1
                                                                   EXHIBIT 10.13
                                FIRST AMENDMENT
                     TO ▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇ LEASE
                                    between
                        DENVER ▇▇▇▇ LIMITED PARTNERSHIP
                                      and
                            ALLOS THERAPEUTICS, INC.
                             Dated October 30, 1995
THIS FIRST AMENDMENT is to that certain lease agreement (the "Lease") dated
October 30, 1995, by and between DENVER ▇▇▇▇ LIMITED PARTNERSHIP ("Lessor") and
ALLOS THERAPEUTICS, INC. ("Lessee") with respect to approximately 4,022 square
feet of space on the third floor, known as Suite 310 (the "Premises"), in the
building known as ▇▇▇▇ ▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇ (the "Building"). In the event
of any conflict between the terms and provisions of the lease and the terms and
provisions of this First Amendment, the terms and provisions of this First
Amendment shall control.
     1) Amendment to Article 4 of the Lease Document.
     Landlord and Tenant do hereby agree that a portion of Article 4, Rent
     Adjustment, Paragraph (a) Real Estate Taxes and Paragraph (b) Operating
     Expenses shall be amended to read "the Base Year 1996 actual expenses".
     This will effectively change the Base Year for Operating Expense and Real
     Estate Tax adjustments from 1995 to 1996.
Except as herein specifically set forth, all other provisions of the Lease shall
remain in full force and effect and be binding upon the parties in accordance
with their terms.
IN WITNESS WHEREOF, the parties have hereunto set their hands and seals the day
and year fist above written.
                                     LESSOR:
                                     AMBERJACK, LTD., General Partner for
                                     DENVER ▇▇▇▇ LIMITED PARTNERSHIP
                                     By:  CB Commercial Real Estate Group, Inc.
                                        ---------------------------------------
                                     Its: As Manager
                                         --------------------------------------
                                     By:  [ILLEGIBLE]
                                        ---------------------------------------
                                     Its: Senior Vice President
                                         --------------------------------------
                                          [ILLEGIBLE]
                                          Asst. V.P.
                                     LESSEE:
                                     ALLOS THERAPEUTICS, INC.
                                     a Virginia corporation
                                     By:  ▇▇▇▇ ▇▇▇▇▇
                                        ---------------------------------------
                                     Its: V.P. Finance & CFO
                                         --------------------------------------