1
                                  EXHIBIT 10.4
IMPERIAL THRIFT
         AND LOAN ASSOCIATION
                          COMMERCIAL SECURITY AGREEMENT
Principal          Loan Date         Maturity       Loan No    Call         Collateral    Account     Officers    Initials
                                                                                          
$1,020,000.00      10-24-1996        11-01-2011                                                         1306
References in the shaded area are for Lender's use only and do not limit the
applicability of this document to any particular loan or item
                                                             
Borrower:  Techniclone International Corporation, a California      Lender:      IMPERIAL THRIFT AND LOAN ASSOCIATION
           Corporation                                                   ▇▇▇ ▇. ▇▇▇▇▇▇▇ ▇▇▇▇▇▇
           ▇▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇                                         ▇▇▇▇▇ ▇▇▇
           ▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇                                              ▇▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇-▇▇▇▇
         THIS COMMERCIAL SECURITY AGREEMENT is entered into between Techniclone
International Corporation, a California Corporation (referred to below as
"Grantor"); and IMPERIAL THRIFT AND LOAN ASSOCIATION (referred to below as
"Lender"). For valuable consideration, Grantor grants to Lender a security
interest in the Collateral to secure the Indebtedness and agrees that Lender
shall have the rights stated in this Agreement with respect to the Collateral,
in addition to all other rights which Lender may have by law.
DEFINITIONS. The following words shall have the following meanings when used in
this Agreement. Terms not otherwise defined in this Agreement shall have the
meanings attributed to such terms in the Uniform Commercial Code. All references
to dollar amounts shall mean amounts in lawful money of the United States of
America.
         AGREEMENT. The word "Agreement" means this Commercial Security
         Agreement, as this Commercial Security Agreement may be amended or
         modified from time to time, together with all exhibits and schedules
         attached to this Commercial Security Agreement from time to time.
         COLLATERAL. The word "Collateral" means the following described
         property of Grantor, whether now owned or hereafter acquired, whether
         now existing or hereafter arising, and wherever located:
                  ALL INVENTORY, CHATTEL PAPER, ACCOUNTS, EQUIPMENT, GENERAL
                  INTANGIBLES AND FIXTURES
         In addition, the word "Collateral" includes all the following, whether
         now owned or hereafter acquired, whether now existing or hereafter
         arising, and wherever located:
                  (a) All attachments, accessions, accessories, tools, parts,
                  supplies, increases, and additions to and all replacements of
                  and substitutions for any property described above.
                  (b) All products and produce of any of the property described
                  in this Collateral section.
                  (c) All accounts, general intangibles, instruments, rents,
                  monies, payments, and all other rights, arising out of a sale,
                  lease, or other disposition of any of the property described
                  in this Collateral section.
                  (d) All proceeds (including insurance proceeds) from the sale,
                  destruction, loss, or other disposition of any of the property
                  described in this Collateral section.
                  (e) All records and data relating to any of the property
                  described in this Collateral section, whether in the form of a
                  writing, photograph, microfilm, microfiche, or electronic
                  media, together with all of Grantor's right, title, and
                  interest in and to all computer software required to utilize,
                  create, maintain, and process any such records or data on
                  electronic media.
         Fixtures are and will be located on the following described real
estate:
              SEE EXHIBIT A ATTACHED HERETO AND MADE A PART HEREOF.
         EVENT OF DEFAULT. The words "Event of Default" mean and include without
         limitation any of the Events of Default set forth below in the section
         titled "Events of Default."
  
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10-24-1996               COMMERCIAL SECURITY AGREEMENT
                                   (Continued)
         GRANTOR. The word "Grantor" means Techniclone International
         Corporation, a California Corporation, its successors and assigns.
         GUARANTOR. The word "Guarantor" means and includes without limitation
         each and all of the guarantors, sureties, and accommodation parties in
         connection with the Indebtedness.
         INDEBTEDNESS. The word "Indebtedness" means the indebtedness evidenced
         by the Note, including all principal and interest, together with all
         other indebtedness and costs and expenses for which Grantor is
         responsible under this Agreement or under any of the Related Documents.
         LENDER. The word "Lender" means IMPERIAL THRIFT AND LOAN ASSOCIATION,
         its successors and assigns.
