EXHIBIT 1
JOINT FILING AGREEMENT
By this Agreement, the undersigned agree that this Statement on Schedule
13G being filed on or about this date, and any subsequent amendments thereto
filed by any of us, with respect to the securities of Orexigen Therapeutics,
Inc. is being filed on behalf of each of us.
July 12, 2010
▇▇▇▇▇ ▇▇▇▇▇
/s/ ▇▇▇▇▇▇▇▇ ▇▇▇▇▇
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By: ▇▇▇▇▇▇▇▇ ▇▇▇▇▇*
Title: Attorney-in-fact
▇. ▇▇▇▇▇ (1999) LTD.
/s/ ▇▇▇▇▇▇▇▇ ▇▇▇▇▇
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By: ▇▇▇▇▇▇▇▇ ▇▇▇▇▇**
Title: Attorney-in-fact for ▇▇▇▇▇ ▇▇▇▇▇,
Chairman of ▇. ▇▇▇▇▇ (1999) Ltd.
SPHERA FUNDS MANAGEMENT LTD.
/s/ ▇▇▇ Senator
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By: ▇▇▇ Senator***
Title: Director
/s/ ▇▇▇▇▇ ▇▇▇▇▇
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By: ▇▇▇▇▇ ▇▇▇▇▇***
Title: Director
/s/ Israel Mor
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Israel Mor
/s/ ▇▇▇▇▇ ▇▇▇▇▇
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▇▇▇▇▇ ▇▇▇▇▇
/s/ ▇▇▇ Senator
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▇▇▇ Senator
* Duly authorized under Special Power of Attorney appointing ▇▇▇▇▇▇▇▇ ▇▇▇▇▇
attorney-in-fact, dated February 9, 2010 by and on behalf of ▇▇▇▇▇ ▇▇▇▇▇
(incorporated herein by reference to Exhibit 2 to the Schedule 13G filed on
February 9, 2010).
** Duly authorized under Special Power of Attorney appointing ▇▇▇▇▇▇▇▇ ▇▇▇▇▇
attorney-in-fact, dated February 9, 2010 by and on behalf of ▇▇▇▇▇ ▇▇▇▇▇ as
Chairman of ▇. ▇▇▇▇▇ (1999) Ltd. (incorporated herein by reference to Exhibit 3
to the Schedule 13G filed on February 9, 2010).
*** Duly authorized by Unanimous Written Consent of the Board of Directors of
Sphera Funds Management Ltd. allowing ▇▇▇ Senator, ▇▇▇▇▇ ▇▇▇▇▇, and Israel Mor,
any two of whom acting together, to bind Sphera Funds Management Ltd. for any
and all matters, dated July 1, 2010, attached hereto as Exhibit 4.
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