NOTE PURCHASE AGREEMENT
     NOTE PURCHASE  AGREEMENT (this  "Agreement"),  dated as of May 23, 2006, by
and between Vyteris Holdings (Nevada),  Inc., a Nevada  corporation  ("Seller"),
and ▇▇▇▇▇▇▇ ▇▇▇▇▇ Specialty  Group,  LLC, a Delaware limited  liability  company
("Buyer").
                                  W I T N E S S E T H:
                                  - - - - - - - - - -
     WHEREAS,  Seller  desires to issue to Buyer,  and Buyer desires to purchase
from Seller, a convertible  subordinated  promissory note,  substantially in the
form of EXHIBIT A hereto, in the principal amount of $500,000 (the "Note");
     WHEREAS,  Seller  has agreed to effect  the  registration  of the shares of
Common Stock  underlying  the Note under the Securities Act of 1933, as amended,
pursuant  to a  registration  statement  substantially  in the form of EXHIBIT B
hereto (the "Registration Rights Agreement"); and
     WHEREAS,  Seller,  pursuant to that certain  securities  purchase agreement
dated  as of  August  19,  2005,  as  same  may be  amended  from  time  to time
("Securities  Purchase Agreement") issued a series of senior secured convertible
debentures,  including  debentures  issued after the original issuance date (the
"Debentures")  in the aggregate  principal  amount of $10.5 million (the "Senior
Debt").
     NOW,  THEREFORE,  in  consideration  of the mutual covenants and agreements
hereinafter  set  forth  herein  and for good and  valuable  consideration,  the
receipt and sufficiency of which are hereby mutually  acknowledged,  the parties
agree as follows:
     1.    SALE AND PURCHASE OF THE NOTE
     1.1.  SALE AND  PURCHASE.  Subject  to the  terms  and  conditions  of this
Agreement, at the Closing (as defined in Section 2.1 hereof), Seller shall issue
to Buyer,  and Buyer shall  purchase  from Seller,  for the  Purchase  Price (as
defined in Section 1.2(a) hereof), the Note.
     1.2.  PURCHASE PRICE AND PAYMENT.
           (a) PURCHASE PRICE. The purchase price for the Note shall be $500,000
(the "Purchase Price").
           (b) PAYMENT OF PURCHASE  PRICE. The  Purchase  Price shall be paid to
Seller by Buyer on the  Closing  Date (as  defined in  Section 2.1 hereof)  via
federal funds wire  transfer(s) of immediately  available  funds,  in accordance
with written instructions provided to Buyer prior to the date hereof.
     2.   CLOSING.
     2.1. TIME AND PLACE.  The closing of the sale and purchase of the Note (the
"Closing")  shall be deemed to take place at the offices of ▇▇▇▇▇▇▇  Krooks LLP,
655 Third Avenue,  20th Floor, New York, New York, at 10:00 a.m., local time, on
the date hereof,  or at such later time or date as Buyer and Seller may mutually
agree in writing.  The date upon which the Closing  shall occur is herein called
the "Closing Date".
     2.2. CLOSING DELIVERIES.
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          (a) SELLER DELIVERIES.  At the Closing,  Seller shall deliver or cause
to be delivered to Buyer the  following:
               (i) the duly executed Note;
               (ii) the duly executed Registration Rights Agreement; and
               (iii)  copies  of  any  consents  necessary  to  effectuate  this
Agreement and to consummate the transactions contemplated hereby.
          (b) BUYER  DELIVERY. At the Closing,  Buyer shall deliver or cause to
be delivered to Seller the Purchase Price.
     3.   TERMS OF THE NOTE.
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     3.1. AMOUNT. The principal amount of the Note shall be $500,000.
     3.2. MATURITY.  Unless  otherwise  converted into the Conversion Shares (as
defined in Section 3.4 hereof) in accordance  with the  provisions  hereof,  the
Note shall  mature on  December  1, 2008,  unless  such date shall be  otherwise
extended in writing by Buyer, in its sole  discretion  (such date, the "Maturity
Date").  On  the  Maturity  Date,  unless,  and to the  extent,  converted  into
Conversion  Shares in accordance  with the provisions  hereof,  all  outstanding
principal and any accrued and unpaid interest due and owing under the Note shall
be immediately paid by Seller.
     3.3. INTEREST,  INTEREST RATE,  PAYMENT.  (a) The Note  shall bear interest
(other  than  interest  accruing  as a result of a failure  by Seller to pay any
amount  when due as set forth in clause  (b) below) at a rate equal to ten (10%)
percent (the "Interest  Rate") per annum on a 360day year.  Interest (other than
interest  accruing as a result of a failure by Seller to pay any amount when due
as set  forth  in  subparagraph  (b)  below)  shall be due and  payable  in cash
semiannually in arrears following the end of each semi-annual period, commencing
with the semiannual  period ended June 30, 2006, pro rated for partial  periods;
PROVIDED,  HOWEVER,  that any interest  accruing on overdue amounts  pursuant to
subparagraph (b) of this Section 3.3 shall be payable on demand.