         NOTE. The word "Note" means the note or credit agreement dated October
         24, 1996, in the principal amount of $1,020,000.00 from Techniclone
         International Corporation, a California Corporation to Lender, together
         with all renewals of, extensions of, modifications of, refinancings of,
         consolidations of and substitutions of the note or credit agreement.
         RELATED DOCUMENTS. The words "Related Documents" mean and include
         without limitation all promissory notes, credit agreements loan
         agreements, environmental agreements, guaranties, security agreements,
         mortgages, deeds of trust, and all other instruments, agreements and
         documents, whether now or hereafter existing, executed in connection
         with the Indebtedness.
OBLIGATIONS OF GRANTOR.   Grantor warrants and covenants to Lender as follows:
         ORGANIZATION. Grantor is a corporation which is duly organized, validly
         existing, and in good standing under the laws of the State of
         California. Grantor has its chief executive office at ▇▇▇▇▇ ▇▇▇▇▇▇▇▇
         ▇▇▇▇▇▇, ▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇. Grantor will notify Lender of any change in
         the location of Grantor's chief executive office.
         AUTHORIZATION. The execution, delivery, and performance of this
         Agreement by Grantor have been duly authorized by all necessary action
         by Grantor and do not conflict with, result in a violation of, or
         constitute a default under (a) any provision of its articles of
         incorporation or organization, or bylaws, or any agreement or other
         instrument binding upon Grantor or (b) any law, governmental
         regulation, court decree, or order applicable to Grantor.
         PERFECTION OF SECURITY INTEREST. Grantor agrees to execute such
         financing statements and to take whatever other actions are requested
         by Lender to perfect and continue Lender's security interest in the
         Collateral. Upon request of Lender, Grantor will deliver to Lender any
         and all of the documents evidencing or constituting the Collateral, and
         Grantor will note Lender's interest upon any and all chattel paper if
         not delivered to Lender for possession by Lender. Grantor hereby
         appoints Lender as his irrevocable attorney-in-fact for the purpose of
         executing any documents necessary to perfect or to continue the
         security interest granted in this Agreement. Lender may at any time,
         and without further authorization from Grantor, file a carbon,
         photographic or other reproduction of any financing statement or of
         this Agreement for use as a financing statement. Grantor will reimburse
         Lender for all expenses for the perfection and the continuation of the
         perfection of Lender's security interest in the Collateral. Grantor
         promptly will notify Lender before any change in Grantor's name
         including any change to the assumed business names of Grantor.
         NO VIOLATION. The execution and delivery of this Agreement will not
         violate any law or agreement governing Grantor or to which Grantor is a
         party, and its certificate or articles of incorporation and bylaws do
         not prohibit any term or condition of this Agreement.
         ENFORCEABILITY OF COLLATERAL. To the extent the Collateral consists of
         accounts, chattel paper, or general intangibles, the Collateral is
         enforceable in accordance with its terms, is genuine, and complies with
         applicable laws concerning form, content and manner of preparation and
         execution and all persons appearing to be obligated on the Collateral
         have authority and capacity to contract and are in fact obligated as
         they appear to be on the Collateral. At the time any account becomes
         subject to a security interest in favor of Lender, the account shall be
         a good and valid account representing an undisputed, bona fide
         indebtedness incurred by the account debtor, for merchandise held
         subject to delivery instructions or theretofore shipped or delivered
         pursuant to a contract of sale, or for services theretofore performed
         by Grantor with or for the account debtor, there shall be no setoffs or
         counterclaims against any such account; and no agreement under which
         any deductions or discounts may be claimed shall have been made with
         the account debtor except those disclosed to Lender in writing.
         LOCATION OF THE COLLATERAL. Grantor, upon request of Lender, will
         deliver to Lender in form satisfactory to Lender a schedule of real
         properties and Collateral locations relating to Grantor's operations,
         including without limitation the following: (a) all real property owned
         or being purchased by Grantor; (b) all real property being rented or
         leased by Grantor; (c) all storage facilities owned, rented, leased, or
         being used by Grantor; and (d) all other properties where Collateral is
         or may be located. Except in the ordinary course of its business,
         Grantor shall not remove the Collateral from its existing locations
         without the prior written consent of Lender.
