WARRANT AGREEMENT
Exhibit
      4.2
THE
      SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
      ACT
      OF 1933 OR ANY APPLICABLE STATE SECURITIES OR “BLUE-SKY” LAWS AND MAY NOT BE
      SOLD, TRANSFERRED, ASSIGNED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF UNLESS
      REGISTERED UNDER SUCH ACT OR UNDER SUCH LAWS, OR PURSUANT TO AN EXEMPTION FROM
      SUCH REGISTRATION.
    This
      WARRANT AGREEMENT is dated and entered into as of October
      25, 2006,
      by and
      between DISCOVERY LABORATORIES, INC., a Delaware corporation (the “Company”),
      and PHARMABIO DEVELOPMENT INC., a North Carolina corporation, doing business
      as
      NovaQuest (“NovaQuest”). Capitalized terms herein that are not otherwise defined
      shall have the respective meanings set forth in the Loan Agreement (as defined
      below).
    WHEREAS,
      the Company and NovaQuest, have entered into the
      Amended
      and Restated Loan Agreement dated
      as of
      December 10, 2001, and amended and restated
      as of
      the date hereof (as amended, the “Loan Agreement”), and other agreements dated
      as of the date hereof; and
    WHEREAS,
      the Company desires to grant to NovaQuest the rights set forth in this Warrant
      Agreement;
    NOW,
      THEREFORE, for good and valuable consideration, the receipt and sufficiency
      of
      which are hereby acknowledged, the parties, intending to be legally bound,
      agree
      as follows:
    1. The
      Warrant.
      The
      Company hereby agrees to issue and sell to NovaQuest, its designees or assigns
      (the “Holder”) up to One Million Five Hundred Thousand (1,500,000) shares (the
“Warrant Shares”) of the Company’s
      common stock, par value $0.001 per share (“Common Stock”), at an exercise price
equal
      to
      Three Dollars
      and Fifty-Eight and Thirteen One-Hundredths Cents ($3.5813) per share (the
“Exercise Price”) (such
      Exercise Price having been calculated as follows: the average of the
      volume-weighted average price (VWAP) (as reported by Bloomberg, L.P.) for the
      ten (10) trading days prior to the date hereof, multiplied by 130%),
      and
      upon the terms and conditions set forth herein.
      The
      Exercise Price and the number of Warrant Shares purchasable upon exercise of
      this Warrant Agreement
      are
      subject to adjustment from time to time as provided in Section 4 of this Warrant
      Agreement. 
    2. Expiration
      Date.
      This
      Warrant Agreement, and the Holder’s right to purchase any of the Warrant Shares,
      will expire at 5:00 p.m. Eastern Time on the seventh anniversary of the date
      of
      this Warrant Agreement (the “Expiration Date”).
    1
        3. Exercise
      of this Warrant Agreement.
      The
      Holder may exercise this Warrant Agreement at any time from and after the date
      hereof and prior to the Expiration Date, in whole or in part, as adjusted from
      time to time as provided in Section 4 of this Warrant Agreement, by: (a) the
      surrender of this Warrant Agreement, with the Exercise Form substantially in
      the
      form attached hereto as Annex A properly completed and executed, at the
      principal office of the Company on a Business Day (as defined below), and (b)
      upon payment by (i) the delivery on a Business Day of a certified check or
      official bank check or wire transfer of immediately available funds, payable
      to
      the order of the Company, (ii) cancellation of an amount of indebtedness of
      the
      Company under the Loan Agreement,
      or (iii)
      a combination of (i) and (ii), in an amount equal to the aggregate purchase
      price for the Warrant Shares being purchased upon such exercise. Upon receipt
      thereof by the Company, the Holder will be deemed to be the holder of record
      of
      the Warrant Shares issuable upon such exercise as of the close of business
      on
      the date of such receipt by the Company, and the Company will promptly execute
      or cause to be executed and delivered to the Holder a certificate or
      certificates representing the aggregate number of Warrant Shares specified
      in
      the Exercise Form. If this Warrant Agreement is exercised only in part, the
      Company will, at the time of delivery of said stock certificate or certificates,
      deliver to the Holder a new Warrant Agreement of like tenor evidencing the
      right
      of the Holder to purchase the remaining Warrant Shares then covered by this
      Warrant Agreement. Upon exercise of this Warrant Agreement and payment of the
      purchase price by the Holder, all Warrant Shares deliverable and issued
      hereunder will be duly authorized, duly and validly issued and outstanding,
      fully paid and nonassessable, and free from taxes, liens or charges. “Business
      Day” shall mean any day other than a Saturday, Sunday or legal holiday on which
      banks in North Carolina and New York are open for the conduct of their banking
      business.
    4. Certain
      Adjustments.
      The
      Exercise Price at which Warrant Shares may be purchased and the number of
      Warrant Shares to be purchased upon exercise of this Warrant Agreement are
      subject to change or adjustment from time to time as follows:
    (a) Merger,
      Sale of Assets, etc.
      If at
      any time while this Warrant Agreement, or any portion hereof, is outstanding
      and
      unexpired there shall be (i) a reorganization (other than a combination,
      reclassification, exchange or subdivision of shares otherwise provided for
      herein), (ii) a merger or consolidation of the Company with or into another
      corporation or entity in which the Company is not the surviving entity, or
      a
      share exchange or reverse triangular merger in which the Company is the
      surviving entity but the shares of the Company’s capital stock outstanding
      immediately prior to the merger or share exchange are exchanged or converted
      by
      virtue of the merger or share exchange into other property, whether in the
      form
      of securities, cash, or otherwise,
      or (iii)
      a sale, lease, license or other transfer of all or substantially all of the
      Company’s properties or assets to any other person or entity, then, as a part of
      such reorganization, merger, consolidation, exchange or transfer, lawful
      provision shall be made so that the Holder shall thereafter be entitled to
      receive upon exercise of this Warrant Agreement, during the period specified
      herein and upon payment of the Exercise Price then in effect, the number of
      shares of stock or other securities or property resulting from such
      reorganization, merger, consolidation, exchange or transfer that a holder of
      the
      shares deliverable upon exercise of this Warrant Agreement would have been
      entitled to receive in such reorganization, merger, consolidation, exchange
      or
      transfer if this Warrant Agreement had been exercised immediately before the
      record date of (or the date of, if no record date is fixed) such reorganization,
      merger, consolidation, exchange or transfer, all subject to further adjustment
      as provided in this Section 4. The foregoing provisions of this Section
      4(a) shall similarly apply to successive reorganizations, consolidations,
      mergers, exchanges and transfers and to the stock or securities of any other
      corporation that are at the time receivable upon the exercise of this Warrant
      Agreement. If the per-share consideration payable to the Holder hereof for
      shares in connection with any such transaction is in a form other than cash
      or
      marketable securities, then the value of such consideration shall be reasonably
      determined in good faith by the Company’s Board of Directors. In all events,
      appropriate adjustment (as reasonably determined in good faith by the Company’s
      Board of Directors) shall be made in the application of the provisions of this
      Warrant Agreement with respect to the rights and interests of the Holder after
      the transaction, to the end that the provisions of this Warrant Agreement shall
      be applicable after that event, as near as reasonably may be, in relation to
      any
      shares or other property deliverable after that event upon exercise of this
      Warrant Agreement.
