CREDIT   AGREEMENT,   dated  as  of  o,  1999,   between  Miravant  Medical
Technologies,   a  Delaware  corporation  (the  "Borrower")  and  o,  a  Swedish
corporation (the "Lender").
                              W I T N E S S E T H :
     WHEREAS,  the  Borrower has  requested  the Lender to commit to lend to the
Borrower,  for general  corporate  purposes,  an aggregate  amount not to exceed
$22,500,000,  in the form of up to six term  loans,  with not more than one such
term loan to be made in each of the six  calendar  quarters  between  January 1,
1999 and June 30, 2000; and
     WHEREAS, the Lender is willing to make such loans, and the additional loans
described  in  Section  3.01(b)  hereof,  on the terms and  conditions  provided
herein;
                  NOW, THEREFORE, the parties agree as follows:
                                    ARTICLE I
                                   Definitions
     Section I.1. Definitions.
     (a) Terms  Generally.  The definitions  ascribed to terms in this Agreement
apply equally to both the singular and plural forms of such terms.  Whenever the
context may require,  any pronoun  shall be deemed to include the  corresponding
masculine,  feminine  and neuter  forms.  The words  "include",  "includes"  and
"including"  shall  be  interpreted  as  if  followed  by  the  phrase  "without
limitation".  The  phrase  "individually  or in the  aggregate"  shall be deemed
general  in scope  and not to refer to any  specific  Section  or clause of this
Agreement. All references herein to the Preamble,  Recitals, Articles, Sections,
Exhibits and Schedules shall be deemed  references to the Preamble and Recitals,
Articles and Sections of, and Exhibits and Schedules to, this  Agreement  unless
the  context  shall  otherwise  require.  The table of  contents,  headings  and
captions  herein shall not be given effect in  interpreting  or  construing  the
provisions of this Agreement. Except as otherwise expressly provided herein, all
references to "dollars" or "$" shall be deemed references to the lawful money of
the United States of America.
     (b) Accounting Terms.  Except as otherwise  expressly  provided herein, the
term  "consolidated"  and all  other  terms  of an  accounting  nature  shall be
interpreted  and  construed in  accordance  with GAAP, as in effect from time to
time; provided,  however,  that, for purposes of determining compliance with any
covenant set forth in Article VII,  such terms shall be construed in  accordance
with  GAAP  as in  effect  on the  date of this  Agreement,  applied  on a basis
consistent  with the  construction  thereof  applied in preparing the Borrower's
audited financial statements referred to in Section 5.01(h).
     (c) Other Terms.  The  following  terms have the meanings  ascribed to them
below or in the Sections of this Agreement indicated below:
     "Additional  Loans"  means,  collectively,  Loans made  pursuant to Section
3.01(b).
     "Affiliate"  means,  with  respect to any  Person,  any other  Person  that
controls, is controlled by, or is under common control with, such Person.
     "Agreement" means this credit agreement, as it may be amended,  modified or
supplemented from time to time.
     "Approved  Subsidiary"  has the  meaning  assigned  to such term in Section
8.02(a).
     "Asset  Disposition"  by any Person means any transfer,  conveyance,  sale,
lease or other disposition by such Person or any of its Subsidiaries  (including
a consolidation  or merger or other sale of any such Subsidiary with, into or to
another  Person  in a  transaction  in  which  such  Subsidiary  ceases  to be a
Subsidiary,  but excluding a disposition  by a Subsidiary of such Person to such
Person or a Wholly Owned Subsidiary of such Person or by such Person to a Wholly
Owned  Subsidiary  of such  Person) of (i) shares of capital  stock  (other than
directors'  qualifying  shares) or other ownership  interests of a Subsidiary of
such Person,  (ii)  substantially all of the assets of such Person or any of its
Subsidiaries  representing  a division or line of business or (iii) other assets
or rights of such Person or any of its Subsidiaries transferred, conveyed, sold,
leased or disposed of on or  subsequent  to the date of this  Agreement for cash
consideration not in excess of, and having a book value or fair market value not
in excess of, $1,000,000 in the aggregate.
     "Assignee" has the meaning assigned to such term in Section 8.02(a).
     "Average Price" means the average of the Closing Prices of the Common Stock
for the 10 Trading Days immediately preceding the Maturity Date.
     "Base  Rate"  means,  for any day,  a rate per  annum  equal to the rate of
interest from time to time publicly  announced by Citibank,  N.A. in The City of
New York as its prime  commercial loan rate in effect on such day. The Base Rate
shall change as and when the foregoing rate shall change. Any change in the Base
Rate shall  become  effective  as of the  opening of business on the day of such
change.
     "Board of Directors" means the board of directors of the Borrower.
     "Borrower" has the meaning assigned to such term in the Preamble.
     "Borrowing Amount" has the meaning set forth in Section 2.02.
     "Borrowing  Date" means,  with respect to any Quarterly  Loan, the Business
Day set forth in the  relevant  Borrowing  Request  as the date  upon  which the
Borrower  desires to borrow such Quarterly Loan;  provided,  however,  that such
Borrowing  Date  shall be not fewer than 10  Business  Days and not more than 20
Business Days  following the Lender's  receipt of such  Borrowing  Request;  and
provided,  further,  that the  Borrowing  Date with  respect to any Loan for the
Quarter consisting of January,  February and March, 1999 may be any Business Day
not fewer than five Business Days and not more than ten Business Days  following
Lender's receipt of the Borrowing Request relating to such Loan.
     "Borrowing  Request" means a request by the Borrower for a Quarterly  Loan,
which shall specify (i) the requested  Borrowing Date, (ii) the Borrowing Amount
for such  Quarterly  Loan,  and (iii) a calculation of the Exercise Price of the
related Warrants.
     "Business Day" means any day that is not a Saturday, Sunday or other day on
which  commercial  banks in The City of New York or in Los Angeles,  California,
are authorized by law to close.
     "Capital  Expenditures"  means,  for  any  period,  the  aggregate  of  all
expenditures  (whether paid in cash or accrued as liabilities and including that
portion of Capital Lease  Obligations  that is capitalized  on the  consolidated
balance  sheet of the  Borrower  and its  Subsidiaries)  by the Borrower and its
Subsidiaries  during  such period that are  included in the  property,  plant or
equipment  reflected in the  consolidated  balance sheet of the Borrower and its
Subsidiaries.
     "Capital  Lease  Obligations"  means,  with  respect  to  any  Person,  the
obligation  of such  Person to pay rent or other  amounts  under any lease  with
respect to any property (whether real,  personal or mixed) acquired or leased by
such Person that is required  by GAAP to be  accounted  for as a liability  on a
consolidated balance sheet of such Person.
     "Closing  Price" means the last  reported sale price regular way on the day
in  question  or, in case no such sale  takes  place on such day,  the  reported
closing bid price regular way of the Common Stock, in each case on the principal
national  securities exchange on which the Common Stock is listed or admitted to
trading,  or, if not listed or  admitted to trading on any  national  securities
exchange,  the  closing  bid price of the Common  Stock on the  Nasdaq  National
Market.  In the case of a closing  price of Common Stock on the Nasdaq  National
Market,  such price shall mean the closing  price  reported in the New York City
edition of The Wall Street Journal or, if not so reported, another authoritative
source.
     "Code"  means the Internal  Revenue  Code of 1986,  as amended from time to
time.
     "Common  Stock" means the common  stock,  par value $.01 per share,  of the
Company and any other stock of the Borrower  into which such common stock may be
converted or reclassified  (other than stock of the Borrower into which unissued
Common  Stock has been  reclassified)  or that may be issued in  respect  of, in
exchange  for, or in  substitution  of, such common stock by reason of any stock
splits,    stock    dividends,    distributions,     mergers,    consolidations,
recapitalizations or other like events.
     "Credit Documents" means,  collectively,  this Agreement; all of the Notes;
that certain Security Agreement, of even date herewith, between the Borrower, as
debtor,  and the  Lender,  as secured  party;  and any  documents  executed  and
delivered,  or filings  made,  pursuant to or in  connection  with such Security
Agreement,  including any financing  statements  filed by the Lender pursuant to
the Uniform  Commercial  Code and any filings made by the Lender with the Patent
and Trademark Office.
     "Current Assets" means, at any date of determination,  consolidated current
assets of the Borrower and its Subsidiaries.
     "Current  Liabilities"  means, at any date of  determination,  consolidated
current liabilities of the Borrower and its Subsidiaries, less the amount of the
current  portion of, and any accrued  interest on,  Indebtedness of the Borrower
and its Subsidiaries.
     "Default" means any event or circumstance  which, with the giving of notice
or the passage of time, or both, would be an Event of Default.
     "Disclosure  Package"  has the  meaning  assigned  to such term in  Section
5.01(h).
     "EBITDA" means,  for any period,  the sum of (i) consolidated net income of
the  Borrower  and  its  Subsidiaries  for  such  period,  adjusted  to  exclude
non-recurring  gains and losses on unusual  items and (ii)  consolidated  income
taxes,  interest  income,  Interest  Expense,   depreciation,  and  amortization
(including, without limitation,  amortization associated with goodwill, deferred
debt expenses, restricted stock and option costs and non-competition agreements)
of the Borrower and its Subsidiaries for such period.
     "Effective Time" has the meaning assigned to such term in Section 6.01.
     "Environmental  Claim"  means  any  claim,  assertion,  demand,  notice  of
violation,  suit,  administrative  or judicial  proceeding,  regulatory  action,
investigation,  information request or order involving any hazardous  substance,
Environmental  Law, noise or odor pollution or any injury or threat of injury to
human health, property or the environment.
     "Environmental  Law" means any federal,  state, local or foreign statute or
common law, regulation,  order, decree,  opinion or agency requirement as now in
effect or  hereinafter  adopted  relating to (i) the  handling,  use,  presence,
disposal  or  release  of  any  hazardous  substance  or  (ii)  the  protection,
preservation  or  restoration  of the  environment,  natural  resources or human
health or safety.
     "ERISA"  means the Employee  Retirement  Income  Security  Act of 1974,  as
amended from time to time.
     "ERISA  Group" means the Borrower and all members of a controlled  group of
corporations and all trades or businesses  (whether or not  incorporated)  under
common  control  which,  together  with the  Borrower,  are  treated as a single
employer  under  Section 414 of the Code or are  considered  to be one  employer
under Section 4001 of ERISA.
     "Event of Default" has the meaning assigned to such term in Section 8.01.
     "Excluded  Taxes"  means all present  and future  taxes,  levies,  imposts,
duties, deductions,  withholdings, fees, liabilities and similar charges imposed
on or measured by the overall net income of the Lender (or any office, branch or
Subsidiary of the Lender) or any  franchise  taxes,  taxes on doing  business or
taxes  measured  by capital or net worth  imposed on the Lender (or any  office,
branch or Subsidiary  of the Lender),  in each case imposed by the United States
of America or any political  subdivision or taxing authority thereof or therein,
or taxes on or  measured  by the  overall  net income of any  office,  branch or
Subsidiary  of the Lender or any taxes,  levies,  imposts,  duties,  deductions,
withholdings,  fees,  liabilities  and  similar  changes  imposed by any foreign
country or subdivision thereof.
     "Exercise  Price"  has the  meaning  assigned  to such term in the  Warrant
Agreement.
     "External   Scaleup  Costs"  means  the  costs  incurred  by  the  Borrower
associated  with the  development of the scale-up of raw  materials,  the active
pharmaceutical  ingredient  and final dose  formulation  necessary to permit the
Product  (as  defined  in  that  certain  Amended  and  Restated   Ophthalmology
Development  & License  Agreement  between the  Borrower and an affiliate of the
Lender) to be  manufactured  by an entity  other than the  Borrower.  Such costs
include,  but are not limited to, the costs of development  work performed,  raw
materials used in development and stability and equipment needed.
     "Federal Reserve Board" means the Board of Governors of the Federal Reserve
System (or any successor Governmental Authority).
     "GAAP" means generally accepted accounting principles,  as set forth in the
opinions and  pronouncements of the Accounting  Principles Board of the American
Institute of Certified Public  Accountants and statements and  pronouncements of
the Financial  Accounting  Standards  Board or in such other  statements by such
other  entities as may be approved by a  significant  segment of the  accounting
profession of the United States of America.
     "Governmental Authority" means any nation or government, any state or other
political subdivision thereof and any entity exercising executive,  legislative,
judicial, regulatory or administrative functions of or pertaining to government.
     "Guaranty" means, with respect to any Person, any obligation, contingent or
otherwise,  of such  Person  guaranteeing  or  having  the  economic  effect  of
guaranteeing any Indebtedness of any other Person (the "primary obligor") in any
manner,  whether  directly or  indirectly,  and including any obligation of such
Person,  (i) to purchase or pay (or advance or supply  funds for the purchase or
payment of) such  Indebtedness or to purchase (or to advance or supply funds for
the  purchase of) any  security  for the payment of such  Indebtedness,  (ii) to
purchase property, securities or services for the purpose of assuring the holder
of such  Indebtedness  of the payment of such  Indebtedness or (iii) to maintain
working capital,  equity capital or the financial  condition or liquidity of the
primary  obligor so as to enable the primary  obligor to pay such  Indebtedness.
The terms "Guaranteed",  "Guaranteeing" and "Guarantor" shall have corresponding
meanings.
     "Hazardous Substance" means any substance, in any concentration or mixture,
that is (i) listed,  classified or regulated  pursuant to any Environmental Law,
(ii)   petroleum   product  or   by-product,   asbestos   containing   material,
polychlorinated  biphenyls,  radioactive material or radon or (iii) any waste or
other substance  regulated by any  Governmental  Authority or any  Environmental
Law.
     "Indebtedness"  means,  with respect to any Person,  (i) all obligations of
such Person for borrowed money or for the deferred purchase price of property or
services (including all obligations,  contingent or otherwise, of such Person in
connection  with  letters  of  credit,   bankers'  acceptances,   Interest  Rate
Protection  Agreements or other similar  instruments,  including currency swaps)
other than indebtedness to trade creditors and service providers incurred in the
ordinary course of business and payable on usual and customary  terms,  (ii) all
obligations  of such  Person  evidenced  by bonds,  notes,  debentures  or other
similar  instruments,  (iii)  all  indebtedness  created  or  arising  under any
conditional  sale or other title  retention  agreement  with respect to property
acquired by such Person  (even  though the  remedies  available to the seller or
lender  under  such  agreement  are  limited  to  repossession  or  sale of such
property),   (iv)  all  Capital  Lease  Obligations  of  such  Person,  (v)  all
obligations  of the types  described in clauses (i),  (ii),  (iii) or (iv) above
secured  by (or for which the  obligee  has an  existing  right,  contingent  or
otherwise,  to be  secured  by)  any  Lien  upon or in any  property  (including
accounts, contract rights and other intangibles) owned by such Person (up to the
value of such  property),  even  though  such  Person has not  assumed or become
liable for the payment of such Indebtedness,  (vi) all preferred stock issued by
such  Person or any  Subsidiary  of such  Person,  valued at the  greater of its
voluntary  or  involuntary   liquidation  preference  plus  accrued  and  unpaid
dividends, (vii) all Indebtedness of others Guaranteed by such Person and (viii)
all Indebtedness of any partnership of which such Person is a general partner.
     "Indemnitee" has the meaning assigned to such term in Section 4.04(b).
     "Interest  Expense" means,  for any period,  consolidated  interest expense
(including  that  attributable  to Capital  Lease  Obligations)  whether paid or
accrued,  of the Borrower and its  Subsidiaries  with respect to all outstanding
Indebtedness of the Borrower and its  Subsidiaries,  including all  commissions,
discounts  and other fees and charges  owed with respect to letter of credit and
bankers'  acceptance  financing  and net costs under  Interest  Rate  Protection
Agreements.
     "Interest  Rate  Protection   Agreement"   means  any  interest  rate  swap
agreement,  interest rate cap agreement or similar hedging arrangement used by a
Person to fix or cap a floating rate of interest on Indebtedness to a negotiated
maximum rate or amount.
