0001193125-25-178022 Sample Contracts

SUMMIT THERAPEUTICS INC. AMENDMENT NO. 1 TO DISTRIBUTION AGREEMENT
Distribution Agreement • August 11th, 2025 • Summit Therapeutics Inc. • Pharmaceutical preparations • New York
DISTRIBUTION AGREEMENT
Distribution Agreement • August 11th, 2025 • Summit Therapeutics Inc. • Pharmaceutical preparations • New York

Summit Therapeutics Inc., a Delaware corporation (the “Company”), confirms its agreement with J.P. Morgan Securities LLC, as agent and/or principal under any Terms Agreement (as defined in Section 1(a) below) (“you” or the “Agent”), with respect to the issuance and sale from time to time by the Company, in the manner and subject to the terms and conditions described below in this Distribution Agreement (this “Agreement”), of Common Stock, $0.01 par value per share (the “Common Stock”), of the Company having an aggregate Gross Sales Price (as defined in Section 2(b) below) of up to $90,000,000 (the “Maximum Amount”) on the terms set forth in Section 1 of this Agreement. Such shares are hereinafter collectively referred to as the “Shares” and are described in the Prospectus referred to below.