    2
        (b) Reclassification,
      etc.
      If the
      Company, at any time while this Warrant Agreement, or any portion hereof,
      remains outstanding and unexpired, by reclassification of securities or
      otherwise, shall change any of the securities as to which purchase rights under
      this Warrant Agreement exist into the same or a different number of securities
      of any other class or classes, this Warrant Agreement shall thereafter represent
      the right to acquire such number and kind of securities as the Holder would
      have
      received if this Warrant Agreement had been exercised in full immediately prior
      to such reclassification or other change or immediately prior to the record
      date
      with respect thereto and the Exercise Price therefor shall be appropriately
      adjusted, all subject to further adjustment as provided in this Section 4.
      The
      foregoing provisions of this Section 4(b) shall similarly apply to successive
      reclassifications or other changes.
    (c) Split,
      Subdivision or Combination of Shares.
      If the
      Company, at any time while this Warrant Agreement, or any portion hereof,
      remains outstanding and unexpired, shall split, subdivide or combine the
      securities as to which purchase rights under this Warrant Agreement exist,
      into
      a different number of securities of the same class, the Exercise Price for
      such
      securities shall be proportionately decreased in the case of a split or
      subdivision or proportionately increased in the case of a combination. Upon
      each
      adjustment in the Exercise Price pursuant to this subsection, the number of
      shares of such securities purchasable hereunder shall be adjusted, to the
      nearest whole share, to the product obtained by multiplying the number of shares
      purchasable immediately prior to such adjustment in the Exercise Price by a
      fraction, the numerator of which shall be the Exercise Price immediately prior
      to such adjustment and the denominator of which shall be the Exercise Price
      immediately thereafter.
    (d) Adjustments
      for Dividends in Stock or Other Securities or Property.
      If
      while this Warrant Agreement, or any portion hereof, remains outstanding and
      unexpired, the holders of the securities as to which purchase rights under
      this
      Warrant Agreement exist at the time shall have received, or, on or after the
      record date fixed for the determination of eligible stockholders, shall have
      become entitled to receive, without payment therefor, other or additional stock
      or other securities or property (other than cash) by way of dividend, then
      and
      in each case, this Warrant Agreement shall represent the right to acquire,
      in
      addition to the number of shares of the security receivable upon exercise of
      this Warrant Agreement and, in addition, without payment of any additional
      consideration therefor, the amount of such other or additional stock or other
      securities or property (other than cash) that such holder would hold on the
      date
      of such exercise had it been the holder of record of the security receivable
      upon exercise of this Warrant Agreement on the date hereof and had thereafter,
      during the period from the date hereof to and including the date of such
      exercise, retained such shares and/or all other additional stock or other
      securities or property (other than cash) available by or to it as aforesaid
      during such period, giving effect to all adjustments called for during such
      period by the provisions of this Section 4.
    3
        (e) Certificate
      as to Adjustments.
      Upon
      the occurrence of each adjustment pursuant to this Section 4, the Company at
      its
      expense shall promptly compute such adjustment in accordance with the terms
      hereof and furnish to each Holder of this Warrant Agreement a certificate signed
      by its Chief Financial Officer setting forth such adjustment and showing in
      detail the event requiring the adjustment, the amount of such adjustment, the
      method by which such adjustment was calculated, the Exercise Price at the time
      in effect, and the number of shares and the amount, if any, of the property
      that
      at the time would be received upon the exercise of this Warrant Agreement,
      together with the facts upon which such adjustment is based. The Company shall,
      upon the reasonable written request of any such Holder, furnish or cause to
      be
      furnished to such Holder a like certificate setting forth: (i) all such previous
      adjustments; (ii) the Exercise Price at the time in effect; and (iii) the number
      of shares and the amount, if any, of other property that at the time would
      be
      received upon the exercise of this Warrant Agreement.
    (f) No
      Impairment.
      The
      Company will not, by amendment of its certificate of incorporation or through
      any reorganization, recapitalization, reclassification, transfer of assets,
      consolidation, merger, business combination, dissolution, issuance or sale
      of
      securities or any other voluntary action, avoid or seek to avoid the intent
      of
      this Section 4 or the observance or performance of any of the terms to be
      observed or performed by the Company under this Section 4 or the other terms
      of
      this Warrant Agreement, but will at all times in good faith assist in the
      carrying out of all the provisions of this Section 4 and in the taking of all
      such action as may be necessary or appropriate in order to protect the rights
      of
      the holder of this Warrant Agreement against impairment. In case any event
      shall
      occur as to which the other provisions of this Section 4 are not strictly
      applicable but as to which the failure to make any adjustment would not fairly
      protect the purchase rights represented by this Warrant Agreement in accordance
      with the essential intent and principles hereof, then, in each such case, the
      Board of Directors of the Company shall in good faith determine the adjustment,
      if any, on a basis consistent with the purchase rights represented by this
      Warrant Agreement. Upon such determination, the Company will promptly deliver
      a
      copy thereof to the Holder and shall make the adjustments described
      therein.
    (g) No
      Adjustment.