         REMOVAL OF COLLATERAL. Grantor shall keep the Collateral (or to the
         extent the Collateral consists of intangible property such as accounts,
         the records concerning the Collateral) at Grantor's address shown
         above, or at such other locations as are acceptable to Lender. Some or
         all of the Collateral may be located at the real property described
         above. Except in the ordinary course of its business, including the
         sales of inventory Grantor shall not remove the Collateral from its
         existing locations without the prior written consent of Lender. To the
         extent that the Collateral consists of vehicles, or other titled
         property, Grantor shall not
  
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10-24-1996               COMMERCIAL SECURITY AGREEMENT
                                   (Continued)
         take or permit any action which would require application for
         certificates of title for the vehicles outside the State of California,
         without the prior written consent of Lender.
         TRANSACTIONS INVOLVING COLLATERAL. Except for inventory sold or
         accounts collected in the ordinary course of Grantor's business,
         Grantor shall not sell, offer to sell, or otherwise Transfer or dispose
         of the Collateral. While Grantor is not in default under this
         Agreement, Grantor may sell inventory, but only in the ordinary course
         of its business and only to buyers who qualify as a buyer in the
         ordinary course of business. A sale in the ordinary course of Grantor's
         business does not include a Transfer in partial or total satisfaction
         of a debt or any bulk sale. Grantor shall not pledge, mortgage,
         encumber or otherwise permit the Collateral to be subject to any lien,
         security interest, encumbrance, or charge, other than the security
         interest provided for in this Agreement, without the prior written
         consent of Lender. This includes security interests even if junior in
         right to the security interests granted under this Agreement. Unless
         waived by Lender, all proceeds from any disposition of the Collateral
         (for whatever reason) shall be held in trust for Lender and shall not
         be commingled with any other funds; provided however, this requirement
         shall not constitute consent by Lender to any sale or other
         disposition. Upon receipt, Grantor shall immediately deliver any such
         proceeds to Lender.
         TITLE. Grantor represents and warrants to Lender that it holds good and
         marketable title to the Collateral, free and clear of all liens and
         encumbrances except for the lien of this Agreement. No financing
         statement covering any of the Collateral is on file in any public
         office other than those which reflect the security interest created by
         this Agreement or to which Lender has specifically consented. Grantor
         shall defend Lender's rights in the Collateral against the claims and
         demands of all other persons.
         COLLATERAL SCHEDULES AND LOCATIONS. As often as Lender shall require,
         and insofar as the Collateral consists of accounts and general
         intangibles, Grantor shall deliver to Lender schedules of such
         Collateral, including such information as Lender may require, including
         without limitation names and addresses of account debtors and agings of
         accounts and general intangibles. Insofar as the Collateral consists of
         inventory and equipment, Grantor shall deliver to Lender, as often as
         Lender shall require, such lists, descriptions, and designations of
         such Collateral as Lender may require to identify the nature, extent,
         and location of such Collateral. Such information shall be submitted
         for Grantor and each of its subsidiaries or related companies.
         MAINTENANCE AND INSPECTION OF COLLATERAL. Grantor shall maintain all
         tangible Collateral in good condition and repair. Grantor will not
         commit or permit damage to or destruction of the Collateral or any part
         of the Collateral. Lender and its designated representatives and agents
         shall have the right at all reasonable times to examine, inspect, and
         audit the Collateral wherever located. Grantor shall immediately notify
         Lender of all cases involving the return, rejection, repossession, loss
         or damage of or to any Collateral; of any request for credit or
         adjustment or of any other dispute arising with respect to the
         Collateral; and generally of all happenings and events affecting the
         Collateral or the value or the amount of the Collateral.
         TAXES, ASSESSMENTS AND LIENS. Grantor will pay when due all taxes,
         assessments and liens upon the Collateral, its use or operation, upon
         this Agreement, upon any promissory note or notes evidencing the
         Indebtedness, or upon any of the other Related Documents. Grantor may
         withhold any such payment or may elect to contest any lien if Grantor
         is in good faith conducting an appropriate proceeding to contest the
         obligation to pay and so long as Lender's interest in the Collateral is
         not jeopardized in Lender's sole opinion. If the Collateral is
         subjected to a lien which is not discharged within fifteen (15) days,
         Grantor shall deposit with Lender cash, a sufficient corporate surety
         bond or other security satisfactory to Lender in an amount adequate to
         provide for the discharge of the lien plus any interest, costs,
         attorneys fees or other charges that could accrue as a result of
         foreclosure or sale of the Collateral. In any contest Grantor shall
         defend itself and Lender and shall satisfy any final adverse judgment
         before enforcement against the Collateral. Grantor shall name Lender as
         an additional obligee under any surety bond furnished in the contest
         proceedings.