          (b) If all or a  portion  of the  principal  amount of the Note or any
interest  payable thereon shall not be repaid when due whether on the applicable
repayment date, by  acceleration  or otherwise,  such overdue amounts shall bear
interest at a rate per annum that is three  percent (3%) above the Interest Rate
I.E., 13%) from the date of such  non-payment  until such amount is paid in full
(as well after as before judgment).
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          (c) All  payments  to be made by Seller  hereunder  or pursuant to the
Note  shall be made,  without  setoff or  counterclaim,  in lawful  money of the
United States by check or wire transfer in immediately available funds.
     3.4. CONVERSION. (a) Subject to Sections 3.4(b) and 3.5 hereof, at any time
prior to the  Maturity  Date,  the Seller  shall have the option to convert  the
entire  principal and interest accrued and owing on the Note, -or any portion of
the principal and/or interest thereof,  into shares (the "Conversion Shares") of
Common Stock at the Conversion  Price. For purposes hereof,  "Conversion  Price"
shall  mean  $2.40  per  share;  PROVIDED,  that if at any time on or after  the
issuance  date of the  Note,  Seller  subdivides  (by  any  stock  split,  stock
dividend, recapitalization,  reorganization,  reclassification or otherwise) its
shares of Common Stock into a greater  number of shares,  then after the date of
record  for  effecting  such   subdivision,   the  Conversion   Price  shall  be
proportionately  reduced,  or  if  Seller  combines  (by  reverse  stock  split,
recapitalization,  reorganization,  reclassification or otherwise) its shares of
Common  Stock into a smaller  number of shares,  the  Conversion  Price shall be
proportionately increased.
Upon  conversion,  Buyer shall be  entitled to receive the number of  Conversion
Shares  calculated  by dividing  the amount being  converted  by the  Conversion
Price.  No  fractional   shares  of  Conversion  Shares  shall  be  issued  upon
conversion.  In lieu of any fractional  shares to which Buyer would otherwise be
entitled,  Seller shall pay cash in an amount equal to such fraction  multiplied
by the Conversion  Price. The Note shall not be subject to automatic  conversion
or to any conversion at the option of Seller.
          (b)  Notwithstanding  the  provision of Section  3.4(a),  if an equity
security or other derivative security  convertible or exercisable into an equity
security of the Company  ("Applicable  Security") is sold in  connection  with a
Qualified  Financing  (as  hereinafter  defined) at any time prior to payment in
full of the principal balance of the Note, all of the principal and interest due
thereunder shall  automatically  become  converted into the Applicable  Security
with the same  rights and  privileges  granted  to  investors  in the  Qualified
Financing. The number of Applicable Securities received upon conversion pursuant
to this Section 3(b) shall be  determined  by dividing the  aggregate  principal
amount due under the Note,  together with any accrued but unpaid interest to the
date of conversion,  by the price per Applicable  Security paid in the Qualified
Financing.  For the purposes of the Note, a "Qualified Financing" shall mean the
Company's  next private  financing of  Applicable  Securities  to investors  (i)
yielding  aggregate gross proceeds  (exclusive of conversion of the Note) to the
Company of at least  $500,000  and (ii)  which  does not  invoke or trigger  the
provisions of Section 4(b) of the Debentures or Section 6(c) of the Warrants (as
such term is defined in the Securities Purchase Agreement.
     3.5. CONVERSION PROCEDURES.  In order to exercise the conversion rights set
forth in Section 3.4(a) hereof,  Buyer shall  surrender the Note,  appropriately
endorsed, to Seller at Seller's principal office,  accompanied by written notice
to Seller  setting  forth the amount of principal  and interest to be converted,
the name or names (with  address(es))  in which the Conversion  Shares  issuable
upon such conversion shall be issued and registered on the books of Seller.  For
purposes hereof,  the "Conversion  Date" shall be deemed to be the date the Note
and notice is received by Seller for  conversion.  Within five (5) business days
after the Conversion Date, Seller shall deliver to Buyer (i) a stock certificate
for the Conversion Shares or (ii) a notice certified by Seller's  Secretary that
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the Conversion  Shares due on such conversion have been issued to and registered
on the books of Seller in the name or names  specified by Buyer.  In the case of
conversion  of less than the entire  principal of and  interest  under the Note,
Seller shall  cancel said Note and shall  execute and deliver a new Note of like
tenor for the  unconverted  amount of the Note  dated the date of  execution  by
Seller  upon  initial  issuance  of  the  Note  notwithstanding  any  subsequent
substitution.
     3.6.  SUBORDINATION.  The Note is expressly and fully  subordinated,  as to
payment  and  liquidation,  to the  payment  in full of the  Debentures  and the
Obligations (as such term is defined in the Securities  Purchase  Agreement) and
the  holder of the Note  acknowledges  and agrees  that the Seller is  expressly
restricted  from  pre-paying any amounts in respect of the principal of the Note
(upon  acceleration or otherwise)  until payment in full of the Debentures.  The
holder of this Note shall not commence any judicial or other collection  efforts
or exercise any other  remedies  prior to the date that is ninety-one  (91) days
following the payment in full of the Debentures. The Note is, and is intended to
be,  "Subordinated  Debt" as such term is  defined  in the  Securities  Purchase
Agreement.
