Summary and Discussion Clause Samples

Summary and Discussion. The model employed in this paper allows us to study the stability of reverse payment agreements between brand and generic challengers that lead to extended monopoly periods. Prior literature has focused on the welfare effects of out of court settlements with and without reverse payments, and under what conditions they may be anti or pro-competitive. We focused instead on when ex ante pay-for-delay deals would be observed in equilibrium, which is equivalent to exclusivity awarded to the first successful challenger, and how it compares to the current system in the US which awards exclusivity to the first filer. Our model combines the first mover advantage for the first generic entrant with the ability of the branded manufacturer to launch an authorized generic to describe the conditions under which such deals are an equilibrium outcome. We do not explore all the other possible explanations for this phenomena. In particular, we show that compared to the first filer system, pay-for-delay deals are more difficult under the first successful challenger system. However even under the latter system, pay-for-delay deals can occur. We also show that pay-for-delay deals can occur even without any exclusivity period, as it happens in Europe. The model also shows that the payment to stay out increases not only in the ‘weakness’ of the underlying patent, but also in the extent of the first mover advantage. This is important because both the US Supreme Court in the case against ▇▇▇▇▇▇▇, and the European Commission (DG Competition) in announcing the €147m fine against Lundbeck and the agreeing generics in a pay- for-delay case, cite the size of the payment as a “workable surrogate” for the weakness of the underlying patent, but ignore the role of the first mover advantage.21 21See p.19 US Supreme Court (2013) and comments by the Director General (DG Competition) of EC, p.9 Italianer (2013). ▇▇▇▇▇▇, ▇▇▇▇▇▇, “Authorized generic entry prior to patent expiry: reassessing incentives for inde- pendent generic entry,” The Review of Economics and Statistics, July 2015, 97 (3), 654–666.‌ ▇▇▇▇ Laboratories, Inc., “▇▇▇▇ and Shire sign three agreements: a product acquisition agreement for Adderall; a product development agreement; and a settlement and license agreement for Adderall XR,” PR Newswire [Press Release] August 14 2006. London, UK. ▇▇▇▇▇▇, ▇▇▇▇▇ ▇. and ▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇, “Brand loyalty, generic entry and price competition in pharmaceuticals in the quarter century after the 198...

Summary and Discussion. N ≥ 1. In total we find 60 Q-classes (point groups) that lead to N ≥ 1 SUSY. 2. These Q-classes decompose in • 22 with an Abelian point group with one or two generators, i.e. ZN or ZN × ZM , out of which 17 lead to exactly N = 1 SUSY, and • 38 with a non-Abelian point group with two or three generators, such as S3 or ∆(216), out of which 35 lead to exactly N = 1 SUSY. That is, there are 52 Q-classes that can lead to models yielding the supersymmet- ric standard model. As we have explained in detail, Q-classes (or point groups) can come with in- equivalent lattices, classified by the so-called Z-classes. In the traditional orbifold literature, Z-classes are given by Lie lattices and a given choice fixes an orbifold geometry. However, as we have pointed out, not all lattices can be described by Lie lattices. Our results on Q-classes potentially relevant for supersymmetric model build- ing are as follows. 3. We find that there are 186 Z-classes, or, in other words, orbifold geometries that lead to N ≥ 1 SUSY. 4. These Z-classes decompose in 71 with an Abelian point group, out of which 60 lead to exactly = 1 ▇▇▇▇, and • 115 with a non-Abelian point group, out of which 108 lead to exactly N = 1 SUSY. Furthermore, space groups can be extended by so-called roto-translations, a com- bination of a twist and a (non-lattice) translation. We provide a full classification of all roto-translations in terms of affine classes, which are, as we discuss, the most suitable objects to classify inequivalent space groups. 5. We find 520 affine classes that lead to N ≥ 1 SUSY. 6. These affine classes decompose in • 162 with an Abelian point group, out of which 138 lead to exactly N = 1 SUSY, and • 358 with a non-Abelian point group, out of which 331 lead to exactly N = 1 SUSY. An important aspect of our classification is that we provide the data for all 138 space groups with Abelian point group and = 1 SUSY required to construct the corresponding models with the C++ orbifolder [46]. Among other things, this allows one to obtain a statistical survey of the properties of the models, which has so far only been performed for the Z6-II orbifold [42]. Our classification also has conceivable importance for phenomenology. For instance, one of the questions is how the ten-dimensional gauge group (i.e. E8 E8 or SO(32)) of the heterotic string gets broken by orbifolding. In most of the models discussed so far, the larger symmetry gets broken locally at some fixed point. Yet it has been arg...

