ATLANTIC PHARMACEUTICALS, INC.
                        AUTOMATIC STOCK OPTION AGREEMENT
RECITALS
         A. The Corporation  has  implemented an automatic  option grant program
under the Plan pursuant to which eligible non-employee members of the Board will
automatically  receive  special  option grants at periodic  intervals over their
period of Board service in order to provide such  individuals  with a meaningful
incentive to continue to serve as members of the Board.
         B.  Optionee  is  an  eligible  non-employee  Board  member,  and  this
Agreement is executed pursuant to, and is intended to carry out the purposes of,
the Plan in connection  with the automatic grant of an option to purchase shares
of Common Stock under the Plan.
         C. All  capitalized  terms in this  Agreement  shall  have the  meaning
assigned to them in the attached Appendix.
                  NOW, THEREFORE, it is hereby agreed as follows:
                  1. Grant of Option. The Corporation hereby grants to Optionee,
as of the Grant  Date,  a  Non-Statutory  Option to purchase up to the number of
Option  Shares  specified  in the  Grant  Notice.  The  Option  Shares  shall be
purchasable from time to time during the option term specified in Paragraph 2 at
the Exercise Price.
                  2.  Option  Term.  This  option  shall have a term of ten (10)
years measured from the Grant Date and shall accordingly  expire at the close of
business on the Expiration  Date,  unless sooner  terminated in accordance  with
Paragraph 5, 6 or 7.
                  3. Limited  Transferability.  This option,  together  with the
special stock appreciation right provided under Paragraph 7(b), shall be neither
transferable  nor  assignable  by Optionee  other than by will or by the laws of
descent and distribution following Optionee's death and may be exercised, during
Optionee's lifetime, only by Optionee. However, this option may also be assigned
in whole or in part during Optionee's lifetime in accordance with the terms of a
Qualified  Domestic  Relations  Order. The assigned portion shall be exercisable
only by the person or persons who acquire a  proprietary  interest in the option
pursuant to such Qualified Domestic Relations Order. The terms applicable to the
assigned  portion  shall  be the  same  as  those  in  effect  for  this  option
immediately  prior to such  assignment  and shall be set forth in such documents
issued to the assignee as the Board may deem appropriate.
                  4.       Exercisability/Vesting.
                           (a) This option shall be immediately  exercisable for
any or all of the Option Shares,  whether or not the Option Shares are vested in
accordance with the Vesting  Schedule and shall remain so exercisable  until the
Expiration Date or sooner termination of the option term under Paragraph 5, 6 or
7.
                           (b) Optionee  shall,  in accordance  with the Vesting
Schedule,  vest in the Option Shares in one or more installments over his or her
period  of Board  service.  Vesting  in the  Option  Shares  may be  accelerated
pursuant to the provisions of Paragraph 5, 6 or 7. In no event,  however,  shall
any additional Option Shares vest following Optionee's cessation of service as a
Board member.
                  5. Cessation of Board Service.  Should Optionee's service as a
Board member cease while this option remains  outstanding,  then the option term
specified  in  Paragraph 2 shall  terminate  (and this option  shall cease to be
outstanding)  prior to the  Expiration  Date in  accordance  with the  following
provisions:
                           (a) Should  Optionee cease to serve as a Board member
for any reason  (other than death or Permanent  Disability)  while  holding this
option,  then the period for exercising this option shall be reduced to a twelve
(12)-month period (commencing with the date of such cessation of Board service),
but in no  event  shall  this  option  be  exercisable  at any  time  after  the
Expiration Date. During such limited period of  exercisability,  this option may
not be exercised in the  aggregate for more than the number of Option Shares (if
any) in which Optionee is vested on the date Optionee  ceases service as a Board
member.  Upon the earlier of (i) the expiration of such twelve (12)-month period
or (ii) the specified  Expiration  Date, the option shall terminate and cease to
be exercisable with respect to any vested Option Shares for which the option has
not been exercised.