     3.7.  PREPAYMENT RIGHTS UPON MERGER,  CONSOLIDATION,  ETC. (a) If, prior to
the Conversion Date, but subject to the provisions of Section 3.6 above,  Seller
proposes to consolidate with, or merge into,  another  corporation or entity, or
to effect  any sale or  conveyance  to another  corporation  or entity of all or
substantially  all of the  assets  of  Seller,  or effect  any  other  corporate
reorganization,  in which the  stockholders of the Seller  immediately  prior to
such  consolidation,  merger or  reorganization  own capital stock of the entity
surviving such merger,  consolidation or  reorganization  representing less than
fifty (50%) percent of the combined voting power of the  outstanding  securities
of such entity  immediately after such  consolidation,  merger or reorganization
(collectively,  a "Liquidation  Event"), then Seller shall provide Buyer with at
least ten (10) days' prior written notice of any such proposed action, and Buyer
will,  at its  option,  have the right to  demand  immediate  prepayment  of all
amounts due and owing under the Note.  Buyer will give Seller  written notice of
such  demand  within  five (5) days after  receiving  notice of the  Liquidation
Event.  All amounts  (including  all accrued and unpaid  interest) due and owing
under the Note  shall be paid by Seller to Buyer  within  five (5) days from the
date of such written  notice via federal funds wire  transfer(s)  of immediately
available  funds,  in  accordance  with written  instructions  to be provided to
Seller by Buyer within at least two (2) business  days after giving  Seller such
written  notice.  The provisions of this Section 3.7(a) shall similarly apply to
successive consolidations or mergers.
          (b) Except as set forth in Sections 3.6, 3.7 (a) and 9 hereof,  Seller
shall not prepay prior to the Maturity Date all or part of this Note without the
express written consent of Buyer.
     3.8  INTENTIONALLY DELETED
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     3.9  ASSURANCES  WITH RESPECT OF  CONVERSION  RIGHTS.  Seller shall not, by
amendment  of its  Certificate  of  Incorporation  or  By-laws  or  through  any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities  or any other  voluntary  action,  avoid or seek to avoid the
observance  or  performance  of any of the  terms to be  observed  or  performed
hereunder by Seller but shall at all times in good faith assist in the carrying
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out of 4 all the  provisions of this Agreement and in taking of all such actions
as may be necessary or appropriate in order to protect the conversion  rights of
Buyer against impairment.
     4.   REPRESENTATIONS AND WARRANTIES OF SELLER. Seller hereby represents and
warrants to Buyer as follows:
     4.1  DUE ORGANIZATION  AND  QUALIFICATION.  Seller  is a  corporation  duly
organized,  validly existing and in good standing under the laws of the State of
Nevada.  Seller has all requisite  power and authority to own, lease and operate
its assets and  properties  and to carry on its business as presently  conducted
and as presently contemplated. Seller is duly qualified to transact business and
is in good standing in each  jurisdiction in which the nature of its business or
the  locations of its property  requires  such  qualification,  except where the
failure to do so would not have a material adverse effect on Seller's  business,
operations, assets or condition (financial or otherwise).
     4.2  POWER AND AUTHORITY.  Seller  has the  requisite  corporate  power and
authority  to  execute  and  deliver  this  Agreement  and all other  agreements
contemplated by this Agreement (including,  without limitation, the Note and the
Registration  Rights  Agreement)  and to perform its  obligations  hereunder and
thereunder.  The execution,  delivery and  performance of this Agreement and all
other agreements contemplated by this Agreement have been duly authorized by all
necessary  corporate action on the part of Seller.  This Agreement has been duly
executed  and  delivered  by Seller and is the valid and binding  obligation  of
Seller,  enforceable against Seller in accordance with its terms, except as such
enforceability may be limited by applicable bankruptcy,  moratorium, insolvency,
reorganization  or other  similar  laws now or  hereafter  in  effect  generally
affecting the enforcement of creditors' rights, specific performance, injunctive
or other  equitable  remedies.  When  executed  and  delivered  by Seller at the
Closing,  each of the Note and the  Registration  Rights  Agreement  will be the
valid and binding obligation of Seller, enforceable against Seller in accordance
with its terms,  except as such  enforceability  may be  limited by  bankruptcy,
moratorium, insolvency, reorganization or other similar laws now or hereafter in
effect  generally  affecting  the  enforcement  of creditors'  rights,  specific
performance, injunctive or other equitable remedies.
