0000950123-10-018222 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisk denote omissions. FIRST AMENDMENT TO LICENSE AND COLLABORATION AGREEMENT

License and Collaboration Agreement • February 26th, 2010 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations

• Contract Type
  License and Collaboration Agreement
• Filed
  February 26th, 2010
• Company
  Alnylam Pharmaceuticals, Inc.
• Industry
  Pharmaceutical preparations

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Asterisks denote omissions. COLLABORATION AGREEMENT BY AND AMONG ALNYLAM PHARMACEUTICALS, INC. AND F. HOFFMANN-LA ROCHE LTD AND HOFFMANN- LA ROCHE INC.

Collaboration Agreement • February 26th, 2010 • Alnylam Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

• Contract Type
  Collaboration Agreement
• Filed
  February 26th, 2010
• Company
  Alnylam Pharmaceuticals, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  Delaware

This Collaboration Agreement (this “Agreement”) is entered into as of the 29th day of October 2009 (the “Effective Date”), by and among F. Hoffmann-La Roche Ltd, a Swiss corporation (“Roche Basel”), having a place of business at Grenzacherstrasse 124, CH-4070 Basel, Switzerland, and Hoffmann-La Roche Inc., a New Jersey corporation (“Roche Nutley”), having a place of business at 340 Kingsland Street, Nutley, New Jersey 07110, U.S.A. (Roche Basel and Roche Nutley, collectively, “Roche”), and Alnylam Pharmaceuticals, Inc., a Delaware corporation, having a place of business at 300 Third Street, 3rd Floor, Cambridge, Massachusetts 02142, U.S.A. (“Alnylam”).