         COMPLIANCE WITH GOVERNMENTAL REQUIREMENTS. Grantor shall comply
         promptly with all laws, ordinances, rules and regulations of all
         governmental authorities, now or hereafter in effect, applicable to the
         ownership, production, disposition, or use of the Collateral. Grantor
         may contest in good faith any such law, ordinance or regulation and
         withhold compliance during any proceeding, including appropriate
         appeals, so long as Lender's interest in the Collateral, in Lender's
         opinion, is not jeopardized.
         MAINTENANCE OF CASUALTY INSURANCE. Grantor shall procure and maintain
         all risks, insurance, including without limitation fire, theft and
         liability coverage together with such other insurance as Lender may
         require with respect to the Collateral, in form, amounts, coverages and
         basis reasonably acceptable to Lender and issued by a company or
         companies reasonably acceptable to Lender. Grantor, upon request of
         Lender, will deliver to Lender from time to time the policies or
         certificates of insurance in form satisfactory to Lender, including
         stipulations that coverages will not be cancelled or diminished without
         at least thirty (30) days' prior written notice to Lender and not
         including any disclaimer of the insurer's liability for failure to give
         such a notice. Each insurance policy also shall include an endorsement
         providing that coverage in favor of Lender will not be impaired in any
         way by any act, omission or default of Grantor or any other person. In
         connection with all policies covering assets in which Lender holds or
         is offered a security interest, Grantor will provide Lender with such
         loss payable or other endorsements as Lender may require. If Grantor at
         any time fails to obtain or maintain any insurance as required under
         this Agreement, Lender may (but shall not be obligated to) obtain such
         insurance as Lender deems appropriate, including if it so chooses
         "single interest insurance," which will cover only Lenders' interest in
         the Collateral.
         APPLICATION OF INSURANCE PROCEEDS. Grantor shall promptly notify Lender
         of any loss or damage to the Collateral. Lender may make proof of loss
         if Grantor fails to do so within fifteen (15) days of the casualty. All
         proceeds of any insurance on the Collateral, including accrued proceeds
         thereon, shall be held by Lender as part of the Collateral. If Lender
         consents to repair or replacement of the damaged or destroyed
         Collateral, Lender shall, upon satisfactory proof of
  
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10-24-1996               COMMERCIAL SECURITY AGREEMENT
                                   (Continued)
         expenditure, pay or reimburse Grantor from the proceeds for the
         reasonable cost of repair or restoration. If Lender does not consent to
         repair or replacement of the Collateral, Lender shall retain a
         sufficient amount of the proceeds to pay all of the Indebtedness, and
         shall pay the balance to Grantor. Any proceeds which have not been
         disbursed within six (6) months after their receipt and which Grantor
         has not committed to the repair or restoration of the Collateral shall
         be used to prepay the Indebtedness.
         INSURANCE RESERVES. Lender may require Grantor to maintain with Lender
         reserves for payment of insurance premiums, which reserves shall be
         created by monthly payments from Grantor of a sum estimated by Lender
         lo be sufficient to produce, at least fifteen (15) days before the
         premium due date, amounts at least equal to the insurance premiums to
         be paid. If fifteen (15) days before payment is due, the reserve funds
         are insufficient, Grantor shall upon demand pay any deficiency to
         Lender. The reserve funds shall be held by Lender as a general deposit
         and shall constitute a non-interest-bearing account which Lender may
         satisfy by payment of the insurance premiums required to be paid by
         Grantor as they become due. Lender does not hold the reserve funds in
         trust for Grantor, and Lender is not the agent of Grantor for payment
         of the insurance premiums required to be paid by Grantor. The
         responsibility for the payment of premiums shall remain Grantor's sole
         responsibility.