     4.3. CAPITALIZATION.  The  capitalization  of the Seller  as of the date of
this  Agreement,  including its authorized  capital stock,  the number of shares
issued and outstanding,  the number of shares issuable and reserved for issuance
pursuant to the Seller's stock option plans and agreements, the number of shares
issuable and reserved for issuance  pursuant to securities (other than the Note)
exercisable  for, or convertible  into or exchangeable  for any shares of Common
Stock and the  number of shares  initially  to be  reserved  for  issuance  upon
conversion  of the Note is set forth on  Schedule  4.3  hereto.  All  issued and
outstanding  shares of capital  stock of the Seller  have been  validly  issued,
fully paid and  non-assessable.  Except as disclosed on Schedule 4.3 hereto, the
Seller owns all of the capital stock of each subsidiary,  which capital stock is
validly  issued,  fully paid and  non-assessable,  and no shares of the  capital
stock of the Seller or any of the subsidiaries are subject to preemptive  rights
or any  other  similar  rights  of the  shareholders  of the  Seller or any such
subsidiary or any liens created by or through the Seller or any such subsidiary.
Except as  disclosed  on Schedule 4.3 or as  contemplated  herein,  there are no
outstanding  options,   warrants,  scrip,  rights  to  subscribe  to,  calls  or
commitments  of any  character  whatsoever  relating to, or securities or rights
convertible into or exercisable or exchangeable for, any shares of capital stock
of the Seller or any 5 of the subsidiaries,  or arrangements by which the Seller
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or any of the subsidiaries is or may become bound to issue additional  shares of
capital  stock of the Seller or any of the  subsidiaries  (whether  pursuant  to
anti-dilution, "reset" or other similar provisions). Schedule 4.3 identifies all
Debt of the  Seller  and the  subsidiaries  currently  outstanding  in excess of
$100,000 individually or in the aggregate as of the date hereof.
     4.4. FINANCIAL  STATEMENTS,  OTHER  INFORMATION.  Seller has filed with the
Securities  and  Exchange  Commission  ("Commission")  all  reports,  schedules,
registration statements and definitive proxy statements that Seller was required
to file with  Commission on or after December 31, 2004  (collectively,  the "SEC
DOCUMENTS").  Seller is not aware of any event occurring or expected to occur as
of the date of this Agreement (other than the transactions effected hereby) that
would require the filing of, or with respect to which Seller  intends to file, a
Form 8-K after the date of this Agreement.  Each SEC Document, as of the date of
the filing  thereof with the Commission (or if amended or superseded by a filing
prior  to the  date of this  Agreement,  then on the  date of such  amending  or
superseding filing),  complied in all material respects with the requirements of
the Securities Act of 1933, as amended ("Securities Act") or Securities Exchange
Act of 1934,  as amended  ("Exchange  Act'),  as  applicable,  and the rules and
regulations  promulgated  thereunder  and,  as of the date of such filing (or if
amended or superseded by a filing prior to the date of this  Agreement,  then on
the  date of such  filing),  such  SEC  Document  (including  all  exhibits  and
schedules  thereto and  documents  incorporated  by  reference  therein) did not
contain an untrue  statement of material  fact or omit to state a material  fact
required to be stated  therein or necessary to make the statements  therein,  in
light of the  circumstances  under  which they were made,  not  misleading.  All
documents  that are required to be filed as exhibits to the SEC  Documents  have
been  filed as  required.  Except as set forth in  Schedule  4.4,  Seller has no
liabilities,  contingent or otherwise,  other than  liabilities  incurred in the
ordinary  course of business that,  under GAAP, are not required to be reflected
in the financial  statements  included in Schedule  4.4.  Except as set forth in
Schedule 4.4, as of their respective  dates, the financial  statements of Seller
included in the SEC Documents  complied as to form in all material respects with
applicable  accounting  requirements  and the published rules and regulations of
the Commission with respect thereto.  The financial  statements  included in the
SEC  Documents  have  been  and  will  be  prepared  in  accordance   with  GAAP
consistently applied at the times and during the periods involved (except (i) as
may be otherwise  indicated in such  financial  statements or the notes thereto,
(ii) in the case of unaudited interim statements, to the extent they may exclude
footnotes or may be condensed  or summary  statements,  or (iii) as set forth in
the SEC  Documents),  and fairly present in all material  respects the financial
position of Seller as of the dates thereof and the results of its operations and
cash  flows  for the  periods  then  ended  (subject,  in the case of  unaudited
statements, to normal year-end adjustments).
     4.5. AUTHORIZATION OF THE NOTE AND CONVERSION SHARES.  All corporate action
on the part of Seller  necessary for the  authorization,  issuance,  sale and/or
delivery of the Note and the capital stock issuable upon  conversion of the Note
(the "Conversion  Shares") has been taken and when issued, sold and delivered in
accordance  with this Agreement  and/or the Note, the Conversion  Shares will be
validly issued and outstanding,  fully paid and nonassessable and not subject to
preemptive,  first refusal or any other  similar  rights of any  stockholder  of
Seller or others.
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     4.6 COMPLIANCE WITH LAWS. To its knowledge,  Seller is in compliance in all
material  respects with all Federal,  state,  local and foreign laws,  statutes,
ordinances,  regulations,  orders,  judgments,  injunctions,  awards or  decrees
(collectively,  "Laws") applicable to it or any of its properties or operations.
Seller has not  received any notice of material  violation  or alleged  material
violation of any Law by it. Seller has all material  licenses,  permits,  orders
and approvals of Federal,  state,  local and foreign  governmental or regulatory
bodies  necessary  for the conduct of its business and  operations  as presently
conducted.