      No
      adjustment in the Exercise Price shall be required unless such adjustment would
      require an increase or decrease of at least
      $0.05
      per
      share of
      Common Stock; provided,
      however,
      that
      any adjustments which by reason of this Section 4(g) are not required to be
      made
      shall be carried forward and taken into account in any subsequent adjustment.
      All calculations under this Section 4 shall be made to the nearest cent or
      to
      the nearest 1/100th
      of a
      share, as the case may be.
    5. Fractional
      Shares.
      Upon
      the exercise of this Warrant Agreement, fractional shares may be issued by
      the
      Company, but the Company may, in lieu of issuing such fractional shares, pay
      a
      sum in cash equal to the excess of the fair market value of such fractional
      share (determined in such reasonable manner as may be prescribed by the Board
      of
      Directors of the Company in its discretion) over the proportional part of the
      per share purchase price represented by such fractional share.
    4
        6. Notices
      of Certain Events.
    In
      case:
    (a)
      the
      Company shall take a record of the holders of its Common Stock (or other stock
      or securities at the time receivable upon the exercise of this Warrant
      Agreement) for the purpose of entitling them to receive any dividend or other
      distribution, or stock subdivision or combination, or any right to subscribe
      for
      or purchase any shares of stock of any class or any other securities, or to
      receive any other right;
      or
    (b)
      of
      any reorganization or recapitalization of the Company, any reclassification
      of
      the capital stock of the Company, any consolidation, merger, share exchange
      or
      other business combination of the Company with or into another corporation
      or
      entity, or any sale, lease, license or other transfer of all or substantially
      all of the assets of the Company to another corporation or entity;
      or
    (c)
      of
      any voluntary dissolution, liquidation or winding-up of the Company, 
    then,
      and
      in each such case, the Company will cause written notice thereof to be delivered
      to the Holder specifying, as the case may be, (i) the date on which a record
      is
      to be taken for the purpose of such dividend, distribution or right, and stating
      the amount and character of such dividend, distribution or right or (ii) the
      date on which such reorganization, recapitalization, reclassification,
      consolidation, merger, share exchange, business combination, transfer,
      dissolution, liquidation or winding-up is to take place, and the time, if any
      is
      to be fixed, as of which the holders of record of Common Stock (or such stock
      or
      securities at the time receivable upon the exercise of this Warrant Agreement)
      shall be entitled to exchange their shares of Common Stock (or such other stock
      or securities) for securities or other property deliverable upon such
      reorganization, reclassification, recapitalization, consolidation, merger,
      share
      exchange, business combination, transfer, dissolution, liquidation or
      winding-up. Such notice shall be delivered at least fifteen (15) Business Days
      prior to the date required to be specified therein pursuant to this Section
      6(c).
    7. Reservation
      of Shares; Listing.
      (a) The
      Company will at all times until the date of exercise of this Warrant Agreement
      in full (the “Exercise Date”) reserve and keep available out of its authorized
      but unissued stock, for the purpose of effecting the exercise of this Warrant
      Agreement, such number of its duly authorized shares of capital stock for which
      this Warrant Agreement is exercisable, and such number of shares of any stock
      into which such stock is convertible, if applicable, as will from time to time
      be sufficient to effect the exercise of this Warrant Agreement. The Company
      will
      from time to time take all steps necessary to amend its certificate of
      incorporation to provide at all times prior to the Exercise Date sufficient
      reserves of shares of capital stock issuable upon exercise of this Warrant
      Agreement and the conversion of such stock, if applicable. If the number of
      authorized but unissued shares of capital stock shall not be sufficient to
      effect the exercise the entire amount of this Warrant Agreement on the Exercise
      Date or the conversion of such stock, if applicable, then in addition to such
      other remedies as shall be available to the Holder, the Company shall take
      all
      such corporate action as is necessary to increase its authorized but unissued
      shares of capital stock to such number of shares as shall be sufficient for
      such
      purposes. 
    5
        (b) The
      Company will at all times use its best efforts to keep the Warrant Shares
      authorized for listing on the NASDAQ
      Global Select Market, NASDAQ Global Market (formerly the NASDAQ National Market)
      or the NASDAQ Capital Market (formerly the NASDAQ Small Cap Market),
      or any
      national securities exchange on which its Common Stock is traded.
    8. No
      Rights as Stockholder; Limitation of Liability.
      This
      Warrant Agreement, as distinct from the shares for which this Warrant Agreement
      is exercisable, will not entitle the Holder to any of the rights of a
      stockholder of the Company, including without limitation any right to vote
      on or
      consent to or receive notice as a stockholder of the Company, as such, in
      respect of any matters whatsoever. No provision of this Warrant Agreement,
      prior
      to the exercise of this Warrant Agreement, and no mere enumeration herein of
      the
      rights or privileges of the Holder, will give rise to any liability of the
      Holder for the purchase price or as a stockholder of the Company, whether such
      liability is asserted by the Company or by creditors of the
      Company.
    9. Transfer
      Restriction.
      Neither
      this Warrant Agreement nor the securities issuable upon exercise hereof have
      been registered under
      the
      Securities Act of 1933,
      as
      amended (the
      “Securities Act”), or the securities or
“blue
      sky” laws
      of
      any state. Neither this Warrant Agreement nor
      the
      securities issuable upon exercise hereof nor any interest or participation
      herein or therein may be sold, assigned, pledged, hypothecated, encumbered
      or in
      any other manner transferred or disposed of except in compliance with the
      Securities Act and the securities laws of each relevant state. Notwithstanding
      anything
      in this
      Warrant Agreement to the contrary,
      the
      Holder
      may
      pledge the
      Warrant Agreement and the Warrant Shares
      in
      connection with bona fide loan transactions in which the
      Holder
      or its
      affiliate is the borrower,
      provided
      that no such pledge shall occur knowingly, after reasonable investigation and
      inquiry, to any person or entity which actively sells, distributes, markets,
      develops, or produces a pharmaceutical product or device which directly competes
      with the Product.
    10. Registration
      Rights.
    (a) Required
      Registration.