     "Investment"  by any Person means any direct or indirect  loan,  advance or
other  extension of credit or capital  contribution to (by means of transfers of
cash or other  property to others or payments  for  property or services for the
account or use of others,  or otherwise),  or purchase or acquisition of capital
stock, bonds, notes,  debentures or other securities or evidence of Indebtedness
or other obligations of or issued by any other Person.
     "Key Agreements" means, collectively, the License Agreement, effective July
1, 1989,  between the  University of Toledo,  the Medical  College of Ohio,  St.
▇▇▇▇▇▇▇  Medical  Center and the Borrower,  as amended prior to the date hereof,
and the  Development and  Distribution  Agreement,  dated May 28, 1996,  between
Iridex Corporation and the Borrower, as amended prior to the date hereof.
     "Lender" has the meaning assigned to such term in the Preamble.
     "Lien" means, with respect to any asset of a Person, (i) any mortgage, deed
of trust, lien, pledge,  encumbrance,  charge or security interest in or on such
asset,  (ii) the  interest  of a vendor or lessor  under  any  conditional  sale
agreement,  capital lease or title retention  agreement  relating to such asset,
and (iii) in the case of securities,  any purchase option, call or similar right
of any other Person with respect to such securities.
     "Loans" means, collectively, the Quarterly Loans and the Additional Loans.
     "Material  Adverse Effect" means any material and adverse effect on (i) the
consolidated  business,  properties,   condition  (financial  or  otherwise)  or
operations,  present or prospective, of the Borrower and its Subsidiaries,  (ii)
the ability of the Borrower  timely to perform any of its material  obligations,
or of the Lender to exercise any remedy,  under any Credit Document or (iii) the
legality, validity, binding nature or enforceability of any Credit Document.
     "Maturity  Date" means the fifth  anniversary of the Borrowing Date for the
first Loan made pursuant to this Agreement.
     "Maximum Quarterly Amount" means, (i) for the Quarter  comprising  January,
February  and  March,  1999,  $3,750,000,  and (ii) for any other  Quarter  (the
"Reference  Quarter"),  the sum of $3,750,000  plus either (A) if and only if no
Quarterly  Loan was made in the  Quarter  immediately  preceding  the  Reference
Quarter  or the  principal  amount of the  Quarterly  Loan  made in the  Quarter
immediately  preceding the Reference Quarter was less than $3,750,000,  then the
amount equal to the amount by which  $3,750,000  exceeds the principal amount of
the  Quarterly  Loan,  if any,  made in the Quarter  immediately  preceding  the
Reference  Quarter,  or (B) if and only if the principal amount of the Quarterly
Loan made in the Quarter  immediately  preceding the Reference Quarter was equal
to or greater than $3,750,000, then zero.
     "Multiemployer  Plan"  means a  multiemployer  plan as  defined  in Section
4001(a)(3) of ERISA to which any member of the ERISA Group is making or accruing
an obligation to make  contributions or has within the preceding five plan years
made or accrued contributions.
     "Net Available Asset Disposition Proceeds" means, with respect to any Asset
Disposition  by any  Person,  all cash or readily  marketable  cash  equivalents
received  (including  by  way of  sale  or  discounting  of a  note,  instalment
receivable or other receivable,  but excluding any other consideration  received
in the form of assumption by the acquiree of Indebtedness  or other  obligations
relating to such  properties  or assets or received in any other  noncash  form)
therefrom  by such  Person,  net of (i)  all  legal,  title  and  recording  tax
expenses,  commissions  and other fees and  expenses  incurred  and all federal,
state, provincial, foreign and local taxes required to be accrued as a liability
as a  consequence  of such Asset  Disposition,  (ii) all  payments  made by such
Person or its Subsidiaries on any  Indebtedness  which is secured by such assets
in accordance  with the terms of any Lien upon or with respect to such assets or
which must by the terms of such Lien, or in order to obtain a necessary  consent
to such Asset  Disposition  or by  applicable  law be repaid out of the proceeds
from such Asset Disposition, and (iii) all distributions and other payments made
to minority interest holders in Subsidiaries of such Person or joint ventures as
a result of such Asset Disposition.
     "Net Available  Securities  Offering  Proceeds" means,  with respect to any
offer or sale of securities by any Person,  all cash or readily  marketable cash
equivalents received therefrom by such Person, net of all underwriting discounts
and commissions,  SEC filing fees, legal fees and disbursements,  printing fees,
fees of national securities exchanges or the Nasdaq National Market and auditing
fees incurred by such Person in connection with such offer or sale.
     "New Site" has the meaning assigned to such term in Section 7.02(e)(ix).
     "Note"  means a  promissory  note of the  Borrower in the form set forth in
Exhibit B, executed and delivered in  accordance  with Section 2.02,  3.01(b) or
6.02(b) in order to evidence a Loan.
     "Operating  Income" of any Person means,  for any period,  the consolidated
operating  income  (or loss) of such  Person  for such  period  determined  on a
consolidated basis in accordance with generally accepted accounting  principles;
provided  that there shall be excluded  therefrom  (a)  noncash  expense  items,
including but not limited to depreciation,  amortization,  noncash  compensation
costs and reserves, (b) the operating income (or loss) of any Person acquired by
such Person or a Subsidiary of such Person in a pooling-of-interests transaction
for any period prior to the date of such  transaction,  (c) the operating income
(but not  operating  loss) of any  Subsidiary of such Person which is subject to
restrictions   which   prevent  the  payment  of  dividends  or  the  making  of
distributions  to  such  Person  to the  extent  of such  restrictions,  (d) the
operating income (or loss) of any Person that is not a Subsidiary of such Person
except to the extent of the amount of dividends or other distributions  actually
paid to such Person by such other Person during such period, (e) gains or losses
on  Asset   Dispositions  by  such  Person  or  its  Subsidiaries  and  (f)  all
extraordinary gains and extraordinary losses.
     "Ophthalmology  Expense"  means,  for any period,  the direct and  indirect
costs incurred by the Company  associated  with the field of  ophthalmology  for
research,  pharmaceutical,  device and manufacturing development and preclinical
and clinical costs,  including,  (but not limited to) general and administrative
costs,  internal  scale-up costs,  preclinical costs as required for NDA filing,
clinical and regulatory  costs,  drug and device  development and  manufacturing
costs and consultants, but excluding External Scaleup Costs.
     "PBGC" means the Pension  Benefit  Guaranty  Corporation  (or any successor
Governmental Authority).
     "Pension Plan" means a Plan that (i) is an employee  pension  benefit plan,
as defined in Section 3(3) of ERISA (other than a  Multiemployer  Plan) and (ii)
is subject to the  provisions  of Title IV of ERISA or is subject to the minimum
funding standards under Section 412 of the Code.
     "Permitted Liens" means, collectively,  the following: (i) Liens for taxes,
assessments or charges not yet due or that are being  contested in good faith by
appropriate  proceedings  and (unless the amount  thereof is not material to the
Borrower's  consolidated  financial  condition) for which adequate  reserves are
being  maintained (in accordance with GAAP);  (ii) deposits or pledges to secure
obligations  under workers'  compensation,  social  security or similar laws, or
under unemployment insurance; (iii) deposits or pledges to secure bids, tenders,
contracts (other than contracts constituting  Indebtedness),  leases,  statutory
obligations,  surety  and  appeal  bonds and other  obligations  of like  nature
arising  in  the  ordinary  course  of  business;  (iv)  mechanics',   workers',
materialmen's  or similar Liens arising in the ordinary  course of business with
respect to  obligations  which are not overdue for a period of more than 30 days
or which are being contested in good faith by appropriate proceedings; (v) Liens
securing  judgments in an amount and for a period not  constituting  an Event of
Default under Section 8.01(i);  (vi) minor imperfections of title on real estate
that do not interfere  materially  with the use of such property or render title
unmarketable;  (vii) any Lien upon or in any property  hereafter acquired by the
Borrower or a Subsidiary  of the  Borrower,  provided  that such Lien is created
contemporaneously  with such acquisition to secure or provide for the payment or
financing of any part of the cost (including  construction  costs) thereof,  and
provided,  further, that such Lien attaches only to the property so acquired and
fixed  improvements  thereon,  accessions  thereto,  replacements  and  proceeds
thereof, and substitutions  therefor;  (viii) Liens existing on the date hereof;
(ix) Liens on equipment leased by the Borrower or any Subsidiary of the Borrower
pursuant  to a  capital  lease in the  ordinary  course of  business  (including
replacements  and  proceeds  thereof,   substitutions  therefor  and  accessions
thereto)  incurred  solely  for the  purpose  of  financing  the  lease  of such
equipment;  (x) leases or subleases  granted to others in the ordinary course of
Borrower's or its Subsidiary's  business not interfering in any material respect
with the business of Borrower  and its  Subsidiaries  taken as a whole,  and any
interest or title of a lessor under any lease; (xi) Liens on assets that existed
at the time such assets were acquired by Borrower or any  Subsidiary  (including
Liens on assets of any corporation that existed at the time it became or becomes
a  Subsidiary  of the  Borrower);  provided  such  Liens  were  not  granted  in
contemplation of or in connection with the acquisition of such asset by Borrower
or any such Subsidiary;  (xii) Liens in favor of customs and revenue authorities
arising as a matter of law to secure  payments of customs  duties in  connection
with the importation of goods;  (xiii) Liens which constitute  rights of set-off
of a  customary  nature or  banker's  Liens with  respect to amounts on deposit,
whether  arising  by  operation  of  law  or by  contract,  in  connection  with
arrangement  entered into with banks in the ordinary  course of business;  (xiv)
Liens on insurance  proceeds in favor of insurance  companies  granted solely as
security  for  financed  premiums;  and  (xv) any Lien  renewing,  extending  or
refinancing  a Lien  permitted by the  foregoing,  provided  that the  principal
amount  secured is not increased and the Lien is not extended to other  property
(other than by a substitution of like property).
     "Person" means any  individual,  sole  proprietorship,  partnership,  joint
venture,   trust,   unincorporated   organization,   association,   corporation,
institution,  public benefit corporation, entity or government (whether Federal,
state,  county,  city,  municipal or otherwise,  including any  instrumentality,
division, agency, body or department thereof).
     "Plan"  means an employee  benefit plan as defined in Section 3(3) of ERISA
(other than a  Multiemployer  Plan) which is maintained or contributed to by the
Borrower or any member of the ERISA Group.
     "Quarter"  means each of the six calendar  quarters  consisting of January,
February and March, 1999; April, May and June, 1999; July, August and September,
1999; October,  November and December, 1999; January,  February and ▇▇▇▇▇, ▇▇▇▇;
and April, May and June, 2000.
     "Quarterly Loan" has the meaning assigned to such term in Section 2.01.
     "Related Person" of any Person means,  without  limitation,  any officer or
director of such Person or any other Person owning 5% or more of the outstanding
common  stock of such Person or 5% or more of the Voting  Stock of such  Person.
For purpose of this Agreement, the Lender and its Affiliates shall not be deemed
to be Related Persons of the Borrower or any of its Subsidiaries.
     "Repayment  Shares"  has  the  meaning  assigned  to such  term in  Section
2.03(b).
     "Responsible Officer" means the chief executive officer,  president,  chief
financial officer, chief accounting officer or treasurer of the Borrower.
     "Sale and Leaseback  Transaction"  of any Person means an arrangement  with
any lender or investor or to which such lender or investor is a party  providing
for the leasing by such Person of any property or asset of such Person which has
been or is being  sold or  transferred  by such  Person  after  the  acquisition
thereof or the completion of construction  or commencement of operation  thereof
to such lender or investor or to any person to whom funds have been or are to be
advanced by such lender or investor on the security of such property or asset.
     "SEC"  means the  Securities  and  Exchange  Commission  (or any  successor
Governmental Authority).
     "Share  Repayment  Amount" has the meaning assigned to such term in Section
2.03(b).
     "Shareholders'  Equity" means, as of any date of  determination,  the total
consolidated  shareholders'  equity  (determined  without  duplication)  of  the
Borrower and its Subsidiaries at such date.
     "Solvent"  means,  with  respect  to a  Person  and  a  specified  date  of
determination, that at such date:
     (a) the present fair saleable value of such Person's assets is in excess of
the total amount of such Person's probable liabilities on its existing debts and
obligations  (including  contingent  liabilities)  as they become  absolute  and
matured;
     (b) such Person is able to pay its debts as they become due; and
     (c) such Person does not have  unreasonably  small capital to carry on such
Person's  business as  theretofore  operated  and all  businesses  in which such
Person then is about to engage.
     "Subsidiary"  means, at any time and with respect to any Person,  any other
Person the shares of stock or other ownership interests of which having ordinary
voting power to elect a majority of the board of  directors or other  matters of
such Person are at the time  owned,  or the  management  or policies of which is
otherwise at the time  controlled,  directly or  indirectly  through one or more
intermediaries  (including  other  Subsidiaries)  or both, by such first Person.
Unless otherwise qualified or the context indicates clearly to the contrary, all
references to a "Subsidiary"  or  "Subsidiaries"  in this  Agreement  refer to a
Subsidiary or Subsidiaries of the Borrower.
     "Surplus" has the meaning assigned to such term in Section 7.02(p).
     "Taxes" has the meaning assigned to such term in Section 4.03.
     "Trading  Day"  means a day on  which  the  principal  national  securities
exchange  on which the shares of Common  Stock are listed or admitted to trading
is open for the  transaction  of business  or, if the shares of Common Stock are
not listed or admitted to trading on any national securities  exchange, a day on
which the Nasdaq National Market is open for the transaction of business.
     "Voting  Stock" of any Person  means  capital  stock of such  Person  which
ordinarily has voting power for the election of directors (or persons performing
similar functions) of such Person.
     "Warrant" has the meaning assigned to such term in the Warrant Agreement.
     "Warrant  Agreement"  means the Warrant  Agreement,  of even date herewith,
between the Borrower and the Lender.
     "Warrant  Certificate" has the meaning assigned to such term in the Warrant
Agreement.
     "Warrant  Number"  means,  with respect to any Quarterly  Loan, a number of
Warrants  equal to the product of (i) the  Borrowing  Amount for such  Quarterly
Loan, divided by (ii) 62.50.
     "Wholly  Owned  Subsidiary"  means,  at any time and  with  respect  to any
Person,  a  Subsidiary,  all the shares of stock of all classes of which  (other
than directors'  qualifying shares) or other ownership interests at the time are
owned  directly or  indirectly  by such Person  and/or one or more other  Wholly
Owned Subsidiaries of such Person.
                                   ARTICLE II
                               The Credit Facility
     Section II.1. Loans. Subject to the terms and conditions of this Agreement,
the Lender  agrees to make a single  term loan  (each,  a  "Quarterly  Loan") in
dollars to the Borrower not more than once in each Quarter in a principal amount
not to exceed the Maximum  Quarterly  Amount per Quarter.  Each  Quarterly  Loan
shall be made on the  applicable  Borrowing  Date only in a principal  amount of
$1,000,000  or an integral  multiple of  $250,000 in excess  thereof,  but in no
event greater than the Maximum Quarterly Amount for such Quarter.
     Section II.2. Borrowing Procedure. In order to borrow a Quarterly Loan, the
Borrower shall deliver a Borrowing  Request to the treasurer of Lender, no later
than 12:00 Noon, New York time, on the thirtieth  Business Day of the Quarter to
which the Loan  relates;  provided,  however,  that any  Borrowing  Request with
respect to a Quarterly Loan for the Quarter consisting of January,  February and
March, 1999 may be furnished to the Lender at any time no later than 12:00 Noon,
New York time, on the fifteenth  Business Day following the Effective Time. Each
Borrowing  Request shall be  accompanied  by a duly executed Note in the form of
Exhibit B, dated as of the Borrowing Date and evidencing a loan in the principal
amount set forth in the Borrowing Request (the "Borrowing  Amount",  which shall
be  $1,000,000 or an integral  multiple of $250,000 in excess  thereof but shall
not exceed the Maximum  Quarterly Amount for such Quarter),  and a duly executed
Warrant Certificate evidencing a number of Warrants equal to the Warrant Number.