     4.7 NO BREACH,  CONSENTS.  Except as set forth on SCHEDULE 4.7 hereto,  the
execution,  delivery  and  performance  of  this  Agreement  by  Seller  and the
consummation  by Seller of the  transactions  contemplated  hereby  will not (i)
result in any lien, pledge, mortgage,  security interest,  claim, lease, charge,
option,  easement,  servitude  or other  encumbrance  whatsoever  (collectively,
"Liens")  upon any of the  property of Seller  (other than in favor of Buyer) or
(ii) violate, conflict with or breach any of the terms and conditions of, result
in a material  modification  of,  accelerate or trigger the rights of any person
under, or constitute (or with notice or lapse of time or both would  constitute)
a default  under (a) any  material  instrument,  contract or other  agreement to
which Seller is a party or by or to which it or any of its  properties  is bound
or subject;  (b)  Seller's  Certificate  of  Incorporation  or By-laws  (and all
amendments  thereto up through the date  hereof);  or (c) any Law  applicable to
Seller or any of its properties or  operations.  Except as set forth on SCHEDULE
4.7, no consent,  approval or  authorization  of, or declaration or filing with,
any governmental authority, stockholder of Seller or other person is required on
the part of Seller in connection with the execution,  delivery or performance of
this  Agreement  or  the  consummation  by it of the  transactions  contemplated
hereby.
     4.8  LITIGATION.  Except as set forth on SCHEDULE 4.8 hereto,  there are no
material suits or actions,  administrative,  arbitration or other proceedings or
governmental  investigations  pending  or,  to  Seller's  knowledge,  threatened
against or affecting  Seller or any of its  properties  or assets.  There are no
judgments,  orders,  injunctions,  decrees or awards against Seller that are not
satisfied  or  remain  outstanding.
     4.9. BROKERS.   Neither  Seller nor any of  Seller's  officers,  directors,
employees or  stockholders  has employed any broker or finder in connection with
the transactions contemplated by this Agreement and no fee is or will be due and
owing to any broker or finder in connection with the  transactions  contemplated
by this Agreement.
     4.10 INTELLECTUAL  PROPERTY.  All of Seller's (i) trademarks,  trade names,
registered trademarks, trademark applications, service marks, registered service
marks and service ▇▇▇▇ applications,  (ii) patents and patent applications,  and
(iii)  licenses with respect to the use of patents or trademarks  owned by other
parties, are set forth on SCHEDULE 4.10 hereto.  Except as set forth on SCHEDULE
4.10,  there is not pending nor, to Seller's  knowledge,  threatened  any claim,
suit or action  contesting or  challenging  the rights of Seller in or to any of
the  material  item of  intellectual  property  owned or used by  Seller  in the
conduct of its business (the "Intellectual  Property") or the validity of any of
the Intellectual Property. To Seller's knowledge,  there is no infringement upon
or unauthorized use of any of the  Intellectual  Property by any third party. No
officer,  director,  equityholder  or  affiliate  of  Seller  nor  any of  their
respective  associates  has any right to or interest in any of the  Intellectual
Property,  including,  without limitation,  any right to payments (by royalty or
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otherwise) in respect of any use or transfer thereof.
     4.11 PERFORMANCE  OF  AGREEMENTS.  Except  as  set forth on  SCHEDULE  4.11
hereto,  no default by Seller exists in the due  performance  under any material
agreement  to which  Seller is a party or to which any of its assets is subject.
     4.12 NO WAIVER OF PRIOR OR FUTURE DEFAULTS.  Seller hereby acknowledges and
agrees  that  this  Agreement  and  Buyer's  purchase  from  Seller of the Note,
pursuant to the terms and conditions hereof,  shall not constitute or operate as
a waiver or release of any default,  or any future  defaults,  under the Default
Notes.
     5.   REPRESENTATIONS AND WARRANTIES OF BUYER.  Buyer hereby  represents and
warrants to Seller as follows:
     5.1  DUE  ORGANIZATION.  Buyer is a duly  organized  legal entity,  validly
existing and in good standing  under the laws of the state of its  organization.
     5.2  POWER OF BUYER. Buyer has the requisite company power and authority to
execute and deliver this  Agreement  and to perform its  obligations  hereunder.
This  Agreement  has been duly  executed and delivered by Buyer and is the valid
and binding  obligation of Buyer,  enforceable  against Buyer in accordance with
its  terms,  except  as  such  enforceability  may  be  limited  by  bankruptcy,
moratorium, insolvency, reorganization or other similar laws generally affecting
the enforcement of creditors' rights, specific performance,  injunctive or other
equitable remedies.
     5.3  NO BREACH.  The execution, delivery and  performance of this Agreement
by Buyer and the consummation by Buyer of the transactions  contemplated  hereby
will not violate,  conflict with or otherwise result in the breach of any of the
terms and conditions of, result in a material  modification of or constitute (or
with notice or lapse of time or both would  constitute)  a default under (i) any
of the organizational documents of Buyer; (ii) any material instrument, contract
or other  agreement to which Buyer is a party or by or to which it or any of its
properties is bound or subject;  or (iii) any Law  applicable to Buyer or any of
its properties or operations.