         INSURANCE REPORTS. Grantor, upon request of Lender, shall furnish to
         Lender reports on each existing policy of insurance showing such
         information as Lender may reasonably request including the following:
         (a) the name of the insurer; (b) the risks insured; (c) the amount of
         the policy; (d) the property insured; (e) the then current value on the
         basis of which insurance has been obtained and the manner of
         determining that value; and (f) the expiration date of the policy. In
         addition, Grantor shall upon request by Lender (however not more often
         than annually) have an independent appraiser satisfactory to Lender
         determine, as applicable, the cash value or replacement cost of the
         Collateral.
GRANTOR'S RIGHT TO POSSESSION AND TO COLLECT ACCOUNTS. Until default and except
as otherwise provided below with respect lo accounts, Grantor may have
possession of the tangible personal property and beneficial use of all the
Collateral and may use it in any lawful manner not inconsistent with this
Agreement or the Related Documents, provided that Grantor's right to possession
and beneficial use shall not apply to any Collateral where possession of the
Collateral by Lender is required by law to perfect Lender's security interest in
such Collateral. Until otherwise notified by Lender, Grantor may collect any of
the Collateral consisting of accounts. At any time and even though no Event of
Default exists, Lender may exercise its rights to collect the accounts and to
notify account debtors to make payments directly to Lender for application to
the Indebtedness. If Lender at any time has possession of any Collateral,
whether before or after an Event of Default, Lender shall be deemed to have
exercised reasonable care in the custody and preservation of the Collateral if
Lender takes such action for that purpose as Grantor shall request or as Lender,
in Lender's sole discretion, shall deem appropriate under the circumstances, but
failure to honor any request by Grantor shall not of itself be deemed to be a
failure to exercise reasonable care. Lender shall not be required lo take any
steps necessary to preserve any rights in the Collateral against prior parties,
nor to protect, preserve or maintain any security interest given to secure the
Indebtedness.
EXPENDITURES BY LENDER. If not discharged or paid when due, Lender may (but
shall not be obligated to) discharge or pay any amounts required to be
discharged or paid by Grantor under this Agreement, including without limitation
all taxes, liens, security interests, encumbrances, and other claims, at any
time levied or placed on the Collateral. Lender also may (but shall not be
obligated to) pay all costs for insuring, maintaining and preserving the
Collateral. All such expenditures incurred or paid by Lender for such purposes
will then bear interest at the rate charged under the Note from the date
incurred or paid by Lender to the date of repayment by Grantor. All such
expenses shall become a part of the Indebtedness and at Lender s option, will
(a) be payable on demand, (b) be added to the balance of the Note and be
apportioned among and be payable with any installment payments to become due
during either (i) the term of any applicable insurance policy or (ii) the
remaining term of the Note, or (c) be treated as a balloon payment which will be
due and payable at the Note's maturity. This Agreement also will secure payment
of these amounts. Such right shall be in addition to all other rights and
remedies to which Lender may be entitled upon the occurrence of an Event of
Default.
EVENTS OF DEFAULT. Each of the following shall constitute an Event of Default
under this Agreement:
         DEFAULT ON INDEBTEDNESS. Failure of Grantor to make any payment when
         due on the Indebtedness.
         OTHER DEFAULTS. Failure of Grantor to comply with or to perform any
         other term, obligation, covenant or condition contained in this
         Agreement or in any of the Related Documents or in any other agreement
         between Lender and Grantor.
         FALSE STATEMENTS. Any warranty, representation or statement made or
         furnished to Lender by or on behalf of Grantor under this Agreement,
         the Note or the Related Documents is false or misleading in any
         material respect, either now or at the time made or furnished.
         DEFECTIVE COLLATERALIZATION. This Agreement or any of the Related
         Documents ceases to be in full force and effect (including failure of
         any collateral documents to create a valid and perfected security
         interest or lien) at any time and for any reason.
         INSOLVENCY. The dissolution or termination of Grantor's existence as a
         going business, the insolvency of Grantor, the appointment of a
         receiver for any part of Grantor's property, any assignment for the
         benefit of creditors, any type of creditor workout, or the commencement
         of any proceeding under any bankruptcy or insolvency laws by or against
         Grantor.
