Table S4. Cumulative risk (95% Confidence Interval) using segregation analysis, major gene models assuming relative risk as a continuous, piecewise linear function of age. The BRCA1 c.5096G>A p.Arg1699Gln (R1699Q); intermediate risk variant (95% Confidence Interval) Age Breast cancer Ovarian cancer Breast cancer Ovarian cancer Breast cancer Ovarian cancer 25 0.03 0.15 0.03 0.06 0.04 0.56 (0.01, 0.06) (0.02, 1.57) (0.01, 0.08) (3.94x10-4, 7.50) (0.01, 0.10) (0.003, 3.73) 30 0.21 0.27 0.22 0.10 0.28 0.96 (0.10, 0.45) (0.03, 2.79) (0.08, 0.57) (7.01x10-4, 12.98) (0.08, 0.73) (0.005, 6.56) 35 0.82 0.42 0.86 0.16 1.09 1.44 (0.38, 1.75) (0.04, 4.34) (0.32, 2.21) (1.10x10-3, 19.63) (0.31, 2.81) (0.008, 10.11) 40 2.22 0.64 2.32 0.24 2.95 2.08 (1.04, 4.70) (0.06, 6.49) (0.87, 5.92) (1.66x10-3, 28.11) (0.85, 7.49) (0.01, 14.87) 45 4.89 0.96 5.10 0.36 6.41 2.98 (2.30, 10.19) (0.10, 9.66) (1.94, 12.72) (2.52x10-3, 39.32) (1.89, 15.95) (0.02, 21.63) 50 8.22 1.51 8.72 0.67 10.62 4.13 (4.22, 16.40) (0.30, 13.68) (3.86, 20.34) (0.12, 51.16) (3.69, 24.88 ) (0.13, 29.53) 55 11.99 2.30 13.05 1.29 15.25 5.39 (6.82, 22.50) (0.66, 17.66) (6.73, 28.18) (0.36, 60.48) (6.06, 32.87) (0.34, 36.61) 60 15.02 3.39 16.82 2.37 18.87 6.65 (9.35, 26.46) (1.21, 20.74) (9.53, 33.35) (0.80, 66.01) (8.15, 37.55) (0.66, 41.30) 65 17.46 4.83 20.28 4.10 21.64 7.80 (11.37, 28.80) (1.99, 21.94) (12.18, 36.99) (1.51, 66.40) (9.93, 40.72) (1.14, 41.82) 70 20.01 6.43 23.89 6.02 24.47 9.07 (13.26, 32.01) (2.78, 24.53) (14.51, 42.42) (2.25, 66.73) (11.29, 46.03) (1.58, 42.50)
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