     5.4  GOVERNMENTAL AND OTHER CONSENTS. No consent, approval or authorization
of, or declaration or filing with, any governmental authority or other person is
required on the part of Buyer in  connection  with the  execution,  delivery and
performance  of this  Agreement by it or the  consummation  of the  transactions
contemplated hereby.
     5.5  INVESTMENT   REPRESENTATIONS.    Buyer  is  acquiring  the  Note  (the
"Securities"),  and any capital stock issuable upon exercise of the  Securities,
for Buyer's own account,  for  investment and not with a view to, or for sale in
connection with, any distribution of such securities or any part thereof.  Buyer
(i) has such knowledge and experience in financial and business  affairs that it
is  capable  of  evaluating  the merits and risks  involved  in  purchasing  the
Securities,  (ii) is able to bear the economic risks involving in purchasing the
Securities,  (iii) is an  "accredited  investor"  as defined  in Rule  501(a) of
Regulation  D  promulgated  under  the  Securities  Act  and  (iv)  has  had the
opportunity  to ask questions of, and receive  answers from,  Seller and persons
                                       8
acting  on  Seller's  behalf  concerning  Seller's  business,   management,  and
financial affairs and the terms and conditions of the Securities.  Buyer's state
of residence is New York.
     5.6. NO BROKER.  Buyer has not employed any broker or finder in  connection
with the transactions contemplated by this Agreement.
     6.   COVENANTS AND AGREEMENTS.
     6.1  PRE-CLOSING COVENANTS AND AGREEMENTS.  The parties hereto covenant and
agree to perform or take any and all such actions to  effectuate  the  following
from the date hereof until the earlier of the Closing Date or the termination of
this Agreement:
          (a) FURTHER ASSURANCES.  Each of the parties shall, prior to or at the
Closing, as may be appropriate, execute such documents and other papers and take
such  other  further  actions  as may be  reasonably  required  to carry out the
provisions hereof and effectuate the transactions  contemplated  hereby,  and in
the Note and the Registration  Rights  Agreement.  Each party shall use its best
efforts to fulfill or obtain the fulfillment of the conditions to its obligation
to effect the Closing,  including  promptly  obtaining any consents  required in
connection herewith.
          (b) ADDITIONAL DISCLOSURE.  Seller shall promptly notify Buyer of, and
furnish Buyer with, any  information  it may reasonably  request with respect to
the occurrence of any event or condition or the existence of any fact that would
cause any of the conditions to Buyer's obligation to consummate the transactions
contemplated by this Agreement not to be fulfilled.
     6.2  POST-CLOSING  COVENANTS AND AGREEMENTS.  Buyer and Seller covenant and
agree from and after the Closing Date to perform or take the following actions:
          (a) RESERVE FOR CONVERSION  SHARES.  Seller shall at all times reserve
and keep available out of its authorized but unissued  shares of Common Stock or
other  securities  for the purpose of issuing  Common Stock or other  securities
upon the  conversion of the Note.  If at any time the number of  authorized  but
unissued shares of Common Stock or other  securities  shall not be sufficient to
satisfy the  conversion of the Note, if any,  Seller shall  forthwith  take such
corporate  action as may be necessary to increase  its  authorized  but unissued
shares of Common Stock or other  securities to such number of shares as shall be
sufficient for such purpose.  If any capital  reorganization  or any Liquidation
Event of Seller  shall be  effected in such a way that  holders of Common  Stock
shall be entitled to receive capital stock, securities or assets with respect to
or in exchange for Common Stock,  then,  as a condition of such  reorganization,
reclassification  or Liquidation Event,  lawful and adequate provisions shall be
made whereby the holder of the Note shall thereafter,  upon conversion, have the
right to receive such shares of capital  stock,  securities  or assets as may be
issued or payable with  respect to or in exchange for the number of  outstanding
shares of such Common Stock into which the Note held at the time of such capital
reorganization, reclassification or Liquidation Event is convertible.
                                       9
     7.   CONDITIONS PRECEDENT TO THE OBLIGATION OF BUYER TO CLOSE.
     7.1  CLOSING. The obligation of Buyer to complete the Closing is subject to
the  fulfillment  on or  prior  to the  Closing  Date  of  all of the  following
conditions, any one or more of which may be waived by Buyer in writing:
     (a)  AGREEMENTS AND CONDITIONS. On or before the Closing Date, Seller shall
have complied with and duly performed and satisfied in all material respects all
agreements  and conditions on its part to be complied with and performed by such
date pursuant to this Agreement.
     (b)  CONSENTS.  Seller  shall  have  obtained  any  consents  necessary  to
effectuate this Agreement and to consummate the transactions contemplated hereby
and delivered copies thereof to Buyer.
     (c)  NOTE. Seller shall have duly executed and delivered to Buyer the Note.
     (d)  REGISTRATION  RIGHTS  AGREEMENT.  Seller shall have duly  executed and
delivered to Buyer the Registration Rights Agreement.