Summary and Discussion. Introduction The concept of coherence in attachment interviews: summary and limitations The AAI as a rich but labor-intensive research tool The validity of the AAI in adolescents: summary and limitations Physiological reactivity during the AAI and during a conflict interaction task: summary and limitations Applications of the AAI

Summary and Discussion. In this section I have offered an analysis of the object agreement pattern in Khanty that neither appeals to GFs, nor assumes that there is one given position in the clause that triggers object agreement. I will discuss the first point in the next section. The second point I believe is an interesting step forward. As noted above, one of the criti- cisms levied against movement approaches to DOM is either finding evidence for the movement, which is not a problem here, but often it is difficult to define the class of elements that would move to a given position. If there is a single characteristic, then it is possible that all elements sharing that feature are attracted to a certain position. If not however, then one is always open to the charge of arbitrariness. ▇▇▇▇▇▇ shows exactly this problem, where it is difficult to generate an exact natural class of elements that trigger object agreement on the verb. For instance, if one would only look at Themes, one could argue that there is a topic position that all agreeing objects lie in. However, whilst ▇▇▇▇▇▇▇▇▇ (2001) argues that goals are more prototypi- cally topical than Themes, and are mapped to the secondary topic role when the direct object is not a topic, such an approach runs into an issue when we consider that fo- cussed causees trigger object agreement. It seems unlikely that something can be both a focus and a topic at the same time, and so it cannot be the case that topicality is the sole feature that is responsible. However, under the approach discussed here we do have a link: all elements that trigger object agreement lie either at the edge, or outside the spell-out domain that is caused by v. Since v is a hard phase in Khanty (by assump- tion), then anything which is within this lower domain will not be able to enter into an Agee relation with F, and object agreement is impossible. 5 A Residue of Object Properties‌ Up to this point, our interest has been in showing that one can analyse object agree- ment in Khanty without employing GFs. However, simply showing that agreement in Khanty can be handled without GFs does not do justice to the approach of ▇▇▇▇▇▇▇▇▇ and ▇▇▇▇▇▇▇▇▇ (2011). Recall from Table 2 above that the arguments that control object agreement on verbs share a number of properties with subjects. This paints them in contrast with objects that do not control agreement on verbs, which do not share these properties. The strength of ▇▇▇▇▇▇▇▇▇ and ▇▇▇▇▇▇▇▇▇’s approach is that it provides an analysi...

Summary and Discussion. In this deliverable, we propose a first screening strategy to identify potential risks of MNMs at early stage of innovation. This deliverable focusses on the first two stages where the potential of a MNM to give rise to human or environmental health risks can be deduced on the basis of a limited set of information (Figure 8, blue part).

Summary and Discussion. We have introduced MVNE, a novel Multi-View Net- work Embedding (MVNE) algorithm for constructing low- dimensional embeddings of multi-view networks. MVNE uses a novel objective function that maximizes the agreement between views based on both the local and global structure of the underlying multi-view network. We have shown that (i) SVNE, the single view version of MVNE, is competitive with or superior to the state-of-the-art single view network embedding methods when the embeddings are used for label- ing unlabeled nodes in the networks; (ii) MVNE substantially outperforms single view methods on integrated view, as well as state-of-the-art multi-view graph methods for aggregating information from multiple views, when the embeddings are used for labeling nodes in multi-view networks; and (iii) MVNE outperforms SVNE, when used to predict node labels in any target view, suggesting that it is able to effectively integrate from all of the views, information that is useful for labeling nodes in the target view.

