Proof of Principle definition

Proof of Principle means that a Candidate Selection Compound has met the PoP Criteria as determined by the JSC pursuant to Section 3.5.
View Source
Proof of Principle means: [***]
View Source
Proof of Principle means that ATLAS Screening is deemed successful with respect to the Initial Target Proteins because either: [***]
View Source

Examples of Proof of Principle in a sentence

  • The Initial Development Period will terminate pursuant to this section if Committee Action determines that, due solely to technical reasons of the pharmaceutical sciences growing from results obtained in the course of the Proof of Principle Studies, that it will not be practicable to develop any Initial Designated Product.

  • In all cases where GSK exercises its Proof of Principle Option, GSK shall be designated the manufacturer for all products that are the subject of such Proof of Principle Option, unless otherwise agreed by GSK and only to the extent that CRXA can grant such rights.

  • Other than the costs of the Proof of Principle Studies or the Patent Review, and the incidental costs of the Project Contacts associated with the development of such a project plan, neither party will devote substantial resources or make substantial expenditures in connection with the Initial Development Period prior to the approval of such project plan by Committee Action.

  • Proof of Principle: Decreased selectivity toward mitochondrial versus cytoplasmic ribosome confers decreased toxicity of compounds disclosed and/or claimed in the TRDF Patent Rights (“Disclosed Compounds”).

  • Dicerna shall also be responsible for the cost of all activities through Proof of Principle for the initial Non-Hepatocyte Neurodegeneration/Pain Targets.

  • Such payment shall not be due for any such Products Directed To a Selected Target after the first Product Directed To that Selected Target achieves Proof of Principle nor, for avoidance of doubt, will it be due for any Selected Target that becomes a Discontinued Target prior to the payment of such amounts.

  • During such ****** period, the parties will conduct the Proof of Principle Studies, and during the *************** of such period, Endo shall conduct the Patent Review (and PPG shall cooperate reasonably therewith).

  • The terms of any license granted to GSK upon exercise of the Proof of Principle Option (the "Proof of Principle Option License") shall be in accordance with the terms set forth in this Section 3.1.2 and the terms set forth on Exhibit 3.

  • Such Research Plan shall also include activities beyond Proof of Principle until IND Approval and the JSC shall determine the allocation of responsibilities between Dicerna and Lilly for each Product, but such activities shall be at Lilly’s cost, and in no case shall Dicerna’s responsibilities exceed those for the Lead Product unless agreed upon by the Parties.

  • Proof of Principle shall be established for a Secondary Field when Durect has received, for a Product Candidate in such Secondary Field, [* * *] Proof of Principle will be positively established for at least [* * *] Secondary Field in Contract Year 3, for [* * *] Secondary Field by the end of Contract Year 4, and for the [* * *] by the end of Contract Year 5; for each such year in which Durect has not met the foregoing Proof of Principle requirements, ALZA will have the right to [* * *].


More Definitions of Proof of Principle

Proof of Principle means that a therapeutically relevant ***** is demonstrated for a Small Molecule or Large Molecule at a dose that can be reasonably translated to a therapeutic dose in man and which does not cause any serious toxic effects in the chosen animal model.
View Source

Related to Proof of Principle

  • Point of Privilege means a matter that a member considers to question their integrity and/or the integrity of the Council.

  • Proof of Interest means a proof of Interest Filed against any of the Debtors in the Chapter 11 Cases.

  • Statement of Preferences means the Issuer's Statement of Preferences of Variable Rate Demand Preferred Shares, dated as of March 31, 2021, as amended from time to time in accordance with the provisions thereof.

  • Nonpayment of premium means the failure or inability of the named insured to discharge any obligation in connection with the payment of premium on a policy of insurance subject to this section, whether the payments are payable directly to the insurer or its agent or indirectly payable under a premium finance plan or extension of credit. [PL 1985, c. 671, §1 (NEW).]

  • proof of identity means the means by which Identity is verified. Proof of Identity may include answers to security questions or the use of a passphrase and may include the use of fingerprints, voiceprints, facial recognition, or other biometric means.