                           (b) Should Optionee die during the twelve  (12)-month
period  following  his or her  cessation  of Board  service,  then the  personal
representative  of Optionee's estate or the person or persons to whom the option
is  transferred  pursuant to Optionee's  will or in accordance  with the laws of
descent and distribution shall have the right to exercise this option for any or
all of the Option  Shares in which  Optionee is vested at the time of Optionee's
cessation of Board service (less any Option Shares  purchased by Optionee  after
such  cessation  of Board  service  but prior to death).  Such right of exercise
shall terminate,  and this option shall  accordingly cease to be exercisable for
such vested Option Shares,  upon the earlier of (i) the expiration of the twelve
(12)-month  period  measured  from the  date of  Optionee's  cessation  of Board
service or (ii) the specified Expiration Date.
                           (c) Should  Optionee  cease service as a Board member
by reason of death or Permanent  Disability,  then all Option Shares at the time
subject  to this  option  but not  otherwise  vested  shall vest in full so that
Optionee (or the personal representative
                                       2.
of Optionee's  estate or the person or persons to whom the option is transferred
upon  Optionee's  death) shall have the right to exercise this option for any or
all of the  Option  Shares as  fully-vested  shares of Common  Stock at any time
prior to the  earlier  of (i) the  expiration  of the twelve  (12)-month  period
measured  from the date of  Optionee's  cessation  of Board  service or (ii) the
specified Expiration Date.
                           (d) Upon  Optionee's  cessation of Board  service for
any  reason  other  than  death  or  Permanent  Disability,  this  option  shall
immediately  terminate and cease to be  outstanding  with respect to any and all
Option  Shares  in which  Optionee  is not  otherwise  at that  time  vested  in
accordance with the normal Vesting Schedule or the special vesting  acceleration
provisions of Paragraph 6 or 7 below.
                           (e) In the event of a Corporate Transaction or Change
in Control, the provisions of Paragraph 6 or 7 shall govern the period for which
this option is to remain  exercisable  following  Optionee's  cessation of Board
service and shall supersede any provisions to the contrary in this paragraph.
                  6.       Corporate Transaction.
                           (a) In the  event  of a  Corporate  Transaction,  all
Option Shares at the time subject to this option but not otherwise  vested shall
automatically vest so that this option shall, immediately prior to the effective
date of such Corporate  Transaction,  become  exercisable  for any or all of the
Option Shares as fully-vested shares of Common Stock.  Immediately following the
Corporate  Transaction,  this option shall terminate and cease to be exercisable
except to the extent assumed by the successor corporation (or parent thereof) in
connection with such Corporate Transaction.
                           (b) If this  option is assumed in  connection  with a
Corporate  Transaction,  then  this  option  shall  be  appropriately  adjusted,
immediately after such Corporate  Transaction,  to apply to the number and class
of securities which would have been issuable to Optionee in consummation of such
Corporate  Transaction had the option been exercised  immediately  prior to such
Corporate  Transaction,  and appropriate  adjustments  shall also be made to the
Exercise Price, provided the aggregate Exercise Price shall remain the same.
                           (c) This  Agreement  shall not in any way  affect the
right of the Corporation to adjust,  reclassify,  reorganize or otherwise change
its capital or business structure or to merge, consolidate,  dissolve, liquidate
or sell or transfer all or any part of its business or assets.
                  7.       Change in Control/Hostile Take-Over.
                           (a) All Option  Shares  subject to this option at the
time of a Change in Control but not otherwise vested shall automatically vest so
that this option shall,
                                       3.
immediately prior to the effective date of such Change in Control,  become fully
exercisable  for all of the Option Shares at the time subject to this option and
may be exercised for all or any portion of such shares as fully-vested shares of
Common Stock. This option shall remain exercisable for such fully-vested  Option
Shares until the earliest to occur of (i) the Expiration  Date,  (ii) the sooner
termination  of this  option in  accordance  with  Paragraph 5 or 6 or (iii) the
surrender of the option in connection with a Hostile Take-Over.
