LICENSE AGREEMENT originally dated as of September 23, 1997 amended and restated in its entirety as of February 22, 2002 by and between ALLIANCE PHARMACEUTICAL CORP. and SCHERING AKTIENGESELLSCHAFT

EXHIBIT 10.1

LICENSE AGREEMENT

originally dated as of September 23, 1997

amended and restated in its entirety

as of February 22, 2002

by and between

ALLIANCE PHARMACEUTICAL CORP.

and

SCHERING AKTIENGESELLSCHAFT

	TABLE OF CONTENTS

		Page

	ARTICLE I DEFINITIONS

SECTION 1.01.	Definitions	1

	ARTICLE II DEVELOPMENT

SECTION 2.01.	Development
SECTION 2.02	Drug Approval Applications	9
SECTION 2.03.	Costs of Development	9
SECTION 2.04.	Right to Engage Third Parties	9
SECTION 2.05.	Schering Portfolio	9

	ARTICLE III LICENSES

SECTION 3.01.	Patent License to Schering	9
SECTION 3.02.	Patent and Trademark License to Alliance	10
SECTION 3.03.	Third Party Technology	10

	ARTICLE IV COMMERCIALIZATION

SECTION 4.01.	Marketing	11
SECTION 4.02.	Tax Considerations	11

	ARTICLE V ROYALTIES

SECTION 5.01.	Schering Product Royalties	12
SECTION 5.02.	Alliance Royalties	14
SECTION 5.03.	Royalty Reports and Payments	16
SECTION 5.04.	Payments; Interest	16
SECTION 5.05.	Taxes	16
SECTION 5.06.	Payments to or Reports by Affiliates	16
SECTION 5.07.	Payment Currency	17

	ARTICLE VI MANUFACTURE AND SUPPLY

SECTION 6.01.	Manufacture and Supply by Alliance	17


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	CONFIDENTIAL TREATMENT

SECTION 6.02.	Regulatory Approval for Manufacturing	17
SECTION 6.03.	Step-in Right of Schering	18
SECTION 6.04.	Technology and Know-How Transfer	18
SECTION 6.05.	Regulatory Approval	18
SECTION 6.06.	DMF	19
SECTION 6.07.	Acceptance and Pricing	19
SECTION 6.08.	Competitive Cost of Goods	19
SECTION 6.09.	Packaging	19

	ARTICLE VII CONFIDENTIALITY

SECTION 7.01.	Confidentiality; Exceptions	20
SECTION 7.02.	Authorized Disclosure	20
SECTION 7.03.	Survival	21
SECTION 7.04.	Termination of Prior Agreement	21
SECTION 7.05.	Publications	21
SECTION 7.06.	Publicity Review	21

	ARTICLE VIII OWNERSHIP OF INTELLECTUAL PROPERTY AND PATENT RIGHTS

SECTION 8.01.	Ownership	22
SECTION 8.02.	Patent Filings	22
SECTION 8.03.	Third Party Patent Rights	22
SECTION 8.04.	Enforcement Rights	22
SECTION 8.05.	Defense and Settlement of Third Party Claims	23
SECTION 8.06.	Patent Expenses	23
SECTION 8.07.	Trademarks	23

	ARTICLE IX REPRESENTATIONS AND WARRANTIES

SECTION 9.01.	Representations and Warranties	23
SECTION 9.02.	Performance by Affiliates	24

	ARTICLE X INFORMATION AND REPORTS

SECTION 10.01.	Information and Reports During Development and Commercialization	24
SECTION 10.02.	Adverse Drug Experiences	25
SECTION 10.03.	Records of Revenues and Expenses	25
SECTION 10.04.	Applicability	26


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	CONFIDENTIAL TREATMENT

	ARTICLE XI TERM AND TERMINATION

SECTION 11.01.	Term	27
SECTION 11.02.	Termination	27
SECTION 11.03.	Surviving Rights	29

	ARTICLE XII INDEMNIFICATION
SECTION 12.01.	Indemnification	29

	ARTICLE XII MISCELLANEOUS
SECTION 13.01.	Assignment	30
SECTION 13.02.	Retained Rights	30
SECTION 13.03.	Force Majeure	30
SECTION 13.04.	Further Actions	31
SECTION 13.05.	No Trademark Rights	31
SECTION 13.06.	Notices	31
SECTION 13.07.	Waiver	32
SECTION 13.08.	Severability	32
SECTION 13.09.	Ambiguities	32
SECTION 13.10.	Governing Law	32
SECTION 13.11.	Headings	32
SECTION 13.12.	Counterparts	32
SECTION 13.13.	Entire Agreement; Amendments	32
SECTION 13.14.	Expenses	33
SECTION 13.15.	Independent Contractors	33
SECTION 13.16.	Use of Names	33


EXHIBITS


EXHIBIT A	Determination of Certain Accounting Terms
EXHIBIT B	Alliance Patents
EXHIBIT C	Alliance HI Patents
EXHIBIT D	Schering HI Patents


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LICENSE AGREEMENT (the "AGREEMENT") originally dated as of September 23, 1997 (the "EFFECTIVE DATE"), and amended and restated in its entirety as of February 22, 2002 (the "RESTATEMENT DATE") by and between ALLIANCE PHARMACEUTICAL CORP., a New York corporation having its principal place of business at ▇▇▇▇ ▇▇▇▇▇▇▇ ▇▇▇▇ ▇▇▇▇, ▇▇▇ ▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇ (hereinafter referred to as "ALLIANCE") and SCHERING AKTIENGESELLSCHAFT, a German corporation having its principal place of business at ▇▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇▇▇▇▇ (hereinafter referred to as "SCHERING"). Alliance and Schering are sometimes referred to herein individually as a "Party" and collectively as the "Parties."

W I T N E S S E T H:

WHEREAS, Schering is a leading multinational health care company;

WHEREAS, Alliance is developing through its research and development activities certain technology for use in ultrasound imaging techniques, and has the right to grant rights and licenses and/or sublicenses under the Alliance Patents (hereinafter defined) and Alliance Know-How (hereinafter defined);

WHEREAS, the Parties entered into a License Agreement dated as of September 23, 1997, as amended by First Amendment to License Agreement dated as of December 30, 1998, Amendment No. 2 to the License Agreement dated December 20/21, 2000, the side letter of December 20, 2000 and the Waiver dated as of October 10, 2001 (collectively, the "ORIGINAL LICENSE AGREEMENT"), pursuant to which, among other things, Alliance granted certain rights and licenses to the Alliance Patents and Alliance undertook certain action to develop and market Products and Schering undertook certain action to develop and market Products;

WHEREAS, the Parties intend to enter into a restructured relationship under the terms and conditions hereinafter set forth;

WHEREAS, the Parties intend to record, characterize and report their activities under this Agreement as separate activities of each of the Parties;

NOW, THEREFORE, in consideration of the foregoing recitals and the mutual covenants and agreements contained herein, the Parties hereto, intending to be legally bound, do hereby agree as follows:

ARTICLE I

DEFINITIONS

SECTION 1.01. DEFINITIONS. The following terms, when capitalized, shall have the following meanings (such meanings to be equally applicable to both the singular and plural forms of the terms defined) as used in this Agreement:

"AFFILIATE" means any person, corporation, partnership, firm, joint venture or other entity which, directly or indirectly, through one or more intermediaries, controls, is controlled by, or is under common control with, Alliance or Schering, as the case may be. As used in this definition, "control" means the possession of the power to direct or cause the direction of the management and policies of an entity, whether through the ownership of the outstanding voting securities or by contract or otherwise.

"AF0150" means a white powder * which, after reconstitution with appropriate diluent, forms an aqueous suspension of perfluorohexane/nitrogen-filled microbubbles with the formulation employed in Phase II Clinical Trials under the United States IND 49,978.

"ALLIANCE HI PATENT" means the Patents listed on Exhibit C.

"ALLIANCE KNOW-HOW" means Information which is within the Control of Alliance and relates to the research, development, manufacture, use, importation, sale or offer for sale of the Product. Notwithstanding anything herein to the contrary, Alliance Know-How shall exclude Alliance Patents.

"ALLIANCE PATENT" means a Patent which covers the research, development, manufacture, use, importation, sale or offer for sale of a Product, which Patent is owned or Controlled by Alliance, including, but not limited to:

(a) any patent listed in Exhibit B hereto or added thereto by written agreement of the Parties during the term of this Agreement;

(b) any patent application listed in exhibit B hereto or added thereto by written agreement of the Parties during the term of this Agreement; and any division, continuation, or continuation-in-part of any such application; and any patent which shall issue based on such application, division, continuation or continuation-in-part;

(d) any foreign counterpart patent application or patent corresponding to any patent identified in (a), (b), or (c), above which is filed or issued in any country in the Alliance Territory; and

(e) any patent or patent application related to or based on any Alliance Know-How related to the Product or the manufacture thereof developed or acquired by alliance prior to or during the term of this Agreement and which is necessary for the use, development, manufacture, market, sale or distribution of any marketed Product and any division, continuation or continuation-in-part of any such patent or patent application; and any patent which shall issue based on such application, division, continuation or continuation-in-part; and any patent which is a reissue, reexamination or extension of any such patent.

* Indicates information that has been omitted because confidential treatment has been requested and filed separately with the Securities and Exchange Commission.


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"ALLIANCE TERRITORY" *

"ALLIANCE PAYMENTS" means all payments made by Alliance to Schering pursuant to Section 5.02 and all payments made by Alliance to Schering which are not required to be made pursuant to this Agreement or otherwise.