Subject  to  satisfaction,  or waiver by the Lender in  writing,  of each of the
applicable  conditions  precedent  contained  in Article  VI, on the  applicable
Borrowing  Date the Lender shall make  available  to the Borrower the  Borrowing
Amount.
     Section II.3.  Repayment.  (a) The aggregate  outstanding  principal of the
Loans shall be repaid in full, together with any accrued interest as of the date
of repayment,  not later than the Maturity Date.  Except as permitted by Section
2.03(b),  such principal and interest shall be repaid in cash.  Repaid Loans may
not be reborrowed.
     (b) If and only if the Common  Stock  shall have been listed or admitted to
trading  on a national  securities  exchange  or quoted on the  Nasdaq  National
Market on each of the 180 calendar  days  preceding  and  including the Maturity
Date,  then on, but not  following,  the Maturity Date, the Borrower may, at its
option, repay all or a portion of the aggregate principal of the Loans, together
with any accrued  interest as of the Maturity  Date, by delivering to the office
of the Lender  theretofore  designated in writing to the Borrower not later than
12:00 Noon, New York time, on the Maturity  Date, (i) an unlegended  certificate
for the number of shares of Common Stock (the  "Repayment  Shares") equal to the
product,  rounded up to the  nearest  whole  number,  of (A) the  portion of the
aggregate  principal of the Loans to be repaid pursuant to this Section 2.03(b),
together with any accrued  interest  thereon as of the Maturity Date (the "Share
Repayment Amount"), divided by (B) the Average Price; (ii) an opinion of counsel
for the Borrower (which counsel shall be satisfactory to the Lender) in the form
of  Exhibit  C;  (iii)  evidence  satisfactory  to the  Lender  of the  previous
expiration or  termination  of any waiting  period (and any  extension  thereof)
applicable to the  acquisition  by the Lender of the Repayment  Shares under the
▇▇▇▇-▇▇▇▇▇-▇▇▇▇▇▇  Antitrust  Improvements  Act of  1976,  as  amended,  and the
previous  receipt of all  governmental  and  contractual  permits,  consents and
approvals   necessary  in  connection  with  such  acquisition;   (iv)  evidence
satisfactory to the Lender of Borrower's  compliance with Section  2.03(c);  and
(v) a certified or official bank check in same day funds equal to the difference
of (A) the aggregate  principal  amount of the Loans,  together with any accrued
interest as of the Maturity Date, minus (B) the Share Repayment Amount.
     (c) The Borrower shall pay all transfer, stamp and other similar taxes that
may be imposed in respect of the  issuance or delivery of the  Repayment  Shares
pursuant to Section  2.03(b) and any and all filing fees  incurred by the Lender
pursuant to Section 2.03(b)(iv).
     Section II.4. Prepayment.  The Borrower may prepay portions of the Loans by
giving  notice to the  treasurer  of the Lender,  by  telephone,  telecopy or in
writing,  not later than 12:00 Noon (if not in writing,  to be so confirmed  not
later than 2:00 P.M.), New York time, on the Business Day preceding the proposed
date of  prepayment.  Each such  prepayment  shall be in an aggregate  principal
amount of ***** or  integral  multiples  of ***** in excess  thereof  (or if the
aggregate  amount  of  outstanding  Loans is less than  *****,  then all of such
lesser amount), together with accrued interest on the principal being prepaid to
the date of prepayment;  provided,  however,  that in the case of any prepayment
pursuant to Section 7.02(n),  7.02(o) or 7.02(p), such prepayment shall be in an
aggregate principal amount equal to ***** of the Net Available Asset Disposition
Proceeds,  ***** of the Net Available  Securities  Offering Proceeds or ***** of
the amount of the Surplus,  as the case may be, in any such case  together  with
accrued interest on the principal being repaid to the date of prepayment,  up to
but not in excess of the aggregate principal amount of, and accrued interest on,
the outstanding Loans. Each partial prepayment shall be applied to the principal
amount of the Loan or Loans designated by the Lender in its sole discretion, and
the  Lender  will  provide  Borrower  with  reasonable  notice  concerning  such
designation. Prepaid Loans may not be reborrowed.
     *****Confidential Treatment Requested
                                   ARTICLE III
                                    Interest
     Section  III.1.  Interest on Loans.  (a) Each Loan shall bear interest from
the date made until the date repaid,  payable pursuant to Section 3.01(b),  at a
rate per annum  equal to the Base Rate in effect  from time to time,  which rate
shall change as and when said Base Rate shall change.
     (b)  Interest  on the Loans  shall be payable in arrears on the last day of
each calendar quarter of each year (each such day, a "Quarterly  Payment Date"),
commencing with the first such Quarterly  Payment Date after the Effective Date,
and on the date  such  Loan is repaid or  prepaid,  in the  manner  set forth in
Section  4.01 or, if and only if  permitted  below,  by the  delivery  of a Note
evidencing  an  additional  loan made  pursuant to this  Agreement  and having a
principal amount equal to the amount of such interest, as set forth below.
          (i) On or prior to the fifth  Business Day  following  each  Quarterly
     Payment  Date prior to January 1, 2001,  the  Borrower  shall  execute  and
     deliver to the  treasurer  of the Lender a Note having a  principal  amount
     equal  to  the  aggregate  amount  of  all  interest  on  Loans  (including
     Additional  Loans) payable on such Quarterly  Payment Date.  Each such Note
     shall evidence an additional loan made pursuant to this Agreement and shall
     bear  interest in the manner and at the rate set forth in Section  3.01(a),
     which  interest  shall be payable  in the manner set forth in this  Section
     3.01(b).
          (ii) All interest on Loans (including Additional Loans) payable on any
     Quarterly Payment Date subsequent to December 31, 2000 shall be paid in the
     manner set forth in Section  4.01;  provided that if and only if EBITDA for
     the calendar quarter ending on such Quarterly  Payment Date does not exceed
     the amount of such interest as is payable on such  Quarterly  Payment Date,
     then,  subject to Section  3.01(b)(iii),  on or prior to the fifth Business
     Day following such  Quarterly  Payment Date, the Borrower shall execute and
     deliver to the  treasurer  of the Lender a Note having a  principal  amount
     equal  to  the  aggregate  amount  of  all  interest  on  Loans  (including
     Additional  Loans) payable on such Quarterly  Payment Date.  Each such Note
     shall evidence an additional loan made pursuant to this Agreement and shall
     bear  interest in the manner and at the rate set forth in Section  3.01(a),
     which  interest  shall be payable  in the manner set forth in this  Section
     3.01(b).
          (iii) The  Borrower  shall not be entitled to pay interest on Loans in
     the manner set forth in Section  3.01(b)(ii) in respect of interest payable
     on any of the  four  Quarterly  Payment  Dates  immediately  following  the
     closing of a primary  offering  or sale of  securities  by the  Borrower in
     which the Net Available  Securities Offering Proceeds from such offering or
     sale equals or exceeds $5,000,000.
     (c) No Warrants shall be issuable in connection with any Additional Loan.
     Section III.2.  Interest on Overdue Amounts. All overdue amounts (including
principal,  interest and fees)  hereunder,  and,  during the  continuance of any
Event of  Default  that  shall have  occurred,  each Loan  shall bear  interest,
payable on demand,  at a rate per annum equal to the sum of (i) 10% and (ii) the
rate of interest  applicable to such Loan,  changing as and when such rate shall
change.
     Section  III.3.  Day Counts.  Interest on Loans shall be  calculated on the
basis of (a) a 365- or, if  applicable,  a 366-day year for the actual number of
days elapsed.
     Section III.4.  Maximum  Interest Rate. (a) Nothing in this Agreement shall
require  the  Borrower  to pay  interest at a rate  exceeding  the maximum  rate
permitted by applicable law.
     (b) If the amount of interest payable to the Lender on any interest payment
date in  respect  of the  immediately  preceding  interest  computation  period,
computed pursuant to this Article III, would exceed the maximum amount permitted
by applicable  law to be charged by the Lender,  the amount of interest  payable
for its account on such interest payment date shall  automatically be reduced to
such maximum permissible amount.
     (c) If the  amount of  interest  payable  to the  Lender in  respect of any
interest  computation  period is reduced  pursuant  to Section  3.04(b)  and the
amount of interest payable for its account in respect of any subsequent interest
computation  period would be less than the maximum amount permitted by law to be
charged by the Lender,  then the amount of  interest  payable in respect of such
subsequent interest computation period shall be automatically  increased to such
maximum permissible amount;  provided that at no time shall the aggregate amount
by which interest paid to the Lender has been increased pursuant to this Section
3.04(c)  exceed the  aggregate  amount by which  interest paid to the Lender has
theretofore been reduced pursuant to Section 3.04(b).
                                   ARTICLE IV
                            Disbursement and Payment
     Section  IV.1.  Method and Time of  Payments.  (a)  Except as  specifically
permitted  by Section  3.01(b),  and except in the case of payments  pursuant to
Sections 3.02, 4.02, 4.03, 4.04 or payments otherwise  specified as payable upon
demand, which payments shall be made forthwith upon written demand therefor, all
payments by the Borrower  hereunder shall be made without setoff or counterclaim
to the Lender in dollars and in immediately available funds at the office of the
Lender  theretofore  designated  in writing to the  Borrower not later than 2:00
p.m., New York time, on the later of the date when due or the fifth Business Day
following  the  Borrower's  receipt of an oral or written  confirmation  made in
response to the request contemplated by Section 4.01(c).
     (b) Whenever  any payment  from the Borrower  shall be due on a day that is
not a Business  Day, the date of payment  thereof  shall be extended to the next
succeeding Business Day. If the date for any payment of principal is extended by
operation  of law or  otherwise,  interest  thereon  shall be  payable  for such
extended time.
     (c)  Promptly  upon receipt of a request by the  Borrower  therefor  (which
request may be made by telephone to the treasurer or any assistant  treasurer of
Pharmacia & Upjohn,  Inc.) the Lender shall confirm the Lender's  calculation of
the amount of any payment due on a particular date.
     Section  IV.2.  Compensation  for  Losses.  If  the  Borrower  revokes  any
Borrowing Request,  then the Borrower shall reimburse the Lender,  promptly upon
demand therefor,  for all fees and costs actually incurred or paid by the Lender
to third  parties in respect of funds  obtained by the Lender for the purpose of
making or maintaining the related Loan, or any portion thereof.  If requested by
the  Borrower,  Lender shall  provide to the Borrower  reasonable  documentation
concerning such fees and costs.
     Section IV.3. Withholding.  All payments under this Agreement and under the
Notes  (including  payments of principal and  interest)  shall be payable to the
Lender free and clear of any and all present and future taxes, levies,  imposts,
duties,  deductions,  withholdings,  fees, liabilities and similar charges other
than Excluded  Taxes  (collectively,  "Taxes").  If any Taxes are required to be
withheld or deducted  from any amount  payable  under this  Agreement,  then the
amount  payable  under this  Agreement  shall be increased to the amount  which,
after deduction from such increased  amount of all Taxes required to be withheld
or deducted therefrom,  will yield to the Lender the amount stated to be payable
under  this  Agreement;  provided,  however,  that  amounts  payable  under this
Agreement shall not be increased in respect of any Taxes required to be withheld
or deducted  solely as a  consequence  of the Lender's  status as a  nonresident
alien,  as such term is defined in the Code.  The  Borrower  shall also hold the
Lender  harmless  and  indemnify it for any stamp or other taxes with respect to
the preparation,  execution, delivery, recording,  performance or enforcement of
the Credit Documents (all of which shall be included within "Taxes").  If any of
the Taxes  specified in this  Section 4.03 are paid by the Lender,  the Borrower
shall,  upon  demand of the  Lender,  promptly  reimburse  the  Lender  for such
payments,  together  with any  interest,  penalties  and  expenses  incurred  in
connection  therewith.  The Borrower shall deliver to the Lender certificates or
other valid  vouchers for all Taxes or other charges  deducted from or paid with
respect to payments made by the Borrower hereunder.
     Section  IV.4.  Expenses;  Indemnity.  (a) The  Borrower  agrees  to pay or
reimburse  the  Lender  for  all  reasonable  costs  and  expenses  incurred  in
connection  with the  enforcement  or  preservation  of any  rights  under  this
Agreement, any other Credit Documents, and any such other documents,  including,
without  limitation,  the reasonable  fees and  disbursements  of counsel to the
Lender (but  excluding fees and  disbursements  incurred on or prior to the date
hereof in negotiating and preparing the Credit  Documents);  provided,  however,
that in the  event  of any  litigation  between  the  Borrower  and  the  Lender
initiated prior to any Event of Default  specified in Section 8.01(g) or (h) and
arising  out of the  matters  set  forth  in  Section  4.04(b)(i),  the fees and
disbursements  of counsel to the Lender  shall be borne by the  Borrower  if and
only if the  Lender  is the  prevailing  party.  The  Borrower  also  agrees  to
indemnify the Lender against any transfer taxes,  documentary taxes, assessments
or charges made by any  Governmental  Authority by reason of the  execution  and
delivery of any Credit Document.
     (b) The  Borrower  agrees  to  indemnify  the  Lender  and  its  directors,
officers,  employees,  agents and  Affiliates  (for purposes of this  paragraph,
each, an "Indemnitee")  against,  and to hold each Indemnitee harmless from, any
and all claims,  liabilities,  damages,  losses,  costs,  charges  and  expenses
(including  fees and  expenses of counsel)  incurred by or asserted  against any
Indemnitee  arising out of, in any way connected with, or as a result of (i) the
execution  or delivery of any Credit  Document or any  agreement  or  instrument
contemplated by any Credit  Document,  the performance by the parties thereto of
their  respective  obligations  under any Credit  Document,  the  enforcement or
preservation by the parties thereto of their respective  rights under any Credit
Document or the  consummation  of the  transactions  contemplated  by any Credit
Document,  (ii)  the use of the  proceeds  of the  Loans  or  (iii)  any  claim,
litigation,  investigation  or  proceeding  relating  to any  of the  foregoing,
whether or not any Indemnitee is a party thereto. The provisions of this Section
4.04(b)  shall not operate or be construed to indemnify the Lender  against,  or
hold it harmless from, any claims, liabilities,  damages, losses, costs, charges
and expenses  (including  fees and expenses of counsel)  incurred by or asserted
against the Lender  arising out of or connected  with any  litigation  initiated
prior to any Event of Default specified in Section 8.01(g) or (h) solely between
the Borrower and the Lender in which the Lender is not the prevailing party.
     (c) All amounts due under this Section 4.04 shall be payable in immediately
available funds upon written demand therefor.
     Section IV.5.  Survival.  The provisions of Sections 4.02,  4.03,  4.04 and
this Section 4.05 shall remain operative and in full force and effect regardless
of the  expiration  of the  term  of this  Agreement,  the  consummation  of the
transactions  contemplated  hereby,  the  repayment  of any of  the  Loans,  the
invalidity or  unenforceability of any term or provision of any Credit Document,
or any investigation made by or on behalf of the Lender.
                                    ARTICLE V
                         Representations and Warranties
     Section V.1.  Representations  and Warranties.  The Borrower represents and
warrants to the Lender as follows:
     (a)  Subsidiaries.  At the date hereof,  the  Borrower has no  Subsidiaries
other than those Persons listed on Schedule 5.01(a).
     (b) Good Standing and Power. The Borrower and each of its Subsidiaries is a
corporation,  duly  incorporated and validly existing in good standing under the
laws of the jurisdiction of its  incorporation;  each has the corporate power to
own its property and to carry on its business as now being  conducted;  and each
is duly qualified to do business and is in good standing in each jurisdiction in
which the character of the properties  owned or leased by it therein or in which
the transaction of its business makes such qualification necessary, except where
the failure to be so qualified,  or to be in good standing,  individually  or in
the  aggregate,  could not  reasonably  be expected  to have a Material  Adverse
Effect.