Summary and Discussion. Through the experiments discussed in this chapter, we describe the evaluation of a GPR37L1 variant identified in a family with a novel progressive myoclonus epilepsy (PME). The homozygous autosomal recessive variant (c.1047G>T, [Genebank NM_004767.3]) identified in the proband (VI:9), and results in a K349N substitution in the third intracellular loop of the receptor. Individuals VI:8 and VI:10, found to be heterozygous and wild type, respectively, are well beyond the age of presentation of all their siblings and are considered clinically unaffected. The youngest members, and the only males in the sibship (VI:11 and VI:12), were also found to be homozygous for the GPR37L1 variant. To date, these youngest individuals have not had a clinical presentation of PME but have exhibited abnormal neurological symptoms: VI:11 has had daily recurrent headaches, two abnormal EEGs, and visual disturbances, while VI:12 has reported daily recurrent headaches (no EEG performed). Interestingly, VI:11, who at the time of the present study is 16 years of age, is beyond the average age of seizure onset of his sisters and cousin. While there are well-known neurodevelopmental differences between males and females (Giatti et al. 2012), and previous studies have identified GPR37L1 as differentially expressed between the sexes (Shi, Zhang, and Su 2016), further observation of the youngest siblings will be required to determine if any sex differences exist in this case. We and others have shown that expression of GPR37L1 and/or GPR37 can mediate cytoprotective effects in vitro (Lundius et al. 2013; ▇▇▇▇▇ et al. 2013).

Summary and Discussion. We have examined associations between child support arrears, payments, and compliance, and accounted for the criminal justice system experience of payers with regard to the length of incarceration, number of prison spells, and length of post-release supervision. Similar to previous reports completed by IRP, we have done so by using a difference-in- difference-in-difference design on a sample of 5,022 fathers, and by estimating results using multiple regression and propensity score matching on a subsample of 1,520 fathers in Milwaukee County Cohort 2. The DDD models include information on whether an individual was eligible for treatment (child support order suspension) through the Milwaukee Prison Project, while the multiple regression and PSM models include information on whether an individual actually had their child support order suspended while incarcerated. Because information on the effect of treatment (not merely intent-to-treat) is particularly pertinent, this summary section focuses on the results of estimating the multiple regression and PSM models. For fathers in Milwaukee County Cohort 2, we find: • Evidence that child support order suspension is associated with a significant reduction in both principal only and total arrears (past due child support), both at the time of release and at one year after release. We also find evidence that incarceration length is positively associated with arrears (both principal only and total) both at the time of release and one year later. • No evidence that child support order suspension significantly increased either the probability that a child support payment was made or the dollar amount of payments, either in the first or second year after release. Thus, treatment is not associated with individual payment behavior. However, among those who were not reincarcerated and remain on probation for two years, we find evidence that correctional supervision— independent of child support order suspension—is associated with both higher payment amounts and an increased probability that any payment was made in both the first and second years after release. • That while suspensions do not affect individual payment behavior, the cumulative effect of the suspension of payment orders for incarcerated payers would likely have an impact on county performance measures. More specifically, suspending payment orders for incarcerated individuals could increase Milwaukee County’s current child support collection rate by approximatel...

Summary and Discussion. This chapter has presented the results of an empirical comparison on different techniques that can be used within Evolution Strategies for finding robust optima. From this empirical study we conclude that the myopic approach can be a very risky approach when aiming to find robust optima. It highly depends on the particularities of the objective function landscape, whether this approach will work. However, because the particularities of the objective function landscape are not known beforehand, this approach is not recommendable.