"AUDIT DISAGREEMENT" shall have the meaning set forth in Section 10.03(b).

"BANKRUPTCY EVENT" shall have the meaning set forth in Section 11.02(c).

"BERLEX" means Berlex Laboratories, Inc., a Delaware corporation.

"BUSINESS DAY" means a day that is not a Saturday or Sunday in the United States or a day on which banking institutions chartered by the State of New York or the United States are required or authorized to be closed.

"CAD INDICATION"*

"CLINICAL WORK" means any work related to human trials to assess the dosing, safety and/or efficacy of a Product and/or to assess a dose and treatment plan employing such Product, including, but not limited to, Phase III Clinical Trials and Phase IV Clinical Trials (in the event such Phase IV Clinical Trials are required by the FDA).

"COMMERCIALIZATION" and "COMMERCIALIZE" shall refer to all activities undertaken relating to the pre-marketing, marketing and sale of a Product.

"COMPETITIVE PRODUCT" means a perfluorocarbon-based product which has obtained Regulatory Approval for use as an ultrasound contrast agent and such use is included in the labeling of such product.

"CONFIDENTIAL INFORMATION" shall have the meaning set forth in Section 7.01.

"CONTROL" or "CONTROLLED" shall refer to possession of the ability to grant a license or sublicense of patent rights, know-how or other intangible rights as provided for herein without violating the terms of any agreement or other arrangement with any Third Party.

"COST OF GOODS " means the cost of Product inventory and other manufacturing costs incurred with respect to the Product sold. Cost of Goods shall be calculated in the manner set forth in Exhibit A.


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"DEVELOPMENT" and "DEVELOP" shall refer to all activities relating to obtaining Regulatory Approval of a Product, and all activities relating to developing the ability to manufacture the same. This includes preclinical testing, toxicology, formulation, bulk production, fill/finish, manufacturing process development, manufacturing, quality assurance and quality control technical support, clinical studies, regulatory affairs and outside counsel regulatory legal services.

"DEVELOPMENT EXPENSES" means the expenses incurred in connection with the Development of a Product. Development Expenses shall include, but are not limited to, toxicological, pharmacokinetic, metabolic or clinical aspects of a Product conducted internally or by individual investigators, of design and manufacture of any required prototype devices, of consultants necessary for the purpose of obtaining and/or maintaining Regulatory Approval of a Product in the Alliance Territory, and costs (and related fees) for preparing, submitting, reviewing or developing data or information for the purpose of submission to a governmental authority to obtain and/or maintain Regulatory Approval of a Product in the Alliance Territory.

"DMF" shall have the meaning set forth in Section 6.06.

"DOLLARS" means the lawful currency of the United States of America.

"DOWNPAYMENT" means any lump sum payment to Alliance for any rights to market or manufacture the Product in the Alliance Territory, specifically excluding payments (i) for the purchase of equity as Alliance at fair market value or (ii) based on sales of the Product.

"DRUG APPROVAL APPLICATION" means an application for Regulatory Approval required to be approved before commercial sale or use of a Product as a drug in a regulatory jurisdiction, including, for the purposes of Regulatory Approval in the United States, a New Drug Application and all supplements filed pursuant to the requirements of the FDA (including all documents, data and other information concerning a Product which are necessary for, or included in, FDA approval to market the Product, as more fully defined in 21 C.F.R. Sections 314.1 et seq.).

"EFFECTIVE DATE" shall have the meaning set forth in the heading to this Agreement.

"EUR" means the lawful currency of the European Monetary Union.

"EUROPE" means the countries which are members of the European Union as such membership may change from time to time.

"FDA" means the United States Food and Drug Administration, or any successor agency.

"FIELD" means, at any date of determination, the development, use, manufacture, distribution, marketing and sale of the Product as an ultrasound contrast agent in all possible indications, in humans or animals.


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"FIRST COMMERCIAL SALE" means the date a Party or its Affiliate or a sublicensee of a Party first sells commercially, pursuant to a Regulatory Approval, a Product in any country of the Alliance Territory or the Schering Territory, as the case may be, provided, however, that where such a first commercial sale has occurred in a country for which pricing or reimbursement approval is necessary for widespread sale, then such sales shall not be deemed a First Commercial Sale until such pricing or reimbursement approval has been obtained.

"FIRST PERIOD" means the period commencing on the First Commercial Sale and ending on the third anniversary of the First Commercial Sale.

"FULLY LOADED COSTS" means all internal and external costs incurred by Berlex in the performance of the services described in Section 6.09(a) as determined by United States Generally Accepted Accounting Principles, applied on a consistent basis, which shall include without limitation the following costs: carrying costs of inventories, direct and indirect labor costs, material costs, and direct and indirect overhead. Fully Loaded Costs of Berlex also shall include all set up costs necessary for Berlex to perform the functions described in Section 6.09(a), regardless of depreciation schedules which may have been established to absorb such costs over a period of time longer than the period during which Berlex will be performing the described services for Alliance.

"INFORMATION" means (i) techniques and data within the Field relating to the Product, including, but not limited to, inventions, practices, methods, knowledge, know-how, skill, trade secrets, experience, test data including pharmacological, toxicological, preclinical and clinical test data, regulatory submissions, adverse reactions, analytical and quality control data, marketing, pricing, distribution, cost, sales and manufacturing data or descriptions and (ii) compounds, compositions of matter, assays and biological materials within the Field relating to the Product.

"LOSSES" shall have the meaning set forth in Section 12.01(a).

"LV INDICATION"*

"MANUFACTURING PARTY" means the Party who is responsible for the (i) manufacturing and supply of the Product for use during Development or (ii) commercial manufacture and supply of the Product.

"MAXIMUM PAYMENT" shall have the meaning set forth in Section 5.01(a)(ii).

"MINIMUM DOWNPAYMENT SHARE"*


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"NET SALES" means the amount invoiced by a Party, its Affiliates or its sublicensees from sales of the Product to Third Parties, less reasonable and customary deductions applicable to the Product for (i) transportation charges and charges such as insurance, relating thereto paid by the selling party; (ii) sales and excise taxes or customs duties paid by the selling party and any other governmental charges imposed upon the sale of the Product and paid by the selling party; (iii) distributors' fees, rebates or allowances actually granted, allowed or incurred; (iv) quantity discounts, cash discounts or chargebacks actually granted, allowed or incurred in the ordinary course of business in connection with the sale of the Product; (v) allowances or credits to customers, not in excess of the selling price of the Product, on account of governmental requirements, rejection, outdating, recalls or return of the Product; (vi) costs of customer programs such as cost effectiveness or patient assistance programs designed to aid in patient compliance to maintain medication schedules; and (vii) a one percent (1%) deduction for bad debts. For the purpose of calculating a Party's Net Sales, the Parties recognize that (a) a Party's customers may include persons in the chain of commerce who enter into agreements with a Party as to price even though title to the Product does not pass directly from a Party to such customers, and even though payment for such Product is not made by such customers directly to a Party and (b) in such cases chargebacks paid by a Party to or through a Third Party (such as a wholesaler) can be deducted by a Party from gross revenue in order to calculate a Party's Net Sales. Any deductions listed above which involve a payment by a Party shall be taken as a deduction against aggregate sales for the period in which the payment is made. Sales of the Product between a Party and its Affiliates or sublicensees solely for research or clinical testing purposes shall be excluded from the computation of Net Sales. Net Sales will be accounted for in accordance with international accounting standards consistently applied.

"NON-MANUFACTURING PARTY" shall be any Party that is not a Manufacturing Party.

"OPTION 1" means the option provided in Section 4.01(b).

"OPTION 1 EFFECTIVE DATE" means the date which is ninety (90) days following the date on which Alliance gives Schering written notice of its intent to exercise Option 1 in accordance with Section 4.01(b) and Section 13.06.

"OPTION 2" means the option provided in Section 4.01(c).

"OPTION 2 EFFECTIVE DATE" means the date which is ninety (90) days following the date on which Alliance gives Schering written notice of its intent to exercise Option 2 in accordance with Section 4.01(c) and Section 13.06.

"PATENT" means (i) valid United States and foreign patents, re-examinations, reissues, renewals, extensions, term restorations, divisionals, continuations and continuations-in-part thereof, and foreign counterparts thereof, and (ii) pending applications for United States and foreign patents and foreign counterparts thereof. "PATENT" also includes a Supplementary Certificate of Protection of a member state of the European Community and any other similar protective rights in any other country.


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"PATENT EXPENSES" means the fees, expenses and disbursements and outside counsel fees, and payments to Third Party agents incurred in connection with the preparation, filing, prosecution and maintenance of Alliance Patents covering the Product within the Field, including Alliance's costs of patent interference and opposition proceedings and actions at law and equity for patent infringement and any sums paid to Third Parties on account of judgments or settlements arising out of Third Party patent claims (other than such judgments or settlements resulting in the payment of royalties).

"PHASE II CLINICAL TRIALS" has the meaning ascribed thereto in 21 C.F.R. Section 312.21(b), as amended from time to time.

"PHASE III CLINICAL TRIALS" has the meaning ascribed thereto in 21 C.F.R. Section 312.21(c), as amended from time to time.

"PHASE IV CLINICAL TRIALS" means product support clinical trials of a Product commenced after receipt of Regulatory Approval in the United States for such Product. These trials shall be considered a part of Clinical Work.