     8.   CONDITIONS PRECEDENT TO THE OBLIGATION OF SELLER TO CLOSE.
     8.1  CLOSING.  The obligation of Seller to  complete the Closing is subject
to the  fulfillment  on or  prior  to the  Closing Date  of all of the following
conditions, any one or more of which may be waived by Seller in writing:
     (a)  AGREEMENTS AND CONDITIONS.  On or before the Closing Date, Buyer shall
have complied  with and  performed  and  satisfied in all material  respects all
agreements  and  conditions  to be  complied  with and  performed  by such  date
pursuant to this Agreement.
     (b)  PAYMENT  OF  PURCHASE  PRICE.  Buyer  shall have  paid  to Seller  the
Purchase Price.
     (c)  REGISTRATION  RIGHTS  AGREEMENT.  Buyer shall have duly  executed  and
delivered to Seller the Registration Rights Agreement.
     9.   EVENTS OF DEFAULT.  If any of the following events (each, an "Event of
Default") shall occur and be continuing:
     (i) Seller shall fail to pay any amount payable under the Note within three
(3) business days after such payment  becomes due in  accordance  with the terms
thereof,
     (ii)  Seller  shall  fail to pay  when due  (following  the  expiration  of
applicable  notice  and  cure  periods,  if  any),  whether  upon  acceleration,
prepayment obligation or otherwise,  any indebtedness and/or other sums payable,
individually or in the aggregate, involving an amount in excess of $100,000;
                                       10
     (iii) Any  representation  or warranty made or deemed made by Seller herein
or in any  other  agreement,  certificate  or  instrument  contemplated  by this
Agreement  or that is  contained  in any  certificate,  document or financial or
other statement furnished at any time under or in connection with this Agreement
shall have been  incorrect in any material  respect on or as of the date made or
deemed made;
     (iv) Seller shall default,  in any material  respect,  in the observance or
performance  of any other  agreement  contained  in this  Agreement or any other
agreement or instrument  contemplated by this Agreement,  and such default shall
continue  unremedied  for a period of twenty (20) days after notice to Seller of
such default;
     (v)  Seller  shall  substantially  curtail,  alter,  modify or  change  its
business operations, as reasonably determined by Buyer; or
     (vi) (a) Seller  shall  commence any case,  proceeding  or other action (x)
under any  existing  or future law of any  jurisdiction,  domestic  or  foreign,
relating to bankruptcy, insolvency, reorganization, conservatorship or relief of
debtors,  seeking to have an order for  relief  entered  with  respect to it, or
seeking to  adjudicate it a bankrupt or  insolvent,  or seeking  reorganization,
arrangement,  adjustment, winding-up, liquidation,  dissolution,  composition or
other relief with respect to it or its debts,  or (y) seeking  appointment  or a
receiver,  trustee,  custodian,  conservator or other similar official for it or
for all or any  substantial  part of its assets,  or Seller shall make a general
assignment  for the benefit of its  creditors;  or (b) there shall be  commenced
against Seller any case,  proceeding or other action of a nature  referred to in
clause  (a) above  that (A)  results  in the entry of an order for relief of any
such  adjudication  of appointment or (B) remains  undismissed,  undischarged or
unbonded  for a period  of sixty  (60)  days;  or (c) there  shall be  commenced
against Seller any case,  proceeding  other action seeking issuance of a warrant
of  attachment,  execution,  distrait  or  similar  process  against  all or any
substantial  part of its  assets  that  results in the entry of an order for any
such relief which shall not have been vacated,  discharged,  or stayed or bonded
pending  appeal  within  sixty (60) days from the entry  thereof;  or (d) Seller
shall take any action in furtherance  of, or indicating its consent to, approval
of, or  acquiescence  in any of the acts set forth in  clauses  (a),  (b) or (c)
above;  or (e) Seller shall generally not, or shall be unable to, or shall admit
in writing its inability to, pay its debts as they become due,
     then, and in any such event, but in all events subject to the provisions of
Section  3.6  above,  (x) if such  event  is an Event of  Default  specified  in
subsection  (vi) above of this Section 9 with  respect to Seller,  automatically
the Note (with all accrued and unpaid  interest  thereon) and all other  amounts
owing  under  this  Agreement  and the Note  shall  immediately  become  due and
payable,  and (y) if such event is any other  Event of  Default,  Buyer may,  by
written notice to Seller, declare the Note (with all accrued and unpaid interest
thereon) and all other amounts owing under this Agreement and the Note to be due
and  payable  forthwith,  whereupon  the same shall  immediately  become due and
payable.  Except as expressly  provided  above in this Section 9,  presentation,
demand, protest and all other notices of any kind are hereby expressly waived by
Seller.
                                       11
     10.   MISCELLANEOUS.
     10.1. PUBLICITY.  Subject  to the  requirements  of the Federal  securities
laws, no publicity  release or  announcement  concerning  this  Agreement or the
transactions contemplated hereby shall be issued without advance approval of the
form and  substance  thereof  by Buyer and Seller  jointly.