         CREDITOR OR FORFEITURE PROCEEDINGS. Commencement of foreclosure or
         forfeiture proceedings, whether by judicial proceeding, self-help,
         repossession or any other method, by any creditor of Grantor or by any
         governmental agency against the Collateral or any other collateral
         securing the Indebtedness. This includes a
  
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10-24-1996               COMMERCIAL SECURITY AGREEMENT
                                   (Continued)
         garnishment of any of Grantor's deposit accounts with Lender. However,
         this Event of Default shall not apply if there is a good faith dispute
         by Grantor as to the validity or reasonableness of the claim which is
         the basis of the creditor or forfeiture proceeding and if Grantor gives
         Lender written notice of the creditor or forfeiture proceeding and
         deposits with Lender monies or a surety bond for the creditor or
         forfeiture proceeding, in an amount determined by Lender, in its sole
         discretion, as being an adequate reserve or bond for the dispute.
         EVENTS AFFECTING GUARANTOR. Any of the preceding events occurs with
         respect to any Guarantor of any of the Indebtedness or such Guarantor
         dies or becomes incompetent. Lender, at its option, may, but shall not
         be required to, permit the Guarantor's estate to assume unconditionally
         the obligations arising under the guaranty in a manner satisfactory to
         Lender, and, in doing so, cure the Event of Default.
         ADVERSE CHANGE. A material adverse change occurs in Grantor's financial
         condition, or Lender believes the prospect of payment or performance of
         the Indebtedness is impaired.
         RIGHT TO CURE. It any default, other than a Default on Indebtedness, is
         curable and if Grantor has not been given a prior notice of a breach of
         the same provision of this Agreement, it may be cured (and no Event of
         Default will have occurred) if Grantor, after Lender sends written
         notice demanding cure of such default, (a) cures the default within
         fifteen (15) days; or (b), it the cure requires more than fifteen (15)
         days, immediately initiates steps which Lender deems in Lender's sole
         discretion to be sufficient, to cure the default and thereafter
         continues and completes all reasonable and necessary steps sufficient
         to produce compliance as soon as reasonably practical.
RIGHTS AND REMEDIES ON DEFAULT. If an Event of Default occurs under this
Agreement, at any time thereafter, Lender shall have all the rights of a secured
party under the California Uniform Commercial Code. In addition and without
limitation, Lender may exercise any one or more of the following rights and
remedies:
         ACCELERATE INDEBTEDNESS. Lender may declare the entire Indebtedness,
         including any prepayment penalty which Grantor would he required to
         pay, immediately due and payable, without notice.
         ASSEMBLE COLLATERAL. Lender may require Grantor to deliver to Lender
         all or any portion of the Collateral and any and all certificates of
         title and other documents relating to the Collateral. Lender may
         require Grantor to assemble the Collateral and make it available to
         Lender at a place to be designated by Lender. Lender also shall have
         full power to enter upon the property of Grantor to take possession of
         and remove the Collateral. If the Collateral contains other goods not
         covered by this Agreement at the time of repossession, Grantor agrees
         Lender may take such other goods, provided that Lender makes reasonable
         efforts to return them to Grantor after repossession.
         SELL THE COLLATERAL. Lender shall have full power to sell, lease,
         transfer, or otherwise deal with the Collateral or proceeds thereof in
         its own name or that of Grantor. Lender may sell the Collateral at
         public auction or private sale. Unless the Collateral threatens to
         decline speedily in value or is of a type customarily sold on a
         recognized market, Lender will give Grantor reasonable notice of the
         time after which any private sale or any other intended disposition of
         the Collateral is to be made. The requirements of reasonable notice
         shall be met if such notice is given at least ten (10) days, or such
         lesser time as required by state law, before the time of the sale or
         disposition. All expenses relating to the disposition of the
         Collateral, including without limitation the expenses of retaking,
         holding, insuring, preparing for sale and selling the Collateral, shall
         become a part of the Indebtedness secured by this Agreement and shall
         be payable on demand, with interest at the Note rate from date of
         expenditure until repaid.
         APPOINT RECEIVER. To the extent permitted by applicable law, Lender
         shall have the following rights and remedies regarding the appointment
         of a receiver: (a) Lender may have a receiver appointed as a matter of
         right, (b) the receiver may be an employee of Lender and may serve
         without bond, and (c) all fees of the receiver and his or her attorney
         shall become part of the Indebtedness secured by this Agreement and
         shall be payable on demand, with interest at the Note rate from date of
         expenditure until repaid.