"PRODUCT" means AF0150 and any drug compounds, drug compositions and medical devices and systems related to perfluorocarbon containing ultrasound imaging products and developed by Alliance pursuant to this Agreement (and with Schering pursuant to the Original License Agreement) which, in the absence of this Agreement, the use, development, manufacture, marketing, sale or distribution of which would result in the infringement of one or more claims in an Alliance Patent or which utilize the Alliance Know-How. For ease of reference, "Product" is generally expressed in the singular in this Agreement, but multiple Products may be Developed or marketed hereunder.

"REGULATORY APPROVAL" means any approvals, product and/or establishment licenses, registrations or authorizations of any federal, state or local regulatory agency, department, bureau or other governmental entity, necessary for the manufacture, use, storage, importation, export, transport or sale of Product in a regulatory jurisdiction.

"RESTATEMENT DATE" shall have the meaning set forth in the heading to this Agreement.

"ROYALTY AVERAGE" shall have the meaning set forth in Section 5.01(a)(iv).

"ROYALTY PERCENTAGE" shall have the meaning set forth in Section 5.01.

"SCHERING TERRITORY"*


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"SCHERING HI PATENT" means the patents listed on Exhibit D.

"SCHERING RECOUPMENT GOAL"*

"SECOND PERIOD" means the period commencing on the third anniversary of the First Commercial Sale and ending on the fourth anniversary of the First Commercial Sale.

"SIGNIFICANT CHANGE" means any change requiring prior approval by the FDA or contemporaneous submission to the FDA of a supplement pursuant to 21 C.F.R. Sections 314.70(b) or (c), as amended from time to time, if such change is made subsequent to FDA approval of the Drug Approval Application in the United States.

"THIRD PARTY" means any entity other than Alliance or Schering and their respective Affiliates and sublicensees.

"THIRD PERIOD" means the period commencing on the fourth anniversary of the First Commercial Sale and ending on the fifth anniversary of the First Commercial Sale.

"TV INDICATION"*

"WRITTEN DISCLOSURE" shall have the meaning set forth in Section 7.06.

ARTICLE II

DEVELOPMENT

SECTION 2.01. DEVELOPMENT. Alliance shall use such efforts as it deems reasonable to execute and substantially perform all Development work for the Product; provided, however,*


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SECTION 2.02. DRUG APPROVAL APPLICATIONS.

(a) RESPONSIBILITY. Alliance shall be responsible in the Alliance Territory for preparing and filing Drug Approval Applications and seeking Regulatory Approvals for the Product, including preparing all reports necessary as part of a Drug Approval Application. All such Drug Approval Applications shall be filed in the name of Alliance. Alliance shall be responsible for prosecuting such Drug Approval Applications. In the event that any regulatory agency threatens or initiates any action to remove a Product from the market, Alliance shall notify Schering of such communication within one Business Day of receipt by Alliance so long as Schering has, or may have, marketing rights under Article IV.

(b) OWNERSHIP. Alliance shall be the legal and beneficial owner of all Drug Approval Applications and related approvals in the Alliance Territory. If Schering chooses to market a Product (as co-marketing partner or on its own), Schering shall have the right, but not the obligation to own the Drug Approval Application.

SECTION 2.03. COSTS OF DEVELOPMENT. All Development Expenses incurred by Alliance for a Product shall be borne by Alliance.

SECTION 2.04. RIGHT TO ENGAGE THIRD PARTIES. In the course of its business, Alliance regularly uses Third Parties to perform certain Development activities. Alliance may continue to do so during the course of this Agreement; provided, however, that any expenses relating to such Third Party Development will be incurred and borne by Alliance at its sole expense.

SECTION 2.05. SCHERING PORTFOLIO. Alliance is aware of the fact that Schering was, as of the Effective Date, and is, as of the Restatement Date, manufacturing and selling Competitive Products in certain countries of the Alliance Territory and will continue to do so in any country of the Alliance Territory suitable, in Schering's view, for such marketing. Alliance agrees that nothing in this Agreement is intended to prevent or prevents Schering from such marketing at its sole discretion.

ARTICLE III

LICENSES

SECTION 3.01. PATENT LICENSE TO SCHERING.

(a) ALLIANCE PATENTS. Alliance grants to Schering an exclusive license (even as to Alliance) under the Alliance Patents and the Alliance Know-How to develop, market, sell, and distribute the Product in the Schering Territory.*

(b) ALLIANCE HI PATENTS. Alliance grants to Schering a non-exclusive worldwide license, without a right to sublicense to any other party than Affiliates, under the Alliance HI Patents to use, develop, manufacture, have manufactured, market, sell and distribute product for use as an ultrasound contrast agent.


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SECTION 3.02. PATENT AND TRADEMARK LICENSE TO ALLIANCE.

(a) SCHERING HI PATENTS. Schering grants to Alliance a non-exclusive worldwide, royalty-free license, without a right to sublicense, under the Schering HI Patents to use, develop, manufacture, have manufactured, market, sell and distribute the Product worldwide for all indications in the Field; provided, however, that Schering agrees to negotiate in good faith the terms on which Alliance would be permitted to sublicense Schering HI Patents to contrast agent manufacturers promptly upon presentation by Alliance of a proposal for such a sublicense (for the avoidance of doubt, Schering has no obligation to enter into any such negotiations which regard to a proposed sublicense for the manufacture of ultrasound equipment).

(b) SCHERING TRADEMARK. At Alliance's election, Schering shall grant to Alliance a non-exclusive royalty-free license in the Alliance Territory, without a right to sublicense, for the use of the trademark "Imavist" to be used in connection with the purposes of this Agreement, such license to terminate as of the first anniversary of the First Commercial Sale.

SECTION 3.03. THIRD PARTY TECHNOLOGY.

(a) EXISTING LICENSES. The licenses granted under Section 3.01 include sublicenses of Third Party technology existing on the Effective Date and licensed to Alliance to the extent that such sublicenses can be so granted. Any royalties payable to Third Parties pertaining to technology discussed in the previous sentence shall either be paid by Alliance or be offset or deducted from royalty payments as provided under Section 5.01.

(b) SUBJECT TO TERMS. The licenses granted under this Section 3.01, to the extent they include sublicenses of Third Party Technology, Shall be subject to the terms and conditions of the license agreement pursuant to which the sublicense is granted. as of the Effective Date and as of the Restatement Date hereof there are no such agreements in place.


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ARTICLE IV

COMMERCIALIZATION

SECTION 4.01. MARKETING.

(a) ALLIANCE TERRITORY AND SCHERING TERRITORY. Subject to Section 4.01(d), Alliance shall be the sole marketing Party with respect to the Product in the Alliance Territory. Subject to Sections 4.01(b) and 4.01(c), Schering shall be the sole marketing Party with respect to the Product in the Schering Territory; provided, however, that Schering has no obligation to Develop or Commercialize the Product in the Schering Territory.

(b) OPTION 1.*

(d) CO-MARKETING, CO-PROMOTION.*

SECTION 4.02. TAX CONSIDERATIONS. Either Party may take advantage of tax considerations which benefit it and not the other Party. In the event that a Party takes advantage of a tax consideration in connection with a Product which benefits it and not the other Party, no compensation to the other Party shall be required; provided, however, that no negative tax implication for the other Party may be an element of such tax benefit.


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ARTICLE V

ROYALTIES

SECTION 5.01. SCHERING PRODUCT ROYALTIES. In further consideration of the rights and licenses granted to Schering under Section 3.01(a) and Section 3.01(b) of this Agreement, Schering shall pay to Alliance the following royalties based on the Net Sales of the Product in the Schering Territory (the "ROYALTY PERCENTAGE"):

(a) SALES IN THE SCHERING TERRITORY. With respect to sales of the Product in the Schering Territory, Schering shall pay royalties in accordance with the following table:

(i) Subject to Section 5.01(b), Schering shall pay to Alliance a royalty on Net Sales of the Product in accordance with the following table:

Category	Total Net Sales/Year ($ millions)	Royalty Percentage (% of Net Sales)	Maximum Payment (% of Net Sales) (Section 5.01(a)(ii))	Royalty Average (% of Net Sales) (Section 5.01(a)(iv))

1.	*	*	*

2.	*	*	*	*

3.	*	*	*	*

4.	*	*	*	*

5.	*	*	*	*

(ii) In any calendar year*

shall not exceed*

any such amount exceeding the Maximum Payment shall be reimbursed by Alliance to Schering. Any * made in accordance with this Section 5.01(a) shall be made after the end of the calendar year for which such adjustment is applicable, and any amount*

Alliance ratably over the next four (4) quarters. Reasonably detailed accounting records to support such adjustments shall be provided to Alliance within sixty (60) days after the end of the calendar year.

(iii) Notwithstanding Section 5.01(a)(i) above, in the event Net Sales of Product*

Net Sales For*


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Net Sales * of such total. Schering shall make such adjustments at the end of the first calendar quarter of the year and shall deliver any necessary payments (with reasonably detailed records of such adjustments) to Alliance within sixty (60) days after the end of the first calendar quarter of such year.

(iv) Notwithstanding Section 5.01(a)(i) above,*

applicable for total Net Sales for the immediately preceding calendar year. Adjustments from amounts paid as royalties pursuant to this section to amounts actually earned as royalties shall be made to fourth quarter payments to Alliance (with reasonably detailed records of such adjustments provided therewith).

