0001193125-04-166817 Sample Contracts

THIRD AMENDMENT TO THE SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 5th, 2004 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances) • New York

THIS THIRD AMENDMENT TO THE SECURITIES PURCHASE AGREEMENT, dated as of September 30, 2004 (the “Third Amendment”), by and between SENETEK PLC, a corporation organized under the laws of England (the “Company”) and the holders of warrants and notes set forth on Schedule 1 hereto (the “Purchasers” or the “Holders”). Capitalized terms used but not otherwise defined herein shall have the meaning set forth in the Purchase Agreement.