Mechanism of Action definition

Mechanism of Action means, with respect to a target, modulation of such target by a compound via a given mechanism of action (whether inhibition or activation).
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Mechanism of Action means Orexin-1 receptor antagonism,
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Mechanism of Action or “MOA” means each of the DCM1 MOA, the HCM1 MOA and the HCM2 MOA.
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Examples of Mechanism of Action in a sentence

  • Following the Parties’ agreement on a Research Plan with respect to such Target via the applicable Mechanism of Action in accordance with Section 2.6.5 (Research Plans for Replacement Target MoAs), the Parties will promptly initiate Research Activities with respect to such Target via the applicable Mechanism of Action in accordance with Section 2.1 (Research Programs).

  • Morphic will not perform any activities with respect to a Research Program or any Target (including the Exploitation of any Compound that modulates such Target via the applicable Mechanism of Action) that are not set forth in the applicable Research Plan for the applicable Research Program.

  • Vancomycin C-Terminus Guanidine Modifications and Further Insights into an Added Mechanism of Action Imparted by a Peripheral Structural Modification.

  • C1-CBP-vancomycin: Impact of a Vancomycin C-Terminus Trimethylammonium Cation on Pharmacological Properties and Insights into Its Newly Introduced Mechanism of Action.

  • See "--Factors Affecting Our Operating Results-- There Is No Certainty of Positive Clinical Trial Outcomes." Mechanism of Action.


More Definitions of Mechanism of Action

Mechanism of Action means, for Selinexor, Verdinexor, or Eltanexor, the binding to the nuclear export protein, Exportin 1, or XPO1, causing inhibition of the activity of XPO1 or otherwise reducing the nuclear export of XPO1’s cargo proteins, and for KPT-9274, it means causing dual inhibition of NAMPT and PAK4.
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Mechanism of Action or “MoA” means the results on the [********] criteria set forth on Schedule 1.82 (based on the corresponding measurement set forth on Schedule 1.82) at the applicable Protein Target Profile, taking each such criterion into account. A compound has “substantially the same” Mechanism of Action or MoA as another compound if (i) the two compounds have the same Protein Target Profile and the results of the first compound and the second compound on each of such measurements at [********] the NNR Subtypes included in the applicable Protein Target Profile are [********] for such measurement shown on Schedule 1.82 (provided that, where there are alternative measurements (or assays used to make such measurement) that may be applicable for a particular criterion (i.e., [********]) determination of whether any compound has substantially the same Mechanism of Action as another compound shall be made using the same measurement(s) (or assay(s)) as was used by Targacept to make such measurement with respect to such first compound) and (ii) neither compound has activity in any material respect [********] at which the other compound does not have activity in any material respect.
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Mechanism of Action. The epipodophyllotoxins exert phase specific spindle poison activity with metaphase arrest, but in contrast to the vinca-alkaloids, have an additional activity of inhibiting cells from entering mitosis. Suppression of tritiated thymidine, uridine, and leucine incorporation in human cells in tissue culture suggests effects against DNA, RNA, and protein synthesis.
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Mechanism of Action means that the relevant Third Party FOB binds to the same antigen as the Product.
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Mechanism of Action means a specific mechanism that contributes to the efficacy of a Compound.
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Mechanism of Action shall have the meaning ascribed to it in Section 6.1.1 hereof.
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Mechanism of Action means the specific biological and/or chemical interaction(s) through which a drug substance produces its pharmacological effect(s).
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