permitted to serve on the scientific advisory board and/or the Board of Directors of private except such restrictive covenants or public companies so long as the companies confidentiality agreements which are not competitors of the Company and such service does not create a conflict of interest with Executive’s employment with the Company and it does not violate the Confidentiality, Inventions, Non-Solicitation and Non-Competition Agreement between Executive and the Company. (a) Location: The Company and the Executive agree that Executive will work a minimum of three business days per week in the Company’s headquarters (currently Cambridge, MA). Executive’s schedule will be agreed upon between Executive and the CEO. It is understood that, in addition to managing the Company’s clinical activities, Executive is expected to play a leadership role in the Company and that, as such, his working in the Company’s headquarters for a minimum of three business days and interacting with employees is a necessary component of his employment. Executive agrees that, when he is working outside the Company’s headquarters, he will be available for calls and to participate in meetings telephonically during regular business hours and as required by business needs. It is further agreed that the needs of the Company may from time-to-time require Executive to spend more than three business days in the Company’s headquarters and Executive will agree to do so as reasonably required in consultation with the CEO. Executive further agrees to travel as required by the Company’s business needs.