Mutations Sample Clauses

Mutations. If and to the extent Mutations of the SARS-CoV-2 virus arise [***]

Mutations. The conserved residues in the NxxxNPxxY motif also seem to be very sensitive to mutation considering the behavior of the point mutants and our previous random mutagenesis results that did not identify any gain-of-function mutant by mutations in this region (Beukers et al., 2004a). Typically, homology models are based on the alignment of entire helical regions between rhodopsin and receptors with unknown structure. Loop areas are normally ignored or modeled based on databases of loop conformations. These models have been used to design experiments as well as to explain experimental data. We used the structure of bovine rhodopsin as a template to build a homology model of the human adenosine A2B receptor to guide the selection of amino acids for site-directed mutagenesis. The recent disclosure of the 3-D structure of the human β2 adrenergic receptor enabled us to make a homology model based on this template too. A structural overlay was made to investigate the differences between the two models with respect to the regions of interest in this study. The following differences were identified, i) the angle between helix 7 and 8, ii) the number of residues to link helix 7 and 8, iii) the location and side chain orientation of residues in the NxxxNPxxY motif, and iv) the nature of the salt bridge between helix 1 and helix 7. These findings suggest that care should be taken to interpret experimental data based on a single model. Cherezov already pointed to the shortcoming of homology models generated from a single structural template, as the structural divergence between two receptors would be quite difficult to predict accurately using only one receptor as a template (Cherezov et al., 2007). His conclusion was drawn from a similarity comparison between the β2 adrenergic receptor crystal structure and homology models of the β2 adrenergic receptor based on the structure of bovine rhodopsin and which were substantiated with biochemical data (Bissantz et al., 2003; Furse and Lybrand, 2003; Gouldson et al., 2004). Since the latter models used bovine rhodopsin as a template, they are more similar to the rhodopsin rather than the real β2 adrenergic receptor structure. Although all class A receptors share a similar backbone consisting of 7 transmembrane domains linked by extracellular and intracellular loops, each receptor has its own characteristics. Slight differences in the structure may result in significant differences in intramolecular interactions. For example, in...

Mutations a) If Licensee finds, induces, observes, or discovers an Essentially Derived Variety (hereinafter “E.D.V.”) such as any mutation or sport in any Licensed Product or Finished Plant, then Licensee shall report the E.D.V. immediately to the Licensor/Agent by registered letter. The letter shall include, at a minimum, the name for the Licensed Product or Finished Plant from which the E.D.V. has been induced, observed or discovered, and a brief description of the E.D.V. b) At the written request of the Licensor/Agent the Licensee shall immediately provide the Licensor/Agent with sufficient material of the E.D.V. c) Licensor or the third party owner of the Licensed Product (hereinafter "Third Party") if the Licensed Product is the subject of a third party license agreement, shall own all right, title and interest in the E.D.V. Licensee hereby assigns all right, title, and interest in the E.D.V. to Licensor or Third Party, if applicable. Licensee agrees to cooperate with Licensor or Third Party by executing any documents Licensor

Mutations. Licensee shall promptly notify NNII of any mutation that appears in any Licensed Cultivar nursery stock in Licensee’s possession or under Licensee’s control. Licensee acknowledges that the ownership of, and title to, any such mutation is retained by WSU. NNII and its representatives shall have unlimited access to Licensee’s premises during normal business hours, upon reasonable notice, to inspect all trees, budwood, and scion wood of the Licensed Cultivar and to remove all mutated plant material.

Mutations. 1. The seller is entitled to make technically necessary changes to the sold goods without prior knowledge or knowledge of the purchaser. 2. Deviations of 10% of the ordered amount and in case of products that have been manufactured especially for the purchaser, deviations of 20%, are allowed. The seller will accordingly invoice the delivered amount to the purchaser. 3. Every delivery of a part of an ordered amount is considered as a separate transaction. The fulfillment or non-fulfillment of the delivery of a part of an ordered amount has no influence on the other parts of the order.