1 EXHIBIT 10.50 DISCOVERY PARTNERS INTERNATIONAL 9640 TOWNE CENTRE DRIVE SAN DIEGO, CA 92121 TEL: (858) 455-8600 FAX: (858) 455-8088 WEB WWW.DISCOVERYPARTNERS.COM The Directorship Agreement dated December 16, 1996 by and between Mr. Dieter Hoehn and...

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                                                                   EXHIBIT 10.50


DISCOVERY PARTNERS
INTERNATIONAL

                                                         ▇▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
                                                             ▇▇▇ ▇▇▇▇▇, ▇▇ ▇▇▇▇▇

                                                             TEL: (▇▇▇) ▇▇▇-▇▇▇▇
                                                             FAX: (▇▇▇) ▇▇▇-▇▇▇▇

                                                   WEB ▇▇▇.▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇.▇▇▇



The Directorship Agreement dated December 16, 1996 by and between ▇▇. ▇▇▇▇▇▇
▇▇▇▇▇ and Discovery Partners International, Inc. (f/k/a IRORI) (the "Company")
is hereby terminated as of this 8th day of May, 2000. Termination of this
Directorship Agreement shall in no way interfere with ▇▇. ▇▇▇▇▇'▇ continued
service on the Company's Board of Directors.


        Discovery Partners International, Inc.


By:     /s/ ▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇
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Its:    CFO
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               /s/ ▇▇▇▇▇▇ ▇▇▇▇▇
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