                           (b) Provided this option has been  outstanding for at
least six (6) months prior to the  occurrence of a Hostile  Take-Over,  Optionee
shall have the  unconditional  right  (exercisable  during  the thirty  (30)-day
period  immediately  following the  consummation  of such Hostile  Take-Over) to
surrender  this option to the  Corporation  in exchange for a cash  distribution
from the Corporation in an amount equal to the excess of (i) the Take-Over Price
of the Option Shares at the time subject to the  surrendered  option (whether or
not  those  Option  Shares  are  otherwise  at the time  vested)  over  (ii) the
aggregate  Exercise  Price payable for such shares.  This Paragraph 7(b) limited
stock  appreciation  right shall in all events  terminate upon the expiration or
sooner  termination of the option term and may not be assigned or transferred by
Optionee.
                           (c) To exercise  the  Paragraph  7(b)  limited  stock
appreciation  right,  Optionee  must,  during  the  applicable  thirty  (30)-day
exercise  period,  provide the  Corporation  with  written  notice of the option
surrender  in which there is specified  the number of Option  Shares as to which
the Option is being  surrendered.  Such notice must be accompanied by the return
of Optionee's  copy of this Agreement,  together with any written  amendments to
such Agreement.  The cash distribution shall be paid to Optionee within five (5)
days following such delivery date, and no approval or consent of the Board shall
be required in connection with such option surrender and cash distribution. Upon
receipt of such cash  distribution,  this option shall be cancelled with respect
to the Option  Shares  subject  to the  surrendered  option (or the  surrendered
portion) and  Optionee  shall cease to have any further  right to acquire  those
Option  Shares  under  this  Agreement.   The  option  shall,  however,   remain
outstanding for the balance of the Option Shares (if any) in accordance with the
terms of this  Agreement,  and the  Corporation  shall issue a new stock  option
agreement (substantially in the same form as this Agreement) for those remaining
Option Shares.
                  8.  Adjustment in Option Shares.  Should any change be made to
the Common Stock by reason of any stock split, stock dividend, recapitalization,
combination  of  shares,  exchange  of  shares  or other  change  affecting  the
outstanding  Common  Stock  as a class  without  the  Corporation's  receipt  of
consideration,  appropriate  adjustments  shall be made to (i) the total  number
and/or class of securities subject to this option and (ii) the Exercise Price in
order to reflect such change and thereby  preclude a dilution or  enlargement of
benefits hereunder.
                                       4.
                  9.  Stockholder  Rights.  The holder of this option  shall not
have any stockholder  rights with respect to the Option Shares until such person
shall have exercised the option,  paid the Exercise Price and become a holder of
record of the purchased shares.
                  10.      Manner of Exercising Option.
                           (a) In order to exercise  this option with respect to
all or any part of the  Option  Shares  for  which  this  option  is at the time
exercisable,  Optionee  (or any other person or persons  exercising  the option)
must take the following actions:
                                  (i) To the extent the option is exercised  for
         vested Option Shares,  execute and deliver to the  Corporation a Notice
         of Exercise for the Option Shares for which the option is exercised. To
         the extent this option is exercised for unvested Option Shares, execute
         and deliver to the Corporation a Purchase Agreement.
                                  (ii) Pay the aggregate  Exercise Price for the
         purchased shares in one or more of the following forms:
                                            (A) cash or check  made  payable  to
                  the Corporation,
                                            (B)  shares of Common  Stock held by
                  Optionee  (or any  other  person  or  persons  exercising  the
                  option) for the requisite  period  necessary to avoid a charge
                  to the Corporation's earnings for financial reporting purposes
                  and valued at Fair Market Value on the Exercise Date, or
                                            (C)  to the  extent  the  option  is
                  exercised for vested Option Shares, through a special sale and
                  remittance  procedure pursuant to which Optionee (or any other
                  person or persons  exercising  the option) shall  concurrently
                  provide   irrevocable   written    instructions   (I)   to   a
                  Corporation-designated  brokerage firm to effect the immediate
                  sale of the purchased shares and remit to the Corporation, out
                  of  the  sale  proceeds  available  on  the  settlement  date,
                  sufficient funds to cover the aggregate Exercise Price payable
                  for the purchased  shares plus all applicable  Federal,  state
                  and local income and employment  taxes required to be withheld
                  by the  Corporation by reason of such exercise and (II) to the
                  Corporation  to deliver  the  certificates  for the  purchased
                  shares  directly to such  brokerage  firm in order to complete
                  the sale.