     (c)  Corporate  Authority.  The  Borrower  has  full  corporate  power  and
authority  to execute and  deliver,  and to incur and  perform  its  obligations
under, each of the Credit  Documents,  all of which have been duly authorized by
all  proper  and  necessary   corporate   action.  No  consent  or  approval  of
stockholders  is required as a condition to the validity or  performance  of, or
the  exercise by the Lender of any of its rights or remedies  under,  any Credit
Document.
     (d) Authorizations. All authorizations, consents, approvals, registrations,
notices,  exemptions  and licenses  with or from any  Governmental  Authority or
other  Person  necessary  for the  execution,  delivery and  performance  by the
Borrower  of, and the  incurrence  and  performance  of each of its  obligations
under,  each of the  Credit  Documents,  and the  exercise  by the Lender of its
remedies  under each of the Credit  Documents have been effected or obtained and
are in full force and effect.
     (e) Binding  Obligation.  This  Agreement  constitutes  and, when issued in
accordance  with the  terms  hereof,  each Note  will  constitute  the valid and
legally  binding  obligation of the Borrower  enforceable in accordance with its
terms,  subject as to  enforcement to  bankruptcy,  insolvency,  reorganization,
moratorium  and similar laws of general  applicability  relating to or affecting
creditors' rights and to general equity principles.
     (f) Litigation.  There are no proceedings or investigations now pending or,
to the knowledge of the Borrower,  threatened  before any court or arbitrator or
before or by any Governmental Authority which, individually or in the aggregate,
could reasonably be expected to have a Material Adverse Effect.
     (g) No Conflicts. There is no statute, regulation, rule, order or judgment,
and no provision of any agreement or instrument binding upon the Borrower or any
of its  Subsidiaries,  or affecting  their  properties,  and no provision of the
certificate of incorporation or bylaws (or similar constitutive  instruments) of
the Borrower or any of its Subsidiaries,  that would prohibit,  conflict with or
in any way impair the execution or delivery of, or the incurrence or performance
of any obligations of the Borrower under, any Credit  Document,  or result in or
require the  creation or  imposition  of any Lien on property of the Borrower or
any  of  its  Subsidiaries  as a  consequence  of the  execution,  delivery  and
performance of any Credit Document.
     (h)  Financial  Condition.  Except  as  disclosed  in  filings  made by the
Borrower with the SEC prior to the date hereof or in the press  releases  issued
by the  Company  since  September  30,  1998 and  prior to the date  hereof  and
attached to that certain letter,  dated the date hereof,  from an officer of the
Borrower to an employee of the Lender  making  reference to this  Section  (such
filings and such press releases collectively, the "Disclosure Package"), (i) The
consolidated  balance  sheet of the Borrower as of December  31, 1997,  together
with consolidated statements of income,  shareholders' equity and cash flows for
the  fiscal  year  then  ended,  reported  upon by  Ernst & Young  LLP,  and the
unaudited  consolidated  balance sheet of the Borrower as of September 30, 1998,
together  with  consolidated  statements  of income  and cash flows for the nine
months then ended,  heretofore  delivered to the Lender,  present fairly, in all
material  respects,   the  Borrower's   consolidated   financial  condition  and
consolidated  results of operations as of the dates and for the periods referred
to  and  have  been  prepared  in  accordance  with  GAAP  consistently  applied
throughout the period involved. There are no material liabilities (whether known
or  unknown,  direct  or  indirect,  fixed  or  contingent,  and of  any  nature
whatsoever)  of the Borrower or any of its  Subsidiaries  as of the date of such
balance sheet that are not reflected therein or in the notes thereto.
          (ii) Except as disclosed in the Disclosure Package,  there has been no
     material adverse change in the business,  properties,  condition (financial
     or otherwise) or operations,  present or  prospective,  of the Borrower and
     its  Subsidiaries  since the date of the balance  sheet dated  December 31,
     1997  referred  to in  Section  5.01(h)(i).  Except  as  disclosed  in  the
     Disclosure  Package,  since  December 31,  1997,  there has not occurred or
     arisen any event,  condition or circumstance  that,  individually or in the
     aggregate, could reasonably be expected to have a Material Adverse Effect.
     (i) Taxes. Each of the Borrower and its Subsidiaries has filed or caused to
be filed all tax returns  that are  required to be filed and paid all taxes that
are  required  to be  shown  to be due and  payable  on said  returns  or on any
assessment  made  against  it or  any of  its  property  and  all  other  taxes,
assessments, fees, liabilities,  penalties or other charges imposed on it or any
of  its  property  by  any  Governmental   Authority,   except  for  any  taxes,
assessments,  fees,  liabilities,  penalties  or other  charges  which are being
contested  in good faith and (unless the amount  thereof is not  material to the
Borrower's  consolidated  financial  condition) for which adequate reserves have
been established in accordance with GAAP.
     (j) Use of Proceeds. The proceeds of the Loans will be used by the Borrower
for general corporate purposes.
     (k) Margin Regulations. The making of the Loans and the use of the proceeds
thereof  as  contemplated  by  the  Credit  Documents  will  not  violate  or be
inconsistent  with  any of  the  provisions  of  Regulation  U,  T or X (or  any
successor regulation or regulations) of the Federal Reserve Board.
     (l) Compliance with ERISA.  Each member of the ERISA Group is in compliance
with the applicable  provisions of ERISA and the Code with respect to each Plan,
except for any  failure so to comply  that,  individually  or in the  aggregate,
could not reasonably be expected to have a Material Adverse Effect. No member of
the ERISA Group has (i) an accumulated  funding  deficiency under Section 412 of
the Code in respect of any Pension Plan,  whether or not waived,  (ii) failed to
make any  contribution  or payment to any Pension Plan, or made any amendment to
any Pension Plan, which has resulted or could result in the imposition of a Lien
or the  posting of a bond or other  security  under  Section  302(f) of ERISA or
Section  401(a)(29) of the Code,  (iii) incurred any liability under Title IV of
ERISA other than a liability  to the PBGC for  premiums  under  Section  4007 of
ERISA, all of which have been paid or (iv) engaged in a transaction with respect
to a Plan,  which (assuming the taxable period of such  transaction,  within the
meaning  of  Section  4975(f)(2)  of the Code,  to have  expired  as of the date
hereof) has  resulted or could  reasonably  be expected to result in such member
being  subject to a material tax or penalty  imposed by Section 4975 of the Code
or Section 502 of ERISA.
     (m)  Not  an  Investment  Company.  Neither  the  Borrower  nor  any of its
Subsidiaries  is (i) an  "investment  company" or a company  "controlled"  by an
"investment  company" within the meaning of the Investment  Company Act of 1940,
as amended,  or (ii)  subject to  regulation  under the Public  Utility  Holding
Company Act of 1935,  the Federal  Power Act,  each as amended,  or any foreign,
federal,  state or local  statute or  regulation  limiting  its ability to incur
indebtedness for money borrowed as contemplated hereby.
     (n)  Properties.  Each of the  Borrower and its  Subsidiaries  has good and
marketable  title to, or valid  leasehold  interests  in, all of its  respective
properties and assets  (excluding  intellectual  property) that are reflected on
the consolidated balance sheet of the Borrower as of September 30, 1998 referred
to in Section 5.01(h),  except for such immaterial properties and assets as have
been disposed of in the ordinary course of business and except for minor defects
in title that do not  interfere  with the ability of the  Borrower or any of its
Subsidiaries  to conduct its business as now  conducted.  Except as set forth in
the Disclosure Package, the Borrower and its Subsidiaries own or are licensed to
use or  otherwise  have the  right to use (or could  obtain  such  ownership  or
licences  or rights on terms not  materially  adverse  to the  Borrower  and its
Subsidiaries, taken as a whole) all of the intellectual property rights that are
reasonably necessary for the operation of their respective businesses.  All such
assets and properties  are so owned or held free and clear of all Liens,  except
Permitted Encumbrances.
     (o) Compliance with Laws and Charter Documents.
     (i) As a result of the Borrower's  performing any of its obligations  under
the Credit  Documents,  neither the Borrower nor any of its Subsidiaries will be
in  violation  of (a)  any  law,  statute,  rule,  regulation  or  order  of any
Governmental  Authority  (including  Environmental Laws) applicable to it or its
properties or assets or (b) its certificate of incorporation or bylaws.
     (ii) Neither the Borrower  nor any of its  Subsidiaries  is in violation of
(A) any law, statute,  rule,  regulation or order of any Governmental  Authority
(including  Environmental  Laws) applicable to it or its properties,  except for
any violations  which could not reasonably be expected,  individually  or in the
aggregate,  to  have a  Material  Adverse  Effect,  or (B)  its  certificate  of
incorporation or bylaws.
     (iii) Each of the Borrower  and its  Subsidiaries  has all  authorizations,
consents, approvals,  registrations,  franchises,  licenses and permits, with or
from  Governmental  Authorities and other Persons as are necessary for it to own
its  properties  and conduct its  business as now  conducted  and the absence of
which could reasonably be expected,  individually or in the aggregate, to have a
Material Adverse Effect.
     (p)  Environmental  Protection.  To the  Borrower's  knowledge,  based upon
reasonable  investigation,  all real property owned or leased by the Borrower or
any of its Subsidiaries is free of  contamination  from any substance that could
result in the  incurrence  of  material  liabilities,  or  constituent  thereof,
currently   identified  or  listed  as  hazardous  or  toxic   pursuant  to  the
Comprehensive Environmental Response,  Compensation and Liability Act, 42 U.S.C.
9601, et seq., or any other Environmental Laws, or any other substance which has
in the past or could at any time in the  future  cause or  constitute  a health,
safety or environmental hazard to any person or property,  including asbestos in
any building, petroleum products, PCBs, pesticides, or radioactive materials. To
the  Borrower's  knowledge,  based upon  reasonable  investigation,  neither the
Borrower nor any of its Subsidiaries has caused or suffered to occur any release
of any Hazardous  Substance into the environment or any other  conditions  that,
individually or in the aggregate,  could reasonably be expected to result in the
incurrence  of  material   liabilities   or  any  material   violations  of  any
Environmental  Laws.  To  the  Borrower's   knowledge,   based  upon  reasonable
investigation,  neither the Borrower nor any of its  Subsidiaries  has caused or
suffered to occur any condition on any of their property that could give rise to
the imposition of any lien under the Environmental  Laws. Except as disclosed in
the  Disclosure  Package,  to the  Borrower's  knowledge,  based  on  reasonable
investigation,  neither  the  Borrower  nor any  Subsidiary  is  engaged  in any
manufacturing or any other operations,  other than the use of petroleum products
for  vehicles,  that  require  the use,  handling,  transportation,  storage  or
disposal of any Hazardous  Substance,  where such operations  require permits or
are otherwise regulated pursuant to the Environmental Laws.
     (q)  Insurance.  All of the  properties  and operations of the Borrower and
each  of its  Subsidiaries  of a  character  usually  insured  by  companies  of
established  reputation  engaged  in the same or a  similar  business  similarly
situated are adequately  insured,  by financially sound and reputable  insurers,
against loss or damage of the kinds and in amounts  customarily  insured against
by such Persons,  and the Borrower and each of its Subsidiaries carry, with such
insurers in customary  amounts,  such other  insurance as is usually  carried by
companies of established  reputation  engaged in the same or a similar  business
similarly situated.
     (r) Adverse  Contracts.  Except as  disclosed  in the  Disclosure  Package,
neither the Borrower nor any of its Subsidiaries is a party to, nor is it or any
of its  property  subject  to or bound by, any  agreement  or  instrument  which
restricts its ability to conduct its business,  or could reasonably be expected,
individually or in the aggregate, to have a Material Adverse Effect.
     (s)  Solvency.  The Borrower  and each of its  Subsidiaries  is and,  after
giving effect to Loans and the other transactions contemplated hereby, and after
payment of all estimated legal,  investment  banking,  accounting and other fees
related  thereto,  the  Borrower and each of its  Subsidiaries  will be Solvent.
Neither the Borrower nor any of its  Subsidiaries is and, after giving effect to
Loans and the other transactions  contemplated  hereby, and after payment of all
estimated legal, investment banking,  accounting and other fees related thereto,
the Borrower and each of its  Subsidiaries  will not be insolvent (as defined in
any of Uniform  Laws  Annotated,  Uniform  Fraudulent  Transfer  Act ss. 2 (West
1985);  Cal. Civ. Code ss.  3439.02 (West 1997);  and Del. Code ▇▇▇. tit. 6, ss.
1302 (1997)).
     (t)  Disclosure.   All   information   relating  to  the  Borrower  or  its
Subsidiaries  delivered  in  writing  to  the  Lender  in  connection  with  the
negotiation,  execution  and  delivery of this  Agreement  and the other  Credit
Documents,  taken  together  with the  information  set forth in the  Disclosure
Package,  is true and  complete in all material  respects.  There is no material
fact of which the Borrower is aware  which,  individually  or in the  aggregate,
would reasonably be expected adversely to influence the Lender's credit analysis
relating to the Borrower and its  Subsidiaries  which has not been  disclosed to
the Disclosure Package.
     Section  V.2  Survival.  All  representations  and  warranties  made by the
Borrower  in  this  Agreement,  and in the  certificates  or  other  instruments
prepared or delivered in connection  with or pursuant to this  Agreement,  shall
(i) be  considered  to have been  relied upon by the  Lender,  (ii)  survive the
making of Loans  regardless of any  investigation  made by, or on behalf of, the
Lender,  and (iii)  continue  in full force and  effect so long as any Loan,  or
other amount payable under any Credit Document remains unpaid.
                                   ARTICLE VI
                              Conditions Precedent
     Section  VI.1.  Conditions  to  the  Availability  of the  Commitment.  The
obligations of the Lender hereunder are subject to, and no Quarterly Loans shall
be made until the earliest time (the "Effective  Time") (which shall be no later
than the close of  business  in The City of New York on the fifth  Business  Day
following the Closing contemplated by that certain Equity Investment  Agreement,
dated as of January 15, 1999,  among the Borrower and certain  Affiliates of the
Lender)  on which each of the  following  conditions  precedent  shall have been
either satisfied or waived in writing by the Lender:
     (a) This  Agreement.  The  Agreement  shall  have  been duly  executed  and
delivered  by each of the Lender and the  Borrower  and each of the other Credit
Documents  shall have been duly  executed  and  delivered by each of the parties
thereto.
     (b)  Evidence of  Corporate  Action.  The Lender  shall have  received  the
following:
     (i) a copy of the  Certificate  of  Incorporation,  of the Borrower,  as in
effect on the Effective  Date,  certified by the Secretary of State of the State
of  Delaware,  and a  certificate  from such  Secretary  of State as to the good
standing  of the  Borrower,  in each case as of a date  reasonably  close to the
Effective Date; and
     (ii) a  certificate  of the  Secretary  or an  Assistant  Secretary  of the
Borrower,  dated the Effective Date, and stating (A) that attached  thereto is a
true and  complete  copy of the bylaws of the Borrower as in effect on such date
and at all  times  since the date of the  resolutions  described  in clause  (B)
below, (B) that attached thereto is a true and complete copy of resolutions duly
adopted by the Board of  Directors of the Borrower  authorizing  the  execution,
delivery and performance of this Agreement,  and that such  resolutions have not
been modified,  rescinded or amended and are in full force and effect,  (C) that
the certificate of  incorporation of the Borrower has not been amended since the
date of the last  amendment  thereto shown on the  certificate  of good standing
furnished  pursuant  to  clause  (i)  above,  and (D) as to the  incumbency  and
signature of each officer executing this Agreement or any document  delivered in
connection herewith on behalf of the Borrower.