      Not
      later than forty-five (45) days following the date hereof (the “Filing Date”),
      the Company shall prepare and file with the Securities and Exchange Commission
      (“SEC”) a registration statement on Form S-3 (except if the Company is not then
      eligible to use Form S-3, in which case such registration statement shall be
      on
      another appropriate form) (the “Registration Statement”) covering the resale of
      all of the Registrable Securities (as defined below) in an offering to be made
      on a continuous basis pursuant to Rule 415 of the Securities Act. The Company
      shall use its commercially reasonable best efforts to cause such registration
      statement to become effective as soon as practicable and in any event not later
      than ninety (90) days following the date hereof and remain effective for the
      period specified in Section 10(d) below. Subject to any modifications that
      are
      responsive to comments, rules or regulations of the SEC, the Registration
      Statement will include a Plan of Distribution, which shall be no more
      restrictive than that included in the Company’s registration statement on Form
      S-3, SEC File No. 333-121297. For purposes of this Agreement, the term
“Registrable Securities” means the Warrant Shares, together with any securities
      issued or issuable upon any stock split, dividend or other distribution,
      recapitalization or similar event with respect to any Registrable Securities.
      Until such time as the Registration Statement is effective, the Company shall
      not grant any registration rights or other rights to register securities under
      the Securities Act that are senior to the rights of the Holder under this
      Section 10(a) or that have the effect of delaying a sale or limiting the number
      of securities which may be sold by the Holder pursuant to the Registration
      Statement or otherwise adversely affect the rights of the Holder under this
      Section 10(a); provided, however, that the foregoing shall not affect any
      pre-existing rights granted to any persons or entities.
    6
        (b) Registration
      Expenses.
      The
      Company shall pay all Registration Expenses (as defined below) in connection
      with any registration, qualification or compliance hereunder. At any time during
      the ninety (90) days following the effective date of the Registration Statement
      (and provided that the Registration Statement has not been withdrawn, suspended
      or otherwise become not effective), the Company may present to the Holder an
      accounting of its reasonable “Registration
      Expenses
      and,
      within thirty (30) days thereafter, the Holder shall reimburse the Company
      for
      such expenses up to an aggregate amount not to exceed Twenty Thousand Dollars
      ($20,000). “Registration Expenses” shall mean all expenses incurred by the
      Company in complying with the registration provisions herein described,
      including without limitation all registration, qualification, notification
      and
      filing fees, printing expenses, fees and disbursements of counsel and
      accountants for the Company, and blue sky fees and expenses. 
    (c) Holder
      Review of Registration Statement.
      Upon
      request received by the Company from the Holder within a reasonable time in
      advance, the Company shall, on or prior to the third trading day prior to the
      filing of the Registration Statement or any related prospectus or any amendment
      or supplement thereto, (i) furnish to the Holder copies of all such documents
      proposed to be filed (including documents incorporated or deemed incorporated
      by
      reference to the extent requested by such person), which documents will be
      subject to the review of the Holder, and (ii) cause its officers and directors,
      counsel and independent certified public accountants to respond to such
      inquiries as shall be necessary, in the reasonable opinion of respective
      counsel, to conduct a reasonable investigation within the meaning of the
      Securities Act.
    (d) Certain
      Company Obligations During Effectiveness of Registration
      Statement.
      From
      the date of effectiveness of the Registration Statement, the Company will use
      its best efforts to: (i) keep such registration effective until the earlier
      of
      (A) such date as all of the Registrable Securities have been resold or (B)
      such
      date as all Registrable Securities may be sold pursuant to Rule 144(k) (or
      any
      successor rule) (collectively, the “Effectiveness Period”); (ii) promptly
      prepare and file with the SEC such amendments and supplements to the
      Registration Statement and the prospectus used in connection with the
      Registration Statement as may be necessary to comply with the provisions of
      the
      Securities Act with respect to the disposition of all securities covered by
      the
      Registration Statement; (iii) furnish such number of prospectuses and other
      documents incident thereto, including any amendment of or supplement to the
      prospectus, as the Holder from time to time may reasonably request; (iv) cause
      the Registrable Securities to be quoted or listed on each stock market or stock
      exchange on which the Common Stock of the Company is then quoted or listed;
      (v)
      provide a transfer agent and registrar for all securities registered pursuant
      to
      the Registration Statement and a CUSIP number for all such securities; (vi)
      avoid the issuance of, or, if issued, promptly notify the Holder and obtain
      the
      withdrawal of, any order suspending the effectiveness of a Registration
      Statement; (vii) promptly notify the Holder of the issuance by the SEC or any
      other federal or state governmental authority of any stop order suspending
      the
      effectiveness of the Registration Statement or the initiation of any proceedings
      for that purpose; (viii) promptly notify the Holder of the occurrence of any
      event or passage of time that makes the financial statements included in the
      Registration Statement ineligible for inclusion therein or any statement made
      in
      the Registration Statement or prospectus or any document incorporated or deemed
      to be incorporated therein by reference untrue in any material respect or that
      requires any revisions to the Registration Statement, prospectus or other
      documents so that, in the case of the Registration Statement or the prospectus,
      as the case may be, it will not contain any untrue statement of a material
      fact
      or omit to state any material fact required to be stated therein or necessary
      to
      make the statements therein, in light of the circumstances under which they
      were
      made, not misleading; (ix) promptly furnish to the Holder, without charge,
      at
      least one conformed copy of the Registration Statement and each amendment
      thereto, including financial statements and schedules, all documents
      incorporated or deemed to be incorporated therein by reference to the extent
      requested by such person, and all exhibits to the extent requested by such
      person (including those previously furnished or incorporated by reference)
      promptly after the filing of such documents with the SEC, provided, that if
      such
      documents are available on the Internet free of charge, then the Company instead
      may satisfy the requirement of this Section 10(d)(ix) by promptly notifying
      the
      Holder of the availability
      of such
      documents (other than periodic financial statements, reports of quarterly
      conference calls and press releases);
      and (x)
      file the documents required of the Company and otherwise use its best efforts
      to
      maintain any required blue sky clearance in North Carolina and such other states
      of the United States specified in writing by the Holder; provided, however,
      that
      the Company shall not be required to qualify to do business in any state in
      which it is not now so qualified or has not so consented.
    7
        (e) Suspension
      of Use of Prospectus.
