0001193125-25-232562 Sample Contracts

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 7th, 2025 • Jade Biosciences, Inc. • Pharmaceutical preparations • Nevada

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of October 6, 2025, by and among Jade Biosciences, Inc., a Nevada corporation (the “Company”), and each of the Persons listed on Exhibit A attached to this Agreement (each, an “Investor” and together, the “Investors”).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • October 7th, 2025 • Jade Biosciences, Inc. • Pharmaceutical preparations

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of October 6, 2025, is entered into by and among Jade Biosciences, Inc., a Nevada corporation (the “Company”), and the several investors signatory hereto (individually as an “Investor” and collectively together with their respective permitted assigns, the “Investors”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Securities Purchase Agreement by and among the parties hereto, dated as of the date hereof (as amended, restated, supplemented or otherwise modified from time to time, the “Purchase Agreement”).

FORM OF PRE-FUNDED WARRANT TO PURCHASE COMMON STOCK
Warrant Agreement • October 7th, 2025 • Jade Biosciences, Inc. • Pharmaceutical preparations • New York

This Warrant is one of a series of similar warrants issued pursuant to that certain Securities Purchase Agreement, dated October 6, 2025, by and among the Company and the Investors identified therein (the “Purchase Agreement”).