(b) MINIMUM PAYMENTS. Notwithstanding anything to the contrary in Section 5.01*

on a country-by-country basis,*

If this Section 5.01(b) becomes applicable, *

The minimum payments referred to in this Section 5.01(b)*

(c) THIRD PARTY ROYALTIES. In the event that after the First Commercial Sale in the Schering Territory, Alliance pays any royalties to Third Parties*

(d) ROYALTY REDUCTION. If the Product is sold in any country in which Alliance does not have valid patent coverage for the Product which would prevent the sale of a generic form of the Product, the royalty obligation set forth in Section 5.01 above with respect to Net Sales attributable to the sale of the product in such country shall be reduced *


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Net Sales attributable to the sale of the Product in such country unless and until Alliance is granted such valid patent coverage for the Product in such country; provided that *

(e) ROYALTY TERM. Except where expressly provided otherwise in this Agreement, all royalties to a Alliance shall be paid, on a country-by-country basis, from the date of the First Commercial Sale of a Product in a country in the Schering Territory until the later of (i) ten (10) years from the First Commercial Sale in such country or (ii) the last to expire of any valid Alliance Patents which covers the use or sale of the Product in such country.

(f) DISCONTINUANCE. Subject to the provisions of Article XI, Schering may discontinue Commercialization of a Product at any time.

(g) LICENSE FOLLOWING EXPIRATION. Upon expiration of the royalty term for a Product in the country as described above, Schering shall thereafter have an exclusive (even as to Alliance), paid-up license to Alliance Know-How to sell, offer for sale, have sold and import that Product in that country. In such event, Schering shall retain responsibility for, and indemnify Alliance from, the payment of all applicable royalties and other obligations owed to a Third Party with respect to the Product.

(h) APPLICABILITY. This Section 5.01 shall be applicable to (i) sales of the Product for the TV Indication until such time as Alliance becomes the sole marketing Party with respect to the Product for the TV indication in all the countries of the world pursuant to Section 4.01(b) and (ii) sales of the Product in all the countries of the world except the United States of America for the CAD Indication until such time as Alliance becomes the Sole marketing Party with respect to the Product in all of the countries of the world for all indications, excluding however the TV Indication, pursuant to Section 4.01(c).

SECTION 5.02. ALLIANCE ROYALTIES. In consideration of funds invested by Schering in the Development of the Product under the Original License Agreement, Alliance shall make the following payments to Schering.

(a) DOWNPAYMENT. Alliance shall pay to Schering a payment equal to * of any Downpayment received by Alliance during the period * PROVIDED HOWEVER, that any payment pursuant to this Section 5.02(a) shall at least equal the Minimum Downpayment Share.

(B) ROYALTY WITH MINIMUM DOWNPAYMENT SHARE. In the event that Schering receives the Minimum Downpayment Share pursuant to Section 5.02(a), Alliance shall pay to Schering a royalty payment equal to, on a country-by-country basis, the following: *

(i) * of Net Sales of Product in the Alliance Territory in the event that Alliance does not exercise either Option 1 or Option 2;

(ii) * of Net Sales of Product in the event that Alliance exercises Option 2 but not Option 1;


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(iii) * of Net Sales of Product in the event that Alliance exercises Option 1 but not Option 2; and

(iv) * of Net Sales of Product in the event that Alliance exercises both Option 1 and Option 2.

(c) ROYALTY WITHOUT MINIMUM DOWNPAYMENT SHARE. In the event that Schering does not receive the Minimum Downpayment Share pursuant to Section 5.02(a), Alliance shall pay to Schering a royalty payment equal to, on a country-by-country basis, the following:

(i) * of Net Sales of Product in the Alliance Territory in the event that Alliance does not exercise either Option 1 or Option 2;

(ii) * of Net Sales of Product in the event that Alliance exercises Option 2 but not Option 1;

(iii) * of Net Sales of Product in the event that Alliance exercises Option 1 but not Option 2; and

(iv) * of Net Sales of Product in the event that Alliance exercises both Option 1 and Option 2.

(d) ROYALTY REDUCTION. Any royalty payments payable pursuant to Section 5.02 shall be reduced, on a country-by-country basis, as set forth below:

(i) *

(ii) *

(iii) *

(iv) *

(e) ROYALTY TERM. Except where expressly provided otherwise in this Agreement, all royalties to Schering shall be paid, on a country-by-country basis, from the First Commercial Sale of a Product in a country in the Alliance Territory until the fifth anniversary of such First Commercial Sale in such country.


	15

(f) DISCONTINUANCE. Subject to the provisions of Article XI, Alliance may discontinue Commercialization of a Product at any time.

SECTION 5.03. ROYALTY REPORTS AND PAYMENTS. Each Party shall make royalty payments to the other Party within sixty (60) days after the end of each calendar quarter in which Net Sales by the Party making such royalty payment occurred. A report summarizing the Net Sales of the Products by each Party during the relevant quarter on a country-by-country basis shall be delivered to the other Party within sixty (60) days following the end of each calendar quarter for which royalties are due.

SECTION 5.04. PAYMENTS; INTEREST.

(a) BUSINESS DAY. Any payments due under this Agreement shall be due on such date as specified in this Agreement and, in the event such date is a day on which commercial banks are not authorized to conduct business in either San Diego, California or Berlin, Germany, then the next succeeding business day, andshall be made by wire transfer to a designated bank account of the receiving Party.

(b) INTEREST. Any failure by a Party to make a payment within five days after the date when due shall obligate such Party to pay interest during the period commencing on the due date and ending on the payment date to the receiving Party at a rate per annum equal to*

and, in the event such a rate is not quoted on such date then on the immediately preceding date such rate is quoted. The interest rate shall be adjusted whenever there is a change* Interest shall be compounded annually in arrears. Such interest shall be due and payable upon the payment of the underlying principal otherwise due and payable.

SECTION 5.05. TAXES. The Party receiving royalties shall pay any and all taxes levied on account of royalties it receives under this Agreement. If laws or regulations require that taxes be withheld, the selling Party will (i) deduct those taxes from the remittable royalty, (ii) timely pay the taxes to the proper taxing authority, and (iii) send proof of payment to the other Party within thirty (30) days of receipt of confirmation of payment from the relevant taxing authority. The selling Party agrees to take all lawful and reasonable efforts to minimize such taxes to the other Party.

SECTION 5.06. PAYMENTS TO OR REPORTS BY AFFILIATES. Any payment required under any provision of this Agreement to be made to either Party or any report required to be made by any Party shall be made to or by an Affiliate of that Party if designated by that Party as the appropriate recipient or reporting entity without relieving such party from responsibility for such payment or report.


	16

SECTION 5.07. PAYMENT CURRENCY. Payments by under this Agreement shall be paid in Dollars by wire transfer of immediately available funds to an account at a commercial bank designated by Alliance or Schering pursuant to this Article V at least ten (10) business days before payment is due. Where payments are based on Net Sales in countries other than the United States, the amount of such Net Sales expressed in the currency of each country shall be converted into Dollars by Schering or Alliance, respectively, as set forth below:

(i) SCHERING: The calculation of royalty payments within Schering is based upon EUR. Therefore, where payments are based on Net Sales in countries other than the member states of the European Monetary Union, the amount of such Net Sales expressed in the currency of each country shall be converted into EUR at the Euro Foreign Exchange Reference Rates published by the European Central Bank in Frankfurt / Main, Germany on the last Business Day of the applicable calendar quarter. The resulting EUR amount will be converted into Dollars again at the Euro Foreign Exchange Reference Rates published by the European Central Bank in Frankfurt / Main, Germany on the last Business Day of the applicable calendar quarter. These Euro Foreign Exchange Reference Rates are, as of the effective date, published on REUTERS screen . If no Euro Foreign Exchange Reference Rate is determined for the relevant currency the parties shall agree upon another reference rate.

(ii) ALLIANCE: The calculation of royalty payments within Alliance is based upon Dollars. Therefore, where payments are based on Net Sales in countries other than the United States, the amount of such Net Sales expressed in the currency of each country shall be converted into Dollars at the 12 p.m. Buying Rates published by the Federal Reserve Bank of New York on REUTERS screen on the last business Day of the applicable calendar quarter. if no 12 p.m. Buying Rate is determined for the relevant currency the parties shall agree upon another reference rate.

ARTICLE VI

MANUFACTURE AND SUPPLY

SECTION 6.01. MANUFACTURE AND SUPPLY BY ALLIANCE. Alliance shall use commercially reasonable efforts, subject to the greater of the capacity of Alliance's San Diego manufacturing facility as of the date hereof or the date of filing of the Drug Approval Application for the United States, to manufacture, or arrange for manufacture of Schering's, or its Affiliates' requirements of at least * of the Product per calendar year ("the Minimum Capacity") for supply to Schering for the Commercialization of the Product in each applicable country in the Schering Territory and/or the Commercialization of the Product in the Alliance Territory after Schering has exercised its option according to Section 4.01(d). Schering hereby agrees to purchase all of its requirements of the Product from Alliance.

SECTION 6.02. MANUFACTURING AND SUPPLY AGREEMENT. As soon as it is clear that Schering will Commercialize the Product, the Parties will negotiate and execute in good faith a manufacturing and supply agreement which shall at least contain, but shall not be limited to, terms on the following topics: orders and forecasts, quality testing and quality control, GMP and regulatory compliance, change management, record keeping, audits and inspection rights, delivery/acceptance/rejections of products, shipment, failure of delivery, product complaints and recalls, technology transfer in case of failure to supply, pharmaceutical responsibilities, joint manufacturing committee, term and termination, and a detailed quality assurance agreement as appendix.