      The
      Holder hereby acknowledges that there may occasionally be times when the Company
      must suspend the use of the prospectus forming a part of the Registration
      Statement until such time as an amendment to the Registration Statement has
      been
      filed by the Company and declared effective by the SEC or until the Company
      has
      amended or supplemented such prospectus. The Holder hereby covenants that it
      will not sell any securities pursuant to said prospectus during the period
      commencing at the time at which the Company gives the Holder notice of the
      suspension of the use of said prospectus and ending at the time the Company
      gives the Holder notice that Holder thereafter may effect sales pursuant to
      said
      prospectus. Notwithstanding anything herein to the contrary, the Company shall
      not suspend use of the prospectus forming a part of the Registration Statement
      by the Holder unless in the good faith opinion of the Company (after
      consultation with its counsel) or its counsel such suspension is required by
      the
      federal securities laws, including without limitation, the rules and regulations
      promulgated thereunder; provided, however, that in the event that such
      suspension is required by the need for an amendment or supplement to the
      Registration Statement or the prospectus forming a part thereof, the Company
      shall use its best efforts to file as soon as practicable such required
      amendments or supplements as shall be necessary for the disposition of the
      Registrable Securities to recommence.
    (f) Holder
      Information for Registration Statement.
      As a
      condition to the inclusion of its Registrable Securities, the Holder shall
      furnish to the Company such information regarding the Holder and the
      distribution proposed by the Holder as the Company may reasonably request in
      order to comply with any applicable law or regulation in connection with any
      registration, qualification or compliance referred to in this Section
      10.
    8
        (g) Indemnification
      and Contribution. 
    (1)
      To
      the extent permitted by applicable law, the Company will indemnify and hold
      harmless each seller of Registrable Securities that were registered pursuant
      to
      the Registration Statement, each underwriter of such Registrable Securities
      thereunder and each other person, if any, who controls such seller or
      underwriter within the meaning of Section 5 of the Securities Act, against
      any
      losses, claims, damages or liabilities, joint or several, to which such seller,
      underwriter or controlling person may become subject under the Securities Act
      or
      other applicable federal or state securities or “blue sky” laws, to the extent
      that such losses, claims, damages or liabilities (or actions in respect thereof)
      arise out of or are based upon any untrue statement or alleged untrue statement
      of any material fact contained in the Registration Statement under which such
      Registrable Securities were registered under the Securities Act, any preliminary
      prospectus or final prospectus contained therein, or any amendment or supplement
      thereof, or arise out of or are based upon the omission or alleged omission
      to
      state therein a material fact required to be stated therein or necessary to
      make
      the statements therein not misleading, and will reimburse each such seller,
      each
      such underwriter and each such controlling person for any legal or other
      expenses reasonably incurred by them in connection with investigating or
      defending any such loss, claim, damage, liability or action; provided,
      however,
      that
      the Company will not be liable, to any such indemnitee if and to the extent
      that
      any such loss, claim, damage or liability arises out of or is based upon an
      (i)
      untrue statement or alleged untrue statement or omission or alleged omission
      so
      made in conformity with information furnished by or on behalf of such indemnitee
      in writing specifically for use in such registration statement or prospectus
      or
      (ii) such untrue statement or alleged untrue statement or omission or alleged
      omission was contained in a preliminary or earlier effective prospectus and
      corrected in a final or amended prospectus, and such holder of Registrable
      Securities failed to deliver a copy of the final or amended prospectus at or
      prior to the confirmation of the sale of the Registrable Securities to the
      buyer
      of such Registrable Securities; provided,
      further,
      that
      the indemnity agreement contained in this Section 10(g)(1) shall not apply
      to
      amounts paid in settlement of any such loss, claim, damage, liability or action
      if such settlement is effected without the consent of the Company, which consent
      shall not be unreasonably withheld, provided that such consent shall not be
      required if the settlement shall include as an unconditional term thereof the
      giving by the claimant or plaintiff to such indemnified party of a release
      of
      the Company from all liability in respect of such claim or
      litigation.
    9
        (2) To
      the
      extent permitted by applicable law, each seller of Registrable Securities that
      were registered pursuant to the Registration Statement, severally and not
      jointly, will indemnify and hold harmless the Company, each person, if any,
      who
      controls the Company within the meaning of Section 15 of the Securities Act,
      each officer of the Company who signs the Registration Statement, each director
      of the Company, each underwriter and each person who controls any underwriter
      within the meaning of the Securities Act, against all losses, claims, damages
      or
      liabilities, joint or several, to which the Company or such officer, director,
      underwriter or controlling person may become subject under the Securities Act
      or
      other applicable federal or state securities or “blue sky” laws, to the extent
      that such losses, claims, damages or liabilities (or actions in respect thereof)
      arise out of or are based upon any untrue statement or alleged untrue statement
      of any material fact contained in the Registration Statement under which such
      Registrable Securities were registered under the Securities Act, any preliminary
      prospectus or final prospectus contained therein, or any amendment or supplement
      thereof, or arise out of or are based upon the omission or alleged omission
      to
      state therein a material fact required to be stated therein or necessary to
      make
      the statements therein not misleading, and will reimburse the Company and each
      such officer, director, underwriter and controlling person for any legal or
      other expenses reasonably incurred by them in connection with investigating
      or
      defending any such loss, claim, damage, liability or action; provided,
      however,
      that
      such seller will be liable hereunder in any such case if and only to the extent
      that any such loss, claim, damage or liability arises out of or is based upon
      an
      untrue statement or alleged untrue statement or omission or alleged omission
      made in reliance upon and in conformity with information pertaining to such
      seller, as such, furnished in writing to the Company by or on behalf of such
      seller specifically for use in such registration statement or prospectus, and
      provided,
      further,
      that
      the indemnity agreement contained in this Section 10(g)(2) shall not apply
      to
      amounts paid in settlement of any such loss, claim, damage, liability or action
      if such settlement is effected without the consent of such seller, which consent
      shall not be unreasonably withheld, provided that such consent shall not be
      required if the settlement shall include as an unconditional term thereof the
      giving by the claimant or plaintiff to such indemnified party of a release
      of
      such seller from all liability in respect of such claim or litigation;
provided,
      further,
      that
      the liability of each seller hereunder shall be limited to the net proceeds
      received for the account of such seller from the sale of Registrable Securities
      covered by such registration statement.