                           Except  to  the  extent   the  sale  and   remittance
                  procedure is utilized in connection with the option  exercise,
                  payment of the  Exercise  Price must  accompany  the Notice of
                  Exercise (or the Purchase
                                       5.
                  Agreement) delivered to the Corporation in connection with the
                  option exercise.
                                  (iii) Furnish to the  Corporation  appropriate
         documentation  that the  person or  persons  exercising  the option (if
         other than Optionee) have the right to exercise this option.
                           (b) As soon after the Exercise Date as practical, the
Corporation  shall  issue to or on behalf of  Optionee  (or any other  person or
persons  exercising this option) a certificate for the purchased  Option Shares,
with the  appropriate  legends  affixed  thereto.  To the extent any such Option
Shares are unvested,  the certificates for those Option Shares shall be endorsed
with an appropriate  legend evidencing the  Corporation's  repurchase rights and
may be held in escrow with the Corporation until such shares vest.
                           (c) In no event may this option be exercised  for any
fractional shares.
                  11.      Compliance with Laws and Regulations.
                           (a) The  exercise of this option and the  issuance of
the Option  Shares  upon such  exercise  shall be subject to  compliance  by the
Corporation  and  Optionee  with all  applicable  requirements  of law  relating
thereto and with all applicable regulations of any stock exchange (or the Nasdaq
National  Market if  applicable)  on which the  Common  Stock may be listed  for
trading at the time of such exercise and issuance.
                           (b)  The  inability  of  the  Corporation  to  obtain
approval from any regulatory body having  authority deemed by the Corporation to
be  necessary to the lawful  issuance  and sale of any Common Stock  pursuant to
this option shall relieve the  Corporation  of any liability with respect to the
non-issuance  or sale of the Common  Stock as to which such  approval  shall not
have been  obtained.  The  Corporation,  however,  shall use its best efforts to
obtain all such approvals.
                  12.  Successors  and Assigns.  Except to the extent  otherwise
provided in Paragraph 3 or 6, the  provisions of this  Agreement  shall inure to
the benefit of, and be binding upon,  the  Corporation  and its  successors  and
assigns and Optionee,  Optionee's assigns and the legal  representatives,  heirs
and legatees of Optionee's estate.
                  13.  Notices.  Any notice required to be given or delivered to
the  Corporation  under  the terms of this  Agreement  shall be in  writing  and
addressed to the  Corporation  at its principal  corporate  offices.  Any notice
required to be given or delivered to Optionee  shall be in writing and addressed
to Optionee at the address  indicated  below  Optionee's  signature  line on the
Grant Notice.  All notices shall be deemed  effective upon personal  delivery or
upon deposit in the U.S.  mail,  postage  prepaid and properly  addressed to the
party to be notified.
                                       6.
                  14.  Construction.  This  Agreement  and the option  evidenced
hereby are made and granted pursuant to the Plan and are in all respects limited
by and subject to the terms of the Plan.
                  15.  Governing  Law.  The   interpretation,   performance  and
enforcement  of this  Agreement  shall be  governed  by the laws of the State of
California without resort to that State's conflict-of-laws rules.
                                       7.
                                    EXHIBIT I
                               NOTICE OF EXERCISE
                  I  hereby   notify   Atlantic   Pharmaceuticals,   Inc.   (the
"Corporation")  that  I  elect  to  purchase   _______________   shares  of  the
Corporation's Common Stock (the "Purchased Shares") at the option exercise price
of  $______________  per share (the "Exercise  Price")  pursuant to that certain
option (the "Option")  granted to me under the  Corporation's  1995 Stock Option
Plan on _______________, 199_____.
                  Concurrently  with the delivery of this Exercise Notice to the
Corporation,  I shall hereby pay to the  Corporation  the Exercise Price for the
Purchased  Shares in accordance  with the  provisions  of my agreement  with the
Corporation  (or other  documents)  evidencing  the  Option  and  shall  deliver
whatever  additional  documents may be required by such agreement as a condition
for exercise.  Alternatively,  I may utilize the special  broker-dealer sale and
remittance procedure specified in my agreement to effect payment of the Exercise
Price for any  Purchased  Shares in which I am vested at the time of exercise of
the Option.