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SECTION 6.03. STEP-IN RIGHT OF SCHERING. Notwithstanding Section 6.01 Schering shall have the right, but not the obligation, to become the manufacturer for its own requirements of the Product

(a) if Alliance is not capable of manufacturing, or arranging for manufacture all of Schering's, or its Affiliates' requirements up to the Minimum Capacity, Alliance shall notify Schering sufficiently in advance, but at least six (6) months prior to the then required transfer of the manufacturing process;

(b) upon two (2) years advanced written notice to Alliance in accordance with Section 13.06 that Schering intends to become a manufacturing party for Schering's, or its Affiliates' requirements of the Product.

SECTION 6.04. TECHNOLOGY AND KNOW-HOW TRANSFER.

(a) In the event Schering becomes a manufacturer of the Product pursuant to Section 6.03 or Section 6.08, Alliance will transfer to Schering all relevant and necessary technology and know-how related to the manufacturing process, including but not limited to manufacturing descriptions, master batch records, executed batch records, release specifications and release testing methods (for active pharmaceutical ingredients, other raw materials, packaging material and finished products), in process testing methods, in process specifications, annual product reviews, validation reports, techniques and formulae, equipment descriptions in order to enable Schering to manufacture the Product for its, or its Affiliates' requirements of Product.

(b) Such transfer shall be done in close coordination with Schering as promptly as possible after receipt of Schering's notice that Schering wants to become a manufacturing party for the Product.

(d) Alliance will, at Schering's cost, give the necessary support and advice to Schering during the transfer and with regard to registration and

regulatory issues linked to such transfer of Product production to a new production site.

SECTION 6.05. REGULATORY APPROVAL FOR MANUFACTURING. Alliance shall use commercially reasonable efforts to make necessary filings to obtain, or to cause a Third Party manufacturer to make necessary filings to obtain, Regulatory Approval for the manufacture of the Product as part of the approval of a Drug Approval Application for each Product. Alliance shall notify Schering without delay of all changes to the process for the manufacture of the Product or its drug substance, whether such changes are Significant Changes or not.


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SECTION 6.06. DMF. Alliance shall be responsible for all testing and document generation (including without limitation all facilities information and related documentation; chemistry, manufacturing, and control information; regulatory methods and controls; assays and reference standards) necessary for filing a drug master file ("DMF") with the FDA for the production of the drug substance from which each Product is formulated. Alliance shall also be responsible for filing such DMF with the FDA for the production of the drug substance from which each Product is formulated.

SECTION 6.07. ACCEPTANCE AND PRICING. With respect to Product that Alliance supplies to Schering for sale,* Schering shall have the right to test Products upon delivery at its expense for compliance with specifications and legal and regulatory requirements*

(i) *

(ii) *

SECTION 6.08. COMPETITIVE COST OF GOODS. If Schering is able to manufacture or to have manufactured the Product for its or its Affiliates' requirements at*

SECTION 6.09. PACKAGING

(a) BERLEX. Schering shall cause Berlex to perform or have performed those services relating to the packaging of the Product for the United States market until such time as Alliance or a designee of Alliance obtains Regulatory Approval to perform such services, but not to exceed one (1) year. Alliance shall use diligent efforts to obtain such Regulatory Approval as promptly as possible. As compensation for such services by Berlex, or under Berlex's direction,*

In the event that Berlex performs the services described above for Alliance for more than one (1) year, then for such additional period,*


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ARTICLE VII

CONFIDENTIALITY

(b) SCHERING PACKAGING. Products manufactured by Alliance shall be supplied to Schering in packaged form as Schering reasonably directs after consultation with Alliance. Packaging and labeling costs incurred by Alliance and/or Schering shall be included in Costs of Goods Sold.

SECTION 7.01. CONFIDENTIALITY; EXCEPTIONS. Except to the extent expressly authorized by this Agreement or otherwise agreed in writing, the Parties agree that the receiving Party shall keep confidential and shall not publish or otherwise disclose or use for any purpose other than as provided for in this Agreement any Information and other information and materials furnished to it by the other Party pursuant to this Agreement or any Information developed during the course of the collaboration hereunder, or any provisions of this Agreement that are the subject of an effective order of the United States Securities Exchange Commission granting confidential treatment pursuant to the United States Securities Act of 1934, as amended (collectively, "CONFIDENTIAL INFORMATION"), except to the extent that it can be established by the receiving Party that such Confidential Information:

(a) was already known to the receiving Party, other than under an obligation of confidentiality, at the time of disclosure by the other Party;

(b) was generally available to the public or otherwise part of the public domain at the time of its disclosure to the receiving Party;

(c) became generally available to the public or otherwise part of the public domain after its disclosure and other than through any act or omission of the receiving Party in breach of this Agreement;

(d) was disclosed to the receiving Party, other than under an obligation of confidentiality, by a Third Party who had no obligation to the disclosing Party not to disclose such information to others; or

(e) was independently discovered and/or developed by the receiving Party as documented in its corporate records.

SECTION 7.02. AUTHORIZED DISCLOSURE. Each Party may disclose Confidential Information hereunder to the extent such disclosure is reasonably necessary in filing or prosecuting patent applications, prosecuting or defending litigation, filing or updating any Drug Approval Application, complying with applicable governmental regulations or conducting pre-clinical or clinical trials, provided that if a Party is required by law or regulation to make any such disclosures of the other Party's Confidential Information it will, except where impracticable for necessary disclosures, for example in the event of medical emergency, give reasonable advance notice to the other Party of such disclosure requirement and, except to the extent inappropriate in the case of patent applications, will use its reasonable efforts to secure confidential treatment of such Confidential Information required to be disclosed. In addition,


	20

and with prior notice to the other Party of each Third Party with whom a confidential disclosure agreement is being entered into, each Party shall be entitled to disclose, under a binder of confidentiality, Confidential Information to any Third Party for the purpose of carrying out the purposes of this Agreement. Nothing in this Article VII shall restrict any Party from using for any purpose any Confidential Information independently developed by it during the course of the collaboration hereunder, or from using Confidential Information that is specifically derived from pre-clinical or clinical trials to carry out Regulatory Approval, marketing, sales or professional services support functions as is customary in the pharmaceutical industry.

SECTION 7.03. SURVIVAL. This Article VII shall survive the termination or expiration of this Agreement.

SECTION 7.04. TERMINATION OF PRIOR AGREEMENT. This Agreement supersedes the Secrecy Agreement between Alliance and Schering dated as of January 14, 1997. All Information exchanged between the Parties under that Agreement shall be deemed Confidential Information and shall be subject to the terms of this Article VII.

SECTION 7.05. PUBLICATIONS. Prior to the launch of a Product, Alliance will determine the overall strategy for publication in support of such Product. Notwithstanding any term of Section 7.06 below, the Parties recognize the need for scientific publications pertaining to development of the Product and the Parties will cooperate to provide for such publications; provided, however, that the right of any Party to withhold or delay consent to publish or delay publication shall be subject to any contractual publication rights of Third Parties involved in research or clinical trials for the Product. The Parties will use reasonable efforts to obtain the voluntary consent of any Third Party granted publication rights related to the Product prior to the Effective Date to comply with reasonable notice and timing requests and will promptly review any publications delivered for review.

SECTION 7.06. PUBLICITY REVIEW. Subject to the further provisions of this Section 7.06 and Section 10.04, no Party shall originate any written publicity, news release, or other announcement or statement relating to this Agreement or to performance hereunder or the existence of an arrangement between the Parties (collectively, "WRITTEN DISCLOSURE"), without the prior prompt review and written approval of the other, which approval shall not be unreasonably withheld or delayed. Notwithstanding the foregoing provisions of this Section 7.06, any Party may make any public Written Disclosure it believes in good faith based upon the advice of counsel is required by applicable law or any listing or trading agreement concerning its publicly traded securities, provided that prior to making such Written Disclosure, the disclosing Party shall provide the other Party with a copy of the materials proposed to be disclosed and provide the receiving Party with an opportunity to promptly review the proposed Written Disclosure. To the extent that the receiving Party reasonably requests that any information in the materials proposed to be disclosed be deleted, the disclosing Party shall request confidential treatment of such information pursuant to Rule 406 of the United States Securities Act of 1933 or Rule 26b-2 of the United States Securities Exchange Act of 1934, as applicable (or any other applicable regulation relating to the confidential treatment of information), so that there be omitted from the materials that are publicly filed any information that the receiving Party reasonably requests to


	21

be deleted. The terms of this Agreement may also be disclosed to (i) government agencies where required by law, or (ii) Third Parties with the prior written consent of the other Party, which consent shall not be unreasonably withheld or delayed, so long as such disclosure is made under a binder of confidentiality and so long as highly sensitive terms and conditions such as financial terms are extracted from the Agreement or not disclosed upon the request of the other Party. All Written Disclosures shall be factual and as brief as is reasonable under the circumstances. Upon request by either Party, the Parties agree to prepare a mutually agreed press release and question and answer document with respect to this Agreement. Each Party agrees that it will use reasonable efforts to cause all Written Disclosures and oral statements relating hereto to be consistent with the answers specified in such question and answer document.

ARTICLE VIII

OWNERSHIP OF INTELLECTUAL PROPERTY AND PATENT RIGHTS

SECTION 8.01. OWNERSHIP. Each Party shall solely own, and it alone shall have the right to apply for, Patents within and outside of the United States for any inventions made solely by that Party's employees or consultants in the course of performing work under this Agreement.

