Common use of Statistical Analyses Clause in Contracts

Statistical Analyses. During the sample size calculations, we anticipated a normal distribution of the arthritis scores. Nevertheless, upon visual inspection of the data, the standards required for parametric statistical testing were not met. Therefore, the non-parametric ▇▇▇▇-▇▇▇▇▇▇▇ U test was applied for all statistical analyses to determine significance of observed differences. To determine whether TP administration had an effect on Pred treatment in the CAIA model and side effects of Pred, significant differences were only determined between the Veh-treated group and the Pred-treated group, with or without TP. Important to note is that, with this study, we want to find out whether analgesia can be applied and would provide us with a similar extent in parameters required to evaluate whether alternatives to Pred are superior. Therefore, no analysis has been performed between the non-TP and TP-treated groups, except when the effect of TP on GR target-gene expression was evaluated. All statistical analyses were performed using GraphPad Prism 9. Notion should be taken when interpreting the p-values since the Veh + TP-treated group included only 3 mice and therefore comparisons to this group cannot reach statistical significance.