Indenture and Guarantee Agreement Sample Contracts

CT CORPORATION September 22,2005 Damion Jackson Davis Polk & Wardwell 99 Gresham Street London, United Kingdom EC2V 7NG
Indenture and Guarantee Agreement • November 25th, 2005 • Shire PLC • Pharmaceutical preparations

RE: Designation to receive service of process in connection with (i) Amended and Restated Indenture dated September 23, 2005 (U.S. $400,000,000) between Shire Finance Limited Issuer, Shire Pharmaceuticals Group PLC and Shire PLC Guarantors to The Bank of New York Trustee; (ii) Amended and Restated Preference Shares Guarantee Agreement dated September 23, 2005 between Shire Pharmaceuticals Group PLC Guarantor, Shire PLC Guarantor, and The Bank of New York Guarantee Trustee.

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