_______________________________, 199___
Date
                                        ________________________________________
                                        Optionee
                                        Address:________________________________
                                        ________________________________________
Print name in exact manner
it is to appear on the
stock certificate:                      ________________________________________
Address to which certificate
is to be sent, if different
from address above:                     ________________________________________
                                        ________________________________________
Social Security Number:                 ________________________________________
                                    APPENDIX
         The following definitions shall be in effect under the Agreement:
         A. Agreement shall mean this Automatic Stock Option Agreement.
         B. Board shall mean the Corporation's Board of Directors.
         C. Change in Control shall mean a change in ownership or control of the
Corporation effected through either of the following transactions:
                (i) the  acquisition,  directly or indirectly,  by any person or
         related group of persons  (other than the  Corporation or a person that
         directly or indirectly  controls,  is controlled by, or is under common
         control with,  the  Corporation)  of beneficial  ownership  (within the
         meaning of Rule 13d-3 of the ▇▇▇▇ ▇▇▇) of  securities  possessing  more
         than fifty  percent  (50%) of the total  combined  voting  power of the
         Corporation's  outstanding  securities pursuant to a tender or exchange
         offer made directly to the Corporation's  stockholders  which the Board
         does not recommend such stockholders to accept, or
               (ii) a change in the  composition  of the Board  over a period of
         thirty-six (36) consecutive  months or less such that a majority of the
         Board members ceases, by reason of one or more contested  elections for
         Board  membership,  to be comprised of individuals  who either (A) have
         been Board members  continuously  since the beginning of such period or
         (B) have been elected or nominated for election as Board members during
         such period by at least a majority of the Board  members  described  in
         clause (A) who were still in office at the time the Board approved such
         election or nomination.
         D. Code shall mean the Internal Revenue Code of 1986, as amended.
         E. Common Stock shall mean the Corporation's common stock.
         F.   Corporate   Transaction   shall  mean  either  of  the   following
stockholder-approved transactions to which the Corporation is a party:
                (i) a merger or  consolidation  in which  securities  possessing
         more than fifty percent (50%) of the total combined voting power of the
         Corporation's  outstanding  securities  are  transferred to a person or
         persons different from the persons holding those securities immediately
         prior to such transaction, or
                                      A-1.
               (ii)  the  sale,   transfer  or  other   disposition  of  all  or
         substantially all of the Corporation's  assets in complete  liquidation
         or dissolution of the Corporation.
         G. Corporation shall mean Atlantic Pharmaceuticals, Inc., a Delaware
corporation.
         H. Domestic  Relations  Order shall mean any judgment,  decree or order
(including  approval  of a property  settlement  agreement)  which  provides  or
otherwise  conveys,   pursuant  to  applicable  State  domestic  relations  laws
(including  community  property laws),  marital property rights to any spouse or
former spouse of Optionee.
         I.  Exercise  Date shall  mean the date on which the option  shall have
been exercised in accordance with Paragraph 10 of the Agreement.
         J. Exercise  Price shall mean the exercise price per share as specified
in the Grant Notice.
         K.  Expiration  Date shall mean the date on which the option expires as
specified in the Grant Notice.
         L. Fair Market  Value per share of Common  Stock on any  relevant  date
shall be determined in accordance with the following provisions:
                (i) If the  Common  Stock is at the time  traded  on the  Nasdaq
         National  Market,  then  the Fair  Market  Value  shall be the  closing
         selling price per share of Common Stock on the date in question, as the
         price is reported by the National  Association of Securities Dealers on
         the Nasdaq  National  Market or any  successor  system.  If there is no
         closing  selling  price for the Common  Stock on the date in  question,
         then the Fair Market  Value shall be the closing  selling  price on the
         last preceding date for which such quotation exists.
               (ii) If the  Common  Stock is at the time  traded  on the  Nasdaq
         SmallCap Market or the  over-the-counter  market,  then the Fair Market
         Value shall be the average of the highest bid and lowest  asked  prices
         per  share  of  Common  Stock  on the date in  question  on the  Nasdaq
         SmallCap  Market or the  over-the-counter  market,  as such  prices are
         reported by the National  Association of Securities Dealers through its
         Nasdaq system or any successor system. If there are no reported bid and
         asked  prices for the Common  Stock on the date in  question,  then the
         Fair  Market  Value  shall be the average of the highest bid and lowest
         asked  prices  on the last  preceding  date for which  such  quotations
         exist.