SECTION 8.02. PATENT FILINGS. Each Party, at its sole discretion and responsibility, shall prepare, file, prosecute and maintain Patents to cover discoveries and inventions made solely by its own employees or consultants.

SECTION 8.03. THIRD PARTY PATENT RIGHTS. Each Party agrees to bring to the attention of the other Party any Third Party Patent it discovers, or has discovered, and which relates to the subject matter of this Agreement.

SECTION 8.04. ENFORCEMENT RIGHTS.

(a) NOTIFICATION OF INFRINGEMENT. If either Party learns of any infringement or threatened infringement by a Third Party of the Alliance Patents, such Party shall promptly notify the other Party and shall provide such other Party with all available evidence of such infringement.

(b) ENFORCEMENT IN THE TERRITORY. Alliance shall have the right, but not the obligation, to institute, prosecute and control at its own expense any action or proceeding with respect to infringement of any Alliance Patents covering the manufacture, use, importation, sale or offer for sale of the product being developed or marketed by counsel of its own choice. Where possible with regard to manpower and time, Schering upon Alliance's request and at Alliance's costs, shall give documentary support and reasonable assistance in such proceedings. Any damages or other monetary awards recovered pursuant to this Section 8.04(b) shall be for the account of Alliance. If Alliance fails or does not want to bring an action or proceeding or otherwise take appropriate action to ▇▇▇▇▇ such infringement within a period of one hundred eighty (180) days of notice by Schering to Alliance requesting such action, Schering shall have the right, but not the obligation, to institute, prosecute and control at its own expense any such action or proceeding with respect to infringement of any Alliance patents.*


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(c) SETTLEMENT WITH A THIRD PARTY. Alliance shall also have the right to control settlement of such action; provided, however, that no settlement shall be entered into without the written consent of the Schering (which consent shall not be unreasonably withheld) if such settlement would materially and adversely affect the interests of Schering.

SECTION 8.05. DEFENSE AND SETTLEMENT OF THIRD PARTY CLAIMS. If a Third Party asserts that a patent, trademark or other intangible right owned by it is infringed by any Product, Alliance will be solely responsible for defending against any such assertions at its cost and expense (subject to the provisions of Section 8.04(b)). Any determination regarding the necessity to license or otherwise obtain rights under or invalidate certain Third Party Patents covering the Product shall be made by Alliance; provided, however, that no settlement may be entered into without the written consent of Schering (which shall not be unreasonably withheld) if such settlement would materially and adversely affect the interests of Schering.*

SECTION 8.06. PATENT EXPENSES. All worldwide Patent Expenses shall be borne by Alliance, subject to the terms of this Agreement.

SECTION 8.07. TRADEMARKS.

(a) SCHERING. Schering shall be responsible for the selection, registration and maintenance of all trademarks which it employs in connection with the Product and shall own and control such trademarks (and pay any costs in connection therewith). Alliance recognizes the exclusive ownership by Schering of any proprietary Schering name, logotype or trademark furnished by Schering (including Schering's Affiliates) for use in connection with the Product. Alliance shall not, either while this Agreement is in effect, or at any time thereafter, register, use or attempt to obtain any right in or to any such name, logotype or trademark or in and to any name, logotype or trademark confusingly similar thereto.

(b) ALLIANCE. Schering hereby reconveys to Alliance all rights to the trademark for "Imagent" granted pursuant to the Original License Agreement.

ARTICLE IX

REPRESENTATIONS AND WARRANTIES

SECTION 9.01. REPRESENTATIONS AND WARRANTIES.

(a) Each of the Parties hereby represents and warrants to the other Party as follows:


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(i) This Agreement is a legal and valid obligation binding upon such Party and enforceable in accordance with its terms. The execution, delivery and performance of the Agreement by such Party does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it is bound, nor violate any law or regulation of any court, governmental body or administrative or other agency having jurisdiction over it.

(ii) Alliance has not, and during the term of the Agreement neither Party will, (x) grant any right to any Third Party relating to the Alliance Patents and to Alliance Know-How in the Field which would conflict with the rights granted to either Party hereunder, and (y) to the best of its knowledge neither party is employing (as an employee or consultant), nor will either Party employ during the term of this Agreement, any person that has been debarred by the FDA.

(iii) To the best of its knowledge Alliance is not obligated under any agreement as of the Effective Date and the Restatement Date to pay any Third Party royalties with respect to the Product. As of the Effective Date and the Restatement Date there are no such agreements in place.

(b) Alliance hereby represents and warrants to Schering as follows:

(i) It has given Schering access to all its pre-clinical and clinical records regarding the Product in existence as of the Effective Date and the Restatement Date.

(ii) As of the Effective Date and the Restatement Date, except as it may have previously disclosed to Schering in writing or otherwise, it has not received any notices of infringement or any written communications relating in any way to a possible infringement with respect to any Alliance Patent.

SECTION 9.02. PERFORMANCE BY AFFILIATES. The Parties recognize that each Party may perform some or all of its obligations under this Agreement through Affiliates; provided, however, that each Party shall remain responsible for and be a guarantor of the performance by its Affiliates and shall cause its Affiliates to comply with the provisions of this Agreement in connection with such performance.

ARTICLE X

INFORMATION AND REPORTS

SECTION 10.01. INFORMATION AND REPORTS DURING DEVELOPMENT AND COMMERCIALIZATION. Schering and Alliance will disclose and make available (subject to any confidentiality agreements or requirements of law) to each other without charge all preclinical, clinical, regulatory, pricing, sales and other Information, including copies of all preclinical and clinical reports, known by Schering or Alliance directly concerning the Product within the Field at any time during the term of this Agreement. Each Party shall own and maintain its own database of clinical trial data accumulated from all clinical trials of the Product for which it was


	24

responsible and of adverse drug event information for the Product. At the option of the requesting Party, such data shall be provided in a computer readable format by the providing Party, to the extent available, which shall also assist in the transfer and validation of such data to the receiving Party. Without limitation of the foregoing, each Party shall supply to the other practice or as a specific request) for purposes of compliance with regulatory requirements.

SECTION 10.02. ADVERSE DRUG EXPERIENCES.

(a) Alliance agrees to provide to Schering for initial and/or periodic submission to government agencies significant information on the Product from preclinical laboratory, animal toxicology and pharmacology studies, as well as adverse drug experience reports from clinical trials and commercial experiences with the Product;

(b) Each party agrees to, in connection with investigational Products, report to the other party as soon as possible (and, in any event, within three (3) days) the receipt of a report of any unexpected or serious experience, if required for the other Party to comply with regulatory requirements;

(c) Each Party agrees to, in connection with marketed Products, report to the other Party within three (3) business days of the receipt of a report of any adverse experience that is serious and unexpected or sooner if required for the other Party to comply with regulatory requirements. Serious adverse experience means any experience that suggests a significant hazard, contraindication, side effect or precaution, or any experience that is fatal or life threatening, is permanently disabling, requires or prolongs inpatient hospitalization, or is a congenital anomaly, cancer, or overdose. An unexpected adverse experience is one not identified in nature, specificity, severity or frequency in the current investigator brochure or the U.S. labeling for the drug; and

(d) If requested by Schering, Alliance agrees to enter into a standard operating procedure by and between the Parties to govern the exchange of information relating to adverse drug experiences and product quality.

SECTION 10.03. RECORDS OF REVENUES AND EXPENSES.

(a) Each Party will maintain complete and accurate records which are relevant to revenues, costs, expenses and payments on a country-by-country basis under this Agreement and such records shall be open during reasonable business hours for a period of two (2) years from creation of individual records for examination at the other Party's expense and not more often than once each year by a certified public accountant selected by the other Party, or the other Party's internal accountants unless the first Party objects to the use of such internal accountants, for the sole purpose of verifying for the inspecting Party the correctness of calculations and classifications of such revenues, costs, expenses or payments made under this Agreement. Each party shall bear its own costs related to such audit; provided, however, that, for any underpayments by a Party greater than five percent (5%), such Party shall pay the other Party the amount of underpayment, interest as provided for in Section 5.04(b) from the

time the


	25

amount was due and the other Party's out-of-pocket expenses. For any underpayments less than five percent (5%) by a Party found under this Section, such Party shall pay the other Party the amount of underpayment. Any overpayments by a Party will be refunded to such Party or credited to future royalties, at such Party's election. Any records or accounting information received from the other Party shall be Confidential Information for purposes of Article VII. Results of any such audit shall be provided to both Parties, subject to Article VII.

(b) If there is a dispute between the Parties following any audit performed pursuant to Section 10.03(a), either party may refer the issue (an "AUDIT DISAGREEMENT") to an independent certified public accountant for resolution. In the event an Audit Disagreement is submitted for resolution by either Party, the Parties shall comply with the following procedures:

(i) The Party submitting the Audit Disagreement for resolution shall provide written notice to the other Party that it is invoking the procedures of this Section 10.03(b).

(ii) Within thirty (30) business days of the giving of such notice, the Parties shall jointly select a recognized international accounting firm to act as an independent expert to resolve such Audit Disagreement.

(iii) The Audit Disagreement submitted for resolution shall be described by the Parties to the independent expert, which description may be in written or oral form, within ten (10) business days of the selection of

such independent expert.

(iv) The independent expert shall render a decision on the matter as soon as practicable.

(v) The decision of the independent expert shall be final and binding unless such Audit Disagreement involves alleged fraud, breach of this Agreement or construction or interpretation of any of the terms and conditions hereof.