         COLLECT REVENUES, APPLY ACCOUNTS. Lender, either itself or through a
         receiver, may collect the payments, rents, income, and revenues from
         the Collateral. Lender may at any time in its discretion transfer any
         Collateral into its own name or that of its nominee and receive the
         payments, rents, income, and revenues therefrom and hold the same as
         security for the Indebtedness or apply it to payment of the
         Indebtedness in such order of preference as Lender may determine.
         Insofar as the Collateral consists of accounts, general intangibles,
         insurance policies, instruments, chattel paper, choses in action, or
         similar property, Lender may demand, collect, receipt for, settle,
         compromise, adjust, ▇▇▇ for, foreclose, or realize on the Collateral as
         Lender may determine, whether or not Indebtedness or Collateral is then
         due. For these purposes, Lender may, on behalf of and in the name of
         Grantor, receive, open and dispose of mail addressed to Grantor; change
         any address to which mail and payments are to be sent; and endorse
         notes, checks, drafts, money orders, documents of title, instruments
         and items pertaining to payment, shipment, or storage or any
         Collateral. To facilitate collection, Lender may notify account debtors
         and obligors on any Collateral to make payments directly to Lender.
         OBTAIN DEFICIENCY. If Lender chooses to sell any or all of the
         Collateral, Lender may obtain a judgment against Grantor for any
         deficiency remaining on the Indebtedness due to Lender after
         application of all amounts received from the exercise of the rights
         provided in this Agreement, Grantor shall be liable for a deficiency
         even if it the transaction described in this subsection is a sale of
         accounts or chattel paper.
  
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10-24-1996               COMMERCIAL SECURITY AGREEMENT
                                   (Continued)
         OTHER RIGHTS AND REMEDIES. Lender shall have all the rights and
         remedies of a secured creditor under the provisions of the Uniform
         Commercial Code, as may be amended from time to time. In addition,
         Lender shall have and may exercise any or all other rights and remedies
         it may have available at law, in equity, or otherwise.
         CUMULATIVE REMEDIES. All of Lenders rights and remedies, whether
         evidenced by this Agreement or the Related Documents or by any other
         writing, shall be cumulative and may be exercised singularly or
         concurrently. Election by Lender to pursue any remedy shall not exclude
         pursuit of any other remedy, and an election to make expenditures or to
         take action to perform an obligation of Grantor under this Agreement,
         after Grantor's failure to perform, shall not affect Lender's right to
         declare a default and to exercise its remedies.
MISCELLANEOUS PROVISIONS. The following miscellaneous provisions are a part of
this Agreement:
         AMENDMENTS. This Agreement, together with any Related Documents,
         constitutes the entire understanding and agreement of the parties as to
         the matters set forth in this Agreement. No alteration of or amendment
         to this Agreement shall be effective unless given in writing and signed
         by the party or parties sought to be charged or bound by the alteration
         or amendment.
         APPLICABLE LAW. This Agreement has been delivered to Lender and
         accepted by Lender in the State of California. If there is a lawsuit,
         Grantor agrees upon Lender's request to submit to the jurisdiction of
         the courts of LOS ANGELES County, the State of California. Lender and
         Grantor to any jury trial in any action, proceeding, or counterclaim
         brought by either Lender or Grantor against the other. (Initial Here
         ____). This Agreement shall be governed by and construed in accordance
         with the laws of the State of California.
         ATTORNEYS FLEES; EXPENSES. Grantor agrees to pay upon demand all of
         Lenders costs and expenses, including attorneys fees and Lenders legal
         expenses, incurred in connection with the enforcement of this
         Agreement. Lender may pay someone else to help enforce this Agreement,
         and Grantor shall pay the costs and expenses of such enforcement. Costs
         and expenses include Lender's attorneys fees and legal expenses whether
         or not there is a lawsuit, including attorneys lees and legal expenses
         for bankruptcy proceedings (and including efforts to modify or vacate
         any automatic stay or injunction), appeals, and any anticipated
         post-judgment collection services. Grantor also shall pay all court
         costs and such additional tees as may be directed by the court.
         CAPTION HEADINGS. Caption headings in this Agreement are for
         convenience purposes only and are not to be used to interpret or define
         the provisions of this Agreement.