                                      A-2.
              (iii)  If the  Common  Stock is at the time  listed  on any  Stock
         Exchange, then the Fair Market Value shall be the closing selling price
         per share of Common Stock on the date in question on the Stock Exchange
         which serves as the primary market for the Common Stock,  as such price
         is officially  quoted in the  composite  tape of  transactions  on such
         exchange.  If there is no closing selling price for the Common Stock on
         the date in  question,  then the Fair Market Value shall be the closing
         selling  price on the last  preceding  date for  which  such  quotation
         exists.
         ▇. ▇▇▇▇▇  Date shall mean the date of grant of the option as  specified
in the Grant Notice.
         ▇.  ▇▇▇▇▇  Notice  shall mean the  Notice of Grant of  Automatic  Stock
Option accompanying the Agreement,  pursuant to which Optionee has been informed
of the basic terms of the option evidenced hereby.
         O.  Hostile   Take-Over  shall  mean  a  change  in  ownership  of  the
Corporation effected through the following transaction:
                  (i) the acquisition,  directly or indirectly, by any person or
         related group of persons  (other than the  Corporation or a person that
         directly or indirectly  controls,  is controlled by, or is under common
         control with,  the  Corporation)  of beneficial  ownership  (within the
         meaning of Rule 13d-3 of the ▇▇▇▇ ▇▇▇) of  securities  possessing  more
         than fifty  percent  (50%) of the total  combined  voting  power of the
         Corporation's  outstanding  securities pursuant to a tender or exchange
         offer made directly to the Corporation's  stockholders  which the Board
         does not recommend such stockholders to accept, and
                  (ii) more than fifty percent (50%) of the acquired  securities
         are accepted  from persons other than the officers and directors of the
         Corporation  subject to the short-swing profit  restrictions of Section
         16 of the 1934 Act.
         P. 1934 Act shall mean the Securities Exchange Act of 1934, as amended.
         Q.  Non-Statutory  Option  shall mean an option not intended to satisfy
the requirements of Code Section 422.
         R. Notice of Exercise  shall mean the notice of exercise in the form of
Exhibit I.
         S.  Option  Shares  shall  mean the  number of  shares of Common  Stock
subject to the option.
                                      A-3.
         T.  Optionee  shall  mean the  person to whom the  option is granted as
specified in the Grant Notice.
         U. Permanent Disability shall mean the inability of Optionee to perform
his or her usual  duties  as a member  of the  Board by reason of any  medically
determinable  physical or mental impairment which is expected to result in death
or has lasted or can be expected to last for a continuous  period of twelve (12)
months or more.
         V. Plan shall mean the Corporation's 1995 Stock Option Plan.
         W. Purchase  Agreement shall mean the stock purchase agreement (in form
and substance  satisfactory to the Corporation) which grants the Corporation the
right to repurchase,  at the Exercise Price,  any and all unvested Option Shares
held by Optionee at the time of Optionee's  cessation of Board service and which
precludes the sale, transfer or other disposition of any purchased Option Shares
while subject to such repurchase right.
         X. Qualified  Domestic  Relations Order shall mean a Domestic Relations
Order which substantially complies with the requirements of Code Section 414(p).
The Corporation  shall have the sole discretion to determine  whether a Domestic
Relations Order is a Qualified Domestic Relations Order.
         Y. Stock  Exchange  shall mean the American  Stock  Exchange or the New
York Stock Exchange.
         Z. Take-Over  Price shall mean the greater of (i) the Fair Market Value
per  share  of  Common  Stock  on the  date the  option  is  surrendered  to the
Corporation in connection with a Hostile  Take-Over or (ii) the highest reported
price per share of Common  Stock paid by the tender  offeror  in  effecting  the
Hostile Take-Over.
         AA. Vesting Schedule shall mean the vesting  schedule  specified in the
Grant Notice.
                                      A-4.