    (3) Promptly
      after receipt by an indemnified party hereunder of notice of the commencement
      of
      any action, such indemnified party shall, if a claim in respect thereof is
      to be
      made against the indemnifying party hereunder, notify the indemnifying party
      in
      writing thereof, but the omission to so notify the indemnifying party shall
      not
      relieve it from any liability which it may have to such indemnified party other
      than under this Section 10(g) and shall only relieve it from any liability
      which
      it may have to such indemnified party under this Section 10(g) if and to the
      extent the indemnifying party is prejudiced by such omission. In case any such
      action shall be brought against any indemnified party and it shall notify the
      indemnifying party of the commencement thereof, the indemnifying party shall
      be
      entitled to participate in and, to the extent it shall wish, to assume and
      undertake the defense thereof with counsel reasonably satisfactory to such
      indemnified party, and, after notice from the indemnifying party to such
      indemnified party of its election so to assume and undertake the defense
      thereof, the indemnifying party shall not be liable to such indemnified party
      under this Section 10(g) for any legal expenses subsequently incurred by such
      indemnified party in connection with the defense thereof other than reasonable
      costs of investigation and of liaison with counsel so selected, provided,
      however,
      that,
      if the defendants in any such action include both the indemnified party and
      the
      indemnifying party, and the indemnified party shall have reasonably concluded
      that there may be reasonable defenses available to it that are different from
      or
      additional to those available to the indemnifying party or if the interests
      of
      the indemnified party reasonably may be deemed to conflict with the interests
      of
      the indemnifying party, the indemnified party shall have the right to select
      a
      separate counsel and to assume and undertake such legal defenses and otherwise
      to participate in the defense of such action, with the reasonable expenses
      and
      fees of such separate counsel and other expenses related to such participation
      to be reimbursed by the indemnifying party as incurred; provided, further,
      that
      the Company shall not have any reimbursement obligation for the expenses and
      fees of more than one such separate counsel for all indemnitees.
    10
        (4) In
      order
      to provide for just and equitable contribution to joint liability under the
      Securities Act in any case in which either (i) any holder of Registrable
      Securities exercising rights under this Agreement, or any controlling person
      of
      any such holder, makes a claim for indemnification pursuant to this Section
      10(g) but it is judicially determined (by the entry of a final judgment or
      decree by a court of competent jurisdiction and the expiration of time to appeal
      or the denial of the last right of appeal) that such indemnification may not
      be
      enforced in such case notwithstanding the fact that this Section 10(g) provides
      for indemnification in such case, or (ii) contribution under the Securities
      Act
      may be required on the part of any such selling holder or any such controlling
      person in circumstances for which indemnification is provided under this Section
      10(g); then, and in each such case, the Company and such holder will contribute
      to the aggregate losses, claims, damages or liabilities to which they may be
      subject (after contribution from others) in such proportion as is appropriate
      to
      reflect the relative fault of the indemnifying party on the one hand and of
      the
      indemnified party on the other, as well as any other relevant equitable
      considerations. The relative fault of the parties shall be determined by
      reference to, among other things, whether the untrue or alleged untrue statement
      of a material fact or the omission to state a material fact relates to
      information supplied by the indemnifying party or by the indemnified party
      and
      the parties’ relative intent, knowledge, access to information and opportunity
      to correct or prevent such statement or omission; provided,
      however,
      that,
      in any such case, (A) no such holder will be required to contribute any amount
      in excess of the public offering price of all such Registrable Securities
      offered by it pursuant to such registration statement; and (B) no person or
      entity guilty of fraudulent misrepresentation (within the meaning of Section
      11(f) of the Securities Act) will be entitled to contribution from any person
      or
      entity who was not guilty of such fraudulent misrepresentation.
    11. Rule
      144 Reporting.
      With a
      view to making available the benefits of certain rules and regulations of the
      SEC that may permit the sale of securities to the public without registration,
      the Company agrees to use
      commercially
      reasonable
      best
      efforts to make and keep public information regarding the Company
      available as contemplated by Rule 144 under the Securities Act and file with
      the
      SEC in a timely manner all reports and other documents required to be
      filed
      by the Company under the Securities Act and the Securities Exchange Act of
      1934,
      as
      amended (the “Exchange Act”),
      and
      furnish a
      written
      report to the Holder upon written request as to the Company’s compliance with
      the reporting requirements of Rule 144 and of the Securities Act and the
      Exchange Act.
    12. SEC
      and Other Information.
      So long
      as this Warrant Agreement is in effect, the Company shall, upon written
      request,
      provide to the Holder,
      within
      three
      (3) Business Days of
      receipt of such written request,
      a copy
      of any publicly available forms, reports or other documents filed
      by the
      Company
      with the
      SEC if such documents are not available on the Internet free of charge. If
      for
      any reason at any time the Company is not required to file annual, quarterly
      and
      other periodic reports with the SEC pursuant to the terms of the Exchange Act,
      then the Company shall make available at no charge to the Holder financial
      statements no later than the time they would be filed with the SEC if the
      Company was required to file such annual, quarterly and other periodic
      reports.
    11
        13. Additional
      Provisions.
      (a) The
      Holder represents, by accepting this Warrant Agreement, that it understands
      that
      this Warrant Agreement and any securities obtainable upon exercise of this
      Warrant Agreement have not been registered for sale under federal or state
      securities or “blue sky” laws and are being offered and sold to the Holder
      pursuant to one or more exemptions from the registration requirements of such
      securities laws. In the absence of an effective registration of such securities
      or an exemption therefrom, any certificates for such securities shall bear
      a
      legend substantially similar to the legend set forth on the first page of this
      Warrant Agreement. The Holder understands that it must bear the economic risk
      of
      its investment in this Warrant Agreement and any securities obtainable upon
      exercise of this Warrant Agreement for an indefinite period of time, as this
      Warrant Agreement and such securities have not been registered under federal
      or
      state securities or blue sky laws and therefore cannot be sold unless
      subsequently registered under such laws, unless an exemption from such
      registration is available. 
    (b) The
      Holder agrees and acknowledges that this Warrant Agreement, or any portion
      hereof, and any such securities will not be sold, transferred, assigned,
      hypothecated or otherwise disposed of unless (i) a registration statement with
      respect to such transfer is effective under the Securities Act and any
      applicable state securities or blue sky laws or (ii) such sale or transfer
      is
      made pursuant to one or more exemptions from the Securities Act.
