0001144204-07-024008 Sample Contracts

LICENSE AGREEMENT by and between INSPIRE PHARMACEUTICALS, INC. and INSITE VISION INCORPORATED Dated as of February 15, 2007
License Agreement • May 10th, 2007 • Insite Vision Inc • Pharmaceutical preparations • New York

This LICENSE AGREEMENT (this “Agreement”), dated as of February 15, 2007 (the “Effective Date”), is made by and between Inspire Pharmaceuticals, Inc., a Delaware corporation having its principal office at 4222 Emperor Blvd., Suite 200, Durham, NC 27703 (“Inspire”), and InSite Vision Incorporated, a Delaware corporation having its principal office at 965 Atlantic Ave., Alameda, CA 94501 (“InSite”). Inspire and InSite are each sometimes referred to individually as a “Party” and together as the “Parties.”

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SUPPLY AGREEMENT FOR ACTIVE PHARMACEUTICAL INGREDIENT by and between INSPIRE PHARMACEUTICALS, INC. and INSITE VISION INCORPORATED Dated as of February 15, 2007
Supply Agreement • May 10th, 2007 • Insite Vision Inc • Pharmaceutical preparations • New York

This SUPPLY AGREEMENT (this “Agreement”) is made and entered into as of the 15th day of February, 2007 (the “Effective Date”) by and between INSPIRE PHARMACEUTICALS, INC., a Delaware corporation having its principal office at 4222 Emperor Boulevard, Suite 200, Durham, North Carolina 27703 (the “Purchaser”), and InSite Vision Incorporated, a Delaware corporation having its principal office at 965 Atlantic Avenue, Alameda, California 94501 (the “Supplier”). The Purchaser and the Supplier are sometimes referred to herein individually as a “Party” and collectively as “Parties.”

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TRADEMARK LICENSE AGREEMENT
Trademark License Agreement • May 10th, 2007 • Insite Vision Inc • Pharmaceutical preparations • New York

This TRADEMARK LICENSE AGREEMENT (this “Agreement”), dated as of February 15, 2007 (the “Effective Date”), is made by and between Inspire Pharmaceuticals, Inc., a Delaware corporation having its principal office at 4222 Emperor Blvd., Suite 200, Durham, NC 27703 (“Inspire”), and InSite Vision Incorporated, a Delaware corporation having its principal office at 965 Atlantic Ave., Alameda, CA 94501 (“InSite”). Inspire and InSite are each sometimes referred to individually as a “Party” and together as the “Parties.”

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EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • May 10th, 2007 • Insite Vision Inc • Pharmaceutical preparations • New York

This Exclusive License Agreement (the “Agreement”), dated as of 15th day of February 2007 (the “Effective Date”), is entered into by and between Pfizer Inc., a Delaware corporation and Pfizer Products, Inc., a Connecticut corporation (hereinafter collectively defined as “Licensor”), and InSite Vision Incorporated, a Delaware corporation (“Licensee”).

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CHANGE IN CONTROL AGREEMENT
Change in Control Agreement • May 10th, 2007 • Insite Vision Inc • Pharmaceutical preparations • California

THIS CHANGE IN CONTROL AGREEMENT (this “Agreement”) is made and entered into as of ___________ __, 2007 (the “Effective Date”) by and between INSITE VISION INCORPORATED, a Delaware corporation (together with its successors and assigns, the “Company”), and S. Kumar Chandrasekaran, Ph.D. (the “Executive”) (collectively, Company and Executive are referred to herein as the “Parties”).

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