(vi) All fees and expenses of the independent expert, including any third party support staff or other costs incurred with respect to carrying out the procedures specified at the direction of the independent expert in connection with such Audit Disagreement, shall be borne by the Party that did not submit the Audit Disagreement in the event that a discrepancy of more than two percent (2%) results from such decision, and by each Party in inverse proportion to the disputed amounts awarded to the Party by the independent expert through such decision (e.g. Alliance disputes $100, the independent expert awards Alliance $50, then each party pays one-half (1/2) of the

independent expert's costs) in all other cases.

SECTION 10.04. APPLICABILITY. This Article X shall be applicable following the Restatement Date (without prejudice to any rights accruing prior to the Restatement Date) only if Schering undertakes Development or Commercialization activities with regard to a Product following the Restatement Date or exercises its option under Section 4.01(d).


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ARTICLE XI

TERM AND TERMINATION

SECTION 11.01. TERM. This Agreement shall commence as of the Effective Date and, unless sooner terminated as provided herein shall continue in effect until no royalties or other payments are payable hereunder to either Alliance or Schering.

SECTION 11.02. TERMINATION.

(a) Notwithstanding any other provision herein, Schering may, prior to Regulatory Approval of a Product, terminate this Agreement on a country by country basis or in its entirety upon one (1) month written notice to Alliance. After receipt of Regulatory Approval of a Product and prior to the First Commercial Sale of said Product in the applicable country, Schering may terminate this Agreement on a country by country basis upon two (2) months written notice to Alliance. After the First Commercial Sale of a Product, Schering may terminate this Agreement on a country by country basis upon three (3) months written notice to Alliance.

(b) Failure by Schering or Alliance to comply with any of the respective material obligations and conditions contained in this Agreement shall entitle the other Party to give the Party in default notice requiring it to cure such

default. If such default is not cured within ninety (90) days after receipt of such notice, the notifying Party shall be entitled (without prejudice to any of its other rights conferred on it by this Agreement) to terminate this Agreement or in the event of an uncured material breach by Alliance, effect the rights of Schering set forth in Section 11.02(e) by giving a notice to take effect immediately. Notwithstanding the foregoing, in the event of a non-monetary default, if the default is not reasonably capable of being cured within the ninety (90) day cure period by the defaulting Party and such defaulting Party is making a good faith effort to cure such default, the notifying Party may not terminate this Agreement, provided however, that the notifying Party may terminate this Agreement if such default is not cured within one hundred eighty (180) days of such original notice of default. The right of either Party to terminate this Agreement as hereinabove provided shall not be affected in any way by its waiver of, or failure to take action with respect to any previous default.

(c) In the event that one of the Parties hereto shall go into liquidation, a receiver or a trustee be appointed for the property or estate of that Party and said receiver or trustee is not removed within sixty (60) days, or the Party makes an assignment for the benefit of creditors (collectively, a "BANKRUPTCY EVENT"), and whether any of the aforesaid Bankruptcy Events be the outcome of the voluntary act of that Party, or otherwise, the other Party shall be entitled to terminate this Agreement (or in the event Alliance suffers such a Bankruptcy Event, Schering may effect its rights described in Section 11.02(e) forthwith by giving a written notice to Alliance.

(d) In the event that this Agreement is terminated by Schering in one or more countries or in its entirety, and in the event that the Agreement is terminated by either Party in its entirety in accordance with Sections 11.02(a), (b) or (c) hereof, Schering will with respect to each country for which the termination applies entirely:


	27

(i) deliver to Alliance the Alliance Know-How and assign to Alliance its rights in said Alliance Know-How and Alliance Patents if any, in either case relating solely to the country that is the subject of the termination;

(ii) not use the Alliance Know-How as long as it has to be kept confidential pursuant to Article VII hereof in such country;

(iii) not infringe any of the Alliance Patents in such country;

(iv) make all payments accrued under this Agreement with respect to such country prior to the effective termination date;

(v) transfer all regulatory filings and approvals related to the Product in such country to Alliance upon Alliance's written request for same;

(vi) transfer to Alliance responsibility for and control of ongoing work of Schering related to the Product, Affiliates and Third Parties in an expeditious and orderly manner with the costs for such work assumed by Alliance as of the date of notice; and

(vii) sell to Alliance, at any time within ninety (90) days of such termination, at Alliance's election, all or any portion of the inventory of the Product owned by Schering or its Affiliates which are intended for sale in such country at a price equal to Schering's or its Affiliate's cost for such inventory. Such election shall be made by Alliance in writing and within thirty (30) days of such election, Schering shall ship at Alliance's cost and direction such inventory to Alliance. Alliance shall pay for such inventory within forty-five (45) days of receipt of such inventory.

(e) In the event of a Bankruptcy Event or a material default described in Sections 11.02(b) and (c) by Alliance (which default is not cured as provided therein), Schering may elect in lieu of terminating this Agreement to declare the license granted pursuant to this Agreement to be irrevocable. From the date of receipt of notice of such election, Alliance shall have no further rights or obligations under this Agreement, except that Alliance may enforce any financial obligations of Schering, including those arising under Article V herein before or after such election, and Schering may enforce any manufacturing and supply obligations of Alliance, including those arising under Section 11.02(f); provided, however, that if such election occurs prior to the First Commercial Sale of the Product, any additional Development Expenses and reasonable costs incurred by Schering to Commercialize the Product as a result of such election shall be credited against amounts payable by Schering to Alliance.

(f) In the event of termination of this Agreement pursuant to this Section 11.02 where the Party terminating this Agreement is the Manufacturing Party, the Manufacturing Party shall continue to provide for manufacture of the Product to the extent provided prior to notice of such termination, from the effective date of such termination until such time as the Non-Manufacturing Party is able to secure an equivalent alternative commercial manufacturing source, as requested by the Non-Manufacturing Party.


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(g) Except where expressly provided for otherwise in this Agreement, termination of this Agreement shall not relieve the Parties hereto of any liability, including any obligation to make payments hereunder, which accrued hereunder prior to the effective date of such termination, nor preclude any Party from pursuing all rights and remedies it may have hereunder or at law or in equity with respect to any breach of this Agreement nor prejudice any Party's right to obtain performance of any obligation.

SECTION 11.03. SURVIVING RIGHTS. The rights and obligations set forth in this Agreement shall extend beyond the term or termination of the Agreement only to the extent expressly provided for herein, or the extent that the survival of such rights or obligations are necessary to permit their complete fulfillment or discharge.

ARTICLE XII

INDEMNIFICATION

SECTION 12.01. INDEMNIFICATION. With respect to the Product (determined on a country by country basis):

(a) Schering and Alliance hereby agree to save, defend and hold the other Party and its agents and employees harmless from and against any and all suits, claims, actions, demands, liabilities, expenses and/or losses, including reasonable legal expenses and attorneys' fees (collectively, "LOSSES") resulting directly from the Development or Commercialization of the Product to the extent such Development or Commercialization was performed by such Party except to the extent such Losses result from the negligence or willful misconduct of the other Party, in which case such Party hereby agrees to save, defend and hold the other Party and its agents and employees harmless from any and all such Losses.

(b) Each indemnified Party agrees to give the indemnifying Party prompt written notice of any Loss or discovery of fact upon which such indemnified Party intends to base a request for indemnification under Sections 12.01(a). Each Party shall furnish promptly to the other copies of all papers and official documents received in respect of any Loss. With respect to any Loss relating solely to the payment of money damages and which will not result in the indemnified Party becoming subject to injunctive or other relief or otherwise adversely affecting the business of the indemnified Party in any manner, and as to which the indemnifying Party shall have acknowledged in writing the obligation to indemnify the indemnified Party hereunder, the indemnifying Party shall have the sole right to defend, settle or otherwise dispose of such Loss, on such terms as the indemnifying Party, in its sole discretion, shall deem appropriate. The indemnifying Party shall obtain the written consent of the indemnified Party, which shall not be unreasonably withheld or delayed, prior to ceasing to defend, settling or otherwise disposing of any Loss if as a result thereof the indemnified Party would become subject to injunctive or other equitable relief or any remedy other than the payment of money, which payment would be the responsibility of the indemnifying Party. The indemnifying Party shall not be liable for any settlement or other disposition of a Loss by the indemnified Party which is reached without the written consent of the indemnifying Party. The reasonable costs and expenses, including reasonable fees and disbursements of counsel incurred by any


	29

indemnified Party in connection with any Loss, shall be reimbursed on a quarterly basis by the indemnifying Party, without prejudice to the indemnifying Party's right to contest the indemnified Party's right to indemnification and subject to refund in the event the indemnifying party is ultimately held not to be obligated to indemnify the indemnified Party.

ARTICLE XIII

MISCELLANEOUS

SECTION 13.01. ASSIGNMENT.

(a) Schering may assign any of its rights or obligations under this Agreement in any country to any of its Affiliates or to any sublicensee as provided in Section 3.01; provided, however, that such assignment shall not relieve Schering of its responsibilities for performance of its obligations under this Agreement.

(b) Alliance may assign any of its rights or obligations under this Agreement in any country to any of its Affiliates or to any sublicensee if permitted by Section 3.02; provided, however, that such assignment shall not relieve Alliance of its responsibilities for performance of its obligations under this Agreement.

(c) Either Party may assign its rights or obligations under this Agreement in connection with a merger or similar reorganization or the sale of all or substantially all of its assets, or otherwise with the prior written consent of the other Party. This Agreement shall survive any such merger or reorganization of either Party with or into, or such sale of assets to, another Party and no consent for such merger, reorganization or sale shall be required hereunder; provided, that in the event of such merger, reorganization or sale, no intellectual property rights of the acquiring corporation shall be included in the technology licensed hereunder.