     (c) Opinions of Counsel. The Lender shall have received a favorable written
opinion,  dated the  Effective  Date,  of Nida &  ▇▇▇▇▇▇▇  PC,  counsel  for the
Borrower, in substantially the form of Exhibit D.
     (d)  Representations  and Warranties.  The  representations  and warranties
contained in Section 5.01 shall be true and correct on the Effective  Date,  and
the Lender shall have received a certificate, signed by a Responsible Officer of
the Borrower, to that effect.
     (e)  Other   Documents.   The  Lender  shall  have   received   such  other
certificates, opinions and other documents as the Lender reasonably may require.
     Section VI.2.  Conditions to All Quarterly  Loans.  The obligations of each
Lender to make each Quarterly Loan are subject to the conditions precedent that,
on the date of each Quarterly Loan and after giving effect thereto,  each of the
following conditions  precedent shall have been satisfied,  or waived in writing
by the Lender:
     (a) Borrowing  Request.  The Lender shall have received a Borrowing Request
in accordance with the terms of this Agreement.
     (b) Note.  The Lender shall have  received a duly executed Note in the form
of Exhibit B, dated as of the Borrowing  Date and evidencing a Quarterly Loan in
an aggregate principal equal to the Borrowing Amount.
     (c) Warrant Certificate.  The Borrower shall have duly issued to the Lender
a number  of  Warrants  equal to the  Warrant  Number  in  connection  with such
Quarterly  Loan and shall  have duly  executed  and  delivered  to the  Lender a
Warrant Certificate evidencing such Warrants.
     (d) No Default.  No Default or Event of Default  shall have occurred and be
continuing,  nor shall any Default or Event of Default  occur as a result of the
making of such Quarterly Loan.
     (e)  Representations  and Warranties;  Covenants.  The  representations and
warranties  contained in Section 5.01 shall have been true and correct when made
and (except to the extent  that any  representation  or warranty  speaks as of a
date  certain)  shall be true and  correct on the  Borrowing  Date with the same
effect as though such representations and warranties were made on such Borrowing
Date;  and the  Borrower  shall  have  complied  with all of its  covenants  and
agreements under the Credit Documents.
     Section  VI.3.  Satisfaction  of  Conditions  Precedent.  Each  of (i)  the
delivery by the Borrower of a Borrowing  Request  (unless the Borrower  notifies
the Lender in writing to the contrary prior to the Borrowing  Date) and (ii) the
acceptance  of the proceeds of a Quarterly  Loan shall be deemed to constitute a
certification  by the  Borrower  that,  as of the  Borrowing  Date,  each of the
conditions  precedent  contained in Sections  6.02(d) and (e) has been satisfied
with respect to any Loans then being made.
                                   ARTICLE VII
                                    Covenants
     Section VII.1. Affirmative Covenants. Until satisfaction in full of all the
obligations of the Borrower under the Credit Documents, the Borrower will:
     (a) Financial Statements; Compliance Certificates. Furnish to the Lender:
     (i) as soon as available,  but in no event more than 60 days  following the
end of each of the first  three  quarters  of each  fiscal  year,  copies of the
Borrower's  Quarterly  Report on Form 10-Q being filed with the SEC, which shall
include a consolidated  balance sheet and  consolidated  income statement of the
Borrower and its Subsidiaries for such quarter;
     (ii) as soon as available, but in no event more than 100 days following the
end of each fiscal year,  a copy of the  Borrower's  Annual  Report on Form 10-K
being  filed  with the SEC,  which  shall  include  the  consolidated  financial
statements of the Borrower and its Subsidiaries,  together with a report thereon
by  Ernst  &  Young  LLP  (or  another  firm  of  independent  certified  public
accountants reasonably satisfactory to the Lender), for such year;
     (iii) together with each report delivered  pursuant to Sections  7.01(a)(i)
and (ii), a certificate  of the Borrower,  signed by a Responsible  Officer,  in
substantially the form of Exhibit E, stating whether, as of the last date of the
financial  statements  included  in such  report,  any  event  has  occurred  or
circumstance  existed which,  individually  or in the  aggregate,  constituted a
Default or Event of  Default  (and,  if so,  detailing  the facts  with  respect
thereto) and whether the Borrower was in compliance with the covenants set forth
in this Article VII,  together with  calculations  to establish  the  Borrower's
compliance with the covenants contained in Section 7.03;
     (iv)  promptly upon the filing by the Borrower with the SEC or any national
securities  exchange or national quotation system of any registration  statement
(other  than a  registration  statement  on Form S-8 or an  equivalent  form) or
regular  periodic  report  (other  than  the  reports  referred  to in  Sections
7.01(a)(i) and (ii)),  notification  of such filing;  and, at the request of any
Lender,  the  Borrower  shall  deliver  to such  Lender  a copy  of such  filing
(excluding exhibits);
     (v) promptly upon the mailing  thereof to the  shareholders of the Borrower
generally  copies of all financial  statements,  reports and proxy statements so
mailed;
     (vi) within five Business Days of any  Responsible  Officer of the Borrower
obtaining  knowledge of any Default or Event of Default of any type specified in
Section  8.01(a),  (b),  (d),  (f), (g), (h) or (l), if such Default or Event of
Default  is then  continuing,  a  certificate  of a  Responsible  Officer of the
Borrower  stating  that such  certificate  is a "Notice of Default"  and setting
forth  the  details  thereof  and the  action  which the  Borrower  is taking or
proposes to take with respect thereto;
     (vii) within ten Business Days of any  Responsible  Officer of the Borrower
obtaining  knowledge of any Default or Event of Default of any type specified in
Section  8.01(c),(e),  (i),  (j) or (k), if such  Default or Event of Default is
then continuing,  a certificate of a Responsible Officer of the Borrower stating
that such  certificate  is a "Notice of Default"  and setting  forth the details
thereof  and the action  which the  Borrower  is taking or proposes to take with
respect thereto; and
     (viii) such additional  information,  reports or statements,  regarding the
business,  financial  condition or results of operations of the Borrower and its
Subsidiaries, as the Lender from time to time may reasonably request.
     (b) Corporate Existence.  Except as permitted by Section 7.02(a), maintain,
and cause each Subsidiary to maintain,  its corporate existence in good standing
and qualify and remain  qualified to do business in each  jurisdiction  in which
the  character of the  properties  owned or leased by it therein or in which the
transaction of its business is such that the failure to qualify, individually or
in the  aggregate,  could  reasonably  be  expected  to have a Material  Adverse
Effect.
     (c)  Conduct  of  Business.   Engage  in  as  its  principal  business  the
development  of  photoselective  drugs and light  producing  and light  delivery
medical devices and related or ancillary  businesses,  including but not limited
to the businesses of the Borrower described in the Disclosure Package; preserve,
renew and keep in full force and effect,  and cause each of its  Subsidiaries to
preserve,  renew and keep in full force and effect,  all franchises and licenses
necessary  or  desirable  in the  normal  conduct  of its and its  Subsidiaries'
business  and  the  loss  of  which,  individually  or in the  aggregate,  could
reasonably be expected to have a Material Adverse Effect;  and comply, and cause
each of its Subsidiaries to comply, with all applicable laws, orders,  rules and
regulations of all Governmental Authorities the failure with which so to comply,
individually  or in the  aggregate,  could  reasonably  be  expected  to  have a
Material Adverse Effect.
     (d)  Authorizations.  Obtain,  make and keep in full  force and  effect all
authorizations from and registrations with Governmental Authorities required for
the validity or enforceability of the Credit Documents.
     (e) Taxes. Pay and discharge, and cause each of its Subsidiaries to pay and
discharge,  all taxes,  assessments and governmental charges upon it, its income
and its properties  prior to the date on which  penalties are attached  thereto,
except to the extent that (i) such taxes,  assessments and governmental  charges
shall be contested in good faith and by appropriate  proceedings by the Borrower
or such  Subsidiary,  as the case may be, (ii) unless the amount  thereof is not
material to the Borrower's  consolidated financial condition,  adequate reserves
are maintained (in accordance with GAAP) by the Borrower or such Subsidiary,  as
the  case may be,  with  respect  thereto,  and  (iii)  any  failure  to pay and
discharge such taxes,  assessments and governmental charges could not reasonably
be  expected,  individually  or in the  aggregate,  to have a  Material  Adverse
Effect.
     (f) Insurance.  Maintain,  and cause each of its  Subsidiaries to maintain,
insurance with reputable  insurance  companies against such risks, of such types
(including  general  liability),  on such  properties  and in such amounts as is
customarily  maintained by similar businesses similarly situated, and provide to
the Lender a certificate or  certificates  of insurance  showing that the Lender
has been named as loss payee by endorsement to the policies for such insurance.
     (g) Inspection.  Permit, and cause each of its Subsidiaries to permit, upon
no fewer  than five  Business  Days'  notice,  the Lender to have one or more of
their officers and employees,  or any other Person  designated by the Lender, to
visit and inspect any of the properties of the Borrower and such  Subsidiary and
to examine the minute books,  books of account and other corporate and financial
records of the Borrower and such Subsidiary,  and discuss its affairs,  finances
and accounts with its officers and with the Borrower's independent  accountants,
during normal business hours and at such other reasonable times, for the purpose
of monitoring the Borrower's compliance with its obligations under agreements to
which the Lender is a party and for no other purpose.
     (h) Maintenance of Records.  For the Borrower and each of its  Subsidiaries
(i) keep  proper  books of record and  account in which  entries  sufficient  to
provide  financial  statements  in  accordance  with  GAAP  will  be made of all
dealings or transactions of or in relation to its business and affairs; (ii) set
up on its books  reserves  with  respect  to all  taxes,  assessments,  charges,
reviews and claims;  and (iii) on a current basis, set up on its books, from its
earnings,  appropriate reserves against doubtful accounts  receivable,  advances
and  investments  and  all  other  proper  reserves   (including  by  reason  of
enumeration,  reserves for  premiums,  if any, due on required  prepayments  and
reserves for depreciation,  obsolescence, or amortization of properties),  which
should be set aside from such  earnings in connection  with its  business.  (All
determinations  pursuant to this  Section  7.01(h)  shall be made in  accordance
with, or as required by, GAAP.)
     (i) Maintenance of Property.  Maintain, keep and preserve and cause each of
its  Subsidiaries  to maintain,  keep and preserve all of its properties in good
repair, working order and condition and from time to time make all necessary and
proper repairs, renewals,  replacements, and improvements thereto, except to the
extent that any  failure so to  maintain,  keep and  preserve  such  properties,
individually  or in the  aggregate,  could not  reasonably be expected to have a
Material Adverse Effect.
     (j) ERISA. Furnish to the Lender:
     (i) within ten days after a Responsible Officer learns that any "reportable
event" (as defined in Section 4043(c) of ERISA),  other than a reportable  event
for  which the  30-day  notice  requirement  has been  waived  by the PBGC,  has
occurred with respect to a Pension Plan, a statement setting forth details as to
such reportable event and the action proposed to be taken with respect thereto;
     (ii) within ten days after receipt  thereof,  a copy of any notice that any
member of the ERISA Group may receive from the PBGC relating to the intention of
the PBGC to terminate any Pension Plan or to appoint a trustee to administer any
Plan;
     (iii) within ten days after filing with any affected party (as such term is
defined in Section  4001 of ERISA) of a notice of intent to  terminate a Pension
Plan,  a copy of such notice and a statement  setting  forth the details of such
termination,  including  the amount of  liability,  if any, of any member of the
ERISA Group under Title IV of ERISA;
     (iv)  within  ten days after the  adoption  of a  material  amendment  to a
Pension Plan if, after giving  effect to such  amendment,  the Pension Plan is a
plan  described  in Section  4021(b) of ERISA,  a  statement  setting  forth the
details thereof;
     (v) within 30 days after  withdrawal from a Pension Plan during a plan year
for which any member of the ERISA  Group  could be subject  to  liability  under
Section 4063 or 4064 of ERISA,  a statement  setting forth the details  thereof,
including the amount of such liability;
     (vi)  within 30 days after  cessation  of  operations  by any member of the
ERISA Group at a facility under the  circumstances  described in Section 4062(e)
of ERISA, a statement setting forth the details thereof, including the amount of
liability  of the  Borrower  or a member of the ERISA  Group  under  Title IV of
ERISA;
     (vii)  within ten days after  adoption of an  amendment  to a Pension  Plan
which would require security to be given to the Pension Plan pursuant to Section
401(a)(29)  of the Code or Section 307 of ERISA,  a statement  setting forth the
details thereof, including the amount of such security;
     (viii)  within ten days after  failure by any member of the ERISA  Group to
make  payment to a Pension  Plan which would give rise to a lien in favor of the
Plan under  Section  302(f) of ERISA,  a  statement  setting  forth the  details
thereof, including the amount of such lien;
     (ix) within ten days after the due date for filing with the PBGC,  pursuant
to  Section  412(n)  of the  Code,  of a notice of  failure  to make a  required
installment or other payment with respect to a Pension Plan, a statement setting
forth  details  as to such  failure  and the  action  proposed  to be taken with
respect thereto; and
     (x) within 30 days after  receipt  thereof by any member of the ERISA Group
from the sponsor of a Multiemployer  Plan, a copy of each notice  concerning the
imposition of withdrawal  liability or the  termination or  reorganization  of a
Multiemployer Plan.
     (k) Notice of Defaults and Adverse Developments. Promptly notify the Lender
upon the  discovery  by any  Responsible  Officer of the  occurrence  of (i) any
Default or Event of Default; (ii) any event, development or circumstance whereby
the financial  statements most recently  furnished to the Lender fail to present
fairly,  in all material  respects,  and in accordance  with GAAP, the financial
condition and operating  results of the Borrower and its  Subsidiaries as of the
date of such financial statements;  (iii) any material litigation or proceedings
that are instituted or threatened (to the knowledge of the Borrower) against the
Borrower or any of its Subsidiaries or any of their respective assets;  (iv) any
event,  development or  circumstance  which,  individually  or in the aggregate,
could  reasonably  be  expected to result in an event or default  (or,  with the
giving  of  notice  or lapse of time or both,  an event of  default)  under  any
Indebtedness  and  the  amount  hereof;  and (v) any  other  development  in the
business  or affairs of the  Borrower or any of its  Subsidiaries  if the effect
thereof would reasonably be expected,  individually or in the aggregate, to have
a Material  Adverse  Effect;  in each case describing the nature thereof and the
action the Borrower proposes to take with respect thereto.
     (l) Environmental  Matters.  (i) Comply, and cause each of its Subsidiaries
to comply, in all material respects with all applicable Environmental Laws, (ii)
notify the Lender promptly after becoming aware of any  Environmental  Claim, or
any fact or circumstance that is reasonably likely to result in an Environmental
Claim or a material  violation  of any  Environmental  Law,  with respect to the
Borrower's  or any of its  Subsidiaries'  properties  or  facilities,  and (iii)
promptly  forward to the Lender a copy of any material  order,  notice,  permit,
application,  or any other  communication  or report received in connection with
any such matters as they may affect such premises.
     Section VII.2.  Negative  Covenants.  Until satisfaction in full of all the
obligations of the Borrower under the Credit Documents, the Borrower will not:
     (a)  Mergers,  Consolidations  and Sales of Assets.  Enter into any merger,
consolidation or share exchange, or acquire assets of any Person, or sell, lease
or otherwise  dispose of any of its assets, or permit any of its Subsidiaries so
to do, except that (i) any such  Subsidiary may merge or consolidate (A) with or
into  the  Borrower,  if the  Borrower  shall  be the  continuing  or  surviving
corporation,  or (B) with or into any one or more Wholly Owned Subsidiary of the
Borrower,(ii)  the Borrower or any Subsidiary of the Borrower may make any Asset
Disposition to the extent permitted by Section 7.02(n) and (iii) the Borrower or
any Subsidiary of the Borrower may acquire assets for cash consideration  which,
together  with  all  other  cash  consideration  paid  by  the  Borrower  or any
Subsidiary  for  assets on or  following  the date of this  Agreement,  does not
exceed  *****,  and may acquire  assets in exchange  for shares of Common  Stock
having a market value at the time of issuance  which,  together  with the market
value at time of  issuance  of all other  shares of Common  Stock  issued by the
Borrower in consideration for or in connection with the acquisition of assets on
or following the date of this  Agreement,  does not exceed *****;  provided that
the amount of Indebtedness assumed or incurred by the Borrower or any Subsidiary
of the Borrower in connection with the acquisition of assets on or following the
date of this  Agreement  pursuant to this  Section  7.02(a)(iii)  may not exceed
****** of the sum of the cash  consideration  paid, and the market value at time
of issuance of Common Stock issued,  in consideration  therefor or in connection
therewith.
