Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin
Confidential
Exhibit 10.49
Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin
This Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin, dated as of December 3, 2007 (“Effective Date”), is entered into by and between Patheon Italia S.p.A. (“Patheon”) and ZymoGenetics, Inc., a Washington corporation (“ZGEN”).
The parties hereby agree that the Manufacturing Services Agreement relating to rhThrombin, dated January 1, 2006 (the “Agreement”) shall be amended as follows:
| 1. | Territory |
Schedule H shall be replaced by the updated Schedule H attached hereto.
| 2. | Ratification of Agreement |
All other terms and obligations of the Agreement shall remain in full force and effect.
IN WITNESS WHEREOF, ZGEN and Patheon have executed this Amendment No. 1 to Manufacturing Services Agreement relating to rhThrombin as of the Effective Date.
| Patheon Italia S.p.A. | ZymoGenetics, Inc. | |||
| /s/ ▇▇▇▇ ▇▇▇▇▇ | /s/ ▇▇▇▇▇▇ ▇. ▇▇▇▇▇ | |||
| ▇▇▇▇ ▇▇▇▇▇ | ▇▇▇▇▇▇ ▇. ▇▇▇▇▇, Ph.D. | |||
| Managing Director Patheon Italia S.p.A. – President Patheon Europe |
Senior Vice President, Technical Operations | |||
| Date: December 3, 2007 | Date: December 5, ▇▇▇▇ | |||
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