(d) This Agreement shall be binding upon and inure to the benefit of the successors and permitted assigns of the Parties. Any assignment not in accordance with this Agreement shall be void.

SECTION 13.02. RETAINED RIGHTS. Nothing in this Agreement shall limit in any respect the right of either Party to conduct research and development and to market products using such Party's technology other than as herein expressly provided.

SECTION 13.03. FORCE MAJEURE. Neither Party shall lose any rights hereunder or be liable to the other Party for damages or losses on account of failure of performance by the defaulting Party if the failure is occasioned by government action, war, fire, explosion, flood, strike, lockout, embargo, act of God, or any other cause beyond the control of the defaulting Party, provided that the Party claiming force majeure has extended all reasonable efforts to avoid or remedy such force majeure, continues to employ such efforts and promptly notifies the other Party of such force majeure event.


	30

SECTION 13.04. FURTHER ACTIONS. Each Party agrees to execute, acknowledge and deliver such further instruments, and to do all such other acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement.

SECTION 13.05. NO TRADEMARK RIGHTS. Except as otherwise provided herein, no right, express or implied, is granted by the Agreement to use in any manner the name "Schering," or any other trade name or trademark of the other Party or its Affiliates in connection with the performance of the Agreement.

ARTICLE 13.06. NOTICES. All notices hereunder shall be in writing and shall be deemed given if delivered personally, mailed by registered or certified mail (return receipt requested), postage prepaid, or sent by express courier service, to the Parties at the following addresses (or at such other address for a Party as shall be specified by like notice; provided, however, that notices of a change of address shall be effective only upon receipt thereof).

(a)	If to Alliance:

	Alliance Pharmaceutical Corp. ▇▇▇▇ ▇▇▇▇▇▇▇ ▇▇▇▇ ▇▇▇▇ ▇▇▇ ▇▇▇▇▇, ▇▇ ▇▇▇▇▇ Attention: President Telecopy: (▇▇▇) ▇▇▇-▇▇▇▇

	With a copy to:

	Stroock & Stroock & ▇▇▇▇▇ LLP ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇ ▇▇▇ ▇▇▇▇, ▇▇ ▇▇▇▇▇-▇▇▇▇ Attention: ▇▇▇▇▇▇ ▇▇▇▇▇▇▇ Telecopy: (▇▇▇) ▇▇▇-▇▇▇▇

(b)	If to Schering:

	▇▇▇▇▇▇▇▇ ▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇▇▇ Attention: Legal Department Telecopy: ++49+ ▇▇-▇▇▇▇ ▇▇▇▇

	With a copy to:

	▇▇▇▇▇▇▇▇ ▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇▇▇ Attention: SBU Diagnostics & Radiopharmaceuticals Telecopy: ++49+ ▇▇-▇▇▇▇ ▇▇▇▇


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SECTION 13.07. WAIVER. Except as specifically provided for herein, the waiver from time to time by either of the Parties of any of their rights or their failure to exercise any remedy shall not operate or be construed as a continuing waiver of same or any other of such Party's rights or remedies provided in this Agreement.

SECTION 13.08. SEVERABILITY. If any term, covenant or condition of this Agreement or the application thereof to any Party or circumstances shall, to any extent or in any country, be held to be invalid or unenforceable, then (i) the remainder of this Agreement, or the application of such term, covenant or condition to Parties or circumstances other than those as to which it is held invalid or unenforceable, shall not be affected thereby and each term, covenant or condition of this Agreement shall be valid and be enforced to the fullest extent permitted by law; and (ii) the Parties hereto covenant and agree to renegotiate any such term, covenant or application thereof in good faith in order to provide a reasonably acceptable alternative to the term, covenant or condition of this Agreement or the application thereof that is invalid or unenforceable, it being the intent of the Parties that the basic purposes of this Agreement are to be effectuated.

SECTION 13.09. AMBIGUITIES. Ambiguities, if any, in this Agreement shall not be construed against any Party, irrespective of which Party may be deemed to have authored the ambiguous provision.

SECTION 13.10. GOVERNING LAW. This Agreement shall be governed by and interpreted under the laws of the State of New York as applied to contracts entered into and performed entirely in New York by New York residents.

SECTION 13.11. HEADINGS. The sections and paragraph headings contained herein are for the purposes of convenience only and are not intended to define or limit the contents of said sections or paragraphs.

SECTION 13.12. COUNTERPARTS. This Agreement may be executed in one or more counterparts (and by facsimile), each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

SECTION 13.13. ENTIRE AGREEMENT; AMENDMENTS. This Agreement, including all Exhibits attached hereto and thereto, and all documents delivered concurrently herewith and therewith, set forth all the covenants, promises, agreements, warranties, representations, conditions and understandings between the Parties hereto and supersede and terminate all prior agreements and understandings between the Parties. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or written, between the Parties other than as set forth herein and therein. No subsequent alteration, amendment, change or addition to this Agreement shall be binding upon the Parties hereto unless reduced to writing and signed by the respective authorized officers of the Parties. This Agreement, including without limitation the exhibits, schedules and attachments thereto, are intended to define the full extent of the legally enforceable undertakings of the Parties hereto,


	32

and no promise or representation, written or oral, which is not set forth explicitly is intended by either party to be legally binding. Both Parties acknowledge that in deciding to enter into the Agreement and to consummate the transaction contemplated thereby neither has relied upon any statement or representations, written or oral, other than those explicitly set forth therein.

SECTION 13.14. EXPENSES. Except as otherwise specified in this Agreement, all costs and expenses, including, without limitation, fees and disbursements of counsel, financial advisors and accountants, incurred in connection with this Agreement and the transactions contemplated hereby shall be paid by the Party incurring such costs and expenses.

SECTION 13.15. INDEPENDENT CONTRACTORS. The status of the Parties under this Agreement shall be that of independent contractors. Neither Party shall have the right to enter into any agreements on behalf of the other Party, nor shall it represent to any person that it has any such right or authority. Nothing in this Agreement shall be construed as establishing a partnership or joint venture relationship between the Parties.

SECTION 13.16. USE OF NAMES. Neither Party shall use the name of the other Party in relation to this transaction in any public announcement, press release or other public document without the written consent of such other Party, which consent shall not be unreasonably withheld or delayed; provided, however, that either Party may use the name of the other Party in any document filed with any regulatory agency or authority, including the FDA and the Securities and Exchange Commission, in which case Schering shall be referred to as "Schering AG, Germany". Alliance agrees not to use the name "Schering" in relation to this

transaction in any press release, public announcement or other public document without the approval of Schering, which approval shall not be unreasonably withheld or delayed.

IN WITNESS WHEREOF, Alliance and Schering have caused this Agreement to be executed as of the date first written above by their respective officers thereunto duly authorized.


	ALLIANCE PHARMACEUTICAL CORP

	By:
		Name:
		Title


	SCHERING AKTIENGESELLSCHAFT

	By:
		Name: ▇▇▇▇-▇▇▇▇▇▇▇ ▇▇▇▇
		Title: Head of SBU DG & RP


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	By:
		Name: ▇▇. ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇
		Title: Licensing and Cooperations DG & RP


	34

EXHIBIT A

DETERMINATION OF CERTAIN ACCOUNTING TERMS

As a supplement to the definitions provided in Article I of the License Agreement (this "AGREEMENT"), originally dated as of September 23, 1997, and amended and restated in its entirety as of February 22, 2002 between ALLIANCE PHARMACEUTICAL CORP. and SCHERING AKTIENGESELLSCHAFT, the following accounting terms shall be further specified as follows, with the intent that the following terms are to be interpreted in accordance with their reasonable and customary meaning within the industry and consistently applied by a Party on a company-wide basis:

1. COST OF GOODS

Cost of Goods shall be equal to the sum of Material Costs, Direct Labor costs and Indirect Costs.

A. "MATERIAL COSTS" shall mean the prices paid for raw material components and purchased finished goods, including any packaging necessary for the shipment of products, which are purchased from outside vendors as well as any freight and duty where applicable.

B. "DIRECT LABOR COSTS" shall mean the labor hours required for an operation for such a Product multiplied by the direct labor rate for work centers within the relevant manufacturing operating unit (including salaries, wages and benefits).

C. "INDIRECT COSTS" shall mean other costs associated with the operating unit(s) manufacturing a Product; provided, however, overhead attributable to unrelated facilities, or parts thereof, shall be excluded and that such Indirect Costs shall exclude costs associated with unused manufacturing capacity. Indirect Costs shall include expenses associated with quality assurance, manufacturing and engineering associated with the operating unit(s) manufacturing a Product and shall include straight line depreciation and property taxes specifically associated with the plant(s) manufacturing a Product.


	A-1

EXHIBIT B

ALLIANCE PATENTS

PATENT NUMBER


	B-1

EXHIBIT C

ALLIANCE HI PATENTS

PATENT NUMBER


	C-1

EXHIBIT D

SCHERING HI PATENTS


INT. NO.		INT. NO.

*		*

*		*

*		*

*		*

*		*

*		*

*

*		*

*		*

*		*

*		*

*		*

*		*

*		*

*		*

*

*

*		*

*


	D-1

LICENSE AGREEMENT originally dated as of September 23, 1997 amended and restated in its entirety as of February 22, 2002 by and between ALLIANCE PHARMACEUTICAL CORP. and SCHERING AKTIENGESELLSCHAFT

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