     *****Confidential Treatment Requested
     (b) Liens.  Create,  incur,  assume or suffer to exist any Lien, other than
Permitted Liens, upon or in any of its or any of its  Subsidiaries'  property or
assets, whether now owned or hereafter acquired.
     (c)   Indebtedness.   Create,   incur,   assume  or  suffer  to  exist  any
Indebtedness, or permit any of its Subsidiaries so to do, except:
     (i) Indebtedness to the Lender under the Credit Documents,
     (ii)  Indebtedness  of the Borrower or any of its  Subsidiaries  secured by
Liens specifically permitted by Section 7.02(b),
     (iii) Guaranties to the extent permitted by Section 7.02(d),
     (iv) Indebtedness existing on the date hereof,
     (v)  Indebtedness  of Borrower to any Subsidiary,  and  Indebtedness of any
Subsidiary to Borrower or any other Subsidiary, and
     (vi) Extension, refinancings, modifications, amendments and restatements of
any of items of Permitted  Indebtedness (i) through (v) above, provided that the
principal amount thereof is not increased.
     (d) Contingent Liabilities.  Assume, Guaranty, endorse,  contingently agree
to purchase or otherwise  become liable upon the obligation of any other Person,
or permit any of its Subsidiaries to do so, except:
     (i) in  connection  with a merger or  consolidation  permitted  by  Section
7.02(a),
     (ii) by the endorsement of negotiable instruments for deposit or collection
or similar transactions in the ordinary course of business,
     (iii) Guaranties by the Borrower of contractual obligations (other than for
the payment of Indebtedness) of any of its Wholly Owned Subsidiaries, and
     (iv) Guaranties existing on the date hereof, but not extensions thereof.
     (e)  Loans  and  Investments.  Make any  Investment  or  permit  any of its
Subsidiaries to do so, except:
     (i) Investments existing on the date hereof,
     (ii) Investments consisting of the endorsement of negotiable instrument for
deposit or collection or similar transaction in the ordinary course of business,
     (iii) Investments accepted in connection with asset dispositions  permitted
by Section 7.02(n),
     (iv)  Investments of the Borrower in or to  Subsidiaries of the Borrower or
of Subsidiaries  of the Borrower in or to other  Subsidiaries of the Borrower or
in or to the Borrower,
     (v) Investments  consisting of travel advances,  employee  relocation loans
and other employee loans and advances in the ordinary course of business,
     (vi) Investments consisting of loans to employees, officers or directors of
the Borrower or its  Subsidiaries  outstanding on the date of this Agreement and
not exceeding an aggregate principal balance of *****,  relating to the purchase
or equity  securities of the Borrower or its  Subsidiaries  pursuant to employee
stock purchase plans approved by the Borrower's Board of Directors,
     *****Confidential Treatment Requested
     (vii) Investments  consisting of loans to employees,  officers or directors
of the Borrower and its  Subsidiaries  made on or subsequent to the date of this
Agreement and not exceeding an aggregate  principal balance of ***** at any time
outstanding,
     *****Confidential Treatment Requested
     (viii)  Investments  in the form of debt  securities  or other  evidence of
Indebtedness of Ramus Medical Technologies acquired or received on or subsequent
to the date of this Agreement pursuant to agreements or instruments in effect on
the  date of this  Agreement  and  having  an  aggregate  principal  amount  not
exceeding *****,
     *****Confidential Treatment Requested
     (ix) *****
     *****Confidential Treatment Requested
     (x) Investments  (including debt  obligations)  received in connection with
the bankruptcy or  reorganization of customers or suppliers and in settlement of
delinquent  obligations  of, and other  disputes  with,  customers  or suppliers
arising in the ordinary course of business,
     (xi)  Investments  pursuant  to or arising  under  currency  agreements  or
interest rate agreements entered into in the ordinary course of business,
     (xii)  Investments  consisting of notes receivable of, or prepaid royalties
and other credit extensions,  to customers and suppliers made or received in the
ordinary course of business, and
     (xiii)   Investments  in  the  form  of  deposit  accounts  and  marketable
securities made pursuant to the cash management policy adopted by the Borrower's
Board  of  Directors  and  furnished  to the  Lender  prior  to the date of this
Agreement.
     (f) Capital Expenditures.  Make any Capital Expenditures,  or permit any of
its Subsidiaries to do so, exceeding ***** in the aggregate for the Borrower and
the Subsidiaries in any one calendar year;  provided that following the earliest
to occur of (i) *****
     *****Confidential Treatment Requested
     (g) Redemptions,  etc. Redeem,  defease (including but not limited to legal
or covenant defeasance),  repurchase,  retire or otherwise acquire or retire for
value  prior to any  scheduled  maturity,  repayment  or sinking  fund  payment,
Indebtedness,  other than Indebtedness to the Lender under the Credit Documents,
or permit any of its Subsidiaries to do so.
     (h)  Dividends  and Purchase of Stock.  Declare any  dividends  (other than
dividends  payable in capital  stock of the Borrower) on any shares of any class
of capital stock, or purchase,  acquire, redeem or retire, or apply any property
or assets to the purchase,  acquisition,  redemption  or  retirement  of, or set
apart  any  sum  for the  payment  of any  dividends  on,  or for the  purchase,
acquisition,  redemption or  retirement  of, or make any other  distribution  by
reduction  of capital  or  otherwise  in respect  of, any shares of any class of
capital  stock  of the  Borrower  or any of  its  Subsidiaries  or any  options,
warrants or rights to purchase or acquire  shares of any class of capital  stock
of the Borrower or any such Subsidiary,  or permit any of its Subsidiaries which
is not a Wholly Owned Subsidiary to do so, except that
     (i) the Borrower may purchase, redeem or otherwise acquire shares of Common
Stock  pursuant to any agreement  existing on the date hereof between it, or any
Subsidiary of the Borrower, and any officer, director, employee or consultant to
the Borrower or any of its  Subsidiaries,  in which the Borrower is obligated or
has the option to repurchase from such officer, director, employee or consultant
shares of Common  Stock upon such  Person's  termination  of  employment  or the
services with the Borrower or any such Subsidiary,
     (ii)  the  Borrower  may  convert,  exchange  or  redeem  any  Indebtedness
outstanding on the date hereof which by its terms is convertible or exchangeable
or constitutes the right to purchase any shares of any class of capital stock of
the Borrower,
     (iii)  *****
     *****Confidential Treatment Requested
     (iv) *****
     *****Confidential Treatment Requested
     (i) Stock of Subsidiaries.  Sell, pledge or otherwise dispose of any shares
of capital stock of any of its Subsidiaries  (except in connection with a merger
or  consolidation  of a Wholly Owned  Subsidiary  of the  Borrower  permitted by
Section  7.02(a) or with the  dissolution  of any Subsidiary of the Borrower) or
permit any of its  Subsidiaries to issue any additional  shares of capital stock
except pro rata to its stockholders.
     (j)  Distributions by  Subsidiaries.  Suffer to exist, or permit any of its
Subsidiaries  to suffer to exist,  any consensual  encumbrance or restriction on
the ability of any such Subsidiary (i) to pay, directly or indirectly, dividends
or make any other  distributions  in  respect  of its  capital  stock or pay any
Indebtedness or other obligation owed to the Borrower or any other Subsidiary of
the Borrower;  (ii) to make loans or advances to the Borrower or any  Subsidiary
of the  Borrower;  or (iii) to  transfer  any of its  property  or assets to the
Borrower.
     (k) Related  Agreements.  Amend,  modify or waive, or permit to be amended,
modified or waived, any provision of the Key Agreements unless,  within not less
than 30 days prior to such amendment, modification or waiver, the Borrower shall
have  given  the  Lender  notice  thereof,  including  all  relevant  terms  and
conditions thereof, and the Lender shall have consented in writing thereto.
     (l) Sale and  Leaseback  Transactions.  Enter  into,  or permit  any of its
Subsidiaries to enter into, any Sale and Leaseback Transaction.
     (m)  Transactions   with  Affiliates  and  Related  Persons.   Directly  or
indirectly  enter  into,  or  permit  any of its  Subsidiaries  to  directly  or
indirectly  enter  into,  on or  following  the  date  hereof,  any  transaction
(including,  without  limitation,  the  purchase,  sale,  lease or  exchange  of
property, the rendering of any service or the making of any loan or advance, but
excluding transactions between the Borrower and Wholly Owned Subsidiaries of the
Borrower)  with any  Affiliate  or Related  Person of the Borrower or any of its
Subsidiaries.
     (n) Asset  Dispositions.  Make any Asset Disposition,  or permit any of its
Subsidiaries to make any Asset Disposition, in one or more related transactions,
unless
     (i) the  Borrower  (or  such  Subsidiary,  as the  case  may  be)  receives
consideration  at the time of such disposition at least equal to the fair market
value of the shares or assets  disposed of (which shall be as determined in good
faith by the Board of Directors and evidenced by a resolution adopted thereby),
     (ii) the  consideration  for such  disposition  consists of cash or readily
marketable cash equivalents or the assumption of Indebtedness of the Borrower or
other obligations  relating to such assets and release from all liability on the
Indebtedness or other obligations assumed, and
     (iii)  ***** of the Net  Available  Asset  Disposition  Proceeds  from such
disposition (including from the sale of any marketable cash equivalents received
therein) are applied by the Borrower (or such  Subsidiary,  as the case may be),
within 48 hours of the  receipt  thereof,  to  prepayment  of Loans  pursuant to
Section 2.04.
     *****Confidential Treatment Requested
     (o) Securities Offerings.  Sell or offer to sell any securities,  or permit
any of its Subsidiaries to offer or sell any securities,  in one or more related
transactions, unless
     (i) the consideration for such disposition consists of cash, and
     (ii) ***** of the Net  Available  Securities  Offering  Proceeds  from such
offering or sale are applied by the  Borrower (or such  Subsidiary,  as the case
may be), within 48 hours of the receipt thereof, to prepayment of Loans pursuant
to Section 2.04.
     *****Confidential Treatment Requested
     (p) Surplus Cashflows. Fail to apply to the prepayment of Loans pursuant to
Section 2.04 at least ***** of the amount (the "Surplus") by which EBITDA in any
calendar quarter exceeds *****.
     *****Confidential Treatment Requested
     Section VII.3 Financial  Covenants.  Until  satisfaction in full of all the
obligations of the Borrower under the Credit Documents, the Borrower will not:
     (a) Shareholders' Equity. Permit Shareholders' Equity as of the last day of
any  calendar  quarter  designated  below to be less than the  amount  set forth
opposite such quarter below.
          Calendar quarter ending       Shareholders' Equity
          March 31, 1999                *****
          June 30, 1999                 *****
          September 30, 1999            *****
          December 31, 1999             *****
          March 31, 2000                *****
          June 30, 2000                 *****
          Each calendar quarter
          ending after June 30, 2000    *****
     *****Confidential Treatment Requested     
     (b)  Current  Ratio.   Permit  the  ratio  of  Current  Assets  to  Current
Liabilities to be less than ***** at any time.
     *****Confidential Treatment Requested
     (c) *****
     (d) *****
     *****Confidential Treatment Requested
                                  ARTICLE VIII
                                Events of Default
     Section VIII.1.  Events of Default.  If one or more of the following events
(each, an "Event of Default") shall occur:
     (a) the Borrower shall fail duly to pay any principal of any Loan when due,
whether at maturity, by notice of intention to prepay or otherwise; or
     (b) the  Borrower  shall  fail duly to pay any  interest,  fee or any other
amount  payable under the Credit  Documents  within five Business Days after the
same shall be due, in the manner set forth in this Agreement; or
     (c) the Borrower shall fail duly to observe or perform any term,  covenant,
or agreement contained in Section 7.02 or 7.03; or
     (d) the  Borrower  shall fail duly to observe  or perform  any other  term,
covenant or agreement  contained in this Agreement,  and such failure shall have
continued  unremedied  for a period of 30 days  following  written notice to the
Borrower thereof; or
     (e) any representation or warranty made or deemed made by the Borrower in a
Credit  Document,  or any statement or  representation  made in any certificate,
report or opinion delivered by or on behalf of the Borrower in connection with a
Credit  Document,  shall prove to have been false or  misleading in any material
respect when so made or deemed made; or
     (f)  the  Borrower  or  any  of  its  Subsidiary  shall  fail  to  pay  any
Indebtedness  (other than  obligations  hereunder) in an amount of ***** or more
when  due;  or any  such  Indebtedness  having  an  aggregate  principal  amount
outstanding  of ***** or more shall become or be declared to be due prior to the
expressed maturity thereof; or
     *****Confidential Treatment Requested
     (g) an involuntary case or other proceeding shall be commenced  against the
Borrower or any of its Subsidiaries seeking liquidation, reorganization or other
relief  with  respect  to it or  its  debts  under  any  applicable  bankruptcy,
insolvency,  reorganization  or similar  law or  seeking  the  appointment  of a
custodian,  receiver,  liquidator,  assignee,  trustee,  sequestrator or similar
official of it or any  substantial  part of its property,  and such  involuntary
case or other proceeding  shall remain  undismissed and unstayed for a period of
more  than 60 days;  or an order or  decree  approving  or  ordering  any of the
foregoing shall be entered and continued unstayed and in effect; or
     (h) the Borrower or any of its Subsidiaries shall commence a voluntary case
or proceeding under any applicable  bankruptcy,  insolvency,  reorganization  or
similar  law or any other case or  proceeding  to be  adjudicated  a bankrupt or
insolvent,  or any of them  shall  consent to the entry of a decree or order for
relief in respect of the Borrower or any such Subsidiary in an involuntary  case
or proceeding under any applicable  bankruptcy,  insolvency,  reorganization  or
other similar law or to the commencement of any bankruptcy or insolvency case or
proceeding  against any of them,  or any of them shall file a petition or answer
or consent seeking  reorganization or relief under any applicable law, or any of
them shall  consent to the filing of such petition or to the  appointment  of or
taking  possession  by a custodian,  receiver,  liquidator,  assignee,  trustee,
sequestrator  or similar  official of the Borrower or any such Subsidiary or any
substantial  part of their  respective  property,  or any of them  shall make an
assignment  for the benefit of creditors,  or any of them shall admit in writing
its inability to pay its debts  generally as they become due, or the Borrower or
any Subsidiary shall take corporate action in furtherance of any such action; or
     (i) one or more judgments  against the Borrower or any of its  Subsidiaries
or attachments against its property, which in the aggregate exceed *****, or the
operation or result of which could be to interfere materially and adversely with
the  conduct of the  business  of the  Borrower  or any such  Subsidiary  remain
unpaid, unstayed on appeal, undischarged,  unbonded, or undismissed for a period
of more than 30 days; or
     *****Confidential Treatment Requested
     (j) notice of intent to terminate a Pension Plan shall have been filed with
any  affected  party (as  defined  in Section  4001 of  ERISA),  or notice of an
application  by the PBGC to  institute  proceedings  to terminate a Pension Plan
pursuant to Section 4042 of ERISA shall have been  received by any member of the
ERISA Group, in each case only if the amount of unfunded benefit liabilities (as
defined in Section  4001(a)(18) of ERISA) as of the date such notice is filed or
received exceeds $500,000;  any member of the ERISA Group incurs liability under
Sections  4062(e),  4063 or 4064 of ERISA in  respect  of a  Pension  Plan in an
amount in excess of $1,000,000;  an amendment is adopted to a Pension Plan which
would  require  security to be given to such  Pension  Plan  pursuant to Section
401(a)(29)  of the Code or  Section  307 of  ERISA in an  amount  in  excess  of
$1,000,000;  any member of the ERISA  Group fails to make a payment to a Pension
Plan which would give rise to a Lien in favor of such Plan under Section  302(f)
of ERISA in an amount in excess of $500,000; or
     (k) any court or governmental  or regulatory  authority shall have enacted,
issued,  promulgated,   enforced  or  entered  any  statute,  rule,  regulation,
judgment,  decree, injunction or other order (whether temporary,  preliminary or
permanent)  which  is in  effect  and  which  prohibits,  enjoins  or  otherwise
restricts, in a manner that, individually or in the aggregate,  could reasonably
be  expected  to  have a  Material  Adverse  Effect,  any  of  the  transactions
contemplated under the Credit Documents; or
     (l) any person or group of persons  (within the meaning of Section 13 or 14
of the Securities  Exchange Act of 1934, as amended),  other than the Lender and
its  Affiliates  and  other  than  any  person  or group of  persons  which  has
beneficial  ownership of 5% or more of the outstanding shares of Common Stock as
of the date of this Agreement,  shall have acquired beneficial ownership (within
the meaning of Rule 13d-3 promulgated by the Securities and Exchange  Commission
under said Act) of 19.9% or more of the outstanding  shares of Common Stock; or,
during  any  period of 24  consecutive  calendar  months,  individuals  who were
directors  of the  Borrower  on the  first  day of such  period  shall  cease to
constitute a majority of the board of directors of the  Borrower;  then,  and at
any time during the  continuance  of such Event of  Default,  the Lender may, by
written  notice to the Borrower  declare any Loans then  outstanding  to be due,
whereupon  the  principal  of the Loans so  declared  to be due,  together  with
accrued  interest  thereon  and any  unpaid  amounts  accrued  under the  Credit
Documents,  shall become forthwith due, without presentment,  demand, protest or
any other  notice of any kind (all of which are hereby  expressly  waived by the
Borrower).