    (c) The
      Holder represents that it has been afforded (i) the opportunity to ask such
      questions as it has deemed necessary of, and to receive answers from,
      representatives of the Company concerning the terms and conditions of this
      Warrant Agreement or the exercise of this Warrant Agreement and the finance
      operations and business of the Company and (ii) the opportunity to request
      such
      additional information which the Company possesses or can acquire without
      unreasonable effort or expense. Nothing contained in this Section 11(c) shall
      alter, amend or change the Holder’s reliance on the representations, covenants
      or warranties contained herein.
    (d) The
      Holder represents that it did not (i) receive or review any advertisement,
      article, notice or other communication published in a newspaper or magazine
      or
      similar media or broadcast over television or radio, whether closed circuit,
      or
      generally available; or (ii) attend any seminar, meeting or investor or other
      conference whose attendees were, to such Holder’s knowledge, invited by any
      general solicitation or general advertising.
    (e) The
      Holder represents that it is an “accredited investor” within the meaning of
      Regulation D promulgated under the Act. Such Holder is acquiring this Warrant
      Agreement for its own account and not with a present view to, or for sale in
      connection with, any distribution thereof in violation of the registration
      requirements of the Act.
    12
        (f) The
      Holder represents that it, either by reason of the Holder’s business or
      financial experience or the business or financial experience of its professional
      advisors (who are unaffiliated with and who are not compensated by the Company
      or any affiliate, finder or selling agent of the Company, directly or
      indirectly), has such sophistication, knowledge and experience in financial
      and
      business matters as to be capable of evaluating the merits and risks of its
      investment in the Company.
    (g) The
      Holder represents that it has the ability to bear the economic risks of its
      investment for an indefinite period of time and could afford a complete loss
      of
      its investment.
    (h) The
      Holder agrees and acknowledges that the representations and warranties made
      by
      the Holder in this Section 13 shall be deemed also to be made at the time of
      the
      exercise of this Warrant Agreement.
    (i) Nothing
      in this Section 13 shall affect in any way the Holder’s obligations under any
      agreement to comply with all applicable securities laws upon resale of the
      Warrant Shares.
    14. Miscellaneous.
    (a) Amendments
      and Waivers.
      This
      Warrant Agreement and any provision hereof may be amended, changed, waived,
      discharged or terminated only by an instrument in writing signed by the party
      against which enforcement of the same is sought.
    (b) Successors
      and Assigns.
      This
      Warrant Agreement is binding upon, and inures to the benefit of, the parties
      and
      their respective successors and assigns, provided that the Holder shall not
      assign or transfer any or all of its rights under this Warrant Agreement,
      knowingly, after reasonable investigation and inquiry, to any person or entity
      which actively sells, distributes, markets, develops, or produces a
      pharmaceutical product or device which directly competes with the Product.
      Any
      assignment or attempted assignment in violation of this Section 14(b) shall
      be
      null and void.
    (c) Loss,
      Theft, Destruction or Mutilation.
      Upon
      receipt by the Company of evidence reasonably satisfactory to it that this
      Warrant Agreement has been lost, stolen, destroyed or mutilated, and in the
      case
      of any lost, stolen or destroyed Warrant Agreement, an indemnity reasonably
      satisfactory to the Company, or in the case of a mutilated Warrant Agreement,
      upon surrender and cancellation hereof, the Company will execute and deliver
      in
      the name of the registered holder of this Warrant Agreement, in exchange and
      substitution for the Warrant Agreement so lost, stolen, destroyed or mutilated,
      a new Warrant Agreement of like tenor and amount.
    (d) Warrant
      Exchangeable for Different Denominations.
      This
      Warrant Agreement is exchangeable, upon the surrender hereof by the Holder
      at
      the principal office of the Company for new Warrant Agreements of like tenor
      representing in the aggregate the right to purchase the number of shares which
      may be purchased hereunder, each of such new Warrant Agreements to represent
      the
      right to purchase such number of Warrant Shares as shall be designated by said
      Holder hereof at the time of such surrender. 
    13
        (e) Law
      Governing.
      This
      Warrant Agreement will be governed by, and construed and enforced in accordance
      with, the internal laws of the State of Delaware. The Holder and the Company
      waive their respective rights to a jury trial with respect to any action, claim,
      or other proceeding arising out of any dispute in connection with this Warrant
      Agreement, any rights or obligations hereunder, or the performance of such
      rights and obligations. The Holder and the Company agree that disputes relating
      to this Warrant Agreement shall be subject to the provisions of the Loan
      Agreement entitled “Internal Review” and “Arbitration” set forth in Sections
      8.14 and
      8.15
thereof,
      respectively, after modifying such Sections so that any references to “Loan
      Documents” or the “Agreement” shall mean this Warrant Agreement and any
      references to the “Borrower” or “Lender” shall mean the Company or the Holder,
      respectively.
    (f) Entire
      Agreement.
      This
      Warrant Agreement constitutes the full and entire understanding and agreement
      among the parties with regard to the subject matter of this Warrant Agreement,
      and supersedes all prior agreements, understandings, inducements or conditions,
      express or implied, oral or written, with respect to the subject matter of
      this
      Warrant Agreement.
    (g) Notices.
      Unless
      otherwise provided herein, all notices, requests, demands and other
      communications required or permitted under this Warrant Agreement shall be
      in
      writing and will be deemed to have been duly made and received: (i) upon
      personal delivery; (ii) three (3) Business Days after deposit with the United
      States Post Office, by registered or certified mail or by first class mail,
      postage prepaid, addressed as set forth below; or (iii) one (1) Business Day
      after deposit with a nationally recognized, overnight courier (for next business
      day delivery), shipping prepaid, addressed as set forth below:
    | (i) | If
                to the Company, then to: | 
Discovery
      Laboratories, Inc.
