Common use of Updates and Amendments Clause in Contracts

Updates and Amendments. On at least an annual basis during the Term (or more frequently as may be required), the JDC shall update or amend the current version of each SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget based on currently available information and data. The JDC shall submit any such update or amendment to the JSC for review and approval. Each such update or amendment shall become effective and shall supersede the previous applicable SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget only upon approval thereof by the JSC. Notwithstanding anything to the contrary herein, if either Party proposes to include new or revised Development activities in a current SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget because those Development activities are required by a Regulatory Authority in the Territory, then the JSC shall approve the inclusion of such Development activities the SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget. Without limiting the JDC’s rights to review and discuss and the JSC’s right to approve each update or amendment to a SYNGAP1 Co-Development Plan or SYNGAP1 Co-Development Budget, the Lead Development Party to whom a particular Development activity is allocated under a SYNGAP1 Co-Development Plan shall have the right, without seeking JDC review or JSC approval, to make operational decisions with respect to the performance of such Development activity to the extent consistent with such SYNGAP1 Co-Development Plan and the SYNGAP1 Co-Development Budget.

Updates and Amendments. On at least an annual basis during the Term (or more frequently as may be required), the JDC JCC shall update or amend the then-current version of each SYNGAP1 Co-Development Commercialization Plan and SYNGAP1 Co-Development Commercialization Budget based on currently available information and data. The JDC JCC shall submit any such update or amendment to the JSC for review and approval. Each such update or amendment shall become effective and shall supersede the previous applicable SYNGAP1 Co-Development Commercialization Plan and SYNGAP1 Co-Development Commercialization Budget only upon approval thereof by the JSC. Notwithstanding anything to the contrary herein, if either Party proposes the Parties acknowledge and agree that to include new or revised Development activities in a current SYNGAP1 Co-Development Plan and SYNGAP1 Co-Development Budget because those Development activities are required by the extent a Regulatory Authority in the Territoryrequires certain Commercialization activities, then the JSC shall approve the inclusion of such Development Commercialization activities in the SYNGAP1 Co-Development Commercialization Plan and SYNGAP1 Co-Development Commercialization Budget. Without limiting the JDCJCC’s rights to review and discuss and the JSC’s right to approve each update or amendment to a SYNGAP1 Co-Development Commercialization Plan or SYNGAP1 Co-Development Commercialization Budget, the Lead Development Commercialization Party to whom a particular Development Commercialization activity is allocated under a SYNGAP1 Co-Development Commercialization Plan shall have the right, without seeking JDC JCC review or JSC approval, to make operational decisions with respect to the performance of such Development Commercialization activity to the extent consistent with such SYNGAP1 Co-Development Commercialization Plan and the SYNGAP1 Co-Development Commercialization Budget.