     10.2. NOTICES.  All notices and other communications  hereunder shall be in
writing  and shall be deemed to have been  given  when  delivered  by hand or by
facsimile transmission,  when telexed, or upon receipt when mailed by registered
or certified mail (return receipt requested), postage prepaid, to the parties at
the  following  addresses  (or at such  other  address  for a party  as shall be
specified by like notice):
    (i)    If to Seller:
           Vyteris Holdings (Nevada),  Inc.
           ▇▇-▇▇ ▇▇▇▇▇▇▇ ▇▇▇▇▇
           ▇▇▇▇ ▇▇▇▇, ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
           Attention: Chief Executive Officer
           Facsimile:  (▇▇▇) ▇▇▇-▇▇▇▇
           With a copy (which copy shall not constitute notice) to:
           ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇ PC
           ▇▇ ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇
           ▇▇▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
           Attention: ▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇, Esq.
           Facsimile: (▇▇▇) ▇▇▇-▇▇▇▇
   (ii)    If to Buyer:
           ▇▇▇▇▇▇▇ ▇▇▇▇▇ Specialty Group, LLC
           ▇▇▇ ▇▇▇▇▇▇▇ ▇▇▇▇▇▇
           ▇▇▇ ▇▇▇▇, ▇▇ ▇▇▇▇▇
           Attention: ▇▇▇▇▇ ▇▇▇▇▇, Esq.
           Facsimile: (▇▇▇) ▇▇▇-▇▇▇▇
           With a copy (which copy shall not constitute notice) to:
           ▇▇▇▇▇▇▇ ▇▇▇▇▇▇ LLP
           ▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇▇ ▇▇▇▇▇
           ▇▇▇ ▇▇▇▇, ▇▇ ▇▇▇▇▇
           Attention: ▇▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇, Esq.
           Facsimile: (▇▇▇) ▇▇▇-▇▇▇▇
     10.3. ENTIRE AGREEMENT;  EXERCISE OF RIGHTS. (a) This Agreement  (including
the Schedules and Exhibits  hereto) and the other Loan  Documents (as defined in
Section  10.6  hereof)  embody the entire  agreement  and  understanding  of the
parties hereto with respect to the subject  matter  hereof.  No amendment of any
provision  of this  Agreement  shall be  effective  unless it is in writing  and
signed by each of the  parties  hereto  and no waiver of any  provision  of this
                                       12
Agreement,  nor  consent to any  departure  by either  party  from it,  shall be
effective  unless it is in writing and signed by the  affected  party,  and then
such waiver or consent shall be effective only in the specific  instance and for
the specific purpose for which given.
     (b)  No failure  on the  part of a  party  to  exercise,  and no  delay  in
exercising,  any right  under  this  Agreement,  or any  agreement  contemplated
hereby,  shall operate as a waiver hereof by such party, nor shall any single or
partial   exercise  of  any  right  under  this  Agreement,   or  any  agreement
contemplated  hereby,  preclude  any other or  further  exercise  thereof or the
exercise of any other right.
     10.4. GOVERNING LAW.  This Agreement  shall be governed by and construed in
accordance  with the laws of the State of New York applicable to agreements made
and to be performed entirely within such jurisdiction.
     10.5. EXPENSES.  Seller  and  Buyer   shall,  subject  to  the  immediately
succeeding sentence,  bear their respective expenses incurred in connection with
the  negotiation,  preparation,  execution and performance of this Agreement and
the consummation of the transactions  contemplated  hereby,  including,  without
limitation, all fees and expenses of agents,  representatives,  counsel, brokers
or finders, and accountants.
     10.6. TRANSFERABILITY.  Subject to securities laws  restrictions of general
applicability,  this Agreement,  the Note and the Registration  Rights Agreement
(collectively, the "Loan Documents") and all rights hereunder and thereunder are
freely and  separately  transferable  and  assignable,  in whole or in part,  by
Buyer.  The foregoing  transferees and assignees shall be entitled to the rights
provided in the Loan  Documents.  Seller may not assign or  delegate  any of its
obligations under the Loan Documents without the prior written consent of Buyer.
For purposes hereof, a sale or exchange by Seller of all or substantially all of
its assets shall  constitute an  assignment/delegation  requiring  Buyer's prior
written consent.
                            [SIGNATURE PAGE FOLLOWS]
                                       13
     IN WITNESS  WHEREOF,  the parties  hereto have  executed this Note Purchase
Agreement on the date first above written.
                                ▇▇▇▇▇▇▇ ▇▇▇▇▇, SPECIALTY GROUP, LLC
                                By: /s/ ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇
                                    -------------------------------------------
                                    Name:  ▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇
                                    Title: Nonmember Manager
                                VYTERIS HOLDINGS (NEVADA), INC.
                                By: /s/ ▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇
                                    -------------------------------------------
                                    Name:   ▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇
                                    Title:  V.P. Operations/Principal
                                            Accounting Officer
                                       15
                                   EXHIBIT A
                                   ---------
                                  Form of Note
                                   EXHIBIT B
                                   ---------
                     Form of Registration Rights Agreement
                                   SCHEDULES
                                   ---------