         NOTICES. All notices required to be given under this Agreement shall be
         given in writing, may be sent by telefacsimile, and shall be effective
         when actually delivered or when deposited with a nationally recognized
         overnight courier or deposited in the United States mail, first class,
         postage prepaid, addressed to the party to whom the notice is to be
         given at the address shown above. Any party may change its address for
         notices under this Agreement by giving formal written notice to the
         other parties, specifying that the purpose of the notice is to change
         the party's address. To the extent permitted by applicable law, if
         there is more than one Grantor, notice to any Grantor will constitute
         notice to all Grantors. For notice purposes, Grantor will keep Lender
         informed at all times of Grantor s current address(es).
         POWER OF ATTORNEY. Grantor hereby appoints Lender as its true and
         lawful attorney-in-fact, irrevocably, with full power of substitution
         to do the following: (a) to demand, collect, receive, receipt for, ▇▇▇
         and recover all sums of money or other property which may now or
         hereafter become due, owing or payable from the Collateral; (b) to
         execute, sign and endorse any and all claims, instruments, receipts,
         checks, drafts or warrants issued in payment for the Collateral; (c) to
         settle or compromise any and all claims arising under the Collateral,
         and, in the place and stead of Grantor, to execute and deliver its
         release and settlement for the claim; and (d) to file any claim or
         claims or to take any action or institute or take part In any
         proceedings, either in its own name or in the name of Grantor, or
         otherwise, which in the discretion of Lender may seem to be necessary
         or advisable. This power is given as security for the Indebtedness, and
         the authority hereby conferred is and shall be irrevocable and shall
         remain in full force and effect until renounced by Lender.
         PREFERENCE PAYMENTS. Any monies Lender pays because of an asserted
         preference claim in Borrower's bankruptcy will become a part of the
         Indebtedness and, at Lender's option, shall be payable by Borrower as
         provided above in the "EXPENDITURES BY LENDER" paragraph.
         SEVERABILITY. If a court of competent jurisdiction finds any provision
         of this Agreement to be invalid or unenforceable as to any person or
         circumstance, such finding shall not render that provision invalid or
         unenforceable as to any other persons or circumstances. If feasible,
         any such offending provision shall be deemed to be modified to be
         within the limits of enforceability or validity; however, if the
         offending provision cannot be so modified, it shall be stricken and all
         other provisions of this Agreement in all other respects shall remain
         valid and enforceable.
         SUCCESSOR INTERESTS. Subject to the limitations set forth above on
         transfer of the Collateral, this Agreement shall be binding upon and
         inure to the benefit of the parties, their successors and assigns.
         WAIVER. Lender shall not be deemed to have waived any rights under this
         Agreement unless such waiver is given in writing and signed by Lender.
         No delay or omission on the part of Lender in exercising any right
         shall operate as a waiver of such right or any other right. A waiver by
         Lender of a provision of this Agreement shall not prejudice or
         constitute a waiver of Lender's right otherwise to demand strict
         compliance with that provision or any other provision of this
  
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   7
10-24-1996               COMMERCIAL SECURITY AGREEMENT
                                   (Continued)
         Agreement. No prior waiver by Lender, nor any course of dealing between
         Lender and Grantor, shall constitute a waiver of any of Lender's rights
         or of any of Grantor's obligations as to any future transactions.
         Whenever the consent of Lender is required under this Agreement, the
         granting of such consent by Lender in any instance shall not constitute
         continuing consent to subsequent instances where such consent is
         required and in all cases such consent may be granted or withheld in
         the sole discretion of Lender.
         WAIVER OF CO-OBLIGOR'S RIGHTS. If more than one person is obligated for
         the Indebtedness, Borrower irrevocably waives, disclaims and
         relinquishes all claims against such other person which Borrower has or
         would otherwise have by virtue of payment of the Indebtedness or any
         part thereof, specifically including but not limited to all rights of
         indemnity, contribution or exoneration.
GRANTOR ACKNOWLEDGES HAVING READ ALL THE PROVISIONS OF THIS COMMERCIAL SECURITY
AGREEMENT, AND GRANTOR AGREES TO ITS TERMS. THIS AGREEMENT IS DATED OCTOBER 24,
1996.
GRANTOR:
Techniclone International Corporation, a California Corporation
By:      /S/ ▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇
         ------------------------------------------------------------------
         ▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇, Chief Financial Officer and Corporate Secretary
LENDER:
IMPERIAL THRIFT AND LOAN ASSOCIATION
By :     /S/
         ------------------------------------------------------------------
         Authorized Officer
  
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