    ▇▇▇▇
      ▇▇▇▇▇ ▇▇▇▇, ▇▇▇▇▇ ▇▇▇
    ▇▇▇▇▇▇▇▇▇▇,
      ▇▇▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇-▇▇▇▇
    Attn:
      Chief Executive Officer and General Counsel
    with
      a
      copy to (which shall not constitute notice):
    ▇▇▇▇▇▇▇▇▇
      ▇▇▇▇▇▇▇ ▇▇▇▇▇ & ▇▇▇▇▇▇▇▇ LLP
    ▇▇▇▇
      ▇▇▇▇▇▇ ▇▇ ▇▇▇ ▇▇▇▇▇▇▇▇
    ▇▇▇
      ▇▇▇▇,
      ▇▇ ▇▇▇▇▇-▇▇▇▇
    Attn:
      ▇▇▇
      ▇. ▇▇▇▇▇
    | (ii) | If
                to NovaQuest, then to: | 
PharmaBio
      Development Inc. (d/b/a NovaQuest)
    ▇▇▇▇
      ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
    ▇▇▇▇▇▇▇▇▇▇
      ▇▇▇▇▇▇▇▇
    ▇▇▇▇▇
      ▇▇▇
    ▇▇▇▇▇▇,
      ▇▇ ▇▇▇▇▇
    Attn:
      President
    14
        with
      a
      copy to (which shall not constitute notice):
    PharmaBio
      Development Inc. (d/b/a NovaQuest)
    ▇▇▇▇
      ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
    ▇▇▇▇▇▇▇▇▇▇
      ▇▇▇▇▇▇▇▇
    ▇▇▇▇▇
      ▇▇▇
    ▇▇▇▇▇▇,
      ▇▇ ▇▇▇▇▇
    Attn:
      General Counsel
    Either
      party may change the address to which communications are to be sent by giving
      five (5) Business Days’ advance notice of such change of address to the other
      party in conformity with the provisions of this Section 14(g).
    (h) Execution;
      Counterparts.
      This
      Warrant Agreement may be executed in counterparts, each of which will be deemed
      to be an original, and all of which will together constitute one and the same
      instrument. The exchange of copies of this Warrant Agreement or amendments
      thereto and of signature pages by facsimile transmission or by email
      transmission in portable digital format, or similar format, shall constitute
      effective execution and delivery of such instrument(s) as to the parties and
      may
      be used in lieu of the original Warrant Agreement or amendment for all purposes.
      Signatures of the parties transmitted by facsimile or by email transmission
      in
      portable digital format, or similar format, shall be deemed to be their original
      signatures for all purposes.
    [Rest
      of page intentionally left blank; signatures on following
      page]
    15
        [Signature
      Page to Warrant Agreement]
    IN
      WITNESS WHEREOF, the parties have caused this Warrant Agreement to be duly
      executed and delivered as of the day and year first written above.
    | DISCOVERY LABORATORIES, INC. | |
| By: /s/ ▇▇▇▇ ▇. ▇▇▇▇▇▇ | |
| Name: ▇▇▇▇ ▇. ▇▇▇▇▇▇ | |
| Title: Executive Vice President and Chief Financial Officer | |
| PHARMABIO DEVELOPMENT INC. | |
| (d/b/a NovaQuest) | |
| By: /s/ ▇▇▇ ▇▇▇▇▇▇▇ | |
| Name: ▇▇▇ ▇▇▇▇▇▇▇ | |
| Title: Senior Vice President, Corporate
                Development | 
16
        ANNEX
      A
    EXERCISE
      FORM
    TO
      BE
      EXECUTED BY THE REGISTERED HOLDER
    TO
      EXERCISE THE ATTACHED WARRANT AGREEMENT OF
    DISCOVERY
      LABORATORIES, INC.
    17
        SUBSCRIPTION
    The
      undersigned, ___________________, pursuant to the provisions of the foregoing
      Warrant Agreement, hereby elects to exercise such Warrant Agreement by agreeing
      to subscribe for and purchase ____________________ shares (the “Warrant Shares”)
      of Common Stock, par value $0.001 per share, of Discovery Laboratories, Inc.
      (the “Company”), and hereby (i) makes payment of $___________ by certified or
      official bank check in payment of the exercise price therefor, and (ii) agrees
      to cancel indebtedness of the Company under the Loan Agreement in an amount
      equal to $___________.
    As
      a
      condition to this subscription, the undersigned hereby represents and warrants
      to the Company that the representations and warranties of Section 13 of the
      Warrant Agreement are true and correct as of the date hereof as if they had
      been
      made on such date with respect to the Warrant Shares. The undersigned further
      acknowledges that the sale, transfer, assignment or hypothecation of the Warrant
      Shares to be issued upon exercise of the Warrant Agreement is subject to the
      terms and conditions contained in Sections 4, 9 and 13 of the Warrant
      Agreement.
    | Dated:_______________________________ | Signature: | _______________________________ | 
| Address: | _______________________________ | |
| _______________________________ | 
ASSIGNMENT
    FOR
      VALUE
      RECEIVED _______________ hereby sells, assigns and transfers unto
      ____________________ the foregoing Warrant Agreement and all rights evidenced
      thereby, and does irrevocably constitute and appoint _____________________,
      attorney, to transfer said Warrant Agreement on the books of Discovery
      Laboratories, Inc. (the “Company”). As a condition to this assignment, the
      Holder acknowledges that its assignee must deliver a written instrument to
      the
      Company that the representations and warranties of Section 13 of the Warrant
      Agreement are true and correct as of the date hereof as if they had been made
      by
      such assignee on such date.
    | Dated:_______________________________ | Signature: | _______________________________ | 
| Address: | _______________________________ | |
| _______________________________ | 
PARTIAL
      ASSIGNMENT
    FOR
      VALUE
      RECEIVED _______________ hereby assigns and transfers unto ____________________
      the right to purchase _______ shares of the Common Stock, par value $.001 per
      share, of Discovery Laboratories, Inc. (the “Company”), as set forth in the
      foregoing Warrant Agreement, and a proportionate part of said Warrant Agreement
      and the rights evidenced thereby, and does irrevocably constitute and appoint
      ____________________, attorney, to transfer that part of said Warrant Agreement
      on the books of the Company. As a condition to this assignment, the Holder
      acknowledges that its assignee must deliver a written instrument to the
      Company that
      the
      representations and warranties of Section 13 of the Warrant Agreement are true
      and correct as of the date hereof as if they had been made by such assignee
      on
      such date.
    | Dated:_______________________________ | Signature: | _______________________________ | 
| Address: | _______________________________ | |
| _______________________________ | 
18