Budget and Timelines Sample Clauses

Budget and Timelines. ​ Investigation into Ampion-mediated inhibition of the inflammasome will include optimizing culture and treatment conditions of inflammatory cell types including several distinct cell types contribute to chronic inflammation in the knee, such as chondrocytes, synoviocytes, and immune cells. The work will likely follow a similar budget and timeline when compared to the chondrogenesis project. ​ ​ ​

Budget and Timelines. ​ ​ The methods listed above will be evaluated, in concert, to determine the most appropriate model for in-house use. All appropriate positive and negative controls will be identified and tested in addition to saline and drug treatment groups in early development to expedite the generation of preliminary data. Due to the extended time needed for these culturing techniques, this phase will take approximately 3-4 months to determine the approach. An additional 3-4 months will be required to gather replicates for statistical analysis. ​ Stem cell methodologies are provided as an alternative approach to the chondrocyte culture techniques mentioned above. If the initial chondrocyte culturing experiments do not appear to meet investigational requirements, the budget listed above can be pivoted to BMMSC reagents with no foreseen adjustment. ​ The synoviocyte proposal is highly dependent on the success of the chondrocyte model characterization and will be performed as necessary. ​ ​ ​

Budget and Timelines. 5.1 The contract will be awarded for a period of four years, 2020 – 2024 including a 3- month inception phase at the start. The budget is up to £6,000,000 (inclusive of any applicable taxes). 5.3 FCDO may, in agreement with the Supplier, extend the contract beyond 4 years for up to an additional 2 years and/or up to an additional £3,000,000 (inclusive of any applicable taxes), subject to programme and supplier performance, the need and situation on the ground, and value for money.