     Section VIII.2.  Assignments.  (a) Upon reasonable prior notice having been
given to the  Borrower,  the Lender may at any time assign to one or more of The
Pharmacia & Upjohn  Company,  Pharmacia & Upjohn B.V.,  Pharmacia & Upjohn AB or
Pharmacia & Upjohn S.p.A. (any such entity, an "Approved  Subsidiary") all, or a
proportionate  part of all, of its rights and obligations  under this Agreement,
and such Approved Subsidiary shall assume such rights and obligations,  pursuant
to a written instrument  executed by such Approved Subsidiary and the Lender. If
there shall have occurred an Event of Default that is continuing, the Lender may
assign to any Person,  other than a Person  which  engages in, as its  principal
business or one of its principal  businesses,  the development of photoselective
drugs or light producing and light delivery  medical devices (any such assignee,
or any Approved  Subsidiary  referred to in the previous sentence being referred
to as an  "Assignee"),  all, or a  proportionate  part of all, of its rights and
obligations under this Agreement, and such Assignee shall assume such rights and
obligations,  pursuant to a written instrument executed by such Assignee and the
Lender.  Any such  Assignee  shall have all the rights  and  obligations  of the
Lender,  and the Lender shall be released  from its  obligations  hereunder to a
corresponding  extent,  and no further  consent or action by any party  shall be
required.
     (b) No Assignee  of the  Lender's  rights  shall be entitled to receive any
greater  payment  under  Section  4.03 or 4.04 than the  Lender  would have been
entitled to receive with respect to the rights transferred,  and amounts payable
under this Agreement  shall not be increased in respect of any Taxes required to
be withheld or deducted  solely as a  consequence  of the  Lender's  status as a
nonresident alien, as such term is defined in the Code.
     Section VIII.3.  Certain  Pledges.  Notwithstanding  any other provision in
this  Agreement,  any Lender may at any time create a security  interest  in, or
pledge,  all or any portion of its rights under this Agreement and any Note held
by it in favor of any Person.
                                   ARTICLE IX
                                  Miscellaneous
     SECTION  IX.1.  APPLICABLE  LAW.  THIS  AGREEMENT  SHALL BE GOVERNED BY AND
CONSTRUED IN  ACCORDANCE  WITH THE LAWS OF THE STATE OF NEW YORK  APPLICABLE  TO
CONTRACTS MADE AND TO BE PERFORMED ENTIRELY WITHIN SUCH STATE.
     SECTION  IX.2.  WAIVER OF JURY.  THE  BORROWER  AND THE LENDER  EACH HEREBY
WAIVES  TRIAL  BY  JURY  IN  ANY  JUDICIAL  PROCEEDING  INVOLVING,  DIRECTLY  OR
INDIRECTLY,  ANY MATTER (WHETHER SOUNDING IN TORT, CONTRACT OR OTHERWISE) IN ANY
WAY ARISING OUT OF, RELATED TO, OR CONNECTED WITH THIS  AGREEMENT,  THE NOTES OR
THE RELATIONSHIPS ESTABLISHED HEREUNDER.
     Section IX.3.  Jurisdiction and Venue; Service of Process. (a) The Borrower
and the Lender each hereby irrevocably submits to the non-exclusive jurisdiction
of any state or federal court in the Borough of Manhattan,  The City of New York
for the  purpose of any suit,  action,  proceeding  or  judgment  relating to or
arising out of any Credit  Document and to the laying of venue in the Borough of
Manhattan,  The City of New  York.  The  Borrower  and the  Lender  each  hereby
irrevocably  waives,  to the fullest  extent  permitted by  applicable  law, any
objection  to the  laying of the venue of any such  suit,  action or  proceeding
brought in the aforesaid courts and hereby irrevocably waives any claim that any
such suit, action or proceeding brought in any such court has been brought in an
inconvenient forum.
     (b) The  Borrower  agrees  that  service of  process in any such  action or
proceeding  may be effected by mailing a copy thereof by registered or certified
mail (or any  substantially  similar  form of  mail),  postage  prepaid,  to the
Borrower at its address  set forth in Section  9.07 or at such other  address of
which the Lender shall have been notified pursuant thereto. The Borrower further
agrees that nothing  herein shall affect the right to effect  service of process
in any other  manner  permitted by law or shall limit the right to ▇▇▇ any other
jurisdiction.
     (c) Each of the Borrower and the Lender  waives,  to the maximum extent not
prohibited by law, any right it may have to claim or recover in any legal action
or proceeding referred to in this Section 9.03 any special, exemplary,  punitive
or  consequential  damages.  The waiver set forth in this Section  9.03(c) shall
terminate  automatically  upon the occurrence of a "Separation Event" as defined
in that certain  stockholder rights protection plan of Pharmacia & Upjohn,  Inc.
in effect on the date of this Agreement, as it may from time to time be amended.
     Section IX.4.  Set-off.  The Borrower hereby authorizes the Lender and each
of its  Affiliates,  upon the  occurrence of an Event of Default and at any time
and from time to time during the  continuance  thereof,  to the  fullest  extent
permitted  by law, to set-off and apply any and all sums  payable by such Lender
or any such Affiliate to or for the credit or the account of the Borrower or any
of its Affiliates  against any of the  obligations of the Borrower or any of its
Affiliates, now or hereafter existing under any Credit Document, irrespective of
whether the Lender shall have made any demand under this  Agreement and although
such  obligations may be unmatured.  The rights of the Lender and its Affiliates
under this Section 9.04 are in addition to other rights and remedies  (including
other rights of set-off) which the Lender and its Affiliates may have.
     Section IX.5.  Amendments and Waivers.  (a) Any provision of this Agreement
may be  amended,  modified,  supplemented  or  waived,  but  only  by a  written
amendment  or  supplement,  or written  waiver,  signed by the  Borrower and the
Lender.
     (b) Except to the extent  expressly set forth therein,  any waiver shall be
effective only in the specific  instance and for the specific  purpose for which
such waiver is given.
     Section IX.6. Cumulative Rights; No Waiver. Each and every right granted to
the  Lender  hereunder  or under  any other  document  delivered  in  connection
herewith,  or allowed the Lender by law or equity,  shall be cumulative  and not
exclusive and may be exercised  from time to time. No failure on the part of the
Lender to  exercise,  and no delay in  exercising,  any right will  operate as a
waiver  thereof,  nor will any single or partial  exercise  by the Lender of any
right preclude any other or future exercise thereof or the exercise of any other
right.
     Section IX.7. Notices. (a) Any communication,  demand or notice to be given
hereunder will be duly given when delivered in writing or by telecopy to a party
at its  address  as  indicated  below or such  other  address  as such party may
specify in a notice to each  other  party  hereto.  A  communication,  demand or
notice given pursuant to this Section 9.07 shall be addressed:
     If to the Borrower, to
                           Miravant Medical Technologies
                           ▇▇▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇
                           ▇▇▇▇▇ ▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
                           Telecopy:  (▇▇▇) ▇▇▇-▇▇▇▇
                           Attention:  ▇▇▇▇ ▇. ▇▇▇▇▇▇▇
     with copies (which, in and of themselves, shall not constitute notice) to
                           Nida & ▇▇▇▇▇▇▇ PC
                           ▇▇▇ ▇▇▇▇▇▇▇ ▇▇▇▇▇▇
                           ▇▇▇▇▇ ▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
                           Telecopy:  (▇▇▇) ▇▇▇-▇▇▇▇
                           Attention:  ▇▇▇▇▇▇ ▇. ▇▇▇▇
     and
                           ▇▇▇▇▇▇ ▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇ & ▇▇▇▇▇▇
                           ▇▇▇ ▇▇▇▇ ▇▇▇▇ ▇▇▇▇
                           ▇▇▇▇ ▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
                           Telecopy:  (▇▇▇) ▇▇▇-▇▇▇▇
                           Attention:  ▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇
     If to the Lender, to
                           Pharmacia & Upjohn, Inc.
                           ▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
                           ▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
                           Telecopy:  (▇▇▇) ▇▇▇-▇▇▇▇
                           Attention:  Treasurer
     and
                           Pharmacia & Upjohn, Inc.
                           ▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
                           ▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
                           Telecopy:    (▇▇▇) ▇▇▇-▇▇▇▇
                         Attention:Senior Vice President of Business Development
     and
                           Pharmacia & Upjohn, Inc.
                           ▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
                           ▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
                           Telecopy:            (▇▇▇) ▇▇▇-▇▇▇▇
                           Attention:           General Counsel
     with a copy (which, in and of itself, shall not constitute notice) to
                           ▇▇▇▇▇▇▇▇ & ▇▇▇▇▇▇▇▇
                           ▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇
                           ▇▇▇ ▇▇▇▇, ▇▇▇ ▇▇▇▇ ▇▇▇▇▇
                           Telecopy:  (▇▇▇) ▇▇▇-▇▇▇▇
                           Attention:  ▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇,
                                              ▇▇▇▇▇▇▇ ▇. ▇▇▇▇
                                              and ▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇
     This Section  9.07 shall not apply to notices  referred to in Article II of
this Agreement, except to the extent set forth therein.
     (b) Unless otherwise  provided to the contrary herein,  any notice which is
required to be given in writing  pursuant to the terms of this  Agreement may be
given by telecopy.
     Section IX.8.  Certain  Acknowledgments.  The Borrower  hereby confirms and
acknowledges that the Lender does not have any fiduciary or similar relationship
to the Borrower and that the  relationship  established by the Credit  Documents
between the Lender and the  Borrower  is solely that of creditor  and debtor and
(b) that no joint venture exists between the Borrower and the Lender.
     Section  IX.9.  Separability.  In case  any  one or more of the  provisions
contained in any Credit Document shall be invalid,  illegal or  unenforceable in
any respect  under any law, the  validity,  legality and  enforceability  of the
remaining  provisions contained herein or in any other Credit Document shall not
in any way be affected or impaired thereby.
     Section IX.10.  Parties in Interest.  This Agreement  shall be binding upon
and inure to the  benefit of the  Borrower  and the Lender and their  respective
successors  and  assigns,  except  that the  Borrower  may not assign any of its
rights  hereunder  without  the prior  written  consent of the  Lender,  and any
purported assignment by the Borrower without such consent shall be void.
     Section IX.11. Execution in Counterparts. This Agreement may be executed in
any number of  counterparts  and by the  different  parties  hereto on  separate
counterparts, each of which when so executed and delivered shall be an original,
but all the counterparts shall together constitute one and the same instrument.
     IN WITNESS  WHEREOF,  the parties  hereto have caused this  Agreement to be
duly executed as of the date first above written.
                                            MIRAVANT MEDICAL TECHNOLOGIES
                                            By:________________________________
                                               Name:
                                               Title:
                                       
                                            By:________________________________
                                               Name:
                                               Title:
                          Subsidiaries of the Borrower
                                                                     Exhibit A
                                             Form of Borrowing Request
                                                            [Date]*
Pharmacia & Upjohn, Inc.
▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
Attention:  Treasurer
                                                 Borrowing Request
Ladies and Gentlemen:
     Reference is made to the Credit Agreement, dated as of o, 1999 (as amended,
modified or  supplemented  from time to time, the "Credit  Agreement"),  between
Miravant  Medical  Technologies  and o.  Capitalized  terms used  herein and not
otherwise  defined herein shall have the meanings  ascribed to such terms in the
Credit Agreement.
     The Borrower  hereby gives you notice,  pursuant to Section  2.02(a) of the
Credit Agreement,  that it requests a Quarterly Loan in a principal amount equal
to the Borrowing  Amount set forth below,  to be made on the Borrowing  Date set
forth below.
                  Borrowing Date:**                           _________, ____
                  Borrowing Amount:***                           $___________
                                     A-4
                  Warrant Number:****                          ___________
     A duly  executed  Note in the form of  Exhibit B to the  Credit  Agreement,
dated as of the Borrowing  Date set forth above and  evidencing a Quarterly Loan
in a  principal  amount  equal to the  Borrowing  Amount  set  forth  above,  is
enclosed.
     A duly executed Warrant  Certificate  evidencing a number of Warrants equal
to the Warrant  Number is enclosed.  The Exercise Price for each such Warrant is
$______,  and the closing bid prices for the 10 Trading Days  preceding this bid
request and a calculation of the Exercise Price are set out below.  The Exercise
Price is the sum of [A] plus [B].
                  Trading Day                        Closing Bid Price
          1.                                                  $
          2.
          3.
          4.
          5.
          6.
          7.
          8.
          9.
         10.                                                           
                                            Total    ____________________
                                            / 10     ____________________ [A]
                                            x 0.40   ____________________ [B]
                                        [A]+[B]      ____________________
                                            Very truly yours,
                                            MIRAVANT MEDICAL TECHNOLOGIES
                                            By:                                
                                               Name:
                                               Title:
                                  Form of Note
                                 PROMISSORY NOTE
$[Principal Amount]                                                    [Date]
                  MIRAVANT  MEDICAL  TECHNOLOGIES,  a Delaware  corporation (the
"Borrower"),  for  value  received,  promises  to  pay to  the  order  of o (the
"Lender"), on [MATURITY DATE], the principal sum of $[PRINCIPAL AMOUNT] pursuant
to and in the manner contemplated by that certain Credit Agreement,  dated as of
o, 1999 (as amended,  modified or  supplemented  from time to time,  the "Credit
Agreement"), between the Borrower and the Lender.
                  The  Borrower  also  promises  to pay  interest  on the unpaid
principal  amount  hereof  from time to time  outstanding,  from the date hereof
until the date of  repayment,  at the rate or rates per annum and on the date or
dates determined pursuant to the Credit Agreement.
                  Payments  of both  principal  and  interest  are to be made in
lawful money of the United States of America in funds  immediately  available to
the Lender at its office or offices  designated  in  accordance  with the Credit
Agreement,  or, if and only if specifically  permitted by Section 2.01(b) of the
Credit Agreement, in the manner set forth in such Section 2.01(b).
                  All  parties  hereto,   whether  as  makers,   endorsers,   or
otherwise, severally waive diligence, presentment, demand, protest and notice of
any kind whatsoever. The failure or forbearance by the holder to exercise any of
its rights  hereunder in any particular  instance shall in no event constitute a
waiver thereof.
                  The Credit Agreement,  among other things, contains provisions
for the acceleration of the maturity hereof upon the happening of certain events
and for the amendment or waiver of certain  provisions  of the Credit  Agreement
and/or  this  Note,  all  upon  the  terms  and  conditions  therein  specified.
Capitalized  terms  used and not  otherwise  defined  herein  have the  meanings
ascribed thereto in the Credit Agreement.
                  THIS NOTE HAS BEEN  DELIVERED IN NEW YORK,  NEW YORK AND SHALL
BE DEEMED TO BE A CONTRACT  MADE UNDER,  GOVERNED BY AND CONSTRUED IN ACCORDANCE
WITH THE LAWS OF THE STATE OF NEW YORK.
                         B-[PG NUMBER]
                  This Note is not  negotiable and may be assigned only upon the
terms and conditions specified in the Credit Agreement.
                          MIRAVANT MEDICAL TECHNOLOGIES
                                                     By:                      
                                                        Name:
                                                        Title:
                                                                        
                                 Exhibit C
                   Form of Opinion of Counsel for the Borrower
                     to be Delivered Upon Payment of Shares
                                                      [TO COME]
                       Form of Opinion of Counsel for the
                 Borrower to be Delivered at the Effective Time
                                    [Effective Date]
Pharmacia & Upjohn, Inc.
▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇
▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇
Ladies and Gentlemen:
                  In connection  with the  execution  and delivery  today of the
Credit Agreement, dated as of o, 1999 (the "Credit Agreement"), between Miravant
Medical  Technologies,  Inc., a Delaware corporation (the "Borrower"),  and o, a
Swedish corporation (the "Lender"), the Security Agreement,  dated as of o, 1999
(the "Security  Agreement"),  among the Borrower,  as debtor, and the Lender, as
Secured Party, and [add references to other Credit Documents] (collectively with
the Credit Agreement and the Security Agreement, the "Credit Documents"), we, as
counsel for the Borrower, have examined such corporate records, certificates and
other documents,  and such questions of law, as we have considered  necessary or
appropriate  for  the  purposes  of  this  opinion.   Upon  the  basis  of  such
examination, it is our opinion that:
                  (1) The Borrower has been duly incorporated and is an existing
         corporation in good standing under the laws of the State of Delaware.
                  (2) Each of the  Credit  Documents  has been duly  authorized,
         executed and delivered, and, if and when duly executed and delivered in
         accordance  with the terms of the Credit  Agreement,  any Notes will be
         duly  authorized,  executed and delivered by the Borrower;  and each of
         the Credit Documents (other than any Notes) constitutes,  and each Note
         (if and when duly executed and  delivered in accordance  with the terms
         of the Credit Agreement) will constitute, the valid and legally binding
         obligation  of  the  Borrower   enforceable  in  accordance   with  its
         respective  terms,  subject  to  bankruptcy,   insolvency,   fraudulent
         transfer,  reorganization,  moratorium  and  similar  laws  of  general
         applicability relating to or affecting creditors' rights and to general
         equity principles.
                             D-[PG NUMBER]
                  (3)  [Opinion on the Warrants and Exercise Shares]
                  (4) All  regulatory  consents,  authorizations,  approvals and
         filings  required  to be  obtained  or made by the  Borrower  under the
         Federal laws of the United States and the laws of the State of New York
         for the  borrowing  by the  Borrower  from the Lender  under the Credit
         Agreement,  the execution and delivery of each of the Credit  Documents
         to the Lender and the  performance  by the  Company of its  obligations
         thereunder have been obtained or made; provided, however, that, insofar
         as  performance  by the Borrower of its  obligations  under each of the
         Credit Documents is concerned,  we express no opinion as to bankruptcy,
         insolvency, fraudulent transfer, reorganization, moratorium and similar
         laws of  general  applicability  relating  to or  affecting  creditors'
         rights or as to general equity principles.
                  (5) The Borrower is not an  "investment  company" or a company
         "controlled"  by an  "investment  company"  within  the  meaning of the
         Investment Company Act of 1940.
                  For  purposes  of this  letter,  terms  defined  in the Credit
Agreement have the meanings set forth therein.
                  The  foregoing  opinion is limited to the Federal  laws of the
United  States and the laws of the State of New York,  and we are  expressing no
opinion as to the effect of the laws of any other jurisdiction.
                  With your  approval,  we have relied as to certain  matters on
information  obtained from public officials,  officers of the Borrower and other
sources  believed by us to be responsible,  and we have assumed that each of the
Credit Documents has been duly authorized, executed and delivered by the parties
thereto other than the Borrower and its  Affiliates,  and that the signatures on
all  documents  examined  by us are  genuine,  assumptions  which  we  have  not
independently verified.
                  This letter is  delivered by us as counsel for the Borrower to
you, and is solely for your benefit.
                                                     Very truly yours,
                                                     NIDA & ▇▇▇▇▇▇▇ PC
                         Form of Compliance Certificate
                             COMPLIANCE CERTIFICATE
                    [For the Fiscal Quarter ending ________]
                      [For the Fiscal Year ending ________]
                  Reference is made to the Credit Agreement, dated as of o, 1999
(as  amended,   modified  or  supplemented   from  time  to  time,  the  "Credit
Agreement"),  between  Miravant  Medical  Technologies  (the  "Borrower") and o.
Pursuant  to Section  7.01(a)(iii)  of the  Credit  Agreement,  the  undersigned
Responsible  Officer of the Borrower hereby  certifies on behalf of the Borrower
that:
                  (a)  During  the period of four  consecutive  fiscal  quarters
ended on ____________, __, such Responsible Officer has obtained no knowledge of
any Default or Event of Default except as follows: [Specify with particularity].
                  The financial statements referred to in Section 7.01(a) of the
Credit  Agreement  which are  delivered  concurrently  with the delivery of this
Compliance  Certificate  fairly  present  the  financial  position,  results  of
operations,  cash flows and changes in shareholders'  equity of the Borrower and
its  Subsidiaries,  subject to normal year-end audit  adjustments  which are not
expected to be material in amount.*
                  (b) The covenant calculations set forth below are based on the
Borrower's  [audited]  balance sheet and statements of earnings,  cash flows and
shareholders'  equity for the fiscal  [quarter] [year] ended  ___________,  ____
(the "Period-End Date").
[Insert calculations demonstrating compliance with Section 7.03 of the Credit 
Agreement]
         IN WITNESS  WHEREOF,  on behalf of the Borrower,  the  undersigned  has
hereto set his or her hand.
Dated:_________, ___
                                            MIRAVANT MEDICAL TECHNOLOGIES
                                            By: _______________________________
                                                A Responsible Officer
                                CREDIT AGREEMENT
                                   dated as of
                                     o, 1999
                                     between
                          MIRAVANT MEDICAL TECHNOLOGIES
                                       and
                                        o
                                        -vii-
                                                  TABLE OF CONTENTS
                                                                              
                                                                                                               
                              ARTICLE IDefinitions
Section 1.01.  Definitions........................................................................................1
         (a)      Terms Generally.................................................................................1
         (b)      Accounting Terms................................................................................2
         (c)      Other Terms.....................................................................................2
                          ARTICLE IIThe Credit Facility
Section 2.01.  Loans.............................................................................................15
Section 2.02.  Borrowing Procedure...............................................................................16
Section 2.03.  Repayment.........................................................................................16
Section 2.04.  Prepayment........................................................................................17
                               ARTICLE IIIInterest
Section 3.01.  Interest on Loans.................................................................................18
Section 3.02.  Interest on Overdue Amounts.......................................................................19
Section 3.03.  Day Counts........................................................................................19
Section 3.04.  Maximum Interest Rate.............................................................................19
                       ARTICLE IVDisbursement and Payment
Section 4.01.  Method and Time of Payments.......................................................................20
               ---------------------------
Section 4.02.  Compensation for Losses...........................................................................20
               -----------------------
Section 4.03.  Withholding.......................................................................................21
               -----------
Section 4.04.  Expenses; Indemnity...............................................................................21
               -------------------
Section 4.05.  Survival..........................................................................................22
               --------
                     ARTICLE VRepresentations and Warranties
Section 5.01.  Representations and Warranties....................................................................23
               ------------------------------
         (a)      Subsidiaries...................................................................................23
                  ------------
         (b)      Good Standing and Power........................................................................23
                  -----------------------
         (c)      Corporate Authority............................................................................23
                  -------------------
         (d)      Authorizations.................................................................................23
                  --------------
         (e)      Binding Obligation.............................................................................23
                  ------------------
         (f)      Litigation.....................................................................................24
                  ----------
         (g)      No Conflicts...................................................................................24
                  ------------
         (h)      Financial Condition............................................................................24
                  -------------------
         (i)      Taxes..........................................................................................25
                  -----
         (j)      Use of Proceeds................................................................................25
                  ---------------
         (k)      Margin Regulations.............................................................................25
                  ------------------
         (l)      Compliance with ERISA..........................................................................25
                  ---------------------
         (m)      Not an Investment Company......................................................................26
                  -------------------------
         (n)      Properties.....................................................................................26
                  ----------
         (o)      Compliance with Laws and Charter Documents.....................................................26
                  ------------------------------------------
         (p)      Environmental Protection.......................................................................27
                  ------------------------
         (q)      Insurance......................................................................................28
                  ---------
         (r)      Adverse Contracts..............................................................................28
                  -----------------
         (s)      Solvency.......................................................................................28
                  --------
         (t)      Disclosure.....................................................................................28
                  ----------
Section 5.02  Survival...........................................................................................29
                         ARTICLE VIConditions Precedent
Section 6.01.  Conditions to the Availability of the
                           Commitment............................................................................29
                           ----------
         (a)      This Agreement.................................................................................29
                  --------------
         (b)      Evidence of Corporate Action...................................................................29
                  ----------------------------
         (c)      Opinions of Counsel............................................................................30
                  -------------------
         (d)      Representations and Warranties.................................................................30
                  ------------------------------
         (e)      Other Documents................................................................................30
                  ---------------
Section 6.02.  Conditions to All Quarterly Loans.................................................................30
               ---------------------------------
         (a)      Borrowing Request..............................................................................30
                  -----------------
         (b)      Note...........................................................................................30
                  ----
         (c)      Warrant Certificate............................................................................30
                  -------------------
         (d)      No Default.....................................................................................31
                  ----------
         (e)      Representations and Warranties; Covenants......................................................31
                  -----------------------------------------
Section 6.03.  Satisfaction of Conditions Precedent..............................................................31
                              ARTICLE VIICovenants
Section 7.01.  Affirmative Covenants.............................................................................31
               ---------------------
         (a)      Financial Statements; Compliance Certificates..................................................31
                  ---------------------------------------------
         (b)      Corporate Existence............................................................................33
                  -------------------
         (c)      Conduct of Business............................................................................33
                  -------------------
         (d)      Authorizations.................................................................................33
                  --------------
         (e)      Taxes..........................................................................................34
                  -----
         (f)      Insurance......................................................................................34
                  ---------
         (g)      Inspection.....................................................................................34
                  ----------
         (h)      Maintenance of Records.........................................................................34
                  ----------------------
         (i)      Maintenance of Property........................................................................35
                  -----------------------
         (j)      ERISA..........................................................................................35
                  -----
         (k)      Notice of Defaults and Adverse Developments....................................................36
                  -------------------------------------------
         (l)      Environmental Matters..........................................................................37
                  ---------------------
Section 7.02.  Negative Covenants................................................................................37
               ------------------
         (a)      Mergers, Consolidations and Sales of Assets....................................................37
                  -------------------------------------------
         (b)      Liens..........................................................................................38
                  -----
         (c)      Indebtedness...................................................................................38
                  ------------
         (d)      Contingent Liabilities.........................................................................38
                  ----------------------
         (e)      Loans and Investments..........................................................................39
                  ---------------------
         (f)      Capital Expenditures...........................................................................40
                  --------------------
         (g)      Redemptions, etc...............................................................................41
                  -----------------
         (h)      Dividends and Purchase of Stock................................................................41
                  -------------------------------
         (i)      Stock of Subsidiaries..........................................................................42
                  ---------------------
         (j)      Distributions by Subsidiaries..................................................................42
                  -----------------------------
         (k)      Related Agreements.............................................................................42
                  ------------------
         (l)      Sale and Leaseback Transactions................................................................43
                  -------------------------------
         (m)      Transactions with Affiliates and Related Persons...............................................43
                  ------------------------------------------------
         (n)      Asset Dispositions.............................................................................43
                  ------------------
         (o)      Securities Offerings...........................................................................43
                  --------------------
         (p)      Surplus Cashflows..............................................................................44
                  -----------------
Section 7.03  Financial Covenants................................................................................44
              -------------------
         (a)      Shareholders' Equity...........................................................................44
                  --------------------
         (b)      Current Ratio..................................................................................44
                  -------------
         (c)      Minimum Operating Income.......................................................................44
                  ------------------------
         (d)      Ophthalmology Expense..........................................................................44
                  ---------------------
                          ARTICLE VIIIEvents of Default
Section 8.01.  Events of Default.................................................................................45
               -----------------
         (a)      ...............................................................................................45
         (b)      ...............................................................................................45
         (c)      ...............................................................................................45
         (d)      ...............................................................................................45
         (e)      ...............................................................................................45
         (f)      ...............................................................................................45
         (g)      ...............................................................................................45
         (h)      ...............................................................................................46
         (i)      ...............................................................................................46
         (j)      ...............................................................................................46
         (k)      ...............................................................................................47
         (l)      ...............................................................................................47
Section 8.02.  Assignments.......................................................................................47
         (b)      ...............................................................................................48
Section 8.03.  Certain Pledges...................................................................................48
                             ARTICLE IXMiscellaneous
SECTION 9.01.  APPLICABLE LAW....................................................................................48
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SECTION 9.02.  WAIVER OF JURY....................................................................................49
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Section 9.03.  Jurisdiction and Venue; Service of Process........................................................49
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Section 9.04.  Set-off...........................................................................................49
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Section 9.05.  Amendments and Waivers............................................................................50
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Section 9.06.  Cumulative Rights; No Waiver......................................................................50
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Section 9.07.  Notices...........................................................................................50
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Section 9.08.  Certain Acknowledgments...........................................................................52
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Section 9.09.  Separability......................................................................................52
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Section 9.10.  Parties in Interest...............................................................................52
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Section 9.11.  Execution in Counterparts.........................................................................53
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                                                      SCHEDULES
Schedule 5.01(a)           Subsidiaries of the Borrower
                                                      EXHIBITS
Exhibit A                   Form of Borrowing Request
Exhibit B                   Form of Note
Exhibit C                   Form of Opinion of Counsel for the Borrower to be Delivered Upon Payment of Shares
Exhibit D                   Form of Opinion of Counsel for the Borrower to be Delivered at the Effective Time
Exhibit E                   Form of Compliance Certificate
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*        See Section 2.02 the Credit Agreement.
**       See the definition of "Borrowing Date" in Section 1.01(c) of the Credit Agreement.
***      See Section 2.01 and the definition of "Maximum Quarterly Amount" in Section 1.01(c) of the Credit Agreement.
****     See the definition of "Warrant Number" in Section 1.01(c) of the Credit Agreement.
*        Insert only in Compliance Certificates accompanying quarterly financial statements delivered pursuant to Section 7.01(a) of
         the Credit Agreement.